Peromyscus leucopus (white-footed mouse): 114688121
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Entry
114688121 CDS
T07241
Symbol
Map2k2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
pleu
Peromyscus leucopus (white-footed mouse)
Pathway
pleu01521
EGFR tyrosine kinase inhibitor resistance
pleu01522
Endocrine resistance
pleu04010
MAPK signaling pathway
pleu04012
ErbB signaling pathway
pleu04014
Ras signaling pathway
pleu04015
Rap1 signaling pathway
pleu04022
cGMP-PKG signaling pathway
pleu04024
cAMP signaling pathway
pleu04066
HIF-1 signaling pathway
pleu04068
FoxO signaling pathway
pleu04071
Sphingolipid signaling pathway
pleu04072
Phospholipase D signaling pathway
pleu04140
Autophagy - animal
pleu04148
Efferocytosis
pleu04150
mTOR signaling pathway
pleu04151
PI3K-Akt signaling pathway
pleu04210
Apoptosis
pleu04218
Cellular senescence
pleu04270
Vascular smooth muscle contraction
pleu04370
VEGF signaling pathway
pleu04371
Apelin signaling pathway
pleu04540
Gap junction
pleu04550
Signaling pathways regulating pluripotency of stem cells
pleu04613
Neutrophil extracellular trap formation
pleu04620
Toll-like receptor signaling pathway
pleu04650
Natural killer cell mediated cytotoxicity
pleu04660
T cell receptor signaling pathway
pleu04662
B cell receptor signaling pathway
pleu04664
Fc epsilon RI signaling pathway
pleu04720
Long-term potentiation
pleu04722
Neurotrophin signaling pathway
pleu04730
Long-term depression
pleu04810
Regulation of actin cytoskeleton
pleu04910
Insulin signaling pathway
pleu04912
GnRH signaling pathway
pleu04915
Estrogen signaling pathway
pleu04916
Melanogenesis
pleu04917
Prolactin signaling pathway
pleu04919
Thyroid hormone signaling pathway
pleu04921
Oxytocin signaling pathway
pleu04926
Relaxin signaling pathway
pleu04929
GnRH secretion
pleu04934
Cushing syndrome
pleu04935
Growth hormone synthesis, secretion and action
pleu05010
Alzheimer disease
pleu05022
Pathways of neurodegeneration - multiple diseases
pleu05132
Salmonella infection
pleu05135
Yersinia infection
pleu05160
Hepatitis C
pleu05161
Hepatitis B
pleu05163
Human cytomegalovirus infection
pleu05164
Influenza A
pleu05165
Human papillomavirus infection
pleu05166
Human T-cell leukemia virus 1 infection
pleu05167
Kaposi sarcoma-associated herpesvirus infection
pleu05170
Human immunodeficiency virus 1 infection
pleu05200
Pathways in cancer
pleu05205
Proteoglycans in cancer
pleu05206
MicroRNAs in cancer
pleu05207
Chemical carcinogenesis - receptor activation
pleu05208
Chemical carcinogenesis - reactive oxygen species
pleu05210
Colorectal cancer
pleu05211
Renal cell carcinoma
pleu05213
Endometrial cancer
pleu05214
Glioma
pleu05215
Prostate cancer
pleu05216
Thyroid cancer
pleu05218
Melanoma
pleu05219
Bladder cancer
pleu05220
Chronic myeloid leukemia
pleu05221
Acute myeloid leukemia
pleu05223
Non-small cell lung cancer
pleu05224
Breast cancer
pleu05225
Hepatocellular carcinoma
pleu05226
Gastric cancer
pleu05230
Central carbon metabolism in cancer
pleu05231
Choline metabolism in cancer
pleu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pleu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
114688121 (Map2k2)
04012 ErbB signaling pathway
114688121 (Map2k2)
04014 Ras signaling pathway
114688121 (Map2k2)
04015 Rap1 signaling pathway
114688121 (Map2k2)
04370 VEGF signaling pathway
114688121 (Map2k2)
04371 Apelin signaling pathway
114688121 (Map2k2)
04066 HIF-1 signaling pathway
114688121 (Map2k2)
04068 FoxO signaling pathway
114688121 (Map2k2)
04072 Phospholipase D signaling pathway
114688121 (Map2k2)
04071 Sphingolipid signaling pathway
114688121 (Map2k2)
04024 cAMP signaling pathway
114688121 (Map2k2)
04022 cGMP-PKG signaling pathway
114688121 (Map2k2)
04151 PI3K-Akt signaling pathway
114688121 (Map2k2)
04150 mTOR signaling pathway
114688121 (Map2k2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
114688121 (Map2k2)
04148 Efferocytosis
114688121 (Map2k2)
09143 Cell growth and death
04210 Apoptosis
114688121 (Map2k2)
04218 Cellular senescence
114688121 (Map2k2)
09144 Cellular community - eukaryotes
04540 Gap junction
114688121 (Map2k2)
04550 Signaling pathways regulating pluripotency of stem cells
114688121 (Map2k2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
114688121 (Map2k2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
114688121 (Map2k2)
04620 Toll-like receptor signaling pathway
114688121 (Map2k2)
04650 Natural killer cell mediated cytotoxicity
114688121 (Map2k2)
04660 T cell receptor signaling pathway
114688121 (Map2k2)
04662 B cell receptor signaling pathway
114688121 (Map2k2)
04664 Fc epsilon RI signaling pathway
114688121 (Map2k2)
09152 Endocrine system
04910 Insulin signaling pathway
114688121 (Map2k2)
04929 GnRH secretion
114688121 (Map2k2)
04912 GnRH signaling pathway
114688121 (Map2k2)
04915 Estrogen signaling pathway
114688121 (Map2k2)
04917 Prolactin signaling pathway
114688121 (Map2k2)
04921 Oxytocin signaling pathway
114688121 (Map2k2)
04926 Relaxin signaling pathway
114688121 (Map2k2)
04935 Growth hormone synthesis, secretion and action
114688121 (Map2k2)
04919 Thyroid hormone signaling pathway
114688121 (Map2k2)
04916 Melanogenesis
114688121 (Map2k2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
114688121 (Map2k2)
09156 Nervous system
04720 Long-term potentiation
114688121 (Map2k2)
04730 Long-term depression
114688121 (Map2k2)
04722 Neurotrophin signaling pathway
114688121 (Map2k2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114688121 (Map2k2)
05206 MicroRNAs in cancer
114688121 (Map2k2)
05205 Proteoglycans in cancer
114688121 (Map2k2)
05207 Chemical carcinogenesis - receptor activation
114688121 (Map2k2)
05208 Chemical carcinogenesis - reactive oxygen species
114688121 (Map2k2)
05230 Central carbon metabolism in cancer
114688121 (Map2k2)
05231 Choline metabolism in cancer
114688121 (Map2k2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
114688121 (Map2k2)
09162 Cancer: specific types
05210 Colorectal cancer
114688121 (Map2k2)
05225 Hepatocellular carcinoma
114688121 (Map2k2)
05226 Gastric cancer
114688121 (Map2k2)
05214 Glioma
114688121 (Map2k2)
05216 Thyroid cancer
114688121 (Map2k2)
05221 Acute myeloid leukemia
114688121 (Map2k2)
05220 Chronic myeloid leukemia
114688121 (Map2k2)
05218 Melanoma
114688121 (Map2k2)
05211 Renal cell carcinoma
114688121 (Map2k2)
05219 Bladder cancer
114688121 (Map2k2)
05215 Prostate cancer
114688121 (Map2k2)
05213 Endometrial cancer
114688121 (Map2k2)
05224 Breast cancer
114688121 (Map2k2)
05223 Non-small cell lung cancer
114688121 (Map2k2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
114688121 (Map2k2)
05170 Human immunodeficiency virus 1 infection
114688121 (Map2k2)
05161 Hepatitis B
114688121 (Map2k2)
05160 Hepatitis C
114688121 (Map2k2)
05164 Influenza A
114688121 (Map2k2)
05163 Human cytomegalovirus infection
114688121 (Map2k2)
05167 Kaposi sarcoma-associated herpesvirus infection
114688121 (Map2k2)
05165 Human papillomavirus infection
114688121 (Map2k2)
09171 Infectious disease: bacterial
05132 Salmonella infection
114688121 (Map2k2)
05135 Yersinia infection
114688121 (Map2k2)
09164 Neurodegenerative disease
05010 Alzheimer disease
114688121 (Map2k2)
05022 Pathways of neurodegeneration - multiple diseases
114688121 (Map2k2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
114688121 (Map2k2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
114688121 (Map2k2)
01522 Endocrine resistance
114688121 (Map2k2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pleu01001
]
114688121 (Map2k2)
Enzymes [BR:
pleu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
114688121 (Map2k2)
Protein kinases [BR:
pleu01001
]
Serine/threonine kinases: STE group
STE7 family
114688121 (Map2k2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
114688121
NCBI-ProteinID:
XP_028718568
LinkDB
All DBs
Position
22:1636252..1652134
Genome browser
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKAQHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSPDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEAEEVDFVGWLCRTLRLKQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctaccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaggcgaacctggtggacttgcagaagaag
ctggaggagctggacctggatgagcagcagcggaagcggctggaggctttccttactcag
aaggccaaggttggcgaactcaaggacgatgacttcgagaggatctcagagctgggcgct
ggcaatggcggtgtggtcacgaaggcccagcacaggccgtcaggcctcatcatggccaga
aagctgatccacctggagatcaagccggccgtgcggaaccagatcatccgggagctgcag
gtgctgcatgaatgcaactccccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggcggctcgctggaccaggtactgaag
gaggccaagcggatccctgaggacatcctggggaaggtcagcattgcggtgctccggggc
ctggcgtacctccgggagaagcaccagatcatgcacagagatgtgaagccctccaatatc
ctggtgaactctcgtggcgagatcaagctgtgtgacttcggggtgagcggccagctgatt
gactccatggccaactcgtttgtggggacacgctcctacatgtctccagagcggctgcag
ggcacgcattactctgtgcagtcagacatctggagcatgggactgtcgctggtggagctg
gccatcgggaggtaccccatccccccacctgatgccaaggaactagaggccagctttggc
cggcctgtggtcgatggtgcggatggagagcctcatagtgtctcgccgcggcccaggccg
cctggacgccccatcagtggtcatgggatggacagccgacctgccatggccatctttgag
ctgctggactacatcgtaaatgagccgcctcccaagctgcccagtggcgtgttcagcccg
gacttccaggagttcgtgaataaatgcctcattaagaacccagcggagcgggcggatctg
aagatgctgatgaaccacgccttcatcaagcgctccgaggcggaggaggtggacttcgtg
ggctggctgtgccgaaccctgcggctgaagcagcccagcacacccacgcgcactgcagtg
tga
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