KEGG   Phascolarctos cinereus (koala): 110198384
Entry
110198384         CDS       T05867                                 
Symbol
BRCA1
Name
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01524  Platinum drug resistance
pcw03440  Homologous recombination
pcw03460  Fanconi anemia pathway
pcw04120  Ubiquitin mediated proteolysis
pcw04151  PI3K-Akt signaling pathway
pcw05206  MicroRNAs in cancer
pcw05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    110198384 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    110198384 (BRCA1)
   03460 Fanconi anemia pathway
    110198384 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    110198384 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    110198384 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    110198384 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    110198384 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:pcw01009]
    110198384 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:pcw04121]
    110198384 (BRCA1)
   03036 Chromosome and associated proteins [BR:pcw03036]
    110198384 (BRCA1)
   03400 DNA repair and recombination proteins [BR:pcw03400]
    110198384 (BRCA1)
Enzymes [BR:pcw01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     110198384 (BRCA1)
Protein phosphatases and associated proteins [BR:pcw01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     110198384 (BRCA1)
Ubiquitin system [BR:pcw04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    110198384 (BRCA1)
  Multi subunit type E3
   BRCC complex
    110198384 (BRCA1)
Chromosome and associated proteins [BR:pcw03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     110198384 (BRCA1)
DNA repair and recombination proteins [BR:pcw03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     110198384 (BRCA1)
    BRCA1-A complex
     110198384 (BRCA1)
    BRCA1-B complex
     110198384 (BRCA1)
    BRCA1-C complex
     110198384 (BRCA1)
    BRCA complex
     110198384 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     110198384 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-RING_UBOX zf-RING_2 zf-C3HC4_4 zf-RING_5 zf-C3HC4_3 RING_XB3-XBAT31 BRCT_2 zf-RING_6 zf-Nse zf-RING_10 zf-ANAPC11 Prok-RING_4
Other DBs
NCBI-GeneID: 110198384
NCBI-ProteinID: XP_020828279
UniProt: A0A6P5J1R9
LinkDB
Position
Unknown
AA seq 1857 aa
MDLSTVSIEEVKNVLIGMQKILECPICLELIKEPVSTTCDHIFCKFCMLKLLSKKKGPSQ
CPLCKDNITKRSLRESTRFNQLVEGLLKTIQAFELDTGFQFSNSQDFSKWEKSTPEPIKK
EAAVIQSMGYRNRTKRFRASEPENSTLESSLGVQLFDLDIRKGSLRRKQKKCIKNNAVYI
ELGSDSSEDSVKNAVCNSVEDQELCQTSPRRTRSKVRLKPKGKAEYELPEGTIKSLQQHQ
PNTEDVHVNEENATEGHPDESQGISSSNLSMEPCGTDTHASSLLPETTSLLPNIDRMNVE
KAELCDKSKQPALARNQQSSLDESKEICSAGKSPGACEQHEQNTHRLCERQELEEKPQHP
ESPRGNPQNGLSGTKLKSSIQKVNEWLSRSNDILASDNSNGRSHEQNAEVPSTLEDGHPN
TADGNSSISEKTDPVADATDDVWPPVPERSCPRPAENNIEDKIFGKTYRRKSSHPNLNYI
TENLFAEAMAPDSLIPPQPPKNTRSKRKRKTISDLQPEDFIRKTDIPVIRKTPEKKNHSV
DQILEREQNDQVMNTANSLPEQKALDGHTVGEVKDVQVLELFSVEKESTFRTGTEPAAGS
TDHGELELNSRDVKMTKKDRLRKKPSVRIVHALELVVDRNPSSSNESELQIDSYPSSEEI
RKGNNSKQKQIRRSRRLQLLSEEIAVGTKMAHKPVDQAEESCISEVFPELKIRNMPARAT
DSLTTDRDQVLASCSFTEEGDERSLEAIPGSKDQDLALSGGEGLQGERAPGSLEALEAPD
TDWDTQESTSLFPADTPQNSKAEPSPHRSHCEIMETPKELLDGCSSKNTESGKEDLRSLM
GQEGQNASKTTTEMEDSELDTQYLQNTFKRSKRQSFALCSSPRQQCMKPSAVPGTVSQQS
PDNATDCGGQEKEKQGNRESSKPVQPKSAVMSLVAACQTEERKPGDHAKCSTTGVSRLCH
IAPLHGGDDCEHIAGNNQGISQVLDGKQSVSPARSSASKTMYTNNLLEERFDEQTTCPET
AMGNESLVQSSLSPVSQSNSREYISKATDLNRFISIGSSGESSQAEEGENKESELNTSPI
LKLVQPQICQQSFPQDNCKEPKRKGKEGNGKLAQAIRTDSSPCLEQTKESTHSSQVWSET
PDLLDSDGEIKESFAESDIKEQSAVFDKVGKSFRVRQSRKSRSPLAHRNPSLTWKSRRQA
RKLESSEEEDTSSEEGELPSFQDLIFGKAASTPSQPTKSKTIAVELPTNKAEENPAFLNR
DIGSASNIQISSGEASQDDNSSQDSECSGSLFSSHSNSLEDLTGKANDKDSALVFGSSKQ
GRSQPRTQEMQSGSEMPKVSQDEGERESDLDEDHHLKDQGVDANLGESASGYDSETSHPG
DISQLSFQSDILTTQQRDTMQDNLKKLQQEMAVLEAVLEQHGSQTSNRPASQESGLCPSV
DQPDLKQTKSEKGAEKTVEYHKSQKAQSLSADNSRAFPEDSSSKNEEPGVEGSSLLESQM
LNGDWSLLGHSRILQKVESSSEEGISRIAVLKEKQQRKPEERSVMVEQSCVLKPDLETVP
ESESGVKVYPEKTECSPQENKDTTLREILNLPTSTCALRSSQLQTVESTNTSASNTPGHS
VRGQLEEACASERVRKGGTGSPRMSLVASGLTPKEHMLVQKFARKTQSTLSNQITEGTTH
VIMKTDAEFVCERTLKYFLGIAGGKWVVSFLWVVQSFKEGKVLPECDFEVRGDVINGRNH
RGPERARESQGVKIFKGLEICCYGPFTDMPTDHLEWMVQLCGASVVKKPSSLRPRLGSSP
VVVVQPDAWEDDSSFQGVGLMCEVPIVTREWVLDSVACYQRQELDTYLICQTSSGCC
NT seq 5574 nt   +upstreamnt  +downstreamnt
atggatttatctacagtcagtattgaagaagtaaagaatgtcctcattgggatgcagaag
atcttagaatgtcctatctgtctggagttgatcaaagagcctgtttctacaacctgtgac
cacatattttgcaaattttgtatgttgaagcttctcagtaagaagaaagggccatctcag
tgtccactgtgcaaggacaacataaccaaaagaagcctacgagaaagtacaagatttaat
cagcttgtagaagggctgctgaaaaccattcaagcttttgagctcgacacaggattccag
ttttcgaacagtcaggatttttcaaaatgggagaagagtactcctgagcccataaagaag
gaagctgctgtcattcaaagtatgggctacagaaaccgcacaaaaagattcagagccagt
gaaccagaaaactcaaccttggaatccagtcttggtgtccagctctttgaccttgacatc
agaaaaggttccctgaggaggaagcaaaagaaatgcattaaaaataatgctgtctacatt
gagttaggatctgattcttctgaagatagtgtaaaaaatgcagtctgtaacagtgtggaa
gaccaagaattgtgccaaacctcaccacgaagaaccagatctaaagtcagattaaagccc
aagggaaaagctgagtatgagttacctgaggggaccataaagagcctgcaacagcatcag
cctaacaccgaggatgtgcacgtcaacgaggagaatgccactgagggacatccagacgag
tctcagggtatttcttcctcaaacttgagtatggagccatgtggcacagacactcatgcc
agctcattacttcctgaaaccaccagtttattgcccaacatagacagaatgaacgtagaa
aaggctgaactctgtgataaaagcaaacagcctgccttagcaaggaaccaacagagcagt
ctcgatgaaagtaaggaaatatgtagtgctgggaagagcccaggtgcctgtgagcagcat
gagcagaatacccatcgtctatgtgagaggcaggaactagaggagaagccacagcaccct
gagagccccagaggtaatcctcagaacggcttgtctggaaccaaactgaaaagcagcatt
cagaaagttaatgagtggttatccagaagcaatgacattttagcctctgataactccaat
ggtaggagccatgagcagaatgcagaggtgcctagcaccttagaagatgggcatccaaat
actgcagatggaaattctagcatttctgagaagactgacccagtggctgatgccactgat
gatgtatggccacctgtgcctgaaagaagctgccctaggcctgcagaaaacaatattgaa
gataaaatatttggaaaaacctatcggagaaagtcaagtcaccctaatttgaattatata
actgaaaacttgtttgctgaagctatggctcctgattctttgatccctccacagcctccc
aaaaacaccaggtcaaagcgtaaaagaaagaccatatctgacctgcagcctgaggatttc
atcaggaagacagacattccagtcattcgcaaaacccctgaaaagaaaaatcactctgtt
gaccaaattctcgaaagagaacaaaatgaccaagtgatgaacacggctaacagtctccct
gaacagaaagccctagatggtcatactgtaggggaagtgaaagatgttcaggtattagaa
ctgttctctgtggagaaagaatccactttcagaactggaacagagcctgcagctggcagc
acagatcacggggaacttgaattaaatagtagagatgtcaaaatgacaaaaaaagacagg
ctgaggaagaagccttcagtcaggattgtccatgctcttgagctcgtagttgatagaaac
ccaagctcttctaatgagagtgaactacagatcgatagctatcccagcagtgaagagata
aggaaaggaaataattctaaacagaagcaaatcagacgcagcagaaggcttcagctgcta
tcagaagaaattgcggttggaaccaagatggcccataagccagttgaccaagcagaagaa
agttgtatcagtgaagtcttcccagaactaaaaataagaaacatgcctgcccgtgctact
gacagtctaactactgatagagatcaagtgttagctagctgcagtttcacagaagaagga
gatgaaaggagcctggaagcaatcccaggcagcaaagaccaagacctggcattgagtgga
ggagaggggttgcaaggtgaaagagccccaggaagcctggaggctttggaggctcctgat
actgattgggacactcaggaaagtacctcattgtttccagctgatactccccaaaattca
aaagcagaacccagtcctcacagaagtcactgtgaaataatggaaacccccaaggaactc
ttagatggttgttcatccaaaaacactgaaagtggcaaagaagatttgaggagcctgatg
ggacaggaaggtcaaaatgcctccaagacaaccacagaaatggaggatagtgaactcgac
acccagtatttacaaaatactttcaaacgttcaaagcgccagtcatttgctctatgttcc
agcccaaggcagcagtgtatgaaaccctctgctgtccctgggactgtaagtcagcagagt
ccagataacgccacagattgtggaggccaggaaaaagaaaagcagggaaacagagaatcc
agcaagcctgtgcagccaaagtctgcagtcatgagcttagttgcggcttgtcagacagag
gagaggaagccaggtgatcatgccaaatgtagcaccacgggagtgtccaggctttgtcac
atagctccattacatggtggcgatgactgtgaacacatcgctggaaacaaccagggaatt
tcacaagttcttgatggaaaacagtcagtttctccagcaaggtcgtctgctagtaaaact
atgtatacaaataacctcctggaggaaaggtttgatgaacagaccacatgtcctgaaaca
gccatgggaaatgaaagcttggtccaaagcagcttaagtccagtaagccaaagtaatagc
agagaatatatttctaaagcaactgacttaaatagatttatcagcataggctctagtgga
gaaagcagtcaggcagaagaaggtgaaaacaaagaatctgaattaaatacatcacccata
ttaaagcttgtgcaaccccaaatctgtcaacaaagctttcctcaggataattgcaaagag
cctaaaagaaaaggaaaggaaggaaatggaaaattagctcaggccatccggacagattca
tccccatgtttagaacaaactaaagagagtacacattcttctcaggtttggtctgagacg
cccgacttgttggacagcgatggtgaaataaaagaaagctttgccgaaagtgacatcaaa
gaacaatctgctgtttttgacaaagttggtaaaagttttcgggtaagacagtctagaaaa
agccgtagccctttagcccatagaaatcccagtttgacttggaaatcccgaagacaggcc
cggaaactggagtcctcagaagaagaagatacctccagtgaagagggagagcttccaagc
tttcaagacttgatatttggcaaagcagcaagcacaccctctcagcccaccaaaagtaaa
actattgccgtagagcttccaacaaacaaggcagaggagaatccagccttcctaaacaga
gatattgggagtgctagcaatattcagatatcatctggggaagcatcccaggatgataat
tccagccaagattctgaatgctctggtagcttattttcttcacactctaattcattagaa
gacttaactggaaaagcaaatgacaaggattctgccttggtgtttggttcttccaaacaa
gggagaagtcagcccagaacccaagaaatgcagagtggcagtgagatgcccaaggtttct
caagatgagggagaaagggaaagtgacctagatgaagaccatcacctcaaggaccagggt
gtggatgcaaatttaggtgaatctgcatctgggtatgacagtgaaacaagccatcctgga
gacatttcacagctatcctttcaaagtgatattttaaccactcagcaaagggacaccatg
caagacaacctgaaaaaactccaacaggaaatggctgtcttagaggctgtcttggagcaa
catggtagtcagacctccaacaggcctgcttctcaggaatctgggctatgcccttccgtg
gaccagccagacttgaaacagaccaaatcagaaaaaggagcagagaaaactgttgaatat
cacaaaagccaaaaggcacaaagcctttcagcagacaactcccgagcatttccagaggat
tccagcagtaaaaatgaagaaccaggagttgaagggtcttcccttttggagtcccaaatg
ttgaatggggattggagcctgcttggccactccaggattcttcaaaaagtagagtcctct
tctgaagagggaatcagtaggattgctgtcctgaaggaaaaacagcagcggaaacctgag
gaacgaagtgtgatggtggagcagtcttgtgtgctgaaaccagacctcgaaacagtccct
gagtcagaatctggagtcaaagtataccctgagaagactgaatgcagcccccaggaaaat
aaggataccaccctaagagagattctcaatctgcccacctcaacttgtgcgctgaggtca
tcccagcttcagactgtagaaagcaccaacacttctgcttctaacactcctggtcacagt
gtgagggggcagctggaggaggcctgtgcctcagagagggtcaggaaaggaggaacaggc
agccccagaatgtcccttgtggcatcgggtttgactcccaaagaacatatgctagtgcag
aagtttgccaggaaaacccagagcactctatctaatcaaattactgaagggaccactcat
gtcataatgaaaacagatgccgagtttgtgtgtgagcggaccctaaagtacttcttgggc
attgcaggagggaaatgggtagtgagttttctgtgggtggtgcagtcttttaaagaaggc
aaggtgctacctgagtgtgactttgaagtcagaggagatgtcatcaatggcagaaaccac
cgaggcccagagagagcaagagaatctcagggggtgaagatcttcaagggcctagaaatc
tgttgctatggaccatttacagacatgccaacagatcacttagagtggatggtgcagctc
tgtggggcctcagtagtgaagaaaccttcctcgttgaggcccagactgggttcttctcca
gttgtggttgtgcagcctgatgcatgggaagatgacagcagttttcagggagtcgggctg
atgtgtgaagtgcccatagtgacccgggagtgggtgctggacagtgttgcctgctatcag
cgccaggaactggacacctacctgatatgtcagacctcctcgggctgctgctga

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