KEGG   Puma concolor (puma): 112861619
Entry
112861619         CDS       T08890                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo01521  EGFR tyrosine kinase inhibitor resistance
pcoo01522  Endocrine resistance
pcoo01524  Platinum drug resistance
pcoo04012  ErbB signaling pathway
pcoo04014  Ras signaling pathway
pcoo04015  Rap1 signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04062  Chemokine signaling pathway
pcoo04066  HIF-1 signaling pathway
pcoo04068  FoxO signaling pathway
pcoo04070  Phosphatidylinositol signaling system
pcoo04071  Sphingolipid signaling pathway
pcoo04072  Phospholipase D signaling pathway
pcoo04081  Hormone signaling
pcoo04140  Autophagy - animal
pcoo04150  mTOR signaling pathway
pcoo04151  PI3K-Akt signaling pathway
pcoo04152  AMPK signaling pathway
pcoo04210  Apoptosis
pcoo04211  Longevity regulating pathway
pcoo04213  Longevity regulating pathway - multiple species
pcoo04218  Cellular senescence
pcoo04360  Axon guidance
pcoo04370  VEGF signaling pathway
pcoo04380  Osteoclast differentiation
pcoo04510  Focal adhesion
pcoo04550  Signaling pathways regulating pluripotency of stem cells
pcoo04611  Platelet activation
pcoo04613  Neutrophil extracellular trap formation
pcoo04620  Toll-like receptor signaling pathway
pcoo04625  C-type lectin receptor signaling pathway
pcoo04630  JAK-STAT signaling pathway
pcoo04650  Natural killer cell mediated cytotoxicity
pcoo04660  T cell receptor signaling pathway
pcoo04662  B cell receptor signaling pathway
pcoo04664  Fc epsilon RI signaling pathway
pcoo04666  Fc gamma R-mediated phagocytosis
pcoo04668  TNF signaling pathway
pcoo04670  Leukocyte transendothelial migration
pcoo04722  Neurotrophin signaling pathway
pcoo04725  Cholinergic synapse
pcoo04750  Inflammatory mediator regulation of TRP channels
pcoo04810  Regulation of actin cytoskeleton
pcoo04910  Insulin signaling pathway
pcoo04914  Progesterone-mediated oocyte maturation
pcoo04915  Estrogen signaling pathway
pcoo04917  Prolactin signaling pathway
pcoo04919  Thyroid hormone signaling pathway
pcoo04923  Regulation of lipolysis in adipocytes
pcoo04926  Relaxin signaling pathway
pcoo04929  GnRH secretion
pcoo04930  Type II diabetes mellitus
pcoo04931  Insulin resistance
pcoo04932  Non-alcoholic fatty liver disease
pcoo04933  AGE-RAGE signaling pathway in diabetic complications
pcoo04935  Growth hormone synthesis, secretion and action
pcoo04960  Aldosterone-regulated sodium reabsorption
pcoo04973  Carbohydrate digestion and absorption
pcoo05010  Alzheimer disease
pcoo05017  Spinocerebellar ataxia
pcoo05020  Prion disease
pcoo05100  Bacterial invasion of epithelial cells
pcoo05135  Yersinia infection
pcoo05142  Chagas disease
pcoo05146  Amoebiasis
pcoo05160  Hepatitis C
pcoo05161  Hepatitis B
pcoo05162  Measles
pcoo05163  Human cytomegalovirus infection
pcoo05164  Influenza A
pcoo05165  Human papillomavirus infection
pcoo05166  Human T-cell leukemia virus 1 infection
pcoo05167  Kaposi sarcoma-associated herpesvirus infection
pcoo05168  Herpes simplex virus 1 infection
pcoo05169  Epstein-Barr virus infection
pcoo05170  Human immunodeficiency virus 1 infection
pcoo05171  Coronavirus disease - COVID-19
pcoo05200  Pathways in cancer
pcoo05203  Viral carcinogenesis
pcoo05205  Proteoglycans in cancer
pcoo05206  MicroRNAs in cancer
pcoo05207  Chemical carcinogenesis - receptor activation
pcoo05208  Chemical carcinogenesis - reactive oxygen species
pcoo05210  Colorectal cancer
pcoo05211  Renal cell carcinoma
pcoo05212  Pancreatic cancer
pcoo05213  Endometrial cancer
pcoo05214  Glioma
pcoo05215  Prostate cancer
pcoo05218  Melanoma
pcoo05220  Chronic myeloid leukemia
pcoo05221  Acute myeloid leukemia
pcoo05222  Small cell lung cancer
pcoo05223  Non-small cell lung cancer
pcoo05224  Breast cancer
pcoo05225  Hepatocellular carcinoma
pcoo05226  Gastric cancer
pcoo05230  Central carbon metabolism in cancer
pcoo05231  Choline metabolism in cancer
pcoo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcoo05415  Diabetic cardiomyopathy
pcoo05417  Lipid and atherosclerosis
pcoo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112861619 (PIK3R1)
   04014 Ras signaling pathway
    112861619 (PIK3R1)
   04015 Rap1 signaling pathway
    112861619 (PIK3R1)
   04370 VEGF signaling pathway
    112861619 (PIK3R1)
   04630 JAK-STAT signaling pathway
    112861619 (PIK3R1)
   04668 TNF signaling pathway
    112861619 (PIK3R1)
   04066 HIF-1 signaling pathway
    112861619 (PIK3R1)
   04068 FoxO signaling pathway
    112861619 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    112861619 (PIK3R1)
   04072 Phospholipase D signaling pathway
    112861619 (PIK3R1)
   04071 Sphingolipid signaling pathway
    112861619 (PIK3R1)
   04024 cAMP signaling pathway
    112861619 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    112861619 (PIK3R1)
   04152 AMPK signaling pathway
    112861619 (PIK3R1)
   04150 mTOR signaling pathway
    112861619 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    112861619 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112861619 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    112861619 (PIK3R1)
   04218 Cellular senescence
    112861619 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112861619 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112861619 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112861619 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112861619 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    112861619 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    112861619 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    112861619 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    112861619 (PIK3R1)
   04660 T cell receptor signaling pathway
    112861619 (PIK3R1)
   04662 B cell receptor signaling pathway
    112861619 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    112861619 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    112861619 (PIK3R1)
   04670 Leukocyte transendothelial migration
    112861619 (PIK3R1)
   04062 Chemokine signaling pathway
    112861619 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112861619 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    112861619 (PIK3R1)
   04929 GnRH secretion
    112861619 (PIK3R1)
   04915 Estrogen signaling pathway
    112861619 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    112861619 (PIK3R1)
   04917 Prolactin signaling pathway
    112861619 (PIK3R1)
   04926 Relaxin signaling pathway
    112861619 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    112861619 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    112861619 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112861619 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112861619 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    112861619 (PIK3R1)
   04722 Neurotrophin signaling pathway
    112861619 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112861619 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    112861619 (PIK3R1)
   04380 Osteoclast differentiation
    112861619 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    112861619 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    112861619 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112861619 (PIK3R1)
   05206 MicroRNAs in cancer
    112861619 (PIK3R1)
   05205 Proteoglycans in cancer
    112861619 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    112861619 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112861619 (PIK3R1)
   05203 Viral carcinogenesis
    112861619 (PIK3R1)
   05230 Central carbon metabolism in cancer
    112861619 (PIK3R1)
   05231 Choline metabolism in cancer
    112861619 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112861619 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112861619 (PIK3R1)
   05212 Pancreatic cancer
    112861619 (PIK3R1)
   05225 Hepatocellular carcinoma
    112861619 (PIK3R1)
   05226 Gastric cancer
    112861619 (PIK3R1)
   05214 Glioma
    112861619 (PIK3R1)
   05221 Acute myeloid leukemia
    112861619 (PIK3R1)
   05220 Chronic myeloid leukemia
    112861619 (PIK3R1)
   05218 Melanoma
    112861619 (PIK3R1)
   05211 Renal cell carcinoma
    112861619 (PIK3R1)
   05215 Prostate cancer
    112861619 (PIK3R1)
   05213 Endometrial cancer
    112861619 (PIK3R1)
   05224 Breast cancer
    112861619 (PIK3R1)
   05222 Small cell lung cancer
    112861619 (PIK3R1)
   05223 Non-small cell lung cancer
    112861619 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112861619 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    112861619 (PIK3R1)
   05161 Hepatitis B
    112861619 (PIK3R1)
   05160 Hepatitis C
    112861619 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    112861619 (PIK3R1)
   05164 Influenza A
    112861619 (PIK3R1)
   05162 Measles
    112861619 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    112861619 (PIK3R1)
   05163 Human cytomegalovirus infection
    112861619 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112861619 (PIK3R1)
   05169 Epstein-Barr virus infection
    112861619 (PIK3R1)
   05165 Human papillomavirus infection
    112861619 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    112861619 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    112861619 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112861619 (PIK3R1)
   05142 Chagas disease
    112861619 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112861619 (PIK3R1)
   05017 Spinocerebellar ataxia
    112861619 (PIK3R1)
   05020 Prion disease
    112861619 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112861619 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    112861619 (PIK3R1)
   05415 Diabetic cardiomyopathy
    112861619 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112861619 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    112861619 (PIK3R1)
   04931 Insulin resistance
    112861619 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112861619 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112861619 (PIK3R1)
   01524 Platinum drug resistance
    112861619 (PIK3R1)
   01522 Endocrine resistance
    112861619 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcoo04131]
    112861619 (PIK3R1)
Membrane trafficking [BR:pcoo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112861619 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 CCDC113_CCDC96_CC Laminin_I
Other DBs
NCBI-GeneID: 112861619
NCBI-ProteinID: XP_025780783
UniProt: A0A6P6I0A4
LinkDB
Position
Unknown
AA seq 725 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLEMIDV
QVLGDAFKRYLMDLPNPVIPVAVYNEMLYLAQEVQSPEEYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLSQISSKNLLNARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgggcgctgtatgattacaaaaaggaacgagaagaa
gatattgacttgcacttgggcgatgtattgactgtgaataaagggtctttagtagctctt
ggattcagtgacggacaggaagccaggcctgaagaaattggctggttaaatggttataat
gaaaccacgggggaaagaggggactttccaggaacttacgttgaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcaaaagctgaagcagacagtgagcaacaacaagctttggctctgccagatcttgct
gagcagtttgcccctcctgacatcgctccgcctcttcttgtgaagctagtggaagccatt
gaaaagaaaggtctggaatgttcaactttatacagaacacagagctccagcaacccagca
gaattacgacagcttcttgattgtgatgccgcctccgtggacttggaaatgatcgatgtg
caagttttaggagacgctttcaaacgctatcttatggacttaccgaatcctgtcattcca
gtagccgtttacaatgagatgctttatttagcccaagaagtacaaagccctgaagaatat
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggcttacg
cttcagtatttgctaaaacatttcttcaagctctctcaaatctccagcaagaatcttctg
aatgcaagagtactctctgaacttttcagccctctgcttttcagattcccagcagccagc
tctgagaatactgaacacctcataaaagttatagaaattttaatctcgaccgagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccacccaaacccactactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgatgggacctttttggtacgagac
gcatctactaaaatgcacggtgattatactcttacactaaggaaaggaggaaataacaag
ttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactaaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtccctagctcagtataatcccaaa
ctggacgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaa
agtcgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccagatg
aaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagagcagtgccaa
agccaagaacggtacagcaaagaatacatagaaaaatttaaacgggaaggcaatgagaaa
gaaatacaaaggattatgcataattatgaaaagttgaagtctcgcatcagcgaaattgtg
gacagtagaagacgactggaggaggacttgaagaaacaggcagctgagtatcgggagatt
gacaagcgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaacgagtggctgggc
aatgagaacactgaagaccaatactcgctggtggaggatgatgaggatttgccgcaccac
gacgagaagacatggaatgtcggcagcagcaacagaaacaaggctgaaaacctactccgg
gggaagcgagatggcaccttcctggtccgggaaagcagtaaacagggctgctatgcctgc
tcggtagtggtggatggcgaagtgaagcactgtgtcatcaacaaaacggcaactggctac
ggctttgccgagccctataacctgtacagctccctgaaagagctggtgctacattaccaa
cacacctcccttgtgcagcacaacgactccctcaacgtcacactagcctacccggtatat
gcacagcagaggcgatga

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