KEGG   Pteropus vampyrus (Indian flying fox): 120603668
Entry
120603668         CDS       T07511                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig00562  Inositol phosphate metabolism
pgig01100  Metabolic pathways
pgig01521  EGFR tyrosine kinase inhibitor resistance
pgig04012  ErbB signaling pathway
pgig04014  Ras signaling pathway
pgig04015  Rap1 signaling pathway
pgig04020  Calcium signaling pathway
pgig04062  Chemokine signaling pathway
pgig04064  NF-kappa B signaling pathway
pgig04066  HIF-1 signaling pathway
pgig04070  Phosphatidylinositol signaling system
pgig04072  Phospholipase D signaling pathway
pgig04360  Axon guidance
pgig04370  VEGF signaling pathway
pgig04613  Neutrophil extracellular trap formation
pgig04650  Natural killer cell mediated cytotoxicity
pgig04658  Th1 and Th2 cell differentiation
pgig04659  Th17 cell differentiation
pgig04660  T cell receptor signaling pathway
pgig04664  Fc epsilon RI signaling pathway
pgig04666  Fc gamma R-mediated phagocytosis
pgig04670  Leukocyte transendothelial migration
pgig04722  Neurotrophin signaling pathway
pgig04750  Inflammatory mediator regulation of TRP channels
pgig04919  Thyroid hormone signaling pathway
pgig04933  AGE-RAGE signaling pathway in diabetic complications
pgig04935  Growth hormone synthesis, secretion and action
pgig05012  Parkinson disease
pgig05022  Pathways of neurodegeneration - multiple diseases
pgig05135  Yersinia infection
pgig05167  Kaposi sarcoma-associated herpesvirus infection
pgig05170  Human immunodeficiency virus 1 infection
pgig05171  Coronavirus disease - COVID-19
pgig05200  Pathways in cancer
pgig05205  Proteoglycans in cancer
pgig05206  MicroRNAs in cancer
pgig05214  Glioma
pgig05223  Non-small cell lung cancer
pgig05225  Hepatocellular carcinoma
pgig05231  Choline metabolism in cancer
pgig05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pgig05417  Lipid and atherosclerosis
Module
pgig_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120603668 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    120603668 (PLCG1)
   04014 Ras signaling pathway
    120603668 (PLCG1)
   04015 Rap1 signaling pathway
    120603668 (PLCG1)
   04370 VEGF signaling pathway
    120603668 (PLCG1)
   04064 NF-kappa B signaling pathway
    120603668 (PLCG1)
   04066 HIF-1 signaling pathway
    120603668 (PLCG1)
   04020 Calcium signaling pathway
    120603668 (PLCG1)
   04070 Phosphatidylinositol signaling system
    120603668 (PLCG1)
   04072 Phospholipase D signaling pathway
    120603668 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    120603668 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    120603668 (PLCG1)
   04660 T cell receptor signaling pathway
    120603668 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    120603668 (PLCG1)
   04659 Th17 cell differentiation
    120603668 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    120603668 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    120603668 (PLCG1)
   04670 Leukocyte transendothelial migration
    120603668 (PLCG1)
   04062 Chemokine signaling pathway
    120603668 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    120603668 (PLCG1)
   04919 Thyroid hormone signaling pathway
    120603668 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    120603668 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120603668 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    120603668 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120603668 (PLCG1)
   05206 MicroRNAs in cancer
    120603668 (PLCG1)
   05205 Proteoglycans in cancer
    120603668 (PLCG1)
   05231 Choline metabolism in cancer
    120603668 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120603668 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    120603668 (PLCG1)
   05214 Glioma
    120603668 (PLCG1)
   05223 Non-small cell lung cancer
    120603668 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    120603668 (PLCG1)
   05171 Coronavirus disease - COVID-19
    120603668 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120603668 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    120603668 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    120603668 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    120603668 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120603668 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    120603668 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120603668 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pgig04131]
    120603668 (PLCG1)
Enzymes [BR:pgig01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     120603668 (PLCG1)
Membrane trafficking [BR:pgig04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    120603668 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    120603668 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 120603668
NCBI-ProteinID: XP_039720274
LinkDB
Position
Unknown
AA seq 1330 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRV
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFCLDEFVT
FLFSKENSVWNSQLDAVCPDTMHNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPSQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCR
PVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSS
NYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGGHCGYVLQPGTMRDEAFDPFDKSS
LRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVGEPSFPPSPH
PPRDTEGSSLRTMTPSSPGGGLRLFPLAFTVDNGLNPMWPAKPFHFQISNPEFAFLRFVV
YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLVKIDIFPAKQENGDL
SPFGGMSLRERSSDASGQLFHGRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPR
RTRVNGDNRL
NT seq 3993 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgaacggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagattgaaggggccattgacattcgtgaaatcaaggag
atccgcccagggaagacctcacgagacttcgatcgctatcaagaggaccctgctttccga
ccggaccagtcacattgctttgtcatcctgtatggaatggaattccgcctgaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggcttgacttggctg
atggaggatacattgcaggcagctacacccctgcagattgagaggtggctgcggaagcag
ttctactcggtggatcggaatcgcgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgagtccccaacatgcgtttcctccgagagcggctgacggac
ctggagcagcgcagcagcgacatcacctatgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggtg
ggggagcggccagagctctgccgagtgtctcttcctgagttccagcagttcctcctggag
taccagggggagctatgggctgtcgaccggctccaggtacaggagttcatgctcagcttc
ctccgagaccccttgcgagagattgaggagccctacttctgcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcggtgtgcccggac
accatgcacaaccctctctcccactactggatctcctcctcgcacaatacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgaattggactgctgggacggcccagatgggatgccagtcatttaccat
ggacacacgctgaccaccaagatcaagttctccgatgtcctgcacaccatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtctatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtgcttggggacacactcctcaccaag
cccgtggacatcgctgccgacgggctcccttcacccagccagctgaagagaaagatcctt
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacgtctgtcatg
tactctgagaatgacatcagcaactccatcaagaatggcatcctctacctagaggacccc
gtgaaccatgagtggtatccccattacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccaaggcaacgaggatgaggaagagcccaaggaggccagtagc
agcacagagctgcactccaacgagaagtggttccacgggaagctcggggcaggacgggac
gggcggcacatcgccgagcgcctgctcaccgagtactgcattgagaccggggcccctgat
ggctccttcctggtgcgcgagagcgagaccttcgtgggcgactacaccctctcgttctgg
cggaacgggaaggtccaacactgccggatccactcccggcaagacgctgggacccccaag
ttcttcctgacagacaacctcgtcttcgactcactctacgacctcatcacgcactaccag
caagtgcccctgcgctgcaacgaattcgagatgcgcctgtcggagcccgtgccacagacc
aatgcccacgagagcaaggagtggtaccatgcaagcctgaccagagcacaggctgagcac
atgctgatgcgtgtcccccgcgatggggccttcctggtgcggaaacggaatgagcccaac
tcctacgccatctctttccgggctgagggcaagatcaagcactgccgtgtccagcaagag
ggccagacagtgatgctgggtaactcagagttcgacagcctcgtcgacctcatcagctac
tacgagaagcacccgctgtaccgcaagatgaagctgcgctaccccattaatgaggaggcg
ctggagaagattggcacagctgagccggactatggggccctgtacgagggacgtaaccct
ggcttctacgtggaggcaaacccgatgccgaccttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagagaggatgagctgactttcaccaagagcgccatcatccagaac
gtggagaagcaggagggaggctggtggcggggagactatggtgggaagaagcagctatgg
ttcccgtcaaactacgtggaagagatggtcagcccggcggccctggagcctgagagggag
cacttggacgagaacagccccttgggggacttactgcggggggtcttggatgtgccagct
tgtcagattgccatccgtcccgagggcaagaacaatcgactgttcgtcttctcaatcagt
atggcatcggcgcagtggtccctggatgtcgctgccgactcacaagaggagctgcaggac
tgggtgaaaaagatccgtgaagtggctcagaccgcagatgccaggctcactgaggggaag
atgatggaacggaggaagaagatcgccctggagctgtctgagcttgtcgtctactgccgg
cctgttccttttgatgaagagaagattggcacagaacgcgcctgctaccgcgacatgtca
tccttcccggaaaccaaggctgagaaatacgtgaacaaggccaagggcaagaagttcctc
cagtacaaccggctgcagctgtcccgcatctaccccaaaggccagcggctggactcttcc
aactatgatcccttgcccatgtggatctgtggcagtcagctggtggccctcaacttccag
accccagacaagcctatgcagatgaaccaggccctcttcatgaccggtgggcactgtggc
tatgtgctgcagcccggcaccatgcgggacgaggcctttgacccctttgataagagcagc
ctccgtgggctggagccatgcgccatctgcatcgaggttctgggcgcccggcatctgccg
aagaatggccggggcattgtgtgtccctttgtggagattgaggtggctggagctgagtat
gacagcaccaagcagaagacagagtttgtgggtgagccttccttccccccatctccgcat
cctcccagagataccgaaggctcctcccttcgcaccatgaccccatcttctccaggcggt
ggcctgaggctttttccccttgctttcacagtggacaatggcttgaaccccatgtggccg
gccaagcccttccacttccagatcagtaaccctgaattcgccttcctgcgctttgtggta
tatgaagaagacatgtttagcgatcagaacttcctggctcaggctactttcccagtgaaa
ggcctaaagacagggtacagagcggtccctttgaagaacaactacagcgaggacctggag
ttggcctccctgctggtcaagatcgacattttccctgccaagcaggagaacggcgacctc
agtccctttggtggtatgtccctgcgggagcggagctctgatgcctcaggccagctgttt
catggccgggcccgcgaaggctcctttgaagcccgctaccagcagccatttgaggatttt
cgcatctcccaggagcatcttgcggaccactttgacagtcgggaacgaagggccccacgg
aggactcgggtcaatggagacaaccgcctctag

DBGET integrated database retrieval system