Phascolarctos cinereus (koala): 110219672
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Entry
110219672 CDS
T05867
Symbol
HSD3B2
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
pcw
Phascolarctos cinereus (koala)
Pathway
pcw00140
Steroid hormone biosynthesis
pcw01100
Metabolic pathways
pcw04913
Ovarian steroidogenesis
pcw04925
Aldosterone synthesis and secretion
pcw04927
Cortisol synthesis and secretion
pcw04934
Cushing syndrome
Module
pcw_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
pcw_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
pcw_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pcw_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
pcw00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
110219672 (HSD3B2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
110219672 (HSD3B2)
04925 Aldosterone synthesis and secretion
110219672 (HSD3B2)
04927 Cortisol synthesis and secretion
110219672 (HSD3B2)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
110219672 (HSD3B2)
Enzymes [BR:
pcw01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
110219672 (HSD3B2)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
110219672 (HSD3B2)
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Paralog
GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
KR
NmrA
RmlD_sub_bind
Motif
Other DBs
NCBI-GeneID:
110219672
NCBI-ProteinID:
XP_020858896
UniProt:
A0A6P5LKI2
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All DBs
Position
Unknown
AA seq
377 aa
AA seq
DB search
MLPMERWSCLVTGAGGFLGQRIVHLLLEEEKELEEIRVLDKVFSPQLLLEFSELKHRTKV
TVMEGDILDEQLLRKACQGITAVIHTACIIDMGLRLRKEVVMNVNLKGTQLLLEACISAN
VPVFLYTSSVEVAGPNSYTKPIQNGHEGMLLESKWYNAYPYSKKLAEKAVLEADGQLLKN
GSIMHTCSLRPMYIYGEGCVFLQNEIIKSLNKNKTFIRSREGSMSNQVYVGNVAWAHVLA
LRALRDSEKAQSIGGEFYYICDDTPPQSYSDFNYQVSKEWGFKLGSKIGIPLTLLYWAAF
LLEMISFMLSPIFIYEPPFNRHLLTLSNSVFTFSYEKAKKDLGYEPRFSWLEAKQKTGQW
IGTVVAQNREYLKTKAP
NT seq
1134 nt
NT seq
+upstream
nt +downstream
nt
atgctgcctatggagaggtggagctgtctggtgactggagcaggaggatttttggggcag
aggatcgtccacctattgctggaggaagaaaaagagctggaggagatccgggtcctggac
aaagtcttcagtcctcagttgctattggaattttcagagctgaagcacaggaccaaggtg
actgtgatggaaggagacattctggatgagcagctcctccgcaaggcctgccagggcatc
actgctgtcattcacaccgcgtgcatcattgacatgggattacggctcagaaaagaagtc
gtaatgaatgtcaacttgaaaggtactcagctcctgttggaagcctgcatctcagctaat
gtgcctgtcttcctctacaccagctctgtagaagtggctggccccaactcatatacaaag
cccatccaaaatgggcatgagggtatgctccttgaaagcaagtggtacaatgcatatccc
tatagcaagaaactggctgagaaggctgtgttggaggctgatgggcagcttctcaagaat
ggctccatcatgcacacctgctccttgaggcccatgtacatctatggggaggggtgcgtt
tttctccaaaatgaaataatcaaatcccttaacaaaaataagacctttataaggagtagg
gagggttccatgagcaaccaagtctatgttggaaatgtggcttgggcacacgtgctggca
ctcagagccctgcgggactctgagaaggcccaaagcattgggggtgagttctattacatc
tgtgatgatacacccccccagagctattctgattttaactatcaagtgagcaaggaatgg
ggcttcaaacttggatcaaaaataggcattcctctaacattactgtattgggcagctttc
ctgttggagatgataagtttcatgctaagccctattttcatttatgaacctcccttcaat
cgtcatttgctaacattgagcaacagtgtttttaccttctcctacgagaaggccaaaaag
gatttgggttatgagcctcgcttcagctggctagaagccaagcagaaaactggtcagtgg
ataggcacggtggtggcacagaacagagagtatctgaagacaaaggccccctga
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