KEGG   Phyllostomus discolor (pale spear-nosed bat): 114501063
Entry
114501063         CDS       T07739                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic01524  Platinum drug resistance
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04081  Hormone signaling
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04152  AMPK signaling pathway
pdic04210  Apoptosis
pdic04211  Longevity regulating pathway
pdic04213  Longevity regulating pathway - multiple species
pdic04218  Cellular senescence
pdic04360  Axon guidance
pdic04370  VEGF signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04625  C-type lectin receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04668  TNF signaling pathway
pdic04670  Leukocyte transendothelial migration
pdic04722  Neurotrophin signaling pathway
pdic04725  Cholinergic synapse
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04923  Regulation of lipolysis in adipocytes
pdic04926  Relaxin signaling pathway
pdic04929  GnRH secretion
pdic04930  Type II diabetes mellitus
pdic04931  Insulin resistance
pdic04932  Non-alcoholic fatty liver disease
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04935  Growth hormone synthesis, secretion and action
pdic04960  Aldosterone-regulated sodium reabsorption
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05017  Spinocerebellar ataxia
pdic05020  Prion disease
pdic05100  Bacterial invasion of epithelial cells
pdic05135  Yersinia infection
pdic05142  Chagas disease
pdic05146  Amoebiasis
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05162  Measles
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05168  Herpes simplex virus 1 infection
pdic05169  Epstein-Barr virus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05171  Coronavirus disease - COVID-19
pdic05200  Pathways in cancer
pdic05203  Viral carcinogenesis
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05218  Melanoma
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05222  Small cell lung cancer
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
pdic05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114501063 (PIK3R1)
   04014 Ras signaling pathway
    114501063 (PIK3R1)
   04015 Rap1 signaling pathway
    114501063 (PIK3R1)
   04370 VEGF signaling pathway
    114501063 (PIK3R1)
   04630 JAK-STAT signaling pathway
    114501063 (PIK3R1)
   04668 TNF signaling pathway
    114501063 (PIK3R1)
   04066 HIF-1 signaling pathway
    114501063 (PIK3R1)
   04068 FoxO signaling pathway
    114501063 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    114501063 (PIK3R1)
   04072 Phospholipase D signaling pathway
    114501063 (PIK3R1)
   04071 Sphingolipid signaling pathway
    114501063 (PIK3R1)
   04024 cAMP signaling pathway
    114501063 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    114501063 (PIK3R1)
   04152 AMPK signaling pathway
    114501063 (PIK3R1)
   04150 mTOR signaling pathway
    114501063 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    114501063 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114501063 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    114501063 (PIK3R1)
   04218 Cellular senescence
    114501063 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114501063 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    114501063 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114501063 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114501063 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    114501063 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    114501063 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    114501063 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    114501063 (PIK3R1)
   04660 T cell receptor signaling pathway
    114501063 (PIK3R1)
   04662 B cell receptor signaling pathway
    114501063 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    114501063 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    114501063 (PIK3R1)
   04670 Leukocyte transendothelial migration
    114501063 (PIK3R1)
   04062 Chemokine signaling pathway
    114501063 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114501063 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    114501063 (PIK3R1)
   04929 GnRH secretion
    114501063 (PIK3R1)
   04915 Estrogen signaling pathway
    114501063 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    114501063 (PIK3R1)
   04917 Prolactin signaling pathway
    114501063 (PIK3R1)
   04926 Relaxin signaling pathway
    114501063 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    114501063 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    114501063 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114501063 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    114501063 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    114501063 (PIK3R1)
   04722 Neurotrophin signaling pathway
    114501063 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114501063 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    114501063 (PIK3R1)
   04380 Osteoclast differentiation
    114501063 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    114501063 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    114501063 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114501063 (PIK3R1)
   05206 MicroRNAs in cancer
    114501063 (PIK3R1)
   05205 Proteoglycans in cancer
    114501063 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    114501063 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    114501063 (PIK3R1)
   05203 Viral carcinogenesis
    114501063 (PIK3R1)
   05230 Central carbon metabolism in cancer
    114501063 (PIK3R1)
   05231 Choline metabolism in cancer
    114501063 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114501063 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114501063 (PIK3R1)
   05212 Pancreatic cancer
    114501063 (PIK3R1)
   05225 Hepatocellular carcinoma
    114501063 (PIK3R1)
   05226 Gastric cancer
    114501063 (PIK3R1)
   05214 Glioma
    114501063 (PIK3R1)
   05221 Acute myeloid leukemia
    114501063 (PIK3R1)
   05220 Chronic myeloid leukemia
    114501063 (PIK3R1)
   05218 Melanoma
    114501063 (PIK3R1)
   05211 Renal cell carcinoma
    114501063 (PIK3R1)
   05215 Prostate cancer
    114501063 (PIK3R1)
   05213 Endometrial cancer
    114501063 (PIK3R1)
   05224 Breast cancer
    114501063 (PIK3R1)
   05222 Small cell lung cancer
    114501063 (PIK3R1)
   05223 Non-small cell lung cancer
    114501063 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114501063 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    114501063 (PIK3R1)
   05161 Hepatitis B
    114501063 (PIK3R1)
   05160 Hepatitis C
    114501063 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    114501063 (PIK3R1)
   05164 Influenza A
    114501063 (PIK3R1)
   05162 Measles
    114501063 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    114501063 (PIK3R1)
   05163 Human cytomegalovirus infection
    114501063 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114501063 (PIK3R1)
   05169 Epstein-Barr virus infection
    114501063 (PIK3R1)
   05165 Human papillomavirus infection
    114501063 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    114501063 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    114501063 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114501063 (PIK3R1)
   05142 Chagas disease
    114501063 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114501063 (PIK3R1)
   05017 Spinocerebellar ataxia
    114501063 (PIK3R1)
   05020 Prion disease
    114501063 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114501063 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    114501063 (PIK3R1)
   05415 Diabetic cardiomyopathy
    114501063 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114501063 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    114501063 (PIK3R1)
   04931 Insulin resistance
    114501063 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114501063 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114501063 (PIK3R1)
   01524 Platinum drug resistance
    114501063 (PIK3R1)
   01522 Endocrine resistance
    114501063 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pdic04131]
    114501063 (PIK3R1)
Membrane trafficking [BR:pdic04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    114501063 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 Laminin_I SH3_9 CCDC113_CCDC96_CC ACDC FANCI_S2
Other DBs
NCBI-GeneID: 114501063
NCBI-ProteinID: XP_028373577
UniProt: A0A6J2M0P0
LinkDB
Position
3:41790457..41873287
AA seq 724 aa
MSAEAYQYRALYDYKKEREEDIDLHLGDILTVNKGSLLALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTETESEQQALALPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLETVDVQ
VLADAFKRYLLDLPNPVIPVAVYNEMISLAQEVQSSEEYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQSSSKNLLTARVLSELFSPLLFRFPAASSENTEHLIKAVEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgaggcgtaccagtacagagcactgtatgactataaaaaggaacgagaagaa
gatattgacttgcacttgggtgatatattgacggtgaataaggggtccttactagctctc
ggattcagtgatggacaggaagccaggccagaagaaattggctggttaaatggctacaat
gaaaccacaggggagagaggggactttccaggaacttatgtagaatatattggaaggaaa
aaaatctcacctcccaccccaaagccccggccacctcgaccccttcctgttgcaccaggt
tcttcgaaaactgaaacagaaagtgagcagcaagctttggcccttccagatctcgcagaa
cagtttgcccctcctgacattgctccacctcttcttatcaagctagtagaagccatcgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtgatgccgcctccatggacttggaaacagttgatgttcaa
gttttagcagatgctttcaaacgctatctcttggacctgccgaatcctgtcattccagta
gctgtttacaatgagatgatttctttagcccaagaagttcaaagctcagaagaatatatc
cagctgttgaagaagctcattaggtcacctaacatacctcatcagtattggcttacactt
cagtatttgctaaaacatttcttcaagctctcccaaagctccagcaaaaaccttctgact
gcaagagtgctctctgaacttttcagccctctgcttttcagattcccagcagccagctct
gagaatactgaacacctcataaaagctgtagaaatcttaatctcaacagaatggaacgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgccgaatggtactggggagatatctctcgg
gaagaagtgaatgaaaaacttcgagacacagctgacgggaccttcttggtacgagacgca
tctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatattccaccgagatgggaaatatggcttctccgacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatatcgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgataggttatatgaggattatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caggagcgctacagcaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaggaa
atacaaaggattatgcataattatgaaaagttaaagtctcgaatcagtgaaattgtggac
agcagaagacgactggaggaagacttgaagaagcaggcagctgagtatcgggagattgac
aaacgcatgaacagcattaagccagaccttatccagctgagaaagaccagagaccaatac
ttgatgtggttgactcagaagggtgttcggcagaagaagctgaacgagtggctgggcaac
gagaacaccgaagaccaatattcgctggtggaagacgacgaggacttgccccaccacgac
gagaagacgtggaatgtcgggagcagcaaccggaacaaagctgagaacctgctgcgaggg
aagcgggacggtactttccttgtccgggaaagcagtaagcagggctgctacgcctgctct
gtggtggtggacggcgaggtgaagcactgcgtcatcaacaaaacggcgacaggctacggc
tttgcggagccctacaacctgtacggctccctgaaagaactggtgctccattaccaacac
acctccctggtgcagcacaacgactccctcaacgtcacactagcctacccggtgtatgcg
cagcagaggcgatga

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