KEGG   Phyllostomus discolor (pale spear-nosed bat): 114503388
Entry
114503388         CDS       T07739                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic04010  MAPK signaling pathway
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04024  cAMP signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04140  Autophagy - animal
pdic04148  Efferocytosis
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04210  Apoptosis
pdic04218  Cellular senescence
pdic04270  Vascular smooth muscle contraction
pdic04370  VEGF signaling pathway
pdic04371  Apelin signaling pathway
pdic04540  Gap junction
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04720  Long-term potentiation
pdic04722  Neurotrophin signaling pathway
pdic04730  Long-term depression
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04912  GnRH signaling pathway
pdic04915  Estrogen signaling pathway
pdic04916  Melanogenesis
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04921  Oxytocin signaling pathway
pdic04926  Relaxin signaling pathway
pdic04929  GnRH secretion
pdic04934  Cushing syndrome
pdic04935  Growth hormone synthesis, secretion and action
pdic05010  Alzheimer disease
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05132  Salmonella infection
pdic05135  Yersinia infection
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05200  Pathways in cancer
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05216  Thyroid cancer
pdic05218  Melanoma
pdic05219  Bladder cancer
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114503388 (MAP2K2)
   04012 ErbB signaling pathway
    114503388 (MAP2K2)
   04014 Ras signaling pathway
    114503388 (MAP2K2)
   04015 Rap1 signaling pathway
    114503388 (MAP2K2)
   04370 VEGF signaling pathway
    114503388 (MAP2K2)
   04371 Apelin signaling pathway
    114503388 (MAP2K2)
   04066 HIF-1 signaling pathway
    114503388 (MAP2K2)
   04068 FoxO signaling pathway
    114503388 (MAP2K2)
   04072 Phospholipase D signaling pathway
    114503388 (MAP2K2)
   04071 Sphingolipid signaling pathway
    114503388 (MAP2K2)
   04024 cAMP signaling pathway
    114503388 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    114503388 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    114503388 (MAP2K2)
   04150 mTOR signaling pathway
    114503388 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114503388 (MAP2K2)
   04148 Efferocytosis
    114503388 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    114503388 (MAP2K2)
   04218 Cellular senescence
    114503388 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    114503388 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    114503388 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114503388 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    114503388 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    114503388 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    114503388 (MAP2K2)
   04660 T cell receptor signaling pathway
    114503388 (MAP2K2)
   04662 B cell receptor signaling pathway
    114503388 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    114503388 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114503388 (MAP2K2)
   04929 GnRH secretion
    114503388 (MAP2K2)
   04912 GnRH signaling pathway
    114503388 (MAP2K2)
   04915 Estrogen signaling pathway
    114503388 (MAP2K2)
   04917 Prolactin signaling pathway
    114503388 (MAP2K2)
   04921 Oxytocin signaling pathway
    114503388 (MAP2K2)
   04926 Relaxin signaling pathway
    114503388 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    114503388 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    114503388 (MAP2K2)
   04916 Melanogenesis
    114503388 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    114503388 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    114503388 (MAP2K2)
   04730 Long-term depression
    114503388 (MAP2K2)
   04722 Neurotrophin signaling pathway
    114503388 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114503388 (MAP2K2)
   05206 MicroRNAs in cancer
    114503388 (MAP2K2)
   05205 Proteoglycans in cancer
    114503388 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    114503388 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    114503388 (MAP2K2)
   05230 Central carbon metabolism in cancer
    114503388 (MAP2K2)
   05231 Choline metabolism in cancer
    114503388 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114503388 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114503388 (MAP2K2)
   05225 Hepatocellular carcinoma
    114503388 (MAP2K2)
   05226 Gastric cancer
    114503388 (MAP2K2)
   05214 Glioma
    114503388 (MAP2K2)
   05216 Thyroid cancer
    114503388 (MAP2K2)
   05221 Acute myeloid leukemia
    114503388 (MAP2K2)
   05220 Chronic myeloid leukemia
    114503388 (MAP2K2)
   05218 Melanoma
    114503388 (MAP2K2)
   05211 Renal cell carcinoma
    114503388 (MAP2K2)
   05219 Bladder cancer
    114503388 (MAP2K2)
   05215 Prostate cancer
    114503388 (MAP2K2)
   05213 Endometrial cancer
    114503388 (MAP2K2)
   05224 Breast cancer
    114503388 (MAP2K2)
   05223 Non-small cell lung cancer
    114503388 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114503388 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    114503388 (MAP2K2)
   05161 Hepatitis B
    114503388 (MAP2K2)
   05160 Hepatitis C
    114503388 (MAP2K2)
   05164 Influenza A
    114503388 (MAP2K2)
   05163 Human cytomegalovirus infection
    114503388 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114503388 (MAP2K2)
   05165 Human papillomavirus infection
    114503388 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114503388 (MAP2K2)
   05135 Yersinia infection
    114503388 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114503388 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    114503388 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    114503388 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114503388 (MAP2K2)
   01522 Endocrine resistance
    114503388 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pdic01001]
    114503388 (MAP2K2)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     114503388 (MAP2K2)
Protein kinases [BR:pdic01001]
 Serine/threonine kinases: STE group
  STE7 family
   114503388 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 114503388
NCBI-ProteinID: XP_028376740
UniProt: A0A6J2MEL3
LinkDB
Position
8:complement(39476046..39501089)
AA seq 401 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGGERGSSSTPWPTSFVGTRSYMSPERL
QGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDTKELEAIFGRPMVDGAEGEPHSISPRPR
PPGRPISGHGVDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERAD
LKMLMNHGFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1206 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggctctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagaggagctagaacttgatgagcagcagaagaagcggctagaagccttcctcacccag
aaggccaaggttggggagctcaaggatgatgacttcgaaaggatctcagagctgggagct
gggaatggtggggttgtcaccaaggtccagcacagaccttcaggcctcatcatggcaaga
aagctgattcacttggagatcaaaccagccattcggaaccagatcatccgtgagctgcag
gtgctgcacgagtgtaactccccgtacatcgtgggcttctacggggccttctacagtgac
ggggagattagcatctgcatggagcacatggacggtggctctctggaccaggtattgaaa
gaagccaagagaattccagaagagatcctggggaaggtcagcattgcggttctccggggc
ctggcgtatctccgggaaaagcaccaaatcatgcaccgagatgtgaaaccatctaacatc
ctcgtcaactcccgaggagagatcaagctgtgtgattttgggggtgagcggggcagctca
tcgactccatggccaacctccttcgtgggaactcgatcctacatgtctccggagcggttg
caaggcactcactactcggtgcagtcggacatctggagcatgggcctgtccctggtagaa
ttgtccatcggaaggtaccccatccccccgccggataccaaggagctggaggccatattt
ggccggcccatggttgatggggcagaaggagagcctcacagcatctcaccacgcccaaga
ccccccggacgccccatcagtggtcatggggtggacagccggccagctatggctatcttt
gaactgctggactatattgtgaatgagcctcctcctaagctgcccagtggtgtcttcacc
caagacttccaggagtttgtgaataaatgcctcattaagaacccagccgagcgagcggat
ctgaagatgctcatgaaccatggcttcatcaaacggtccgaggtggaagaagtggatttt
gctggctggctgtgtaaaacgctgcgtctgaaccagcccagcacgcctacacgtaccgct
gtgtga

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