KEGG   Phascolarctos cinereus (koala): 110223395
Entry
110223395         CDS       T05867                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw01522  Endocrine resistance
pcw01524  Platinum drug resistance
pcw04012  ErbB signaling pathway
pcw04014  Ras signaling pathway
pcw04015  Rap1 signaling pathway
pcw04024  cAMP signaling pathway
pcw04062  Chemokine signaling pathway
pcw04066  HIF-1 signaling pathway
pcw04068  FoxO signaling pathway
pcw04070  Phosphatidylinositol signaling system
pcw04071  Sphingolipid signaling pathway
pcw04072  Phospholipase D signaling pathway
pcw04081  Hormone signaling
pcw04140  Autophagy - animal
pcw04150  mTOR signaling pathway
pcw04151  PI3K-Akt signaling pathway
pcw04152  AMPK signaling pathway
pcw04210  Apoptosis
pcw04211  Longevity regulating pathway
pcw04213  Longevity regulating pathway - multiple species
pcw04218  Cellular senescence
pcw04360  Axon guidance
pcw04370  VEGF signaling pathway
pcw04380  Osteoclast differentiation
pcw04510  Focal adhesion
pcw04550  Signaling pathways regulating pluripotency of stem cells
pcw04611  Platelet activation
pcw04613  Neutrophil extracellular trap formation
pcw04620  Toll-like receptor signaling pathway
pcw04625  C-type lectin receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
pcw04650  Natural killer cell mediated cytotoxicity
pcw04660  T cell receptor signaling pathway
pcw04662  B cell receptor signaling pathway
pcw04664  Fc epsilon RI signaling pathway
pcw04666  Fc gamma R-mediated phagocytosis
pcw04668  TNF signaling pathway
pcw04670  Leukocyte transendothelial migration
pcw04722  Neurotrophin signaling pathway
pcw04725  Cholinergic synapse
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04810  Regulation of actin cytoskeleton
pcw04910  Insulin signaling pathway
pcw04914  Progesterone-mediated oocyte maturation
pcw04915  Estrogen signaling pathway
pcw04917  Prolactin signaling pathway
pcw04919  Thyroid hormone signaling pathway
pcw04923  Regulation of lipolysis in adipocytes
pcw04926  Relaxin signaling pathway
pcw04929  GnRH secretion
pcw04930  Type II diabetes mellitus
pcw04931  Insulin resistance
pcw04932  Non-alcoholic fatty liver disease
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04935  Growth hormone synthesis, secretion and action
pcw04960  Aldosterone-regulated sodium reabsorption
pcw04973  Carbohydrate digestion and absorption
pcw05010  Alzheimer disease
pcw05017  Spinocerebellar ataxia
pcw05020  Prion disease
pcw05100  Bacterial invasion of epithelial cells
pcw05135  Yersinia infection
pcw05142  Chagas disease
pcw05146  Amoebiasis
pcw05160  Hepatitis C
pcw05161  Hepatitis B
pcw05162  Measles
pcw05163  Human cytomegalovirus infection
pcw05164  Influenza A
pcw05165  Human papillomavirus infection
pcw05166  Human T-cell leukemia virus 1 infection
pcw05167  Kaposi sarcoma-associated herpesvirus infection
pcw05168  Herpes simplex virus 1 infection
pcw05169  Epstein-Barr virus infection
pcw05170  Human immunodeficiency virus 1 infection
pcw05171  Coronavirus disease - COVID-19
pcw05200  Pathways in cancer
pcw05203  Viral carcinogenesis
pcw05205  Proteoglycans in cancer
pcw05206  MicroRNAs in cancer
pcw05207  Chemical carcinogenesis - receptor activation
pcw05208  Chemical carcinogenesis - reactive oxygen species
pcw05210  Colorectal cancer
pcw05211  Renal cell carcinoma
pcw05212  Pancreatic cancer
pcw05213  Endometrial cancer
pcw05214  Glioma
pcw05215  Prostate cancer
pcw05218  Melanoma
pcw05220  Chronic myeloid leukemia
pcw05221  Acute myeloid leukemia
pcw05222  Small cell lung cancer
pcw05223  Non-small cell lung cancer
pcw05224  Breast cancer
pcw05225  Hepatocellular carcinoma
pcw05226  Gastric cancer
pcw05230  Central carbon metabolism in cancer
pcw05231  Choline metabolism in cancer
pcw05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
pcw05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110223395 (PIK3R2)
   04014 Ras signaling pathway
    110223395 (PIK3R2)
   04015 Rap1 signaling pathway
    110223395 (PIK3R2)
   04370 VEGF signaling pathway
    110223395 (PIK3R2)
   04630 JAK-STAT signaling pathway
    110223395 (PIK3R2)
   04668 TNF signaling pathway
    110223395 (PIK3R2)
   04066 HIF-1 signaling pathway
    110223395 (PIK3R2)
   04068 FoxO signaling pathway
    110223395 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    110223395 (PIK3R2)
   04072 Phospholipase D signaling pathway
    110223395 (PIK3R2)
   04071 Sphingolipid signaling pathway
    110223395 (PIK3R2)
   04024 cAMP signaling pathway
    110223395 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    110223395 (PIK3R2)
   04152 AMPK signaling pathway
    110223395 (PIK3R2)
   04150 mTOR signaling pathway
    110223395 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110223395 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110223395 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    110223395 (PIK3R2)
   04218 Cellular senescence
    110223395 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110223395 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    110223395 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110223395 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110223395 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    110223395 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    110223395 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    110223395 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    110223395 (PIK3R2)
   04660 T cell receptor signaling pathway
    110223395 (PIK3R2)
   04662 B cell receptor signaling pathway
    110223395 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    110223395 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    110223395 (PIK3R2)
   04670 Leukocyte transendothelial migration
    110223395 (PIK3R2)
   04062 Chemokine signaling pathway
    110223395 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110223395 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    110223395 (PIK3R2)
   04929 GnRH secretion
    110223395 (PIK3R2)
   04915 Estrogen signaling pathway
    110223395 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    110223395 (PIK3R2)
   04917 Prolactin signaling pathway
    110223395 (PIK3R2)
   04926 Relaxin signaling pathway
    110223395 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    110223395 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    110223395 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110223395 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110223395 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    110223395 (PIK3R2)
   04722 Neurotrophin signaling pathway
    110223395 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110223395 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    110223395 (PIK3R2)
   04380 Osteoclast differentiation
    110223395 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    110223395 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    110223395 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110223395 (PIK3R2)
   05206 MicroRNAs in cancer
    110223395 (PIK3R2)
   05205 Proteoglycans in cancer
    110223395 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    110223395 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    110223395 (PIK3R2)
   05203 Viral carcinogenesis
    110223395 (PIK3R2)
   05230 Central carbon metabolism in cancer
    110223395 (PIK3R2)
   05231 Choline metabolism in cancer
    110223395 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110223395 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110223395 (PIK3R2)
   05212 Pancreatic cancer
    110223395 (PIK3R2)
   05225 Hepatocellular carcinoma
    110223395 (PIK3R2)
   05226 Gastric cancer
    110223395 (PIK3R2)
   05214 Glioma
    110223395 (PIK3R2)
   05221 Acute myeloid leukemia
    110223395 (PIK3R2)
   05220 Chronic myeloid leukemia
    110223395 (PIK3R2)
   05218 Melanoma
    110223395 (PIK3R2)
   05211 Renal cell carcinoma
    110223395 (PIK3R2)
   05215 Prostate cancer
    110223395 (PIK3R2)
   05213 Endometrial cancer
    110223395 (PIK3R2)
   05224 Breast cancer
    110223395 (PIK3R2)
   05222 Small cell lung cancer
    110223395 (PIK3R2)
   05223 Non-small cell lung cancer
    110223395 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110223395 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    110223395 (PIK3R2)
   05161 Hepatitis B
    110223395 (PIK3R2)
   05160 Hepatitis C
    110223395 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    110223395 (PIK3R2)
   05164 Influenza A
    110223395 (PIK3R2)
   05162 Measles
    110223395 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    110223395 (PIK3R2)
   05163 Human cytomegalovirus infection
    110223395 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110223395 (PIK3R2)
   05169 Epstein-Barr virus infection
    110223395 (PIK3R2)
   05165 Human papillomavirus infection
    110223395 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    110223395 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    110223395 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110223395 (PIK3R2)
   05142 Chagas disease
    110223395 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110223395 (PIK3R2)
   05017 Spinocerebellar ataxia
    110223395 (PIK3R2)
   05020 Prion disease
    110223395 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110223395 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    110223395 (PIK3R2)
   05415 Diabetic cardiomyopathy
    110223395 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110223395 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    110223395 (PIK3R2)
   04931 Insulin resistance
    110223395 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110223395 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110223395 (PIK3R2)
   01524 Platinum drug resistance
    110223395 (PIK3R2)
   01522 Endocrine resistance
    110223395 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcw04131]
    110223395 (PIK3R2)
Membrane trafficking [BR:pcw04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110223395 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 SH3_2 Ribosomal_L22e Mod_r
Other DBs
NCBI-GeneID: 110223395
NCBI-ProteinID: XP_020864542
UniProt: A0A6P5M1G0
LinkDB
Position
Unknown
AA seq 740 aa
MGSAEGFQYRALYQYHKEREEDLDLLPGDILVVSKGTLEALGFQDGDEQSPHHIGWILGV
NERTKQKGDFPGTYVEYLGPVKIALPSHRPRGHRPLPATPGAGPVRPRDSPEPAGTLLPD
LPEQFVPPEAAPPILQKLVEAIEHKGLDSEMLYRPSGCAMRPLRIDWTLSDVDQWDVATL
SEALKGYLQALPRPLVPPGAHGDMLHALQEIAGPASAAASAGWRRQQLQAVLEPPLVPLH
NALTLRFLLQHLRRVARQAQAQAQGSGLGPRALSEIFGPLLLRLPATGPEQTPDFSALFL
EMLLQEQEEEEEEPVPPALPPKPPKPKVQAGSLSNGSHAPLQEAEWYWGDISREEVNEKL
RDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGQYGFSEPLTFGSVVELITH
YRHESLAQYNAKLDTRLLYPVSKHQQDQVVKEDSIEAVGEQLKVYHQQYQDKSREYDLLY
EEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKDYLERFRREGNEKEIQRILMN
SEKLKSRIAEIHDSKMKLEQDLRAQAADNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQK
GARQKKINEWLGIKNDTEDQYSMVDEEEDLPHQEERTWYVGKINRGRAEEMLSGKRDGTF
LIRESSQRGCYACSVVVDGDTKHCVIYKTVTGYGFAEPYNLYASLKDLVLHYKHTSLVQH
NDSLNVTLAHPVLSPPPPAR
NT seq 2223 nt   +upstreamnt  +downstreamnt
atgggcagcgccgagggcttccagtaccgggccctttaccagtaccacaaggagcgtgag
gaggaccttgacttgctccctggcgacatcctcgtagtgagcaagggcacgctggaggct
ctcggattccaggatggcgatgagcagagccctcaccacatcggctggatcctcggcgtc
aatgagcgtaccaagcagaagggagacttcccaggcacttatgtggagtatctgggtcct
gtgaagatcgccctgccctcccaccgcccccgaggccacaggccgttgccggccacgcca
ggggcagggcctgtccgtccccgggactcccctgagccagctggtaccctgctccctgac
ctgccggagcagtttgtccctcccgaggcagcaccgcccatccttcagaagttggtggaa
gccattgaacacaaagggctggacagcgagatgctctatagaccatctggttgtgcgatg
cggccactcagaattgactggactctgagtgacgtggatcagtgggatgtggccaccctt
tctgaggccctgaagggctacctacaagctttgcccaggccccttgtgccacctggagcc
catggagatatgcttcatgccttgcaggagatagccggtccagcctcagcggcggcatca
gcgggatggaggaggcagcagctgcaggcagtgctggagcctcccctggtgcccctgcac
aacgccctgactctgcgcttcctgctccagcacctgcggagggtggcccggcaggcccag
gcccaagcccagggcagcggcctgggcccccgggccctctcagagatctttggacctctc
ctccttcggctgccggccactgggcctgagcagacccctgacttctcggctctgttcctg
gaaatgctgctacaggagcaggaggaggaggaggaggagccagtgcccccagccctaccc
ccaaagcctcccaaacccaaggtccaggctggtagcttgtctaatggaagccacgccccc
cttcaggaagctgagtggtattggggcgacatttccagggaagaggtgaatgagaaactt
cgtgacactccagatggtaccttcctcgtccgggacgcatctagcaagatccagggtgaa
tacacgctgaccctcaggaagggcggtaataacaaactgatcaaagtcttccaccgagat
gggcagtacggcttctccgagcccctgacctttggctccgtggtggagctcatcacccac
tacagacacgagtcgctggcccagtacaatgccaagctggacactcggctgctctatccc
gtgtccaagcatcagcaggaccaggtggtgaaggaggacagcatcgaggccgttggtgaa
cagctgaaggtttatcatcagcagtaccaggacaagagccgagaatatgacctgctctat
gaggaatatacccgtacttcccaggagctgcagatgaagcgcacagccatcgaggccttc
aacgagaccatcaaaatctttgaggagcagggccagacacaggaaaagtgcagcaaggat
tacctggaacgcttccggcgagagggcaatgagaaggagattcagcggatcctgatgaat
tctgagaagctcaagtcccgaatagcagagattcacgacagcaaaatgaagctggagcag
gacctgcgggcccaggcagccgacaaccgagagatagacaaacgcatgaacagcctcaag
cctgacctcatgcagctacggaaaatccgggaccagtacctagtgtggctcacccagaag
ggagcccggcagaagaagattaatgagtggctgggaatcaagaacgatactgaagaccag
tattctatggtggatgaggaagaggacctgccccatcaggaggagcggacgtggtacgtt
gggaagatcaaccgaggtcgggcagaggagatgctgagtggcaagcgggatggcaccttc
ctcatccgtgagagcagccagcggggatgctacgcctgttcggtggtggtggacggagac
accaaacactgcgtcatctacaaaacggtgaccggctatggttttgccgagccctacaac
ctgtacgcctccctcaaggacttggtgctacattacaagcatacgtcgctggttcagcat
aacgactccctcaatgtgacgctggcccaccccgtgctgtctccaccaccgcctgcccgc
tga

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