Peromyscus leucopus (white-footed mouse): 114695106
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Entry
114695106 CDS
T07241
Symbol
Irs2
Name
(RefSeq) insulin receptor substrate 2
KO
K07187
insulin receptor substrate 2
Organism
pleu
Peromyscus leucopus (white-footed mouse)
Pathway
pleu04022
cGMP-PKG signaling pathway
pleu04068
FoxO signaling pathway
pleu04081
Hormone signaling
pleu04140
Autophagy - animal
pleu04152
AMPK signaling pathway
pleu04211
Longevity regulating pathway
pleu04213
Longevity regulating pathway - multiple species
pleu04910
Insulin signaling pathway
pleu04920
Adipocytokine signaling pathway
pleu04923
Regulation of lipolysis in adipocytes
pleu04930
Type II diabetes mellitus
pleu04931
Insulin resistance
pleu04932
Non-alcoholic fatty liver disease
pleu04935
Growth hormone synthesis, secretion and action
pleu05010
Alzheimer disease
pleu05206
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:
pleu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
114695106 (Irs2)
04022 cGMP-PKG signaling pathway
114695106 (Irs2)
04152 AMPK signaling pathway
114695106 (Irs2)
09133 Signaling molecules and interaction
04081 Hormone signaling
114695106 (Irs2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
114695106 (Irs2)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
114695106 (Irs2)
04923 Regulation of lipolysis in adipocytes
114695106 (Irs2)
04920 Adipocytokine signaling pathway
114695106 (Irs2)
04935 Growth hormone synthesis, secretion and action
114695106 (Irs2)
09149 Aging
04211 Longevity regulating pathway
114695106 (Irs2)
04213 Longevity regulating pathway - multiple species
114695106 (Irs2)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
114695106 (Irs2)
09164 Neurodegenerative disease
05010 Alzheimer disease
114695106 (Irs2)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
114695106 (Irs2)
04932 Non-alcoholic fatty liver disease
114695106 (Irs2)
04931 Insulin resistance
114695106 (Irs2)
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Motif
Pfam:
IRS
PH
PH_11
MEKK4_N
Motif
Other DBs
NCBI-GeneID:
114695106
NCBI-ProteinID:
XP_028728137
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Position
17:complement(911881..937277)
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AA seq
1337 aa
AA seq
DB search
MASAPLPGPPAPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA
AAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRSGDGGSGIAATGGSCSASLPGVLGGSAGAAGSD
DYGLITPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQL
MNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRP
RSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVR
TASEGDGGAAAGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAG
GALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGPHPHLPHPLHHPQGQRPS
SGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGEFYGYM
SMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRA
TFSGSSGRLCPSFPASSPKMAYHPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALR
SGGPSSRKSDDYMPMSPTSVSAPKQILQPRSAAAALPPSGAAGPAPPSGPGRTFPVNGGT
NYKANSPAESSPEDSGYMRMWCGSKLSMENADPKLLPNGDYLNMSPSEAGAAAGTPPDFF
SAALRGGGGEGLKGVPGHCYSSLPRSYKAPYSCSGDSDQYVLMSSPVGRILEEERLEPQA
TPGTSQLAGAFGAAGGGHTQPHHSAVPSPMRPSGSGGRPEGFLGQRCRAVRPTRLSLEGL
QTLPSMQEYPLPTEPKSPGEYINIDFGEAGTCLSPPAPPLLASAASSSSLLSASSPASSL
GSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGGTHSGDTVGSMDGLLSPEVSSPYPPL
PPRPSASPSSLQQPLPPAPGELYRLPPAPAATSQGPTAAGPSSSSEPGDNGDYTEMAFGV
AATPPQPIAAPPKPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRAD
PQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGGSGILGGSDEP
PTSPGQAQPSPAVPPAPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDV
SDEPGSLSQSQPQHPQPGDKSSWGRTRSLGGLLSSVGSSGASGVCGGPGTGALPSASTYA
SIDFLSHHLKEATVVKE
NT seq
4014 nt
NT seq
+upstream
nt +downstream
nt
atggctagcgcgcccctgcctgggccccccgcgccagcgggcggggacggcccgaacctc
aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag
aagcacggccacaagcgcttcttcgtgctgcgcggccccggcacgggcggcgacgaggca
gccgcggccggggggtcgccaccgcagccgccgcggctggagtactacgagagcgagaag
aagtggaggagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgcctgaac
atcaacaagcgcgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag
tacttcgccgtggcggcggaaaacgagcaggagcaggagggctggtaccgcgcgctcacc
gacttggtcagcgagggtcgctctggcgacgggggctcgggcatcgcggccaccggcggg
tcctgcagcgcctctctcccaggcgtcctgggcggctcggcgggcgccgctggctccgat
gactacgggctcataacgcccgccacggcagtctaccgcgaggtgtggcaggtgaacctg
aagcccaagggtctgggccagagcaaaaacctgacgggtgtgtaccgcctatgcctgtct
gcgcgcaccatcggcttcgtgaagctcaattgcgagcagccgtcggtgacgctgcagctt
atgaacatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgctcg
gccgtcaccggccccggcgagctgtggatgcaagccgacgactcggtggtggcgcagaac
atccatgagaccatcctggaggccatgaaggcgctcaaggagctctttgagttccggcct
cgcagcaagagtcagtcgtccgggtcgtcggccacgcaccccatcagcgtgccgggcgcg
cgccgccaccaccacctggtcaacctgccccctagccagaccggcctggtgcgccgctcg
cgcaccgacagcctggcggccaccccgccagcagccaagtgcacctcgtgtcgggtccgt
acggccagtgagggcgacggcggcgcggcggccggggccgggacggcgggaggcagaccg
atgtcggtggccgggagccccctgagtcccgggccggtgcgcgcgcccctgagccgctcg
cacaccctgagcgccggctgcggaggccggccgagcaaagtcacgctggcgccggcaggg
ggcgccctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgcctgcagcc
accagccccggcagcctgtcctccagcagtgggcacggctcgggctcctacccgctcccc
cccggcccccacccgcatctgcctcatccgctgcaccacccccaaggccagcgtccgtcc
agcggcagtgcctccgcgtccggctcccccagtgacccgggtttcatgtcccttgacgag
tatggctccagccctggcgacctgagagccttcagtagccacaggagcaacacgcccgag
tcaatcgcggagaccccgccagctagggatggcagtgggggcgaattctatgggtacatg
agcatggatagacccctgagccactgcggccgcccttaccgtagggtctctggggatggg
gcccaggacctggacagaggactgaggaagaggacttactccctgactacacctgcccgg
cagaggccagtaccccagccttcctctgcctccctggatgagtatactctcatgcgggcc
accttctctgggagttcaggtcgcctctgcccatctttcccggcatcctctcccaaaatg
gcctaccacccttacccagaggactatggagacattgagattggctctcacaagagttcc
agcagtaacctgggggcagatgatggctacatgcccatgacccctggggcggccctcagg
agtggtggccccagtagccgcaagagtgatgattacatgcccatgagccccaccagtgta
tctgcccccaagcagatcctgcagcccaggtcagcggcggcagccttgccgccctcagga
gcagcagggccagcgcccccttcagggccagggaggaccttcccagtgaacgggggcacc
aactacaaagccaactccccagcggagagctccccagaagatagcggctacatgcgcatg
tggtgtggctccaagctgtccatggagaacgcagacccaaagctgctccccaacggggac
tacctcaatatgtcccccagcgaggctggtgctgccgcgggcacgccacctgacttcttc
tcagcggctttgcgcggaggcggcggcgagggcctcaaaggtgtccctggccactgctac
agctctctgccccgctcttacaaggccccctattcttgcagtggggacagtgaccagtat
gtgctcatgagctcccctgttgggcgaatcttggaagaggagaggctggaaccccaggcc
accccagggacctcccagttggccggcgcctttggggcagctgggggtggccatacccag
cctcatcactcagcagtgccttcccccatgaggccgagtggtagcggtggccgccctgag
ggcttcctgggccagcgctgtcgggcagtaagacccacgcgcttatctctggagggactg
cagacccttcctagcatgcaagagtaccctctacccacagagcccaagagccctggcgag
tacatcaacattgacttcggggaggcgggcacctgtctgtccccgcctgccccgcctctg
ctggcctcggcggcttcgtcctcgtcgctgctttcagccagtagtcctgcctcgtccctg
ggttcgggtaccccgggcaccagcagtgatagccgccagcgctccccgctctccgactat
atgaacttggacttcagttctcccaagtcccctaagcctggcggcacccatagtggggac
accgtgggctccatggatggccttctctccccagaggtctcatccccatacccaccactg
ccccctcgcccttcggcctccccgtcttccctgcagcagcctctgccacccgccccgggg
gagctctaccgcctgcctccagcacccgctgccacttcccagggccccactgctgctggc
ccctcatcgtcctcggagcctggggataacggtgactataccgagatggcctttggtgtg
gctgccaccccgccacaacctatcgcagcacccccaaagcccgaaggtgcccgagtggcc
agtcccacatccggcttgaagcgcctaagtctcatggatcaggtgtctggggtagaggcc
tttcttcaagtcagccagccccctgatccccaccggggtgccaaggtcatccgtgcggac
ccacagggcgggagacgtcgccacagttcagagaccttctcctctaccaccaccgtcacc
cctgtgtccccgtccttcgcccacaactccaagcgccacaattcggcctcggtggaaaac
gtctctctcaggaaaagcagcgaaggcggcagtggcatcctgggaggaagcgatgagcca
cccacatccccgggacaggcgcagccctcgccagctgtgccaccggcgccgcaggctagg
ccgtggaacccaggccagcccggagctttgattggctgtcccggaggcagcagttctccc
atgcgcagagagacctccgtgggtttccagaacggcctcaactatatcgccattgacgtg
agtgatgagccggggtccttgtcccagtctcagccgcagcatccacagccaggagacaag
agctcctggggccggacccgtagccttggggggctcctcagctccgtcggaagctctggc
gccagcggggtgtgtgggggcccaggcactggagccttgccctctgccagcacctacgca
agcatcgacttcttgtcccatcacttgaaggaagccacagtcgtgaaagagtga
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