KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123824527
Entry
123824527         CDS       T07912                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas01521  EGFR tyrosine kinase inhibitor resistance
phas01522  Endocrine resistance
phas01524  Platinum drug resistance
phas04012  ErbB signaling pathway
phas04014  Ras signaling pathway
phas04015  Rap1 signaling pathway
phas04024  cAMP signaling pathway
phas04062  Chemokine signaling pathway
phas04066  HIF-1 signaling pathway
phas04068  FoxO signaling pathway
phas04070  Phosphatidylinositol signaling system
phas04071  Sphingolipid signaling pathway
phas04072  Phospholipase D signaling pathway
phas04081  Hormone signaling
phas04140  Autophagy - animal
phas04150  mTOR signaling pathway
phas04151  PI3K-Akt signaling pathway
phas04152  AMPK signaling pathway
phas04210  Apoptosis
phas04211  Longevity regulating pathway
phas04213  Longevity regulating pathway - multiple species
phas04218  Cellular senescence
phas04360  Axon guidance
phas04370  VEGF signaling pathway
phas04380  Osteoclast differentiation
phas04510  Focal adhesion
phas04550  Signaling pathways regulating pluripotency of stem cells
phas04611  Platelet activation
phas04613  Neutrophil extracellular trap formation
phas04620  Toll-like receptor signaling pathway
phas04625  C-type lectin receptor signaling pathway
phas04630  JAK-STAT signaling pathway
phas04650  Natural killer cell mediated cytotoxicity
phas04660  T cell receptor signaling pathway
phas04662  B cell receptor signaling pathway
phas04664  Fc epsilon RI signaling pathway
phas04666  Fc gamma R-mediated phagocytosis
phas04668  TNF signaling pathway
phas04670  Leukocyte transendothelial migration
phas04722  Neurotrophin signaling pathway
phas04725  Cholinergic synapse
phas04750  Inflammatory mediator regulation of TRP channels
phas04810  Regulation of actin cytoskeleton
phas04910  Insulin signaling pathway
phas04914  Progesterone-mediated oocyte maturation
phas04915  Estrogen signaling pathway
phas04917  Prolactin signaling pathway
phas04919  Thyroid hormone signaling pathway
phas04923  Regulation of lipolysis in adipocytes
phas04926  Relaxin signaling pathway
phas04929  GnRH secretion
phas04930  Type II diabetes mellitus
phas04931  Insulin resistance
phas04932  Non-alcoholic fatty liver disease
phas04933  AGE-RAGE signaling pathway in diabetic complications
phas04935  Growth hormone synthesis, secretion and action
phas04960  Aldosterone-regulated sodium reabsorption
phas04973  Carbohydrate digestion and absorption
phas05010  Alzheimer disease
phas05017  Spinocerebellar ataxia
phas05020  Prion disease
phas05100  Bacterial invasion of epithelial cells
phas05135  Yersinia infection
phas05142  Chagas disease
phas05146  Amoebiasis
phas05160  Hepatitis C
phas05161  Hepatitis B
phas05162  Measles
phas05163  Human cytomegalovirus infection
phas05164  Influenza A
phas05165  Human papillomavirus infection
phas05166  Human T-cell leukemia virus 1 infection
phas05167  Kaposi sarcoma-associated herpesvirus infection
phas05168  Herpes simplex virus 1 infection
phas05169  Epstein-Barr virus infection
phas05170  Human immunodeficiency virus 1 infection
phas05171  Coronavirus disease - COVID-19
phas05200  Pathways in cancer
phas05203  Viral carcinogenesis
phas05205  Proteoglycans in cancer
phas05206  MicroRNAs in cancer
phas05207  Chemical carcinogenesis - receptor activation
phas05208  Chemical carcinogenesis - reactive oxygen species
phas05210  Colorectal cancer
phas05211  Renal cell carcinoma
phas05212  Pancreatic cancer
phas05213  Endometrial cancer
phas05214  Glioma
phas05215  Prostate cancer
phas05218  Melanoma
phas05220  Chronic myeloid leukemia
phas05221  Acute myeloid leukemia
phas05222  Small cell lung cancer
phas05223  Non-small cell lung cancer
phas05224  Breast cancer
phas05225  Hepatocellular carcinoma
phas05226  Gastric cancer
phas05230  Central carbon metabolism in cancer
phas05231  Choline metabolism in cancer
phas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
phas05415  Diabetic cardiomyopathy
phas05417  Lipid and atherosclerosis
phas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:phas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123824527 (PIK3R1)
   04014 Ras signaling pathway
    123824527 (PIK3R1)
   04015 Rap1 signaling pathway
    123824527 (PIK3R1)
   04370 VEGF signaling pathway
    123824527 (PIK3R1)
   04630 JAK-STAT signaling pathway
    123824527 (PIK3R1)
   04668 TNF signaling pathway
    123824527 (PIK3R1)
   04066 HIF-1 signaling pathway
    123824527 (PIK3R1)
   04068 FoxO signaling pathway
    123824527 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    123824527 (PIK3R1)
   04072 Phospholipase D signaling pathway
    123824527 (PIK3R1)
   04071 Sphingolipid signaling pathway
    123824527 (PIK3R1)
   04024 cAMP signaling pathway
    123824527 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    123824527 (PIK3R1)
   04152 AMPK signaling pathway
    123824527 (PIK3R1)
   04150 mTOR signaling pathway
    123824527 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123824527 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123824527 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    123824527 (PIK3R1)
   04218 Cellular senescence
    123824527 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123824527 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123824527 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123824527 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123824527 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    123824527 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    123824527 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    123824527 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    123824527 (PIK3R1)
   04660 T cell receptor signaling pathway
    123824527 (PIK3R1)
   04662 B cell receptor signaling pathway
    123824527 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    123824527 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    123824527 (PIK3R1)
   04670 Leukocyte transendothelial migration
    123824527 (PIK3R1)
   04062 Chemokine signaling pathway
    123824527 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123824527 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    123824527 (PIK3R1)
   04929 GnRH secretion
    123824527 (PIK3R1)
   04915 Estrogen signaling pathway
    123824527 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    123824527 (PIK3R1)
   04917 Prolactin signaling pathway
    123824527 (PIK3R1)
   04926 Relaxin signaling pathway
    123824527 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    123824527 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    123824527 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123824527 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    123824527 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    123824527 (PIK3R1)
   04722 Neurotrophin signaling pathway
    123824527 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123824527 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    123824527 (PIK3R1)
   04380 Osteoclast differentiation
    123824527 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    123824527 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    123824527 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123824527 (PIK3R1)
   05206 MicroRNAs in cancer
    123824527 (PIK3R1)
   05205 Proteoglycans in cancer
    123824527 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    123824527 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123824527 (PIK3R1)
   05203 Viral carcinogenesis
    123824527 (PIK3R1)
   05230 Central carbon metabolism in cancer
    123824527 (PIK3R1)
   05231 Choline metabolism in cancer
    123824527 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123824527 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123824527 (PIK3R1)
   05212 Pancreatic cancer
    123824527 (PIK3R1)
   05225 Hepatocellular carcinoma
    123824527 (PIK3R1)
   05226 Gastric cancer
    123824527 (PIK3R1)
   05214 Glioma
    123824527 (PIK3R1)
   05221 Acute myeloid leukemia
    123824527 (PIK3R1)
   05220 Chronic myeloid leukemia
    123824527 (PIK3R1)
   05218 Melanoma
    123824527 (PIK3R1)
   05211 Renal cell carcinoma
    123824527 (PIK3R1)
   05215 Prostate cancer
    123824527 (PIK3R1)
   05213 Endometrial cancer
    123824527 (PIK3R1)
   05224 Breast cancer
    123824527 (PIK3R1)
   05222 Small cell lung cancer
    123824527 (PIK3R1)
   05223 Non-small cell lung cancer
    123824527 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123824527 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    123824527 (PIK3R1)
   05161 Hepatitis B
    123824527 (PIK3R1)
   05160 Hepatitis C
    123824527 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    123824527 (PIK3R1)
   05164 Influenza A
    123824527 (PIK3R1)
   05162 Measles
    123824527 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    123824527 (PIK3R1)
   05163 Human cytomegalovirus infection
    123824527 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123824527 (PIK3R1)
   05169 Epstein-Barr virus infection
    123824527 (PIK3R1)
   05165 Human papillomavirus infection
    123824527 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    123824527 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    123824527 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123824527 (PIK3R1)
   05142 Chagas disease
    123824527 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123824527 (PIK3R1)
   05017 Spinocerebellar ataxia
    123824527 (PIK3R1)
   05020 Prion disease
    123824527 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123824527 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    123824527 (PIK3R1)
   05415 Diabetic cardiomyopathy
    123824527 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123824527 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    123824527 (PIK3R1)
   04931 Insulin resistance
    123824527 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123824527 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123824527 (PIK3R1)
   01524 Platinum drug resistance
    123824527 (PIK3R1)
   01522 Endocrine resistance
    123824527 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:phas04131]
    123824527 (PIK3R1)
Membrane trafficking [BR:phas04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123824527 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 AAA_13 SH3_2 Laminin_I CCDC113_CCDC96_CC SH3_9 ACDC FANCI_S2
Other DBs
NCBI-GeneID: 123824527
NCBI-ProteinID: XP_045703676
LinkDB
Position
Unknown
AA seq 724 aa
MSAEAYQYRALYDYKKEREEDIDLHLGDILTVNKGSLLALGFSDGQEARPEDIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEAESEQQALALPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLETVDVQ
VLADAFKRYLLDLPNPVIPVAVYNEMISLAQEVQSSEEYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQSSSKNLLTARVLSELFSPLLFRFPAASSENTEHLIKAVEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgaggcgtaccagtacagagcactgtatgactataaaaaggaacgagaagaa
gatattgacttgcacttgggtgatatattgacggtgaataaggggtccttactagctctc
ggattcagtgacggacaggaagccaggccagaagatattggctggttaaatggctacaat
gaaaccacaggggagagaggggactttccaggaacttatgtagaatatattggaaggaaa
aaaatctcacctcccaccccaaagccccggccacctcgaccccttcctgttgcaccaggt
tcttcgaaaactgaagcagaaagtgagcagcaagctttggcccttccggatctcgcagaa
cagtttgcccctcctgacattgctccacctcttcttatcaagctagtagaagccatcgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtgatgccgcctccatggacttggaaacagttgatgttcaa
gttttagcagacgctttcaaacgctatctcttggacctgccgaatcccgtcattccagta
gctgtttacaatgagatgatttctttagcccaagaagttcaaagctcagaagaatatatc
cagctgttgaagaagctcattaggtcacctaacatacctcatcagtattggcttacgctt
cagtatttgctgaaacatttcttcaagctctcccaaagctccagcaaaaaccttctgact
gcaagagtgctctctgaacttttcagccctctgcttttcagattcccagcagccagctct
gagaatactgaacacctcataaaagcggtagaaatcttaatctcaacagaatggaacgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgccgaatggtactggggagacatctctcgg
gaagaagtgaatgaaaaacttcgagacacagctgacgggaccttcttggtacgagacgca
tctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatattccaccgagatgggaaatatggcttctccgacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatatcgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagactatatgaggattatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caggagcgctacagcaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaggaa
atacaaaggattatgcataattatgaaaagttaaagtctcgaatcagtgaaattgtggac
agcagaagacgactggaggaagacttgaagaagcaggcggctgagtatcgggagattgac
aaacgcatgaacagcatcaaaccagacctcatccagctgagaaagaccagagatcaatac
ttgatgtggttgactcagaaaggtgttcggcagaagaagctgaacgagtggctgggcaac
gaaaacaccgaagaccaatattcgctggtggaagacgacgaggacttgccccaccacgac
gagaagacgtggaatgtcgggagcagcaaccggaacaaagctgagaacctgctgcgaggg
aagcgggacggcactttccttgtccgggaaagcagtaagcagggctgctacgcctgctct
gtggtggtggacggcgaggtgaagcactgcgtcatcaacaaaacagcgaccggctatggc
tttgccgagccctacaacctgtacggctccctgaaagaactggtgctccattaccaacac
acctccctggtgcagcacaacgactccctcaacgtcacactagcctacccggtgtatgcg
cagcagaggcgatga

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