KEGG   Propionibacterium freudenreichii subsp. freudenreichii DSM 20271: RM25_1057
Entry
RM25_1057         CDS       T03860                                 
Name
(GenBank) Methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
pfre  Propionibacterium freudenreichii subsp. freudenreichii DSM 20271
Pathway
pfre00270  Cysteine and methionine metabolism
pfre00450  Selenocompound metabolism
pfre00670  One carbon pool by folate
pfre01100  Metabolic pathways
pfre01110  Biosynthesis of secondary metabolites
pfre01230  Biosynthesis of amino acids
pfre04980  Cobalamin transport and metabolism
pfre04981  Folate transport and metabolism
Module
pfre_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:pfre00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    RM25_1057
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    RM25_1057
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    RM25_1057
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    RM25_1057
   04980 Cobalamin transport and metabolism
    RM25_1057
Enzymes [BR:pfre01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     RM25_1057
SSDB
Motif
Pfam: S-methyl_trans Pterin_bind Met_synt_B12 B12-binding_2 B12-binding CdhD
Other DBs
NCBI-ProteinID: AJQ90774
LinkDB
Position
1221773..1225240
AA seq 1155 aa
MLGHEVILGDGAMGTMLQAAVLGPDDFEGHDGCNEILNVTRPDVILDIHRAYLAAGSDVI
ETNTFGANAAALGEYGITDRLAELAGAGARLARQAADEAGPGHWVFGSIGPGTKLPTLGH
IDFVTLRDAYYTQVSAMIDGGVDAVQIETCQDLLQAKAAVIGARRAARDAHVDLPIIVDI
TVETTGTMLLGSETGAALTSLAPLGVDVIGLNCATGPTEMSEHLRYLSAHADCAVMAMPN
AGLPELTADGAVYPLGPDEFARAQLDYVERYGLAIVAGCCGTTPEHIARLRAALGAHRPV
EHRDPELVNTVSSLYSEVELRQETSYLAVGERTNANGSKAFREAMLAGDLETCIDLAKAQ
SREGAHCLDLCVDYVGRDGVDDMAELSQRFSTAVTLPVMLDSTEPEVIRSGLEHLAGRCI
INSVNFEDGDQPGSRFARLMPIIAEHGAAVVALTIDEEGQARTAERKVAIAERLVDQLVG
TWGMDEGDILVDCLTFPIATGQEETRRDGLETLNAISEFKRRHPRAGTTLGVSNISFGLN
AAARVVLNSVFLHEAVEAGLDSAIVRAAKIMPMERIDPEQRQVALDLIYDRRTPDYDPLT
RMLDMFAGVSSADVRAEHAAELAALPLNERLRQRIIDGDTNGLTDDLDEALRTRGALDIL
NSDLLEGMKTVGELFGSGQMQLPFVLQSAETMKRAVAHLEPHMDSTDEAGKGTLVLATVK
GDVHDIGKNLVDIIVSNNGYTVVNLGIKQPISAIVEAAKQNHADAIGMSGLLVKSTMVMK
DNLAELDRLGVGKDFPVMLGGAALTRTFVEDDLQRDFSGQVRYAKDAFEGLSLMDSVMAI
KHGDPDAALPEPRKHRVVARPRATVEPADGGPVRSDVARPVPGSLDVPRAPWFGNRMAKG
IGLAEITEWLDERALFTGRWGLRGPRKTDGTRDLIEQEGRPRLRGWLDRIAAEGLAVPGV
VYGYFPCYSQGNTLILLDPTTPEALDSEASRFDFPRQAAGRRLCIADFFRDRREAEEFGP
DTVALQLVTMGERFSQVTAELFAANAYRDYLELHGLSVQLAEALAELWHHRIRTELGIAG
EDGEMTAMLQKQAYRGGRYSFGYGACPDLDQRSLIEDLLQPDRIGVHLSEEFQLHPEQST
DAIVVTHPEAKYFNT
NT seq 3468 nt   +upstreamnt  +downstreamnt
gtgctcggccacgaggtgattctcggtgacggggccatgggaaccatgctccaggccgcc
gttctcgggccggacgatttcgagggacacgatggctgtaacgagatcctcaatgtcacg
cgccccgatgtgatcctcgatatccatcgcgcctatctggccgccggttcagacgtcatc
gaaaccaataccttcggggcgaatgccgccgccctgggggaatacggaatcaccgatcgc
ctggccgagctggccggtgccggcgcacgccttgcccgtcaggccgccgacgaggccggc
cccggccactgggtgttcggttccatcgggccgggcaccaagctgccgaccctgggccac
atcgacttcgtcaccctgcgtgacgcctactacacccaggtctcggccatgatcgacggc
ggtgtggacgcggtccagatcgaaacctgccaggacctgctgcaggccaaggcggccgtg
atcggcgccaggcgcgccgcacgcgacgcccacgtcgacctcccgatcatcgtggacatc
acggtggagacgaccggcaccatgctgctgggcagcgagaccggggctgccctgacgagc
ctggcaccactgggcgtggacgtcatcgggctcaattgcgccaccggccccaccgagatg
agcgagcacctgcgctatctgtcggcccacgccgactgcgccgtgatggccatgccgaat
gccgggctgcccgaactgaccgccgacggggcggtctacccgctgggacccgatgagttc
gcccgggcacaactcgactacgtcgaacgctacgggctggcgatcgtcgccggatgctgc
ggcaccacccccgagcacatcgcgcggctgcgtgccgcgctcggcgcccaccgacccgtg
gagcaccgcgacccggaactggtcaacactgtgtccagcctctactccgaggtggagctg
cgccaggagaccagctacctggccgtgggggagcggaccaatgcgaacgggtccaaggcc
ttccgcgaggccatgctcgccggagacctggagacctgcatcgacctggccaaggcacag
agtcgggaaggcgcccactgcctcgacctgtgcgtcgactacgtgggacgcgacggcgtc
gacgacatggccgagctgtcacaacggttctccacagcagtgacgctgccggtgatgctg
gattccaccgagcccgaggtcatccgctcgggcctcgagcacctggccggacggtgcatc
atcaactcagtcaacttcgaggacggggaccagcccggatcccggtttgcccgcctgatg
ccgatcatcgccgagcacggcgccgccgtggtcgccctgacgatcgacgaggagggccag
gcccgcaccgccgaacgcaaggtcgccatcgccgagcgactggtcgatcaactcgtgggc
acctggggcatggacgagggagacatcctcgtcgactgcctcaccttcccgatcgccacc
ggccaggaggagacccgccgcgacggactggagacgctcaacgccatctccgagttcaag
cgccgccatccacgggccggcaccaccctgggcgtgtccaatatctccttcgggctgaac
gcggccgcccgcgtcgtactcaactcggtgttcctgcacgaggcggtcgaggcaggactg
gactcggcgatcgtgcgggccgccaagatcatgccgatggaacgcatcgatcccgaacag
cgacaggtcgccctggacctgatctacgatcgccgcacccccgactacgacccgttgacc
aggatgctcgacatgttcgccggcgtctcgtcggccgatgtgcgcgccgagcacgccgcc
gaactcgccgcgctgccactgaacgaacggttgcgccagcgcatcatcgacggcgacacc
aacggactcaccgacgacctcgacgaggccctgcgcacccgcggggcactcgacatcctc
aattccgacctgctcgagggcatgaagaccgtcggggagctcttcgggtcgggccagatg
cagctcccgttcgtcctgcagtccgccgagacgatgaagcgggccgtcgcgcacctggaa
ccccacatggattccactgacgaggcggggaagggcaccctggtgctcgccaccgtcaag
ggcgatgtccacgacatcggcaagaacctggtcgacatcatcgtgtccaacaacggctac
accgtggtgaacctgggcatcaagcagccgatcagcgccatcgtcgaggcggcgaagcag
aaccacgccgacgccatcgggatgagtggcctgttggtgaagtcgacgatggtgatgaag
gacaacctcgccgagctcgaccgactcggggtgggcaaggacttccccgtgatgctcggc
ggtgccgccctgacccgcaccttcgtcgaggacgacctgcagcgcgacttctccgggcag
gtgcgctatgcgaaggatgccttcgaggggctcagcctgatggattccgtgatggcgatc
aagcacggcgatccggacgcggccctgcccgagccgcgcaagcaccgcgtggtcgccagg
ccgcgcgccacggtcgaaccggccgacggtgggccggtgcgctccgacgtcgcacgcccc
gtgcccggatctctggacgtgccccgcgcgccgtggttcggcaatcggatggccaagggc
atcggactggccgagatcaccgaatggctcgacgagcgtgccttgttcaccggacgatgg
ggattgcgcggacccaggaagaccgacggcacgcgcgacctgatcgaacaggagggacgt
ccccgcctgcggggctggctcgaccggatcgccgccgagggcctggcggttcccggcgtg
gtctatggctatttcccctgctactcgcaggggaacaccctgatcctgctggaccccacc
acccccgaagccctcgactccgaggccagtcgcttcgacttcccccggcaggcggcaggc
cgccgcctgtgcatcgccgacttcttccgcgatcgccgcgaggccgaggaattcggtccc
gacaccgtggccctgcagttggtgaccatgggggagcggttctcgcaggtcaccgccgag
ctgttcgctgcgaatgcctaccgcgactacctcgaactccacgggctgtcggtgcaactg
gccgaggcattggccgagctgtggcaccaccgcatccgcaccgaactgggcatcgccggc
gaggacggcgagatgaccgccatgttgcagaagcaggcctatcgcgggggacgctacagc
ttcggctatggcgcctgccccgacctggaccaacgctccctgatcgaggacctgctgcag
cccgaccgcatcggcgtgcacctgagcgaggagttccagctgcatcccgaacagtccacc
gacgccatcgtcgtcactcatcccgaggccaagtacttcaacacctga

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