Phyllostomus hastatus (greater spear-nosed bat): 123813640
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Entry
123813640 CDS
T07912
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
phas
Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas01521
EGFR tyrosine kinase inhibitor resistance
phas01522
Endocrine resistance
phas04010
MAPK signaling pathway
phas04012
ErbB signaling pathway
phas04014
Ras signaling pathway
phas04015
Rap1 signaling pathway
phas04022
cGMP-PKG signaling pathway
phas04024
cAMP signaling pathway
phas04066
HIF-1 signaling pathway
phas04068
FoxO signaling pathway
phas04071
Sphingolipid signaling pathway
phas04072
Phospholipase D signaling pathway
phas04140
Autophagy - animal
phas04148
Efferocytosis
phas04150
mTOR signaling pathway
phas04151
PI3K-Akt signaling pathway
phas04210
Apoptosis
phas04218
Cellular senescence
phas04270
Vascular smooth muscle contraction
phas04370
VEGF signaling pathway
phas04371
Apelin signaling pathway
phas04540
Gap junction
phas04550
Signaling pathways regulating pluripotency of stem cells
phas04613
Neutrophil extracellular trap formation
phas04620
Toll-like receptor signaling pathway
phas04650
Natural killer cell mediated cytotoxicity
phas04660
T cell receptor signaling pathway
phas04662
B cell receptor signaling pathway
phas04664
Fc epsilon RI signaling pathway
phas04720
Long-term potentiation
phas04722
Neurotrophin signaling pathway
phas04730
Long-term depression
phas04810
Regulation of actin cytoskeleton
phas04910
Insulin signaling pathway
phas04912
GnRH signaling pathway
phas04915
Estrogen signaling pathway
phas04916
Melanogenesis
phas04917
Prolactin signaling pathway
phas04919
Thyroid hormone signaling pathway
phas04921
Oxytocin signaling pathway
phas04926
Relaxin signaling pathway
phas04929
GnRH secretion
phas04934
Cushing syndrome
phas04935
Growth hormone synthesis, secretion and action
phas05010
Alzheimer disease
phas05022
Pathways of neurodegeneration - multiple diseases
phas05132
Salmonella infection
phas05135
Yersinia infection
phas05160
Hepatitis C
phas05161
Hepatitis B
phas05163
Human cytomegalovirus infection
phas05164
Influenza A
phas05165
Human papillomavirus infection
phas05166
Human T-cell leukemia virus 1 infection
phas05167
Kaposi sarcoma-associated herpesvirus infection
phas05170
Human immunodeficiency virus 1 infection
phas05200
Pathways in cancer
phas05205
Proteoglycans in cancer
phas05206
MicroRNAs in cancer
phas05207
Chemical carcinogenesis - receptor activation
phas05208
Chemical carcinogenesis - reactive oxygen species
phas05210
Colorectal cancer
phas05211
Renal cell carcinoma
phas05213
Endometrial cancer
phas05214
Glioma
phas05215
Prostate cancer
phas05216
Thyroid cancer
phas05218
Melanoma
phas05219
Bladder cancer
phas05220
Chronic myeloid leukemia
phas05221
Acute myeloid leukemia
phas05223
Non-small cell lung cancer
phas05224
Breast cancer
phas05225
Hepatocellular carcinoma
phas05226
Gastric cancer
phas05230
Central carbon metabolism in cancer
phas05231
Choline metabolism in cancer
phas05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
phas00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
123813640 (MAP2K2)
04012 ErbB signaling pathway
123813640 (MAP2K2)
04014 Ras signaling pathway
123813640 (MAP2K2)
04015 Rap1 signaling pathway
123813640 (MAP2K2)
04370 VEGF signaling pathway
123813640 (MAP2K2)
04371 Apelin signaling pathway
123813640 (MAP2K2)
04066 HIF-1 signaling pathway
123813640 (MAP2K2)
04068 FoxO signaling pathway
123813640 (MAP2K2)
04072 Phospholipase D signaling pathway
123813640 (MAP2K2)
04071 Sphingolipid signaling pathway
123813640 (MAP2K2)
04024 cAMP signaling pathway
123813640 (MAP2K2)
04022 cGMP-PKG signaling pathway
123813640 (MAP2K2)
04151 PI3K-Akt signaling pathway
123813640 (MAP2K2)
04150 mTOR signaling pathway
123813640 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
123813640 (MAP2K2)
04148 Efferocytosis
123813640 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
123813640 (MAP2K2)
04218 Cellular senescence
123813640 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
123813640 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
123813640 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
123813640 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
123813640 (MAP2K2)
04620 Toll-like receptor signaling pathway
123813640 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
123813640 (MAP2K2)
04660 T cell receptor signaling pathway
123813640 (MAP2K2)
04662 B cell receptor signaling pathway
123813640 (MAP2K2)
04664 Fc epsilon RI signaling pathway
123813640 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
123813640 (MAP2K2)
04929 GnRH secretion
123813640 (MAP2K2)
04912 GnRH signaling pathway
123813640 (MAP2K2)
04915 Estrogen signaling pathway
123813640 (MAP2K2)
04917 Prolactin signaling pathway
123813640 (MAP2K2)
04921 Oxytocin signaling pathway
123813640 (MAP2K2)
04926 Relaxin signaling pathway
123813640 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
123813640 (MAP2K2)
04919 Thyroid hormone signaling pathway
123813640 (MAP2K2)
04916 Melanogenesis
123813640 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
123813640 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
123813640 (MAP2K2)
04730 Long-term depression
123813640 (MAP2K2)
04722 Neurotrophin signaling pathway
123813640 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123813640 (MAP2K2)
05206 MicroRNAs in cancer
123813640 (MAP2K2)
05205 Proteoglycans in cancer
123813640 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
123813640 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
123813640 (MAP2K2)
05230 Central carbon metabolism in cancer
123813640 (MAP2K2)
05231 Choline metabolism in cancer
123813640 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
123813640 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
123813640 (MAP2K2)
05225 Hepatocellular carcinoma
123813640 (MAP2K2)
05226 Gastric cancer
123813640 (MAP2K2)
05214 Glioma
123813640 (MAP2K2)
05216 Thyroid cancer
123813640 (MAP2K2)
05221 Acute myeloid leukemia
123813640 (MAP2K2)
05220 Chronic myeloid leukemia
123813640 (MAP2K2)
05218 Melanoma
123813640 (MAP2K2)
05211 Renal cell carcinoma
123813640 (MAP2K2)
05219 Bladder cancer
123813640 (MAP2K2)
05215 Prostate cancer
123813640 (MAP2K2)
05213 Endometrial cancer
123813640 (MAP2K2)
05224 Breast cancer
123813640 (MAP2K2)
05223 Non-small cell lung cancer
123813640 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
123813640 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
123813640 (MAP2K2)
05161 Hepatitis B
123813640 (MAP2K2)
05160 Hepatitis C
123813640 (MAP2K2)
05164 Influenza A
123813640 (MAP2K2)
05163 Human cytomegalovirus infection
123813640 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
123813640 (MAP2K2)
05165 Human papillomavirus infection
123813640 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
123813640 (MAP2K2)
05135 Yersinia infection
123813640 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
123813640 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
123813640 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
123813640 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123813640 (MAP2K2)
01522 Endocrine resistance
123813640 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
phas01001
]
123813640 (MAP2K2)
Enzymes [BR:
phas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
123813640 (MAP2K2)
Protein kinases [BR:
phas01001
]
Serine/threonine kinases: STE group
STE7 family
123813640 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
CAMSAP_CC1
Kdo
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
123813640
NCBI-ProteinID:
XP_045686710
LinkDB
All DBs
Position
Unknown
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDTKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHGFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagaggagctagagcttgatgagcagcagaagaagcggctagaagccttcctcacccag
aaggccaaggttggggagctcaaggatgatgacttcgaaaggatctcagagctgggagcc
gggaatggcggggttgtcaccaaggtccagcacagaccttcaggcctcatcatggcaaga
aagctgattcacttggagatcaagccggccatccggaaccagatcatccgtgagctgcag
gtgctgcacgagtgtaactccccgtacatcgtgggcttctacggggccttctacagtgac
ggggagattagcatctgcatggagcacatggacggtggctctctggaccaggtattgaaa
gaagccaagagaattccagaagagatcctggggaaggtcagcattgcggttctccggggc
ctggcatatctccgggaaaagcaccaaattatgcaccgagatgtgaaaccatctaacatc
ctcgtcaactcccgaggagagatcaagctgtgtgattttggggtgagcgggcagctcatc
gactccatggctaactccttcgtgggaacgcgatcctacatgtctccggagcggttgcaa
ggcactcactactcggtgcagtcggacatctggagcatgggcctgtccctggtagagttg
tccatcggaaggtaccccatccccccgccggataccaaggagctggaggccatatttggc
cggcccatggttgatggggcagaaggagagcctcacagcatctcaccgcgcccaagaccc
cccggacgccccatcagtggtcatgggatggacagccggccagctatggctatcttcgaa
ctgctggactatattgtgaatgagcctcctcctaagctgcccagtggtgtcttcacccaa
gacttccaggagtttgtgaataaatgcctcattaagaacccagccgagcgagcagatctg
aagatgctcatgaaccatggcttcatcaaacggtccgaggtggaagaagtggattttgct
ggctggttgtgtaaaacgctgcgtctgaaccagcccagcacgcctacgcgtactgctgtg
tga
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