KEGG   Pteropus vampyrus (Indian flying fox): 120606549
Entry
120606549         CDS       T07511                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig01521  EGFR tyrosine kinase inhibitor resistance
pgig01522  Endocrine resistance
pgig01524  Platinum drug resistance
pgig04012  ErbB signaling pathway
pgig04014  Ras signaling pathway
pgig04015  Rap1 signaling pathway
pgig04024  cAMP signaling pathway
pgig04062  Chemokine signaling pathway
pgig04066  HIF-1 signaling pathway
pgig04068  FoxO signaling pathway
pgig04070  Phosphatidylinositol signaling system
pgig04071  Sphingolipid signaling pathway
pgig04072  Phospholipase D signaling pathway
pgig04081  Hormone signaling
pgig04140  Autophagy - animal
pgig04150  mTOR signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04152  AMPK signaling pathway
pgig04210  Apoptosis
pgig04211  Longevity regulating pathway
pgig04213  Longevity regulating pathway - multiple species
pgig04218  Cellular senescence
pgig04360  Axon guidance
pgig04370  VEGF signaling pathway
pgig04380  Osteoclast differentiation
pgig04510  Focal adhesion
pgig04550  Signaling pathways regulating pluripotency of stem cells
pgig04611  Platelet activation
pgig04613  Neutrophil extracellular trap formation
pgig04620  Toll-like receptor signaling pathway
pgig04625  C-type lectin receptor signaling pathway
pgig04630  JAK-STAT signaling pathway
pgig04650  Natural killer cell mediated cytotoxicity
pgig04660  T cell receptor signaling pathway
pgig04662  B cell receptor signaling pathway
pgig04664  Fc epsilon RI signaling pathway
pgig04666  Fc gamma R-mediated phagocytosis
pgig04668  TNF signaling pathway
pgig04670  Leukocyte transendothelial migration
pgig04722  Neurotrophin signaling pathway
pgig04725  Cholinergic synapse
pgig04750  Inflammatory mediator regulation of TRP channels
pgig04810  Regulation of actin cytoskeleton
pgig04910  Insulin signaling pathway
pgig04914  Progesterone-mediated oocyte maturation
pgig04915  Estrogen signaling pathway
pgig04917  Prolactin signaling pathway
pgig04919  Thyroid hormone signaling pathway
pgig04923  Regulation of lipolysis in adipocytes
pgig04926  Relaxin signaling pathway
pgig04929  GnRH secretion
pgig04930  Type II diabetes mellitus
pgig04931  Insulin resistance
pgig04932  Non-alcoholic fatty liver disease
pgig04933  AGE-RAGE signaling pathway in diabetic complications
pgig04935  Growth hormone synthesis, secretion and action
pgig04960  Aldosterone-regulated sodium reabsorption
pgig04973  Carbohydrate digestion and absorption
pgig05010  Alzheimer disease
pgig05017  Spinocerebellar ataxia
pgig05020  Prion disease
pgig05100  Bacterial invasion of epithelial cells
pgig05135  Yersinia infection
pgig05142  Chagas disease
pgig05146  Amoebiasis
pgig05160  Hepatitis C
pgig05161  Hepatitis B
pgig05162  Measles
pgig05163  Human cytomegalovirus infection
pgig05164  Influenza A
pgig05165  Human papillomavirus infection
pgig05166  Human T-cell leukemia virus 1 infection
pgig05167  Kaposi sarcoma-associated herpesvirus infection
pgig05168  Herpes simplex virus 1 infection
pgig05169  Epstein-Barr virus infection
pgig05170  Human immunodeficiency virus 1 infection
pgig05171  Coronavirus disease - COVID-19
pgig05200  Pathways in cancer
pgig05203  Viral carcinogenesis
pgig05205  Proteoglycans in cancer
pgig05206  MicroRNAs in cancer
pgig05207  Chemical carcinogenesis - receptor activation
pgig05208  Chemical carcinogenesis - reactive oxygen species
pgig05210  Colorectal cancer
pgig05211  Renal cell carcinoma
pgig05212  Pancreatic cancer
pgig05213  Endometrial cancer
pgig05214  Glioma
pgig05215  Prostate cancer
pgig05218  Melanoma
pgig05220  Chronic myeloid leukemia
pgig05221  Acute myeloid leukemia
pgig05222  Small cell lung cancer
pgig05223  Non-small cell lung cancer
pgig05224  Breast cancer
pgig05225  Hepatocellular carcinoma
pgig05226  Gastric cancer
pgig05230  Central carbon metabolism in cancer
pgig05231  Choline metabolism in cancer
pgig05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pgig05415  Diabetic cardiomyopathy
pgig05417  Lipid and atherosclerosis
pgig05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    120606549 (PIK3R2)
   04014 Ras signaling pathway
    120606549 (PIK3R2)
   04015 Rap1 signaling pathway
    120606549 (PIK3R2)
   04370 VEGF signaling pathway
    120606549 (PIK3R2)
   04630 JAK-STAT signaling pathway
    120606549 (PIK3R2)
   04668 TNF signaling pathway
    120606549 (PIK3R2)
   04066 HIF-1 signaling pathway
    120606549 (PIK3R2)
   04068 FoxO signaling pathway
    120606549 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    120606549 (PIK3R2)
   04072 Phospholipase D signaling pathway
    120606549 (PIK3R2)
   04071 Sphingolipid signaling pathway
    120606549 (PIK3R2)
   04024 cAMP signaling pathway
    120606549 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    120606549 (PIK3R2)
   04152 AMPK signaling pathway
    120606549 (PIK3R2)
   04150 mTOR signaling pathway
    120606549 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    120606549 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120606549 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    120606549 (PIK3R2)
   04218 Cellular senescence
    120606549 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120606549 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    120606549 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120606549 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120606549 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    120606549 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    120606549 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    120606549 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    120606549 (PIK3R2)
   04660 T cell receptor signaling pathway
    120606549 (PIK3R2)
   04662 B cell receptor signaling pathway
    120606549 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    120606549 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    120606549 (PIK3R2)
   04670 Leukocyte transendothelial migration
    120606549 (PIK3R2)
   04062 Chemokine signaling pathway
    120606549 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120606549 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    120606549 (PIK3R2)
   04929 GnRH secretion
    120606549 (PIK3R2)
   04915 Estrogen signaling pathway
    120606549 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    120606549 (PIK3R2)
   04917 Prolactin signaling pathway
    120606549 (PIK3R2)
   04926 Relaxin signaling pathway
    120606549 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    120606549 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    120606549 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    120606549 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    120606549 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    120606549 (PIK3R2)
   04722 Neurotrophin signaling pathway
    120606549 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120606549 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    120606549 (PIK3R2)
   04380 Osteoclast differentiation
    120606549 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    120606549 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    120606549 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120606549 (PIK3R2)
   05206 MicroRNAs in cancer
    120606549 (PIK3R2)
   05205 Proteoglycans in cancer
    120606549 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    120606549 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    120606549 (PIK3R2)
   05203 Viral carcinogenesis
    120606549 (PIK3R2)
   05230 Central carbon metabolism in cancer
    120606549 (PIK3R2)
   05231 Choline metabolism in cancer
    120606549 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120606549 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120606549 (PIK3R2)
   05212 Pancreatic cancer
    120606549 (PIK3R2)
   05225 Hepatocellular carcinoma
    120606549 (PIK3R2)
   05226 Gastric cancer
    120606549 (PIK3R2)
   05214 Glioma
    120606549 (PIK3R2)
   05221 Acute myeloid leukemia
    120606549 (PIK3R2)
   05220 Chronic myeloid leukemia
    120606549 (PIK3R2)
   05218 Melanoma
    120606549 (PIK3R2)
   05211 Renal cell carcinoma
    120606549 (PIK3R2)
   05215 Prostate cancer
    120606549 (PIK3R2)
   05213 Endometrial cancer
    120606549 (PIK3R2)
   05224 Breast cancer
    120606549 (PIK3R2)
   05222 Small cell lung cancer
    120606549 (PIK3R2)
   05223 Non-small cell lung cancer
    120606549 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120606549 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    120606549 (PIK3R2)
   05161 Hepatitis B
    120606549 (PIK3R2)
   05160 Hepatitis C
    120606549 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    120606549 (PIK3R2)
   05164 Influenza A
    120606549 (PIK3R2)
   05162 Measles
    120606549 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    120606549 (PIK3R2)
   05163 Human cytomegalovirus infection
    120606549 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120606549 (PIK3R2)
   05169 Epstein-Barr virus infection
    120606549 (PIK3R2)
   05165 Human papillomavirus infection
    120606549 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    120606549 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    120606549 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    120606549 (PIK3R2)
   05142 Chagas disease
    120606549 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120606549 (PIK3R2)
   05017 Spinocerebellar ataxia
    120606549 (PIK3R2)
   05020 Prion disease
    120606549 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120606549 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    120606549 (PIK3R2)
   05415 Diabetic cardiomyopathy
    120606549 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    120606549 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    120606549 (PIK3R2)
   04931 Insulin resistance
    120606549 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    120606549 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120606549 (PIK3R2)
   01524 Platinum drug resistance
    120606549 (PIK3R2)
   01522 Endocrine resistance
    120606549 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pgig04131]
    120606549 (PIK3R2)
Membrane trafficking [BR:pgig04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    120606549 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 Ribosomal_L22e Laminin_I
Other DBs
NCBI-GeneID: 120606549
NCBI-ProteinID: XP_039723799
UniProt: A0A6P3QYH9
LinkDB
Position
Unknown
AA seq 728 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDLLVVSRAALQVLGVAEGSERCPQNVGWMPGL
NERTRQRGDFPGTYVEFLGPVALSRPGPRPRGPRPLPARPQEGAPEPGPTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPPLRTDWSLSDVDQWDAATLADGIKGFLLA
LPSPIMTPEAAAEARRALREAVGPIGPVLEPPTLPLHHALTLRFLLQHLGRMARRAPAPG
PAVRALGTAFGPLLQLRAAPPSPPPPGGAPDGTELFPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPTPIGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLIAHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQELRAQALDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGTRQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGLGFAEPYNLYGSLKELVLHYQHTSLVQHNDALTVTLAHPVRAPG
PGPPPTTR
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggctggcgctgagggcttccagtaccgtgcactgtacccatttcgtcgggagcggcca
gaggacctggagctgctaccaggcgacttgctggtggtgagccgggcagccctgcaggtc
ctgggtgtggccgagggcagtgagcgctgcccacagaacgtgggctggatgcctggcctc
aacgaacgcacacggcagcgcggtgattttccaggcacctatgtcgagttcctggggcct
gtggccctgtccaggcctggccctcgcccccgtggcccccgcccactgcccgccaggccc
caagagggggcccccgagccaggccccacactccctgacctgcctgagcagttctcccca
cctgatgtggctccccctctcctggtgaagcttgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcctcccctgcgcacagactggtccttgagc
gacgtggatcagtgggatgcggcaactctggcggatggcatcaagggcttcttgctggcg
ctgccctcgcccatcatgacaccggaggccgcggccgaggctcgccgggccctgcgggag
gccgtgggacccatagggccagtgctggagcccccgacgctgccactgcaccatgcgctc
acgctgcgcttcctgctccagcaccttggtcgcatggcccggcgtgcccctgcccctggc
ccagcggtgcgagccctgggcactgccttcgggccgctcctgcagctgcgcgctgctccg
ccttcgccgcctccgccagggggcgcacccgatgggactgagctcttccccgacttcccg
gccttgctggtggaaaagttgcttcaggagcacctagaggagcaggaggttgcaccacca
gcactgccacctaaaccacccaaagcaaagcccacccccatagggctggccaatgggggg
agcccaccctccctgcaggatgctgagtggtactggggtgacatctccagggaggaggtg
aacgaaaaactccgggacacacctgatggtaccttcctggtccgagatgcctccagcaag
atccagggagagtacactctgaccctcaggaaaggcgggaacaacaagctgattaaggtc
ttccaccgcgacgggcactacggcttctcggaaccactcaccttctgctctgttgtggac
ctcattgcccactaccgccatgagtccctggcccagtacaacgccaaactggacacgcgg
ctcctctaccctgtatccaagtaccagcaggaccagattgtcaaggaggacagtgtggag
gcagtgggtgcccagctcaaagtctaccaccagcagtaccaggacaagagccgcgagtac
gaccagctctacgaggagtacacacgtacctcccaggaactacagatgaagcgcaccgca
attgaggccttcaatgaaaccatcaagatctttgaagagcagggccagacgcaagagaag
tgtagcaaggaatatctggaacgcttccggcgtgagggcaatgagaaagagatgcagaga
atcctgctgaactcggagcgactcaagtctcgcattgctgagatccatgagagccgcacg
aagctggaacaggagctgcgggcacaggccttggacaaccgggagatcgacaagcgcatg
aacagcctaaagccagacctcatgcagctgcgcaagatccgagaccagtacctggtatgg
ctcacccagaaaggcacccggcagaagaaaatcaacgaatggttggggatcaaaaatgag
actgaggaccagtacgccctgatggaggacgaggatgacctgccccaccacgaggaacgc
acctggtacgtgggcaagatcaaccgcacacaggctgaggaaatgctgagcggcaaacga
gacggcaccttcctcatccgtgagagcagccagcgaggctgctacgcctgctctgtggtg
gtggatggcgacaccaagcactgcgttatctaccgcacggccaccggcttgggctttgca
gagccctacaatctgtatgggtccttaaaggagctggtgctgcattaccaacacacctcc
ttggtgcagcacaacgacgcgctcactgtcacattggcccaccctgttcgagcccctggc
cccggacccccacccaccacccgctga

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