Puma concolor (puma): 112859389 Help Entry 112859389         CDS       T08890                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism pcoo  Puma concolor (puma) Pathway pcoo00230   Purine metabolism pcoo01100   Metabolic pathways pcoo01522   Endocrine resistance pcoo04015   Rap1 signaling pathway pcoo04020   Calcium signaling pathway pcoo04022   cGMP-PKG signaling pathway pcoo04024   cAMP signaling pathway pcoo04062   Chemokine signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04081   Hormone signaling pcoo04082   Neuroactive ligand signaling pcoo04114   Oocyte meiosis pcoo04211   Longevity regulating pathway pcoo04213   Longevity regulating pathway - multiple species pcoo04261   Adrenergic signaling in cardiomyocytes pcoo04270   Vascular smooth muscle contraction pcoo04371   Apelin signaling pathway pcoo04540   Gap junction pcoo04611   Platelet activation pcoo04713   Circadian entrainment pcoo04714   Thermogenesis pcoo04720   Long-term potentiation pcoo04723   Retrograde endocannabinoid signaling pcoo04724   Glutamatergic synapse pcoo04725   Cholinergic synapse pcoo04727   GABAergic synapse pcoo04742   Taste transduction pcoo04750   Inflammatory mediator regulation of TRP channels pcoo04911   Insulin secretion pcoo04912   GnRH signaling pathway pcoo04913   Ovarian steroidogenesis pcoo04914   Progesterone-mediated oocyte maturation pcoo04915   Estrogen signaling pathway pcoo04916   Melanogenesis pcoo04918   Thyroid hormone synthesis pcoo04921   Oxytocin signaling pathway pcoo04923   Regulation of lipolysis in adipocytes pcoo04925   Aldosterone synthesis and secretion pcoo04926   Relaxin signaling pathway pcoo04927   Cortisol synthesis and secretion pcoo04928   Parathyroid hormone synthesis, secretion and action pcoo04934   Cushing syndrome pcoo04935   Growth hormone synthesis, secretion and action pcoo04970   Salivary secretion pcoo04971   Gastric acid secretion pcoo04972   Pancreatic secretion pcoo04976   Bile secretion pcoo05032   Morphine addiction pcoo05163   Human cytomegalovirus infection pcoo05166   Human T-cell leukemia virus 1 infection pcoo05200   Pathways in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     112859389 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     112859389 (ADCY8)    04371 Apelin signaling pathway     112859389 (ADCY8)    04020 Calcium signaling pathway     112859389 (ADCY8)    04072 Phospholipase D signaling pathway     112859389 (ADCY8)    04024 cAMP signaling pathway     112859389 (ADCY8)    04022 cGMP-PKG signaling pathway     112859389 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     112859389 (ADCY8)    04081 Hormone signaling     112859389 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     112859389 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     112859389 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     112859389 (ADCY8)    04062 Chemokine signaling pathway     112859389 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     112859389 (ADCY8)    04923 Regulation of lipolysis in adipocytes     112859389 (ADCY8)    04912 GnRH signaling pathway     112859389 (ADCY8)    04913 Ovarian steroidogenesis     112859389 (ADCY8)    04915 Estrogen signaling pathway     112859389 (ADCY8)    04914 Progesterone-mediated oocyte maturation     112859389 (ADCY8)    04921 Oxytocin signaling pathway     112859389 (ADCY8)    04926 Relaxin signaling pathway     112859389 (ADCY8)    04935 Growth hormone synthesis, secretion and action     112859389 (ADCY8)    04918 Thyroid hormone synthesis     112859389 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     112859389 (ADCY8)    04916 Melanogenesis     112859389 (ADCY8)    04925 Aldosterone synthesis and secretion     112859389 (ADCY8)    04927 Cortisol synthesis and secretion     112859389 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     112859389 (ADCY8)    04270 Vascular smooth muscle contraction     112859389 (ADCY8)   09154 Digestive system    04970 Salivary secretion     112859389 (ADCY8)    04971 Gastric acid secretion     112859389 (ADCY8)    04972 Pancreatic secretion     112859389 (ADCY8)    04976 Bile secretion     112859389 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     112859389 (ADCY8)    04727 GABAergic synapse     112859389 (ADCY8)    04725 Cholinergic synapse     112859389 (ADCY8)    04720 Long-term potentiation     112859389 (ADCY8)    04723 Retrograde endocannabinoid signaling     112859389 (ADCY8)   09157 Sensory system    04742 Taste transduction     112859389 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     112859389 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     112859389 (ADCY8)    04213 Longevity regulating pathway - multiple species     112859389 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     112859389 (ADCY8)    04714 Thermogenesis     112859389 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112859389 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     112859389 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112859389 (ADCY8)    05163 Human cytomegalovirus infection     112859389 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     112859389 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     112859389 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112859389 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     112859389 (ADCY8) Enzymes [BR:pcoo01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      112859389 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD AGTRAP Motif Other DBs NCBI-GeneID:  112859389 NCBI-ProteinID:  XP_025778382 UniProt:  A0A6P6HRG5 LinkDB All DBs Position Unknown AA seq 1252 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG SGSRGSGKASDAAGGGPNHHAAQLSGDSALPLYSLGPGERAHSSGGTKVFPERSGSGSGS GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVVVQVAIPRLAVISINQVMAQAVLFMCMNTAGTFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLTLPE DIVKESVSFSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSCPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGDFFVQTTG ISILYSPVSLLFFLSRARQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKQLLNENINTGIIKGHYNRRTLLTPSGPEPGAQAEGADKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctgagcggcagcgaggaactctacaccattcacccg acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgaggcacatcaccgagcagcgcttcattcacgggcaccggggcagcggcggcggc agcgggagtagaggctccggcaaagcctcggacgctgcaggcggcggccccaaccaccac gcggcgcagctgtccggggactcggcgctgcccctctactcgctgggccccggggagaga gcgcacagctccggtggcaccaaagtcttcccggaacgcagcgggagcggcagcggcagc ggcagcgggggcgggggcgatctgggcttcctgcacctggactgcgccccgagcaactcg gatttcttcctcaatgggggctatagctaccgaggggtcattttccccactctgcgcaac tccttcaagtccagggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggtcctc cacctgagcctggcctcggcccccatggacccgctcaagggcattctcctgggcttcttc actggcatcgaggtggtgatctgcgcgctcgtggtggtcaggaaggacaccacctcgcac acgtacctgcagtacagcggcgtggtcacttgggtggccatgaccacccagatcttggca gcaggcctcggctacgggcttctgggtgatggcatcggctacgtcctcttcacgctgttc gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctgggcacc tcgctgctgcaggtggtcgtgcaggtggccattccccggctggcggtcatctccatcaac caggtgatggcccaggcagtgctgttcatgtgtatgaacacggctggaaccttcatcagt tacctgtcagaccgggcccagcgccaagccttcctggagacacggaggtgtgtggaggcc aggctgcgcctggagacggaaaaccaaagacaggagcggctcgtgctgtctgtgcttccc cggtttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacctgcag caccaattccatcggatctacatccaccgctatgagaatgtcagtattcttttcgcagat gtgaaaggatttaccaacctctccacaaccttgtctgcccaggagctggtcaggatgctc aacgagctctttgccagatttgatcgactggcccacgagcatcactgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttccagagccccgccaggaccacgcc cactgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcaagg acgaagcatgatgttgacatgcggatcggaatccactcgggctcggtgctgtgtggcgtg ttgggtctgagaaagtggcagtttgatgtctggtcttgggatgtggacatcgcgaacaaa cttgagtctggaggaatccctgggaggattcacatttccaaagccacgctggactgcctc aacggtgactataatgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag cataacatagagacctatttgattaagcagcctgaggagagtctactgacgttgcccgaa gacattgtcaaggagtcggtgagcttctcagacaggagaaacagtggggcgacattcaca gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggacgaagtattcaagtcaaacttggtctgtgca tttatcgttctcctatttatcacggcaatccaaagtttgcttccttcttcaagggtgatg ccaatggccatccagttttccatcctgatcatgctgcactcggctctggtcctcatcacc acggcagaagattacaagtgtttgcctctggtcctccggaaaacttgctgttggattaac gagacctacttagcccggaacgtcatcatctttgcatccatcttgattaacttcctgggc gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact ttcaattcctcagctgtgtttacagatatctgctcctgcccagagtacttcgtcttcact ggggtgttggccatggtgacctgtgcggttttcctccgcctgaactctgtcctgaagctg gccgtgctgctgattatgattgccatctacgcgctgctgactgagaccgtctacgcgggc ctcttcctgcgctatgacaacctaaaccacagcggagatttctttgtgcaaaccacgggg ataagtatattatactcacctgtttcccttctcttctttctctctcgtgcccggcagctg gagtacacggcccgcctggacttcctttggcgagtgcaggccaaagaggagatcaacgag atgaaggagctcagggagcacaatgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaacgaggagctgtattcccaatcttatgat gccgttggggtgatgttcgcctccatcccggggtttgcagacttttactctcagactgag atgaataaccagggagtagaatgcctgcgtctgttgaatgagatcattgctgacttcgat gagctgctaggcgaagaccggtttcaggacattgaaaagattaagaccatcggcagcacc tacatggccgtgtcgggcctgtcacctgaaaaacagcaatgtgaagacaagtggggacat ctgtgtgccctggccgacttctccctcgccctgaccgaaagcatacaggagatcaacaaa cattccttcaacaatttcgaactccggattggcatcagtcacggctccgtggtagctggg gtcatcggcgctaagaagccacagtatgacatttggggcaaaactgtgaacctggcgagc cgaatggacagcacaggggtcagcggcaggatccaagtccccgaggagacctatctcatc ctgaaggaccagggctttgccttcgactaccgaggggagatctacgtgaagggcatcagt gagcaggaagggaaaatcaaaacgtactttctcctgggaagagtccaacccaacccgttc atcctgcccccgagaagactgcccgggcagtactcactggccgcagtcgtcctgggcctt gtccagtccctcaacaggcaaaggcagaagcagttgctcaatgagaacatcaacacaggg atcatcaagggccactacaaccggcggactttgctgacacccagtgggccagagcccggg gcccaggctgagggcgccgacaagtccgatttgccatga

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