Phascolarctos cinereus (koala): 110223345 Help Entry 110223345         CDS       T05867                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism pcw  Phascolarctos cinereus (koala) Pathway pcw04062   Chemokine signaling pathway pcw04151   PI3K-Akt signaling pathway pcw04217   Necroptosis pcw04550   Signaling pathways regulating pluripotency of stem cells pcw04630   JAK-STAT signaling pathway pcw04658   Th1 and Th2 cell differentiation pcw04659   Th17 cell differentiation pcw05161   Hepatitis B pcw05162   Measles pcw05166   Human T-cell leukemia virus 1 infection pcw05169   Epstein-Barr virus infection pcw05200   Pathways in cancer pcw05203   Viral carcinogenesis pcw05223   Non-small cell lung cancer pcw05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:pcw00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     110223345 (JAK3)    04151 PI3K-Akt signaling pathway     110223345 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     110223345 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     110223345 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     110223345 (JAK3)    04659 Th17 cell differentiation     110223345 (JAK3)    04062 Chemokine signaling pathway     110223345 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     110223345 (JAK3)    05203 Viral carcinogenesis     110223345 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     110223345 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     110223345 (JAK3)    05161 Hepatitis B     110223345 (JAK3)    05162 Measles     110223345 (JAK3)    05169 Epstein-Barr virus infection     110223345 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     110223345 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcw01001]     110223345 (JAK3) Enzymes [BR:pcw01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      110223345 (JAK3) Protein kinases [BR:pcw01001]  Non-receptor tyrosine kinases   JAK family [OT]    110223345 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl FERM_C_FAK1 SH2 ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  110223345 NCBI-ProteinID:  XP_020864464 UniProt:  A0A6P5M1B5 LinkDB All DBs Position Unknown AA seq 1103 aa AA seqDB search MAPLGEDTPLIEQRSYSLSSSEAGSLQVLLCPRNPGSPQVLTFSFGEYSAEQLCVQAAKA CGILPVCHALFALATEDLSCWFPPNHVFMVEDATVQILLYRIRFVFPNWLGLEKCYRFGL QKDRANAILDFPVLEYLFAQSRSDFITGRMNLTLSLKEQGECLSLAVLDLTRMAQEQGLC SKEILRSISYKACIPGSFRRLIQSLSFMTRKRYRQMVHRALQRVASCQADVHSIMLKYLM DLERLKSTRASETFEGRTPGATSGRDSNCLIHVAGDSGISWTPEGSESPQPFCDFPEIVD IGIKQACREGHLSESRLVTVTKTDNRILEVEFPALREALSFISLVDGYYRLTTDAHHYFC KEVAPPQLLENIDNQCHGPIMSEFAVNKLKLGGSVPGSYVLRQSPQDFNSFLLTVCIQTS LGPDYKGCLIHRDVSGNLFLSGLSRAHSSLRQLLESSRGCGLLVDGTALSLSSCCPPRPK EKSNLIIVRRDCTLTPAQAWPQPQCQLNQMMFHKIPADSLEWHENLGHGSFTKIYRGSRL DKVDGETHKVEILLKVMDSTHQNCIESFLEAASIMSQVSHQHLVLLHGVCMAGDSIMVQE FVRWGALDTHLRKCGPLVPASWKLQVAKQLSYALNYLEDKGIIHGNISSKKVLLAREGTG GSPPFIKLSDPGVSPTVLTKEMLTDRIPWLAPECLWDAKLLSLESDKWSFGATLWEIFSG GTIPLSALEPTKKLQFYKEKQQLPALKWTELATLIGQCMEYTPHLRPSFRAIIRDLNSLI TSDYELLSDLSPSAVAARDGLWSSAHLMAGQDPTLFEERHLKYISLLGKGNFGSVELCRY DPLGDNTGALVAVKQLQNSGPQQLQDFQREVQILKALHSDFIVKYRGVCYGPGRQSLRLV MEYLPNGCLRDYLQRHRAHLDPCFLLLYASQICKGMEYLGSQRYVHRDLANRNILVESES HVKIGDFGLAKLLPQDKEYYVVREPGQSPIFWYAPESLSDNIFSRESDVWSFGVVLYELY TYSDKAHSPSEEFFRMMACDRSMPILCHLLELLTEGRRLPTPPGCPGEVREIMRSCWAYN PKDRPSFCALGPRLDALWAGRRG NT seq 3312 nt NT seq  +upstreamnt  +downstreamnt atggcgcctctgggggaggacacccccctgattgaacagcggtcctacagcctctcctcc agcgaggccggctccctgcaagtgctcctgtgtccccgaaacccagggtccccgcaggtc ctcaccttctcctttggggagtactctgctgaacagctctgtgtgcaggctgccaaggcc tgcgggatcttgcctgtatgccatgctctctttgccctggccactgaagacctgtcctgc tggttcccacccaaccacgtcttcatggtggaagatgctaccgtccaaattctcctttac aggatccgatttgtcttcccaaactggctcggcctggagaagtgttaccgctttgggcta cagaaggaccgagccaacgccatcctggacttcccggttctcgagtatctctttgctcag tcccgaagtgacttcatcactgggaggatgaatctgactctgagccttaaggagcaggga gagtgcctgagcctggcagtgttggacctgactcggatggcacaggagcagggcctgtgc tccaaggagattctcaggagcatcagctacaaagcctgtatcccaggaagcttccgacga ttgattcagagtctcagcttcatgactcggaagcgttatcgtcagatggtgcaccgagcc ctgcagagagtggcatcctgccaggcagatgtgcactcaatcatgctaaaatacctcatg gacctggagaggctgaaatccacccgggcttcagagaccttcgagggccggacgccaggg gctacatctggccgggactccaactgtctcatccacgtggcgggagacagcggcatctcc tggacccctgagggcagtgagagcccacagcctttctgcgatttccctgaaatcgttgat atcggcatcaagcaggcctgcagggaaggtcatctcagcgagagccgactggtcactgtt accaagactgacaacaggatcctggaagttgaatttccagctctaagggaggcgctgtcc tttatctctctggttgatggctactaccgactcacaactgatgcccaccactacttctgc aaagaggtggccccaccccagctcttggagaacattgacaaccaatgccatggtcccatc atgtccgagtttgccgtgaacaagctgaagttgggggggtcagttccgggatcctacgtc cttcggcaaagcccccaggacttcaacagcttcctcctcactgtctgtatccagacgtcc ctgggcccagactacaagggctgcttaatccaccgggacgtttcagggaacctcttcttg tctgggctgagccgggcccacagcagcctgcgacagctgctggagtcctccaggggctgc gggctccttgtagatgggactgcactgagcctcagtagctgctgtccccccaggcccaaa gagaagtccaacctgatcatagtgagaagggattgcaccttaaccccagcccaggcctgg cctcagccccagtgccagctcaaccaaatgatgttccacaaaatccctgctgacagcttg gagtggcatgagaacctgggccacggctccttcaccaagatctaccgtggtagccgcctg gataaggtggacggggagacccacaaggtagagatcctgctcaaggtgatggacagcaca caccagaactgcattgagtccttcctagaggctgccagcatcatgagtcaagtgtcccac cagcacctggtgctgctgcatggtgtctgcatggcaggagatagtatcatggtacaggag tttgtgagatggggggcactcgatacccacttacggaagtgcgggcccctggtacctgcc agttggaagctccaagtggccaagcaactttcttacgctctcaactacctggaagacaaa ggcatcatccatggcaatatctcctccaagaaggtcctcctagcgagggaaggaactggg gggagcccccctttcatcaagctcagcgaccctggggtcagtcccactgtgctgaccaaa gagatgctcactgaccggatcccctggctggctcccgagtgtctgtgggatgccaagctg ctgagcctggaatctgacaagtggagctttggggcaacactctgggagatattcagtggg ggcaccattcccctaagtgccctggagcccaccaagaaactccagttctacaaggagaag cagcagctgccagccctgaaatggacagagctagccaccctgatcggccagtgcatggag tacactcctcacctgcggccctccttccgagccatcatccgggatctcaatagcctcatc acctcagattatgagctcctctcagatctctcacctagtgctgtggcggctcgggatgga ctctggagcagcgctcacctgatggctggccaggaccccaccctctttgaggagagacac cttaaatatatctccctgctgggcaagggcaactttggcagtgtggaattgtgtcgctat gacccgctgggagataacacgggagcgctggtggcagtcaagcagctacagaacagtggg ccccagcagcttcaggacttccagcgagaggtgcagattctgaaagcattacacagtgac ttcatagtcaaatatcgaggcgtctgctatggcccaggccgacagagtctgcgcctcgtt atggaatacctccccaacggctgcctccgggactacctgcagcgtcaccgggcccaccta gacccctgtttcctcctcctctacgcttcccagatctgcaagggaatggaatacctgggc tctcagcgatatgttcacagagacttagccaacaggaacatcttggtggagagtgagagc cacgtgaagattggagactttggcctggccaaacttcttccccaggacaaagaatactac gtagtcagggagcctggccagagccccatcttctggtatgccccagagtccttgtcagac aacatcttctccagggagtctgatgtctggagttttggcgtggtcctctatgagctttat acatatagtgacaaagcccacagcccttcagaggagttcttccgaatgatggcatgtgac cgctccatgcccatcctctgccacctgctggagctgcttacggagggcaggcggttgccc actcctcctggctgcccaggagaggttcgagagatcatgaggagctgttgggcctacaac cccaaggaccggccttccttctgtgccctggggccccggcttgatgctttgtgggctggg cgcagagggtag

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