KEGG   Pipistrellus kuhlii (Kuhl's pipistrelle): 118703803
Entry
118703803         CDS       T07682                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pkl  Pipistrellus kuhlii (Kuhl's pipistrelle)
Pathway
pkl01521  EGFR tyrosine kinase inhibitor resistance
pkl01522  Endocrine resistance
pkl01524  Platinum drug resistance
pkl04012  ErbB signaling pathway
pkl04014  Ras signaling pathway
pkl04015  Rap1 signaling pathway
pkl04024  cAMP signaling pathway
pkl04062  Chemokine signaling pathway
pkl04066  HIF-1 signaling pathway
pkl04068  FoxO signaling pathway
pkl04070  Phosphatidylinositol signaling system
pkl04071  Sphingolipid signaling pathway
pkl04072  Phospholipase D signaling pathway
pkl04081  Hormone signaling
pkl04140  Autophagy - animal
pkl04150  mTOR signaling pathway
pkl04151  PI3K-Akt signaling pathway
pkl04152  AMPK signaling pathway
pkl04210  Apoptosis
pkl04211  Longevity regulating pathway
pkl04213  Longevity regulating pathway - multiple species
pkl04218  Cellular senescence
pkl04360  Axon guidance
pkl04370  VEGF signaling pathway
pkl04380  Osteoclast differentiation
pkl04510  Focal adhesion
pkl04550  Signaling pathways regulating pluripotency of stem cells
pkl04611  Platelet activation
pkl04613  Neutrophil extracellular trap formation
pkl04620  Toll-like receptor signaling pathway
pkl04625  C-type lectin receptor signaling pathway
pkl04630  JAK-STAT signaling pathway
pkl04650  Natural killer cell mediated cytotoxicity
pkl04660  T cell receptor signaling pathway
pkl04662  B cell receptor signaling pathway
pkl04664  Fc epsilon RI signaling pathway
pkl04666  Fc gamma R-mediated phagocytosis
pkl04668  TNF signaling pathway
pkl04670  Leukocyte transendothelial migration
pkl04722  Neurotrophin signaling pathway
pkl04725  Cholinergic synapse
pkl04750  Inflammatory mediator regulation of TRP channels
pkl04810  Regulation of actin cytoskeleton
pkl04910  Insulin signaling pathway
pkl04914  Progesterone-mediated oocyte maturation
pkl04915  Estrogen signaling pathway
pkl04917  Prolactin signaling pathway
pkl04919  Thyroid hormone signaling pathway
pkl04923  Regulation of lipolysis in adipocytes
pkl04926  Relaxin signaling pathway
pkl04929  GnRH secretion
pkl04930  Type II diabetes mellitus
pkl04931  Insulin resistance
pkl04932  Non-alcoholic fatty liver disease
pkl04933  AGE-RAGE signaling pathway in diabetic complications
pkl04935  Growth hormone synthesis, secretion and action
pkl04960  Aldosterone-regulated sodium reabsorption
pkl04973  Carbohydrate digestion and absorption
pkl05010  Alzheimer disease
pkl05017  Spinocerebellar ataxia
pkl05020  Prion disease
pkl05100  Bacterial invasion of epithelial cells
pkl05135  Yersinia infection
pkl05142  Chagas disease
pkl05146  Amoebiasis
pkl05160  Hepatitis C
pkl05161  Hepatitis B
pkl05162  Measles
pkl05163  Human cytomegalovirus infection
pkl05164  Influenza A
pkl05165  Human papillomavirus infection
pkl05166  Human T-cell leukemia virus 1 infection
pkl05167  Kaposi sarcoma-associated herpesvirus infection
pkl05168  Herpes simplex virus 1 infection
pkl05169  Epstein-Barr virus infection
pkl05170  Human immunodeficiency virus 1 infection
pkl05171  Coronavirus disease - COVID-19
pkl05200  Pathways in cancer
pkl05203  Viral carcinogenesis
pkl05205  Proteoglycans in cancer
pkl05206  MicroRNAs in cancer
pkl05207  Chemical carcinogenesis - receptor activation
pkl05208  Chemical carcinogenesis - reactive oxygen species
pkl05210  Colorectal cancer
pkl05211  Renal cell carcinoma
pkl05212  Pancreatic cancer
pkl05213  Endometrial cancer
pkl05214  Glioma
pkl05215  Prostate cancer
pkl05218  Melanoma
pkl05220  Chronic myeloid leukemia
pkl05221  Acute myeloid leukemia
pkl05222  Small cell lung cancer
pkl05223  Non-small cell lung cancer
pkl05224  Breast cancer
pkl05225  Hepatocellular carcinoma
pkl05226  Gastric cancer
pkl05230  Central carbon metabolism in cancer
pkl05231  Choline metabolism in cancer
pkl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pkl05415  Diabetic cardiomyopathy
pkl05417  Lipid and atherosclerosis
pkl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pkl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118703803 (PIK3R1)
   04014 Ras signaling pathway
    118703803 (PIK3R1)
   04015 Rap1 signaling pathway
    118703803 (PIK3R1)
   04370 VEGF signaling pathway
    118703803 (PIK3R1)
   04630 JAK-STAT signaling pathway
    118703803 (PIK3R1)
   04668 TNF signaling pathway
    118703803 (PIK3R1)
   04066 HIF-1 signaling pathway
    118703803 (PIK3R1)
   04068 FoxO signaling pathway
    118703803 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    118703803 (PIK3R1)
   04072 Phospholipase D signaling pathway
    118703803 (PIK3R1)
   04071 Sphingolipid signaling pathway
    118703803 (PIK3R1)
   04024 cAMP signaling pathway
    118703803 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    118703803 (PIK3R1)
   04152 AMPK signaling pathway
    118703803 (PIK3R1)
   04150 mTOR signaling pathway
    118703803 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118703803 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118703803 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    118703803 (PIK3R1)
   04218 Cellular senescence
    118703803 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118703803 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    118703803 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118703803 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118703803 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    118703803 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    118703803 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    118703803 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    118703803 (PIK3R1)
   04660 T cell receptor signaling pathway
    118703803 (PIK3R1)
   04662 B cell receptor signaling pathway
    118703803 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    118703803 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    118703803 (PIK3R1)
   04670 Leukocyte transendothelial migration
    118703803 (PIK3R1)
   04062 Chemokine signaling pathway
    118703803 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118703803 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    118703803 (PIK3R1)
   04929 GnRH secretion
    118703803 (PIK3R1)
   04915 Estrogen signaling pathway
    118703803 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    118703803 (PIK3R1)
   04917 Prolactin signaling pathway
    118703803 (PIK3R1)
   04926 Relaxin signaling pathway
    118703803 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    118703803 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    118703803 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118703803 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118703803 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    118703803 (PIK3R1)
   04722 Neurotrophin signaling pathway
    118703803 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118703803 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    118703803 (PIK3R1)
   04380 Osteoclast differentiation
    118703803 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    118703803 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    118703803 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118703803 (PIK3R1)
   05206 MicroRNAs in cancer
    118703803 (PIK3R1)
   05205 Proteoglycans in cancer
    118703803 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    118703803 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118703803 (PIK3R1)
   05203 Viral carcinogenesis
    118703803 (PIK3R1)
   05230 Central carbon metabolism in cancer
    118703803 (PIK3R1)
   05231 Choline metabolism in cancer
    118703803 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118703803 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118703803 (PIK3R1)
   05212 Pancreatic cancer
    118703803 (PIK3R1)
   05225 Hepatocellular carcinoma
    118703803 (PIK3R1)
   05226 Gastric cancer
    118703803 (PIK3R1)
   05214 Glioma
    118703803 (PIK3R1)
   05221 Acute myeloid leukemia
    118703803 (PIK3R1)
   05220 Chronic myeloid leukemia
    118703803 (PIK3R1)
   05218 Melanoma
    118703803 (PIK3R1)
   05211 Renal cell carcinoma
    118703803 (PIK3R1)
   05215 Prostate cancer
    118703803 (PIK3R1)
   05213 Endometrial cancer
    118703803 (PIK3R1)
   05224 Breast cancer
    118703803 (PIK3R1)
   05222 Small cell lung cancer
    118703803 (PIK3R1)
   05223 Non-small cell lung cancer
    118703803 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118703803 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    118703803 (PIK3R1)
   05161 Hepatitis B
    118703803 (PIK3R1)
   05160 Hepatitis C
    118703803 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    118703803 (PIK3R1)
   05164 Influenza A
    118703803 (PIK3R1)
   05162 Measles
    118703803 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    118703803 (PIK3R1)
   05163 Human cytomegalovirus infection
    118703803 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118703803 (PIK3R1)
   05169 Epstein-Barr virus infection
    118703803 (PIK3R1)
   05165 Human papillomavirus infection
    118703803 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118703803 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    118703803 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118703803 (PIK3R1)
   05142 Chagas disease
    118703803 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118703803 (PIK3R1)
   05017 Spinocerebellar ataxia
    118703803 (PIK3R1)
   05020 Prion disease
    118703803 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118703803 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    118703803 (PIK3R1)
   05415 Diabetic cardiomyopathy
    118703803 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118703803 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    118703803 (PIK3R1)
   04931 Insulin resistance
    118703803 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118703803 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118703803 (PIK3R1)
   01524 Platinum drug resistance
    118703803 (PIK3R1)
   01522 Endocrine resistance
    118703803 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pkl04131]
    118703803 (PIK3R1)
Membrane trafficking [BR:pkl04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118703803 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 SH3_1 SH3_2 Laminin_I CCDC113_CCDC96_CC SH3_9
Other DBs
NCBI-GeneID: 118703803
NCBI-ProteinID: XP_036266918
LinkDB
Position
Unknown
AA seq 744 aa
MSAEGYQYRALYDYKKEREEDIDLHLDDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEAETEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCGECHGAIDTDGND
SAYLSVSDAASVDLEAVDVQVLADAFKRYLSDLPNPVIPVAVYNEMISLAPEVQSSEDYI
QLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQSSSKNLLTAGVLSELFSPLLFRLPAASS
ENAEPLRKVIEILISTEWSERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISR
EEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNS
VVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKS
REYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKE
IQRIMHNYEKLKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQY
LMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRG
KRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQH
TSLVQHNDSLNVTLAYPVYAQQRR
NT seq 2235 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcactctacgattacaaaaaggagcgagaagaa
gacattgacttgcacttggatgacatattgaccgtgaataaagggtccttagtagctctt
ggatttagcgatggacaggaagccaggcctgaagaaattggctggttaaatggctacaat
gaaaccacaggggagagaggggacttcccaggaacttatgtagaatatattgggaggaaa
aaaatctcacctcccaccccgaagccccggccacctcgacccctcccggtggcaccaggt
tcctcgaaaactgaagcagaaactgagcagcaagctttgacccttccggatcttgcagaa
cagtttgcccctcctgacatcgctccacctcttcttatcaagctagtagaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtggtgagtgccatggagctatagatacagatggcaacgac
agtgcttacctttctgtttcggatgccgcctccgtggacttggaagcagttgatgttcaa
gttttagcagacgctttcaaacgctatctctcggacctaccaaatcccgtcattcctgta
gctgtttacaatgaaatgatttctttagccccagaagtacaaagctccgaagactacatc
cagctgttgaagaagctcattaggtcacctaacatacctcatcagtattggcttacgctt
cagtatttgctcaaacatttcttcaagctctcccaaagctccagcaagaacctcttgact
gcaggagtgctctcggaacttttcagccctctgcttttcagactccccgcagccagctct
gagaatgctgaacccctccgaaaagttatagaaattttaatctcaacagaatggagcgag
cgacagccagcaccagcactgcctcctaaaccaccaaaacctactactgtggccaacaac
ggtatgaataacaatatgtccttacaagatgctgagtggtactggggagatatctcgagg
gaggaagtgaatgaaaaacttcgagatacagccgacggaacctttttggtacgagatgca
tctactaaaatgcatggagattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatacggcttctcggacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaagttactttacccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatatcgaagctgtaggaaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggactatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaaca
caggagcgctacagtaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgagaagttaaaatctcggatcagcgagattgtggac
agcagaagaagactggaggaagacttgaagaagcaggcagctgagtaccgggagattgac
aagcgcatgaacagcattaagcctgacctcattcaactgaggaagacgagagaccagtac
ttgatgtggctgactcagaaaggtgttcggcagaagaagttgaacgagtggctgggcaat
gaaaacactgaagaccaatattcgctggtggaggatgacgaggatctgccccaccatgac
gagaagacctggaatgtcggaagcagcaaccgaaacaaggccgagaacctgctacgaggg
aagcgagacggcactttcctggtccgggaaagcagcaaacagggctgctacgcctgctct
gtggtggtggacggcgaggtaaagcactgtgtcataaacaaaacggctactggctacggc
tttgcggagccctataacctgtacagctccctcaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaacgtcaccctagcctacccagtatatgcg
cagcagaggcgatga

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