Pteropus vampyrus (Indian flying fox): 120596309 Help Entry 120596309         CDS       T07511                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism pgig  Pteropus vampyrus (Indian flying fox) Pathway pgig04020   Calcium signaling pathway pgig04371   Apelin signaling pathway pgig04713   Circadian entrainment pgig04730   Long-term depression pgig04921   Oxytocin signaling pathway pgig05017   Spinocerebellar ataxia pgig05020   Prion disease pgig05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pgig00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120596309 (RYR1)    04020 Calcium signaling pathway     120596309 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     120596309 (RYR1)   09156 Nervous system    04730 Long-term depression     120596309 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     120596309 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     120596309 (RYR1)    05020 Prion disease     120596309 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     120596309 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pgig01009]     120596309 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pgig04147]     120596309 (RYR1)    04040 Ion channels [BR:pgig04040]     120596309 (RYR1) Protein phosphatases and associated proteins [BR:pgig01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      120596309 (RYR1) Exosome [BR:pgig04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    120596309 (RYR1) Ion channels [BR:pgig04040]  Voltage-gated cation channels   Ryanodine receptor    120596309 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  120596309 NCBI-ProteinID:  XP_039710847 LinkDB All DBs Position Unknown AA seq 5031 aa AA seqDB search MGDGGEGEDEVQFLRTDDDVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSGMYLSC LTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPISSGCEEGYVTGGHVLRLFHGHMDECLTISSADSDD QRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VVDASKAHTKATSFCFRISKEKLDMAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKRKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTAGLYNQFIKGLDS FSGKPRGSGPPAGTALPIEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCALF STNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYS KWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVARLVTSPGQHLLAPEDVVSCCLDLNVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSLVESQSRWDRVRIFRAEKS YVVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFG RPWQSGDVVGCMIDLTENTIIFTLNGEILMSDSGSETAFREIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVARM DGTVDTPPCLRLSHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPAE DEARAAEPDTDYENLRRSAGRWGETEGGKEGTAKEGLPGATSQAGVEAQPVRAENEKDAT TEKNKKRGFLFKAKKAAMMTQTPATPALPRLPREVVPADDRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNIHSSLKCSNCYMVWGGDF VSSGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNSAPQCPPRLEVQMLMPISWSRMPNRFLQVETQRA GERLGWAVQCQEPLIMMALHIPEENRCMDILELSERLNLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTP ETRAITLFPSGKSADNGPRRHGLPGVGVTTSLRPPHHFSPPCFVVALPVAGVAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDV KQILKMIEPEVFTEEEEEEEEEEEEEEDEEEKEEDEEEEAQEKEDEEKEEEETAEGDKEE SLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQGNQRDRYHLL MKAFTMSAAETARRTREFRSPPQEQINMLVHFKDGEEVEDCPLPEEMQQDLLEFHQDLLA HCGIQLEGEEEEPEEEATLGSRLMSLLEKVRLVKKKEKSPEEELPAEESKPESLQELVSH TVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSMEDTMSLLECLG QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVF VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRRD RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL VPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQEFLLH VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD SMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMP LKLLTNHYERCWKYYCLPTGWANFGITSEEELHLTRKLFWGIFDSLAHKKYDSELYRMAM PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE YTHEKWAFDKIQNNWSYGENIDEDLKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE WTIEKAREGEEEKVEKKKTRKISQSAQTYDPREGYNPQPPDLSGVTLSRELQAMAEQLAE NYHNTWGRKKKQELETKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG LKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLDAVVSSGRVEKSPHEQEIKFFAK ILLPLIKQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTRN SYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC PDIPMLERLMADIRGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEMPPPALPAGA PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLHSHFIP TIGRLCKRAGKVVAEEEQLRLEAKAEAEEGEILVRDEFSVLCRDLYALYPLLIRYVDNNR AHWLTEPDPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK SGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRYALKDT DEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYH LEQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKATWILTE DHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDFLYMAY ADIMAKSCHLEEGAENSEAEEEAEVSFEEKEMEKQRLLYQQARLHNRGAAEMVLQMISAC KGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNA FERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQ TGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLT EYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVM LLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRG LISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPAREIGFNVAVL LTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWE MPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEPEEDDDEGA AEAGAEGAEEGAAGPEGAAGPAAAGAAARAAAAATRALRGLSYRGLRRRVRRLRRLTARE AAAAVGALLWAVVARAGAAGAGAAAGALRLLWGSLFGGGLVEGAKKVTVTELLAGMPDPT GDEVHGEQPSGPSGDADGEGEGEGAGDAAEGAGDEEAAAHEAGPGGADRAVAVADGGPFR PDGAPGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGEEEEVPPEPEPEPEPEKTDAENGE KEDVPEPPPEPPKKTAPPPPPPKKEEAGGGGLEFWGELEVQRVKFLNYLSRNFYTLRFLA LFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDLAGAGSGGGSGWGSGVGEEAEDDEDEN MVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGL YITEQPEDDDVKGQWNRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLA TLEITAHNERKPAPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNN FFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKS EDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVII ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLA NYMFFLMYLINKDKTEYTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15096 nt NT seq  +upstreamnt  +downstreamnt atgggagacggaggagagggtgaggacgaggtccagttcctgaggacggacgacgacgtg gtcctgcaatgcagcgccaccgtgctcaaggaacagctcaaactctgcctggcagccgag ggctttggcaaccgcctctgcttcctggagcccaccagcaatgcccagaatgtgcccccc gatctggccatctgctgcttcgtcttggagcagtctctgtccgtccgagccctgcaggag atgctggccaacactgtggaggccggcgtggagtcgtcccagggtgggggacacaggacg ctcctgtatggccatgccatcctgctccggcacgcacacagcggcatgtacctgagctgc ctcaccacctcccgctccatgactgacaaactggccttcgatgtgggactgcaggaggat gcaacaggagaggcctgttggtggacaatgcacccagcctccaaacagaggtctgaagga gaaaaggtccgcgtcggggatgacctcattctcgttagtgtctcctctgagcgctacctg cacctgtcaacggccagcggggagctccaggttgacgcctccttcatgcagacactgtgg aacatgaaccccatctcctctggctgcgaagagggttacgtgactggaggccatgtcctc cgcctctttcacggacacatggatgagtgtctgactatctcctccgctgacagtgatgac cagcgcagactcgtccattacgaggggggagctgtgtgcacccacgctcgctccctctgg agactggagcctctgagaatcagctggagtgggagccacctgcgctggggccagccgctt cgcatccggcatgtcaccacagggcggtacctggcgctcaccgaggaccagggcctggtg gtggttgacgccagcaaggcccacactaaggccacctccttctgtttccgcatctccaag gaaaagctggatatggcccccaagcgggatgtagaaggcatgggcccccccgagatcaag tatggagagtcactgtgcttcgtgcagcatgtagcctcaggcctgtggctcacctatgct gccccggaccccaaggccctgcggctcggcgtgctcaagaggaaggccatgctgcaccag gaaggccacatggatgatgcgctgtccctgacccgctgccagcaggaggagtcccaggct gcccgcatgatccacagcactgccggcctgtacaaccagttcatcaaaggcctggacagc ttcagcgggaagccacggggctcagggccgccggctggcacagcgctgcccatcgagggc gtcatcctgagcctgcaagacctcatcggctacttcgagccgccctccgaggagctgcag cacgaggagaagcagagcaaactgcgcagcttgcgcaaccgccagagcctcttccaggag gaggggatgctctccctggtcctgaattgcatcgaccgcctaaatgtctacaccacagct gcccactttgctgagtttgccggggaggaggcagccgagtcctggaaagagattgtgaac ctgctctatgaactcctggcttctctgatccgtggcaatcgtaccaactgtgccctcttc tccaccaatttggattggttggtcagcaagctggataggctggaggcctcatctgggatc ctagaagtgctatactgtgtcctgattgagagtcctgaggtcctgaacatcatccaagag aaccacatcaagtcaatcatctcactcctggacaaacatgggaggaaccacaaggtgctg gatgtgctgtgttccctgtgtgtgtgtaatggcgtggccgtgcgctccaaccaagatctc attactgagaacttactgcctggccgtgagcttctgctccagacaaacctcatcaactat gtcaccagcatccgccctaacatctttgtgggccgagcagagggcactacgcagtacagc aaatggtactttgaggtgatggtggatgaagtggctccattcctgacagctcaggccacc cacctacgggtgggctgggccctcactgagggctacagcccctacccagggggcggcgaa ggctggggcggcaacggggttggcgacgatctctattcctatggatttgatgggctgcat ctctggacaggacatgtggcacggctggtgacttctccagggcagcacctcttggcccct gaggatgtggtcagctgctgcctggacctcaacgttccatccatctccttccgcatcaat ggctgtcctgtgcagggtgtctttgaggccttcaaccttgatgggctcttcttccctgtt gtcagcttctcagccggtgtcaaggtgcggttcctccttggtggccgccacggtgaattc aagttccttcccccgcctggctacgccccatgccatgaggctgtactccctcgagagcga ctccacctggaacccatcaaggagtaccggcgggaggggccaagggggccacacctggtg ggccccagccgctgcctctcacacaccgactttgtgccctgccctgtggacactgtccag attgtcctgcctccccatctggagcgtattcgggagaagctggcagagaacattcatgaa ctctgggcactgactcgcatcgagcaaggctggacctatggcccggttcgggatgacaat aagaggctgcacccatgtcttgtgaacttccacagcctaccagagccggagaggaattac aacctgcagatgtcaggggagacgctcaagacactgctggcgctgggctgccacgtgggc atggcagatgagaaggcggaggacaacctaaagaagacaaaactccccaagacgtacatg atgagcaatgggtacaaaccagcacccctggacctgagccacgtgcggctgacaccggcg cagaccacgttggtggacaggctggcagaaaatgggcacaacgtgtgggcacgagaccgt gtggcccagggctggagctacagtgccgtgcaggacatccccgcacgccgaaaccctcgc ctcgtgccctaccgcctactggacgaggccaccaagcgcagcaacagggacagcctctgc caggccgtgcgcaccctgctgggctatggctacaacattgagccgcctgaccaggagccc agtctggtggagagccagtctcgctgggaccgggtgcgcatcttccgggcagagaaatcc tatgtggtgcagagcggccgctggtacttcgagttcgaggcggtcaccacaggagagatg cgagtgggctgggcaaggcccgagctgaggcctgatgtggagctgggagctgatgagctg gcctatgtcttcaacgggcaccgtggccagcgctggcacttgggcagtgaaccatttggg cgcccctggcagtcgggtgatgtcgtgggctgcatgatcgacctcacagagaacaccatt atcttcaccctcaatggcgagatcctcatgtccgattcgggctccgaaacagccttccgg gaaatcgagattggggatggcttcctgcccgtgtgcagcttgggacctggccaggtgggt cacctgaatctgggtcaggacgtgagctccctgcggttctttgccatctgcggtctccag gaaggctttgagccattcgctatcaacatgcagcgcccggtcaccacctggttcagcaaa agccttccccagtttgaggctgtgccccttgagcacccccactatgaggtggcccgtatg gacggcactgtggacactcccccctgcctgcgcctgagccaccgcacctggggctcccag aacagcctggtggagatgctcttcctccggctgagccttccagtccagttccaccagcac ttccgctgcactgcaggggccaccccgctggcgtcccccggcctgcagcccccggccgag gacgaggcccgggcagcggaaccggacaccgactacgaaaacctgcgccgctcggctggg cgctggggcgagaccgaagggggcaaagagggaactgccaaggaggggctgcccggggcc acctcccaggctggggtagaggcccaacctgtcagggcagagaatgagaaggatgccacc acagagaagaacaagaagagagggttcttattcaaggccaagaaggccgccatgatgact cagacgccagccacccccgctctgccccgactccctcgtgaggtggtgcccgccgatgac cgtgatgaccctgagatcatcctcaacaccaccacgtactattactccgtgagggtcttt gctggtcaggagcccagctgcgtgtgggtgggctgggtcacccccgattaccatcagcac gacatgaacttcgacctcagcaaggtccgggcagtgacggtgacaatgggggacgaacaa ggcaacatccacagcagcctcaagtgcagcaactgctacatggtgtggggcggggacttc gtgagctctgggcagcagggccggatcagccacacggaccttgtcattggctgcctggtg gacttggccactggcctaatgacctttacagccaatggcaaggagagcaacacctttttc caggtggaacccaacacgaagctctttcctgccgtctttgtcctgcccacgcaccagaac gtcatccagtttgagctggggaagcagaagaacatcatgccactctcggccgccatgttt ctgagtgaacgcaagaactcagctccacagtgcccgccgcggctcgaggtgcagatgctg atgcccatctcttggagccgcatgcccaaccgcttcctgcaggtggagacacagcgagcc ggcgagcggctgggctgggccgtgcagtgccaggagccgctgatcatgatggcactgcac atccctgaggagaaccggtgcatggacatcctggagctgtccgagcgcctgaacctgcag cggttccattcccacaccctccgcctctatcgcgctgtgtgcgccttgggcaacaaccgc gtggcgcatgctctgtgcagccacgtggaccaggcgcagctgctgcacgccctggaggac gcgcacctgcctggcccgctgcgtgctggctactacgacctcctcatcagcatccacctc gaaagtgcctgccgcagccgccgctctatgctctccgagtacatcgtgcccctcacgcca gagacccgcgccatcacactcttcccatctggaaaaagcgcagataatggtccccgccgc cacggcctgcctggcgttggcgtcaccacctcgctgcggcctccacaccatttctcaccc ccctgtttcgtggttgccctgccagttgctggagtggcagaagcccctgcccgcctcagt cccagcatccctctggaggccctgcgggacaaagcactgagaatgctgggggaggcggtg cgagatggcggacagcacgcacgcgaccctgttggggggtctgtggagttccagtttgtg cccgtgctcaagcttgtgtccaccctgctggtgatgggtatctttggtgatgaggatgtg aaacagatattgaagatgattgagcctgaagtattcactgaggaagaggaggaggaagag gaagaggaggaggaagaggaagatgaagaggagaaggaggaggatgaggaggaggaggca caggagaaggaagatgaagaaaaggaggaagaggagacagcagaaggggacaaagaagaa agcttggaggaaggtctgctccagatgaaattgccagagtctgtgaaattacagatgtgc cacctactggagtatttctgtgaccaagagctgcagcaccgcgtggagtccctggcagcc tttgcagagcgctatgtggacaagcttcagggcaaccagcgggaccgctaccacctcctc atgaaagccttcaccatgtctgcagctgagactgcccgacgtacccgagagttccgctcg ccaccccaggagcagatcaacatgctagtgcacttcaaagatggtgaggaagtggaagat tgtcctcttcctgaagagatgcaacaggatttgcttgaatttcatcaagacctgctggct cactgtggaattcagctggagggggaggaggaggaaccagaggaagaggccaccctgggc agccgcctcatgagcctgttggagaaagtgcggctggtgaagaagaaggaaaagagccct gaggaggagctgcctgctgaggagagcaaacccgagtcgctgcaggaattggtgtcccac acagtggtgcgctgggcccaggaggactttgtgcagagccccgagctggtacgggccatg tttagcctcctgcaccggcagtatgacgggcttggggagctgctgcgtgccctgccccgg gcgtacaccatctcgccatcctccatggaggacaccatgagtctgcttgagtgcctcggc cagatccgctcgctgctcatcgtgcagatgggcccccaggaggagaacctcatgatccag agcatcgggaacatcatgaacaacaaagtcttttaccagcacccgaacctgatgcgggcg ctgggcatgcacgagacagtcatggaggtcatggtgaacgtcctcgggggtggtgaatcc aaggagatccggttccccaagatggtgacgagctgctgccgcttcctctgctacttctgt cgcatcagccggcagaaccagcgctccatgttcgaccacctgagctacctgctggagaac agtggcatcggcctgggcatgcagggctccacacccctggacgtggcagctgcctctgtc attgacaacaacgagctggctttggcattgcaggagcaggacctggagaaggtggtatcc tacctggcgggctgtggccttcagagctgccccatgctcctggccaaagggtacccggat atcggctggaacccctgcggcggtgagcgctacctggacttcctgcgcttcgctgtcttt gtcaacggcgagagcgtggaggagaacgccaacgtggtggtgcggctgctcatccgcaag cctgagtgcttcgggccggccctgcgcggcgagggcggctcggggctgctggctgccatc gaggaggccatccgcatctccgaggaccctgcgcgggatggcccaggcgtccgcagggac cggcggcgggaacacttcggggaggagccccctgaggaaaaccgggtgcacctgggacac gctatcatgtccttctacgctgccttgatcgacctgcttggacgctgtgcaccagagatg catttaatccaagccggcaaaggtgaggccctgcggatccgtgccatcctgcgctcctta gtgcccctggacgaccttgtaggcatcatcagcctcccgctgcagatccccacactgggc aaagatggggctctggtacagccaaagatgtcggcatcctttgtgccggaccacaaggca tccatggtgctcttcctggaccgtgtgtatggcatcgagaaccaggaattcttgctgcat gtgctggatgtggggttcctgccagacatgagggcagccgcctcgctagacacggccacc ttcagcaccaccgagatggcgctggcgcttaaccgctacctgtgcctggcggtgctgccg ctcatcaccaaatgtgctccactctttgcgggaaccgagcaccgcgccatcatggtggac tccatgcttcacacggtgtaccgcctgtcccgcggccgctcactcaccaaggcacagcgc gacgtcatcgaggattgcctcatggcgctctgcaggtacatccggccgtccatgctacag cacctgctgcggcgcctggtgtttgacgtgcccatccttaacgagttcgccaagatgccg ctcaagctcctcaccaaccactatgagcgctgttggaaatattactgcttgcccacgggc tgggccaactttggcatcacctcagaggaagagctgcacctcacgaggaaactcttctgg ggcatctttgactcactggcccacaagaagtatgactcagagctgtaccgcatggctatg ccatgtctatgcgccatcgcaggggccctgcccccagactacgtagacgcctcatactca tcgaaggctgagaaaaaggccacggtggatgctgaaggcaactttgatcctcgacctgtg gagaccctcaacgtgatcattccagagaagctggactccttcattaacaagtttgcggag tacacacatgagaagtgggccttcgacaagatccagaacaactggtcctacggggagaac atagatgaggacctgaagacccaccccatgctgagaccctacaagaccttctcagagaag gacaaagagatttaccgctggcccatcaaggaatccttgaaggccatgattgcctgggaa tggacgatagagaaggccagagagggtgaggaggagaaggtggagaagaagaagactcgg aagatctcccaaagtgctcagacttacgatccgcgagaaggctacaacccccagcctcct gacctcagcggagttaccctgtcccgggagctgcaggccatggcggaacagctggcggaa aattaccacaacacctgggggcggaagaagaagcaggagcttgagaccaagggtggtggg acccaccccctgctggtcccctatgacacgctcacggccaaggagaaagcacgagatcga gagaaggcccaggagctgctgaagttcctgcagatgaacggttatgcggtcaccagaggc cttaaggacatggagctggatacgtcttccattgagaaacggttcgcctttggcttcctg cagcagctgctgcgctggatggacatttcccaggagtttatcgcccacctcgacgctgtg gtcagcagtggacgagtggaaaagtccccgcatgaacaagagattaaattctttgccaag atcctgctccctttgatcaagcagtacttcaccaaccactgcctgtatttcctgtccaca cctgccaaagtgctgggcagtggtggccacgcctccaacaaggagaaggaaatgatcacc agcctcttctgcaagcttgccgctcttgtccgtcaccgagtctctctctttgggacggat gccccagctgtggtcaactgtcttcacatcctggcacgctccctggatgccaggacggtg atgaagtcaggccctgagattgtgaaggctggccttcgttccttctttgagagtgcctca gaggacatcgagaagatggtggagaacctgcggctaggcaaagtgtcacaggcacgcacg caagtgaagggtgtgggccagaacctcacctacaccaccgtggcgctgctgcctgtcctc accaccctcttccagcacatcgcccagcaccagtttggagatgatgtcatcttggatgat gtccaggtctcgtgctaccgaacgctgtgcagtatctactctctaggaacgaccaggaac tcttatgtggaaaagctgcggccagcgcttggggagtgcctggcccgcctggcagcggcc atgccggtcgcgttcctggagcctcagctgaatgagtacaacgcctgctcggtgtacacc accaagtctccccgggagcgggccatcctagggctccccaacagcgtggaagagatgtgt cccgacatcccaatgctggagcggctcatggcagacatcagggggctggccgagtcgggg gcccgctacacggagatgccacatgtcatcgagatcactctgcccatgctgtgcagctat ctgccccgctggtgggagcgcggacctgagatgcccccacccgccctgcccgctggggcc cccccgccctgcacagctgtcacctctgaccacctcaactccctgctggggaacatcctg cgaatcatcgtcaacaacctgggcatcgatgaggcctcgtggatgaagcggctcgctgtg tttgcccagcctattgtgagccgggcccggcccgagctcctgcactcacacttcatcccg accatcgggcggctgtgcaagcgggcggggaaggtggtggccgaggaggagcagctgcgc ctggaggctaaggcggaagctgaggagggggagatcctggtgcgggatgagttctctgtg ctctgccgggacctgtacgctctctatccactgctcatccgctacgtggacaacaacagg gcccactggctgacagagcctgaccccagtgccgaggagctgttcaggatggtgggcgag atcttcatctactggtccaagtcccacaactttaagcgtgaggagcagaacttcgtggtc cagaatgagatcaacaacatgtcgtttctgactgcagacaacaagagcaaaatggccaag tcaggtggctcagaccaggaacgcacgaagaagaagcgccgaggggaccggtactctgtg cagacgtcgctgattgtggccacactcaagaagatgctgcccattggcttgaacatgtgt gcacccactgaccaggacctcatcacgctggccaagactcgctacgccctgaaagacaca gatgaggaagtccgggaatttttgcaaaacaaccttcaccttcagggaaaggttgaaggt tccccttctctgcgctggcagatggccctgtaccggggcctacccggccgcgaggaggac gccgacgacccggagaagatcgtgcgcagagtccaggaggtgtctgcggtgctctaccat ctggagcagatcgagcacccttacaagtctaagaaggctgtgtggcacaagctcttgtcc aagcagcgccgaagggcggtcgttgcctgtttccgcatgacccctctgtacaacctgccc acgcaccgggcatgtaacatgttcctggagagctacaaggccacatggatcctgactgaa gaccacagttttgaggaccgcatgatagatgacctttcaaaagcaggggagcaggaggag gaagaggaagaggtggaggagaagaagccagaccccctgcaccagctcgtcctgcacttc agccgcacagccttgactgaaaagagcaaactggatgaggatttcctgtatatggcatat gcggatatcatggcaaagagctgccacctggaggagggagcggagaacagtgaagctgaa gaagaggctgaggtttctttcgaggagaaagagatggagaagcagaggctcctgtaccag caggcgcggctgcacaaccggggggctgcagagatggtgctccagatgatcagtgcctgc aaaggagagactggcgccatggtgtcctccaccctgaagctgggcatctccatcttaaat gggggtaatgctgatgtgcagcagaaaatgttggattatctgaaggacaagaaggaagtt ggcttcttccagagtatccaggcgctgatgcagacatgcagcgtcctggatctcaatgca ttcgagagacagaacaaggcagaggggctgggcatggtgaacgaggatggaactgtcatc aaccgccagaacggagagaaggtcatggcagatgacgaattcacccaagacctgttccga ttcctgcaattgctctgcgaggggcataataatgatttccaaaactacctacggacacag acggggaacacgaccactattaacatcatcatctgtacagtggactaccttctgcggctg caggaatccatcagcgacttctactggtactactccggcaaggatgtcattgaggagcaa ggcaagaggaacttttctaaggccatgtcggtagctaaacaggtgttcaacagcctcacc gagtacatccagggcccctgcaccgggaaccagcagagcctggcgcacagccgcctctgg gacgccgtggtgggattcctgcacgtatttgcccacatgatgatgaagctcgctcaggac tcgagccagatcgagctgttgaaggagctgctggatctacagaaggacatggtggtgatg ttgctgtcactactggaagggaacgtggtgaacggcatgattgcccggcagatggtagac atgctggtggaatcttcatccaacgttgagatgatcctcaagttcttcgacatgttcctg aaactcaaggacatagtgggctcggaggccttccaggactacgtcactgatccccgtggc ctcatctccaagaaggacttccagaaggccatggacagccagaagcagttcactggtcca gaaatccagttcctgctttcgtgctccgaggcggatgagaatgagatgatcaactgtgag gagttcgccaaccgcttccaggagccagcccgcgaaatcggctttaacgtggcggtactg ctgaccaatctgtcggagcacgtgccccacgacccgcgcctgcgcaacttcctagagctg gcagagagcatcctcgagtacttccggccctacctgggtcgcatcgagatcatgggcgcc tctcgccgcattgagcgcatctactttgagatctcggagaccaaccgcgcccaatgggag atgccgcaggtgaaggagtccaagcgccagttcatcttcgacgtggtgaacgagggcggc gagtcggagaagatggagctcttcgtgagcttctgcgaggacaccatcttcgagatgcag atcgccgcgcagatctcggagcccgagggcgagcccgaggaggacgacgacgagggcgcg gccgaggcgggcgccgagggcgccgaggaaggcgcggcggggcccgagggcgcggcgggg ccggcggcggcgggcgcggcggcgcgcgcggcggcggcggcgactcgggccctgcgcggg ctcagctaccgcgggttgcggcggcgcgtgcggcggctgcggcggctgacggcgcgcgag gcggcggcggcggtgggcgcgctcctctgggccgtggtggcgcgtgcgggggcggcgggc gcgggggcggcggcgggcgctctgcgtctgctctggggctccctcttcgggggcggcctc gtggagggggccaagaaggtgactgtgaccgagctgctggccggcatgcccgaccccacg ggcgacgaggtgcacggcgagcagccgtccgggcccagcggcgacgcggacggcgagggc gagggcgagggcgcgggcgacgccgcggagggcgcgggcgacgaggaggcggcggcgcac gaggccggcccgggaggcgctgaccgggccgtggcggtggccgacgggggacccttccgg cctgacggggccccaggaggcctcggggacatgggtgacacgacgccggcggagccgccc acgcccgagggctcccccatcctcaagaggaagctgggggtggatggagaggaagaggag gtgcctccggaaccagagcctgagcccgagcctgagaaaactgatgccgagaatggggag aaggaagatgttcccgagcccccgccagagccccccaagaagacagcacctcctccacct cctccaaagaaggaggaagccggaggtgggggcctggaattttggggagagctggaagtg cagagggtgaagttcttgaactacctctcccggaatttttacaccctgcgattccttgcc ctcttcctggcatttgccatcaacttcatcttgctgttttataaggtctcagactctcca ccaggggaggatgacatggagggctcagcagctggggacctggcaggcgctgggtctggc ggcggctctggctggggctcaggggttggtgaggaagcggaggacgacgaggatgagaac atggtgtactacttcctggaggagagcacaggctacatggagcctgccttgcgttgctta agcctgctgcatacactggtggcctttctctgcatcattggctacaactgcctcaaggta cccctggtgatcttcaagcgggagaaggagctggcccggaagctggagtttgacggcctc tatatcaccgagcagcctgaggacgatgacgtgaaggggcagtggaaccgactggtgctc aatacaccgtcgttccccagcaactattgggacaagtttgtcaagcggaaggtcctggac aagcacggggacatctttgggcgggagcggatcgccgagctgctgggcatggatctggcc acgctggagatcacagcccacaacgagcgcaagccagctccaccgcccgggctgcttacc tggctcatgtccatcgacgtcaagtaccagatttggaagttcggggtcatcttcacagac aattccttcctgtacctgggctggtacatggtgatgtccctcctcgggcactacaacaac ttcttctttgctgcccacctcctggacatcgccatgggggtcaagacgctgcgtaccatc ctctcctctgtcacccacaacgggaaacagctggtgatgaccgtgggcctcctggcggtg gtggtctacctgtacactgtggtggccttcaacttcttccgcaagttctacaacaaaagc gaggatgaggatgagcctgacatgaaatgtgatgacatgatgacgtgttacctgtttcac atgtacgtgggtgtccgagctggtgggggcattggggacgagattgaggacccggcaggt gatgaatatgagctgtaccgggtggtcttcgacatcaccttcttcttctttgtcatcatc atcctgctggccatcatccagggtctgatcattgatgcttttggcgagctccgagaccaa caagagcaagtgaaggaagatatggagaccaagtgcttcatctgcggcattggcagtgat tactttgacaccacaccacatgggttcgagacccacacgctagaagagcacaacctggcc aattacatgtttttcctgatgtacctgataaacaaggacaagacagaatacactggtcag gagtcctatgtttggaagatgtaccaagagagatgctgggacttcttcccggctggtgac tgtttccgcaagcagtacgaggaccagctcagttga

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