KEGG   Propithecus coquereli (Coquerel's sifaka): 105826612
Entry
105826612         CDS       T08746                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq01521  EGFR tyrosine kinase inhibitor resistance
pcoq01522  Endocrine resistance
pcoq01524  Platinum drug resistance
pcoq04012  ErbB signaling pathway
pcoq04014  Ras signaling pathway
pcoq04015  Rap1 signaling pathway
pcoq04024  cAMP signaling pathway
pcoq04062  Chemokine signaling pathway
pcoq04066  HIF-1 signaling pathway
pcoq04068  FoxO signaling pathway
pcoq04070  Phosphatidylinositol signaling system
pcoq04071  Sphingolipid signaling pathway
pcoq04072  Phospholipase D signaling pathway
pcoq04081  Hormone signaling
pcoq04140  Autophagy - animal
pcoq04150  mTOR signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04152  AMPK signaling pathway
pcoq04210  Apoptosis
pcoq04211  Longevity regulating pathway
pcoq04213  Longevity regulating pathway - multiple species
pcoq04218  Cellular senescence
pcoq04360  Axon guidance
pcoq04370  VEGF signaling pathway
pcoq04380  Osteoclast differentiation
pcoq04510  Focal adhesion
pcoq04550  Signaling pathways regulating pluripotency of stem cells
pcoq04611  Platelet activation
pcoq04613  Neutrophil extracellular trap formation
pcoq04620  Toll-like receptor signaling pathway
pcoq04625  C-type lectin receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
pcoq04650  Natural killer cell mediated cytotoxicity
pcoq04660  T cell receptor signaling pathway
pcoq04662  B cell receptor signaling pathway
pcoq04664  Fc epsilon RI signaling pathway
pcoq04666  Fc gamma R-mediated phagocytosis
pcoq04668  TNF signaling pathway
pcoq04670  Leukocyte transendothelial migration
pcoq04722  Neurotrophin signaling pathway
pcoq04725  Cholinergic synapse
pcoq04750  Inflammatory mediator regulation of TRP channels
pcoq04810  Regulation of actin cytoskeleton
pcoq04910  Insulin signaling pathway
pcoq04914  Progesterone-mediated oocyte maturation
pcoq04915  Estrogen signaling pathway
pcoq04917  Prolactin signaling pathway
pcoq04919  Thyroid hormone signaling pathway
pcoq04923  Regulation of lipolysis in adipocytes
pcoq04926  Relaxin signaling pathway
pcoq04929  GnRH secretion
pcoq04930  Type II diabetes mellitus
pcoq04931  Insulin resistance
pcoq04932  Non-alcoholic fatty liver disease
pcoq04933  AGE-RAGE signaling pathway in diabetic complications
pcoq04935  Growth hormone synthesis, secretion and action
pcoq04960  Aldosterone-regulated sodium reabsorption
pcoq04973  Carbohydrate digestion and absorption
pcoq05010  Alzheimer disease
pcoq05017  Spinocerebellar ataxia
pcoq05020  Prion disease
pcoq05100  Bacterial invasion of epithelial cells
pcoq05135  Yersinia infection
pcoq05142  Chagas disease
pcoq05146  Amoebiasis
pcoq05160  Hepatitis C
pcoq05161  Hepatitis B
pcoq05162  Measles
pcoq05163  Human cytomegalovirus infection
pcoq05164  Influenza A
pcoq05165  Human papillomavirus infection
pcoq05166  Human T-cell leukemia virus 1 infection
pcoq05167  Kaposi sarcoma-associated herpesvirus infection
pcoq05168  Herpes simplex virus 1 infection
pcoq05169  Epstein-Barr virus infection
pcoq05170  Human immunodeficiency virus 1 infection
pcoq05171  Coronavirus disease - COVID-19
pcoq05200  Pathways in cancer
pcoq05203  Viral carcinogenesis
pcoq05205  Proteoglycans in cancer
pcoq05206  MicroRNAs in cancer
pcoq05207  Chemical carcinogenesis - receptor activation
pcoq05208  Chemical carcinogenesis - reactive oxygen species
pcoq05210  Colorectal cancer
pcoq05211  Renal cell carcinoma
pcoq05212  Pancreatic cancer
pcoq05213  Endometrial cancer
pcoq05214  Glioma
pcoq05215  Prostate cancer
pcoq05218  Melanoma
pcoq05220  Chronic myeloid leukemia
pcoq05221  Acute myeloid leukemia
pcoq05222  Small cell lung cancer
pcoq05223  Non-small cell lung cancer
pcoq05224  Breast cancer
pcoq05225  Hepatocellular carcinoma
pcoq05226  Gastric cancer
pcoq05230  Central carbon metabolism in cancer
pcoq05231  Choline metabolism in cancer
pcoq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcoq05415  Diabetic cardiomyopathy
pcoq05417  Lipid and atherosclerosis
pcoq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105826612 (PIK3R1)
   04014 Ras signaling pathway
    105826612 (PIK3R1)
   04015 Rap1 signaling pathway
    105826612 (PIK3R1)
   04370 VEGF signaling pathway
    105826612 (PIK3R1)
   04630 JAK-STAT signaling pathway
    105826612 (PIK3R1)
   04668 TNF signaling pathway
    105826612 (PIK3R1)
   04066 HIF-1 signaling pathway
    105826612 (PIK3R1)
   04068 FoxO signaling pathway
    105826612 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    105826612 (PIK3R1)
   04072 Phospholipase D signaling pathway
    105826612 (PIK3R1)
   04071 Sphingolipid signaling pathway
    105826612 (PIK3R1)
   04024 cAMP signaling pathway
    105826612 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    105826612 (PIK3R1)
   04152 AMPK signaling pathway
    105826612 (PIK3R1)
   04150 mTOR signaling pathway
    105826612 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105826612 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105826612 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    105826612 (PIK3R1)
   04218 Cellular senescence
    105826612 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105826612 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105826612 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105826612 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105826612 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    105826612 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    105826612 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    105826612 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    105826612 (PIK3R1)
   04660 T cell receptor signaling pathway
    105826612 (PIK3R1)
   04662 B cell receptor signaling pathway
    105826612 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    105826612 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    105826612 (PIK3R1)
   04670 Leukocyte transendothelial migration
    105826612 (PIK3R1)
   04062 Chemokine signaling pathway
    105826612 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105826612 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    105826612 (PIK3R1)
   04929 GnRH secretion
    105826612 (PIK3R1)
   04915 Estrogen signaling pathway
    105826612 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    105826612 (PIK3R1)
   04917 Prolactin signaling pathway
    105826612 (PIK3R1)
   04926 Relaxin signaling pathway
    105826612 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    105826612 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    105826612 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105826612 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105826612 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    105826612 (PIK3R1)
   04722 Neurotrophin signaling pathway
    105826612 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105826612 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    105826612 (PIK3R1)
   04380 Osteoclast differentiation
    105826612 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    105826612 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    105826612 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105826612 (PIK3R1)
   05206 MicroRNAs in cancer
    105826612 (PIK3R1)
   05205 Proteoglycans in cancer
    105826612 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    105826612 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105826612 (PIK3R1)
   05203 Viral carcinogenesis
    105826612 (PIK3R1)
   05230 Central carbon metabolism in cancer
    105826612 (PIK3R1)
   05231 Choline metabolism in cancer
    105826612 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105826612 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105826612 (PIK3R1)
   05212 Pancreatic cancer
    105826612 (PIK3R1)
   05225 Hepatocellular carcinoma
    105826612 (PIK3R1)
   05226 Gastric cancer
    105826612 (PIK3R1)
   05214 Glioma
    105826612 (PIK3R1)
   05221 Acute myeloid leukemia
    105826612 (PIK3R1)
   05220 Chronic myeloid leukemia
    105826612 (PIK3R1)
   05218 Melanoma
    105826612 (PIK3R1)
   05211 Renal cell carcinoma
    105826612 (PIK3R1)
   05215 Prostate cancer
    105826612 (PIK3R1)
   05213 Endometrial cancer
    105826612 (PIK3R1)
   05224 Breast cancer
    105826612 (PIK3R1)
   05222 Small cell lung cancer
    105826612 (PIK3R1)
   05223 Non-small cell lung cancer
    105826612 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105826612 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    105826612 (PIK3R1)
   05161 Hepatitis B
    105826612 (PIK3R1)
   05160 Hepatitis C
    105826612 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    105826612 (PIK3R1)
   05164 Influenza A
    105826612 (PIK3R1)
   05162 Measles
    105826612 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    105826612 (PIK3R1)
   05163 Human cytomegalovirus infection
    105826612 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105826612 (PIK3R1)
   05169 Epstein-Barr virus infection
    105826612 (PIK3R1)
   05165 Human papillomavirus infection
    105826612 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105826612 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    105826612 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105826612 (PIK3R1)
   05142 Chagas disease
    105826612 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105826612 (PIK3R1)
   05017 Spinocerebellar ataxia
    105826612 (PIK3R1)
   05020 Prion disease
    105826612 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105826612 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    105826612 (PIK3R1)
   05415 Diabetic cardiomyopathy
    105826612 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105826612 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    105826612 (PIK3R1)
   04931 Insulin resistance
    105826612 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105826612 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105826612 (PIK3R1)
   01524 Platinum drug resistance
    105826612 (PIK3R1)
   01522 Endocrine resistance
    105826612 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcoq04131]
    105826612 (PIK3R1)
Membrane trafficking [BR:pcoq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105826612 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 SH3_9 Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 105826612
NCBI-ProteinID: XP_012520054
Ensembl: ENSPCOG00000021158
UniProt: A0A2K6FX29
LinkDB
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLSGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFTPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSSPAELRQLLDCDTASVDLEMIDVH
VLADAFKRYLLDLPNPVIPVAVYSEMISLAPEVQSSEEYIQLLKKFIRSPNIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFPAASSDNTEHLIKVIEILISTEWNE
RQPAPALPPKPPKPTTIANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagcgccgaggggtaccagtacagagcgctatatgattataaaaaggaaagagaagaa
gatattgacttgcatttgggtgacattttgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaagtggctataat
gaaaccacaggggagaggggggactttccaggaacttacgtagaatatattggaaggaag
aaaatttcgcctcccacaccaaagccccggccacctcggccccttcctgttgcaccaggt
tcttcgaaaactgaagcagacgttgagcaacaagccttgactctcccggatcttgcagag
cagtttacccctcctgacgttgccccccctcttcttatcaagctcgtggaagccatcgaa
aagaaaggtctggaatgttcaactctatacagaacccagagctccagcagccccgcagaa
ttacgacagcttcttgattgtgacacggcctctgtggacttggaaatgatcgacgtgcac
gttttagcagacgctttcaaacgctatctgctggacttaccaaatcctgtcattccggta
gccgtttacagcgaaatgatttctttagccccagaagtacaaagctccgaagaatatatc
cagctgttgaagaagttcattaggtcgcctaacatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctcttgaat
gcaagagtgctctctgaaattttcagccctatgcttttcagattcccagcagccagctct
gataatactgaacacctcataaaagttatagaaattttaatctcaactgaatggaacgaa
cgacaacctgcaccagcactgcctcctaaaccaccaaaacccactactatagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgca
tcaactaaaatgcatggtgattatacccttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgggatgggaaatatggcttctctgacccattaaccttcaattcc
gtggttgaactaataaaccactaccggaatgaatctctagctcagtataatcccaaactg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgtacctcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caggagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttaaagtctcgaatcagtgaaattattgac
agtagaagacgactagaggaagacttgaagaagcaggcagctgagtaccgagagattgac
aaacgtatgaacagcattaaaccagacctcattcaattgagaaagacgagagaccaatac
ctgatgtggttgactcaaaaaggtgttcgtcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatctgccccaccatgac
gagaagacgtggaacgtcgggagcagcaaccgaaacaaagctgaaaacctgctgcgaggg
aaacgggacggcactttccttgtgcgggagagcagcaaacagggctgctacgcctgctcc
gtagtggtggacggcgaagtaaagcattgtgtcataaacaagacagcaacgggctatggc
ttcgccgagccctataacttgtacagctctctgaaggaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtatatgca
cagcagaggcgatga

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