Puma concolor (puma): 112860207 Help Entry 112860207         CDS       T08890                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism pcoo  Puma concolor (puma) Pathway pcoo00230   Purine metabolism pcoo01100   Metabolic pathways pcoo01522   Endocrine resistance pcoo04015   Rap1 signaling pathway pcoo04020   Calcium signaling pathway pcoo04022   cGMP-PKG signaling pathway pcoo04024   cAMP signaling pathway pcoo04062   Chemokine signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04081   Hormone signaling pcoo04082   Neuroactive ligand signaling pcoo04114   Oocyte meiosis pcoo04211   Longevity regulating pathway pcoo04213   Longevity regulating pathway - multiple species pcoo04261   Adrenergic signaling in cardiomyocytes pcoo04270   Vascular smooth muscle contraction pcoo04371   Apelin signaling pathway pcoo04540   Gap junction pcoo04611   Platelet activation pcoo04713   Circadian entrainment pcoo04714   Thermogenesis pcoo04723   Retrograde endocannabinoid signaling pcoo04724   Glutamatergic synapse pcoo04725   Cholinergic synapse pcoo04727   GABAergic synapse pcoo04750   Inflammatory mediator regulation of TRP channels pcoo04911   Insulin secretion pcoo04912   GnRH signaling pathway pcoo04913   Ovarian steroidogenesis pcoo04914   Progesterone-mediated oocyte maturation pcoo04915   Estrogen signaling pathway pcoo04916   Melanogenesis pcoo04918   Thyroid hormone synthesis pcoo04921   Oxytocin signaling pathway pcoo04922   Glucagon signaling pathway pcoo04923   Regulation of lipolysis in adipocytes pcoo04925   Aldosterone synthesis and secretion pcoo04926   Relaxin signaling pathway pcoo04927   Cortisol synthesis and secretion pcoo04928   Parathyroid hormone synthesis, secretion and action pcoo04934   Cushing syndrome pcoo04935   Growth hormone synthesis, secretion and action pcoo04970   Salivary secretion pcoo04971   Gastric acid secretion pcoo04972   Pancreatic secretion pcoo04976   Bile secretion pcoo05032   Morphine addiction pcoo05163   Human cytomegalovirus infection pcoo05166   Human T-cell leukemia virus 1 infection pcoo05200   Pathways in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     112860207 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     112860207 (ADCY2)    04371 Apelin signaling pathway     112860207 (ADCY2)    04020 Calcium signaling pathway     112860207 (ADCY2)    04072 Phospholipase D signaling pathway     112860207 (ADCY2)    04024 cAMP signaling pathway     112860207 (ADCY2)    04022 cGMP-PKG signaling pathway     112860207 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     112860207 (ADCY2)    04081 Hormone signaling     112860207 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     112860207 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     112860207 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     112860207 (ADCY2)    04062 Chemokine signaling pathway     112860207 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     112860207 (ADCY2)    04922 Glucagon signaling pathway     112860207 (ADCY2)    04923 Regulation of lipolysis in adipocytes     112860207 (ADCY2)    04912 GnRH signaling pathway     112860207 (ADCY2)    04913 Ovarian steroidogenesis     112860207 (ADCY2)    04915 Estrogen signaling pathway     112860207 (ADCY2)    04914 Progesterone-mediated oocyte maturation     112860207 (ADCY2)    04921 Oxytocin signaling pathway     112860207 (ADCY2)    04926 Relaxin signaling pathway     112860207 (ADCY2)    04935 Growth hormone synthesis, secretion and action     112860207 (ADCY2)    04918 Thyroid hormone synthesis     112860207 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     112860207 (ADCY2)    04916 Melanogenesis     112860207 (ADCY2)    04925 Aldosterone synthesis and secretion     112860207 (ADCY2)    04927 Cortisol synthesis and secretion     112860207 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     112860207 (ADCY2)    04270 Vascular smooth muscle contraction     112860207 (ADCY2)   09154 Digestive system    04970 Salivary secretion     112860207 (ADCY2)    04971 Gastric acid secretion     112860207 (ADCY2)    04972 Pancreatic secretion     112860207 (ADCY2)    04976 Bile secretion     112860207 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     112860207 (ADCY2)    04727 GABAergic synapse     112860207 (ADCY2)    04725 Cholinergic synapse     112860207 (ADCY2)    04723 Retrograde endocannabinoid signaling     112860207 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     112860207 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     112860207 (ADCY2)    04213 Longevity regulating pathway - multiple species     112860207 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     112860207 (ADCY2)    04714 Thermogenesis     112860207 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112860207 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     112860207 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112860207 (ADCY2)    05163 Human cytomegalovirus infection     112860207 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     112860207 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     112860207 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112860207 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     112860207 (ADCY2) Enzymes [BR:pcoo01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      112860207 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  112860207 NCBI-ProteinID:  XP_025779217 UniProt:  A0A6P6HTQ1 LinkDB All DBs Position Unknown AA seq 1038 aa AA seqDB search MPFMATFWQRFAKANACIEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLV IWMCLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTASSHTVV LSICLSATPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIK LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSIL YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLP NHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTL ANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRS PHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQH NFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYR ATALPAFKYYVTCACLILFCIFIVQILVLPKTSILGISFGAAFLLLACILFVCFAGQLLQ CSKKASASLLWLLKSSSIIADRPWPRVSLTVLTTAIILTMAVFNMFFLSDPEEAIPPTAN TSNTSLSALNNQAVILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMAALVGY NTILLHTHAHVLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFL WKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASI PDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSA VPSQEHTQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGA QKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKT YFVNTEMSRSLSQSNVAS NT seq 3117 nt NT seq  +upstreamnt  +downstreamnt atgccgttcatggccacgttctggcagcgctttgccaaagccaacgcctgcatcgaagtc gaagaccacgtggcgtttttaataacagtcccaactgccctggcgatcttctttgcgata ttcatcctcgtgtgcatcgagtccgtgtttaagaagctgctacgccttttctctttggtg atatggatgtgtctggtggccatggggtacttgttcatgtgctttggaggcaccgtctcc ccctgggaccaggtgtccttcttcctcttcattatcttcgtggtatacaccatgctcccc ttcaacatgcgagacgccatcatcgccagcgtgctcacggcctcctcccacaccgtcgtg ctgagcatctgcctgtccgcaacgcccggggccaaggagcacctggtctggcagatcctg gccaacgtgatcattttcatctgtgggaacctggcgggagcgtatcacaagcacctcatg gaacttgctctgcagcagacgtaccaggacacgtgcaattgcatcaagtcccggatcaag ctggaatttgaaaagcgtcagcaggagcgtctcctgctgtctctgttgccggctcacata gccatggagatgaaagctgagatcatccagaggctgcagggccccaaagccggccaaatg gaaaacacaaacaactttcacaacctgtatgttaagcgacacaccaatgtgagtatcctg tacgcagacatcgttggcttcacccggttggccagcgactgctccccaggagagctggtc cacatgctgaacgagctctttggaaagttcgatcagattgcaaaggagaatgagtgcatg agaataaaaattttgggagactgctactactgcgtgtccggactccccatatctctcccg aaccatgccaagaattgtgtgaaaatgggactggatatgtgtgaagccataaagaaagtg agggacgccaccggcgtggatatcaacatgcgcgttggagtgcattctgggaacgtcctc tgcggcgtgatcggtctgcagaagtggcagtatgacgtgtggtcacatgacgttacctta gccaatcacatggaagccggaggggttcctggacgtgttcacatttcttctgtcaccttg gaacacttgaatggcgcttataaagtggaggaaggagatggtgacatcagagacccatat ttaaaacagcacctggtgaaaacctactttgtaatcaaccccaagggggaacgacggagt cctcacctcttcagacctcgccacaccctcgatggagccaagatgagggcttccgtccgc atgacccggtacctggagtcctggggagcagccaagccctttgcacacctgcatcaccga gatagcatgaccacagagaacggcaagatcagcaccacggatgtgccaatgggtcagcat aattttcaaaaccgtaccttaagaaccaagtcgcaaaagaagagatttgaggaagaatta aatgaaaggatgattcaagcaattgatggaattaatgcacaaaagcagtggctcaagtct gaagacattcagagaatctcgctcctgttctacaataaaatactagaaaaagaataccga gccaccgcactgccagcgttcaagtattacgtgacctgcgcgtgtctcatattgttctgc atttttatcgtgcagattctggtattacccaagacgtccattctcgggatctcctttgga gccgcgtttctcttgcttgcctgtatccttttcgtctgctttgctggacagcttttgcaa tgcagcaagaaggcctccgcctctctcctgtggctgctgaagtcgtccagcatcatcgcg gaccggccctggccgcgggtctccctcacggtcctcaccaccgccatcatcctgaccatg gccgtgttcaacatgtttttcctgagcgacccagaggaagccattcctccgactgccaac acatcaaacacaagtctttctgccttaaacaatcaggcagtgattctgcgtgcacagaat ttgtttttcctcccgtactttatctacagctgcattctgggactgatttcctgctcggtt ttcctgcgggtgaattacgagttgaaaatgctgatcatgatggcggcgttggtaggctac aacaccatccttctccacactcacgcccatgtcctggacgactacagccaggtcttattt gagagaccaggcatttggaaagacctgaagaccatgggctcagtgtctctctttatattt ttcatcacactgcttgttctgggtagacagaatgaatattactgtaggttagacttcttg tggaagaacaagttcaaaaaagagcgggaggagatagaaaccatggagaacttgaaccgc gtgctgctggagaacgtgctgcccgcgcacgtggccgaacatttcctggcccggagcctg aagaacgaggagttgtaccaccagtcctacgactgtgtctgtgtcatgtttgcttccatt ccggatttcaaggaattctacacagaatcggatgtgaacaaggagggcttggaatgcctt cggctcctgaacgagatcatcgccgactttgatgatctgctgtccaagccgaaattcagt ggagttgaaaagattaagaccatcggcagcacgtatatggccgcgaccggtctgagcgcc gtgcccagccaggagcatacccaggagcccgagaggcagtacatgcatatcggcaccatg gtggagtttgcctttgccctggtggggaagctggacgctatcaacaaacactccttcaat gacttcaagctgcgagtgggtattaaccatgggcctgtaatagccggtgtgattggagct cagaagccacaatacgatatctggggcaacaccgtgaatgtggccagcaggatggacagc accggcgtgctggacaaaatacaggtcactgaggagacaagcctcatcctccagaccctg ggttacacgtgcacatgtcgaggaataatcaacgtgaaaggcaagggggagctgaagacg tactttgtaaacacagaaatgtcaaggtccctttcccagagcaacgtggcatcctga

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