Phascolarctos cinereus (koala): 110200253 Help Entry 110200253         CDS       T05867                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism pcw  Phascolarctos cinereus (koala) Pathway pcw04022   cGMP-PKG signaling pathway pcw04068   FoxO signaling pathway pcw04081   Hormone signaling pcw04140   Autophagy - animal pcw04150   mTOR signaling pathway pcw04151   PI3K-Akt signaling pathway pcw04152   AMPK signaling pathway pcw04211   Longevity regulating pathway pcw04213   Longevity regulating pathway - multiple species pcw04722   Neurotrophin signaling pathway pcw04910   Insulin signaling pathway pcw04920   Adipocytokine signaling pathway pcw04923   Regulation of lipolysis in adipocytes pcw04930   Type II diabetes mellitus pcw04931   Insulin resistance pcw04932   Non-alcoholic fatty liver disease pcw04935   Growth hormone synthesis, secretion and action pcw04960   Aldosterone-regulated sodium reabsorption pcw05010   Alzheimer disease pcw05206   MicroRNAs in cancer pcw05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcw00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     110200253 (IRS1)    04022 cGMP-PKG signaling pathway     110200253 (IRS1)    04151 PI3K-Akt signaling pathway     110200253 (IRS1)    04152 AMPK signaling pathway     110200253 (IRS1)    04150 mTOR signaling pathway     110200253 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     110200253 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     110200253 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     110200253 (IRS1)    04935 Growth hormone synthesis, secretion and action     110200253 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     110200253 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     110200253 (IRS1)   09149 Aging    04211 Longevity regulating pathway     110200253 (IRS1)    04213 Longevity regulating pathway - multiple species     110200253 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     110200253 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     110200253 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     110200253 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     110200253 (IRS1)    04932 Non-alcoholic fatty liver disease     110200253 (IRS1)    04931 Insulin resistance     110200253 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 TFIIA FlaX Motif Other DBs NCBI-GeneID:  110200253 NCBI-ProteinID:  XP_020831144 UniProt:  A0A6P5JJ37 LinkDB All DBs Position Unknown AA seq 1366 aa AA seqDB search MDWDWPRPGLIFTPQGHETPINSLAGDSDFSSSCFSSELRRGRRIKRDLDQGQGGGCIFF LNRFPPSPLADLFACAVFGGGAHSPTHPLVFLPTPSSLLGGWGTSSSRSGSMASPPEGDG CFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSGAPKRSIPLES CFNINKRADSKNKHLVALYTRDEHFAIAADSESEQESWYQALLQLHNRAKGHHLHHSHHE AAAFGVGGGGGGSCSGSSGLGEGGEDSSYGEMAPGPAFKEVWQVILKPKGLGQTKNLIGI YRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDD SVVAQNMHETILEAMRAMSEEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRR SRTESVTATSPASVVGGKPCSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHSHRHRGS SRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSD GGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKTTPNLTAPNGH YNLSRSGNGHRYTPGAGPSPATVGDEAATAAELEKSFRKRTHSAGTSPTISHQKTPSQSS VASIEEYTEMMPSYPPCSAAGSGSRVQAYRHSAFVPTHSYPEECLDIHPLEERGGHHHRG DTPVLHTDDGYMPMSPGVAPVPSGRKSGGDYMPMSPKSVSAPQQIINPSRRHSQRVDPNG YMMMSPSGSCSPDSAGGSGSSNVAASGNNYGKLWTNGVGGHHHPHHVHPKLSSESSDVKL PCSSDYINMSPAGDSATSSPSDCYYGPDDPQNKAIYSYYSLPRSFKHTQQQQQQQQQLQQ QQLQQQQQQQQQRRGEPEDGVRHHHLRLSVSSGRLLYATAAEDSSSSASSDSLGGGGGAQ EGAHGHHHHQPLQQHLARKMDMVAQTRSRLTRPTRLSLDGPKASTLPRAREQPQQPLLPP EPKSPGEYVNIEFVGDQPGYSHGSAIPLCSPTVRCPSQRQPAPREDETGSEEYMNMDLRP PRRPACQESFVAKAGRACPLPTGVGGVCRPSRVVPNSQDYVTMQVGGPCPGCADASLSYV VMQTSRASEESSVPAAAATAPSPSFTTTSPSLPQHQGQAELASRPSLLGGPKGPGGISAF TRVNLSPSRNQSAKVIRADPQGCRRRHSSETFSSTPSAARGSNVAVPFGAGGAGGSGASA SSEDVKRHSSASFENVWLKPGDLGAPPSRKEPSQTSGGAAGLENGLNYIDLDLVKDFNHR PQECPPLLQPSHQPCGNGAASGNGCSSEDLSAYASINFQKQPEDLP NT seq 4101 nt NT seq  +upstreamnt  +downstreamnt atggattgggactggcctcgtccaggactgattttcaccccccaagggcatgaaacaccc ataaactctctcgctggggattctgacttctcgagcagctgcttttcttctgagctccgg cgggggagaagaatcaaaagagatttggatcaaggacaagggggaggttgtatttttttt ttaaaccgttttcccccctctcctctggctgacttgtttgcatgtgctgtgtttggggga ggtgcccactctcccacccacccgcttgtatttctgcccacccctagttccttgctcggt ggctggggcaccagcagcagccgcagcggcagcatggcgagcccaccggagggggacggc tgcttctccgacgtgaggaaggtgggctacctccgcaaacccaagagcatgcacaaacgc ttcttcgtcctgcgggcggccagtgaggccgggggtccagcccgcctggagtactatgag aacgaaaagaagtggagacacaaatctggtgcccccaagcgctctatcccgctggagagc tgtttcaacatcaacaagcgggctgactccaaaaacaaacacctggtagccctctacacc cgggatgaacattttgccattgccgcggacagcgagtcagagcaggagagctggtaccag gcgctcctgcagctccacaaccgggccaaggggcatcacttgcaccattcccaccacgag gctgcagcttttggagtgggaggaggaggagggggaagctgcagcggcagctccggcctg ggagaaggcggtgaggacagtagctatggtgaaatggccccaggaccagcattcaaggaa gtttggcaagtgatcctgaagcctaagggcttggggcagacaaagaacctgattggcatc taccggctctgtctgaccagtaagacaatcagctttgtgaagctgaactccgaggcggcc gcagtggtcctccagttgatgaacattcgcaggtgtggtcactcagaaaacttctttttt attgaggtggggcgctctgcagtgactgggcctggggagttctggatgcaagtggatgac tccgtggttgcacagaatatgcatgagaccatcctggaagccatgcgggccatgagtgag gagttccggccccgcagcaagagccagtcctcctcgaactgctccaaccccatcagtgtg cctctgcgcaggcatcacctcaataacccgccaccaagccaagtggggctcacccggaga tcccggactgagagcgtcacagccacttccccggccagcgtggtgggtgggaagccctgt tctttccgtgtccgggcctccagtgacggagaaggcaccatgtcccgaccggcttcagtg gatgggagtcctgtgagtcccagtaccaatcggacccattctcaccggcatcggggcagc tcccggttgcacccacccctcaaccacagccgttccatcccaatgccctcctcccggtgt tccccttcagccacgagtcctgtcagcttatcttccagcagcaccagtggtcatgggtca acttcagactgcctcttccctaggaggtctagtgcttcagtatctggctcacccagtgat gggggcttcatctcttctgatgaatacggctctagcccttgtgacttccgaagttccttc cgaagtgtcaccccagattccctgggtcataccccaccagctaggggtgaagaagagctg agcaattatatctgcatgggaggcaagaccacgcctaacttgacagcccccaatggccac tataacctatccagaagtggcaatgggcaccggtacaccccgggagctggcccaagtcct gctacagttggagatgaggcagccactgctgcagaactagagaagagtttccgcaagaga actcactcagcagggacttctcctaccatttcccaccagaagacaccttcgcagtcctct gtagcatccattgaggagtacacagagatgatgccttcctacccaccctgctcagcagct ggcagtgggagccgagtgcaagcgtaccgacactcagcctttgtacccacccattcgtat cccgaggaatgtctggacattcatccattagaggagcgaggtggccaccatcaccggggg gacacgccagtgctacacacagatgatggctacatgcctatgtctcctggagtagccccg gtacccagtggccgaaagagtggtggagattacatgcctatgagccccaagagcgtgtct gccccacagcagatcatcaaccccagccgccgccattcccagagggtagaccccaatggc tacatgatgatgtctcccagtggtagctgttcccctgacagcgcaggtggatctggcagc agcaacgtcgctgcttctgggaacaactatggcaagttatggacaaatggggttggtggc caccatcaccctcaccacgttcacccaaagctgtcttcggagagcagtgacgtgaaacta ccttgcagcagtgattacatcaacatgtccccagctggggactctgctaccagcagcccc tctgactgctactatggcccagatgacccacaaaacaaggccatctactcctactactct ttgccaagatccttcaaacacactcagcaacagcagcagcagcagcagcagcttcagcag cagcagcttcagcagcagcagcagcagcagcagcagcgtagaggggaacctgaagatggt gtccggcatcatcacctgcgcctctcagtcagctcaggccgcctgctctatgccacagct gcagaggactcctcttcttctgctagcagtgacagcctgggaggaggtggaggtgcacag gaaggggcacatggccatcaccaccatcagcctctgcagcagcacctggcccggaaaatg gatatggttgcacagaccaggagccgcctaactcggcccacgaggctgtctctggatggc cccaaggccagcaccttacctagagcccgggagcagccacagcagcctcttcttcctcca gaacccaagagcccaggagagtacgtgaacattgagtttgtgggagaccagccaggctac tcccatggctcagccatccctctctgctctcccacagtgaggtgcccatcccagcgacag ccagcccccagagaagatgagactggctctgaggaatatatgaacatggacttgagacct ccccggaggcctgcctgtcaagaaagttttgtggcgaaggctggaagagcatgccccctg cccaccggggtgggtggtgtgtgtaggcccagccgagtggtgccaaacagccaggattac gtgaccatgcaggtgggtgggccctgtccaggctgtgcagatgcctccctcagctatgtg gttatgcaaacaagcagggcttcagaagagtccagcgtcccagccgctgcagctactgcc ccttccccctcttttacaaccacctccccctctctcccccagcatcaaggacaggcagag ctggctagccgcccatccctgttaggaggtccaaagggacctggagggattagcgccttt acccgcgtgaacctcagtcccagccgcaaccagagtgccaaagtgatccgggctgacccc caagggtgccggaggcgtcacagctcagagaccttttcctctactcctagtgctgcccgg ggcagtaatgttgcagtgccctttggggccggtggcgcaggtggctctggggccagtgcc agcagtgaagatgttaaacgccacagttctgcctcctttgaaaatgtctggctaaagcct ggggatctgggggccccccccagcaggaaggagccatcccaaacgagtgggggtgcagca ggtttagagaatggactcaactatatcgacctggatttggtcaaggattttaatcaccgg ccccaggagtgtcccccactgctgcaaccttctcatcagccgtgtggcaatggtgcggcc agtgggaacggctgctccagtgaggatctaagcgcctatgctagcattaactttcagaag cagcccgaggaccttccatag

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