Peromyscus leucopus (white-footed mouse): 114706546
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Entry
114706546 CDS
T07241
Symbol
Itch
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X1
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
pleu
Peromyscus leucopus (white-footed mouse)
Pathway
pleu04120
Ubiquitin mediated proteolysis
pleu04144
Endocytosis
pleu04330
Notch signaling pathway
pleu04668
TNF signaling pathway
pleu04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
pleu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
114706546 (Itch)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
114706546 (Itch)
04668 TNF signaling pathway
114706546 (Itch)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
114706546 (Itch)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
114706546 (Itch)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pleu04131
]
114706546 (Itch)
04121 Ubiquitin system [BR:
pleu04121
]
114706546 (Itch)
Enzymes [BR:
pleu01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
114706546 (Itch)
Membrane trafficking [BR:
pleu04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
114706546 (Itch)
Ubiquitin system [BR:
pleu04121
]
Ubiquitin ligases (E3)
HECT type E3
114706546 (Itch)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
114706546
NCBI-ProteinID:
XP_028744798
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All DBs
Position
4:131396447..131512736
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AA seq
866 aa
AA seq
DB search
MSDSGSQLHSVGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPTSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVITL
QLLGDKEPTETIGDLSVCLDGLQVEAEVVTNGETSCSESISQNDDGCRPKDETRVSTNGS
DDPEVAASGENKRTNGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSESD
GSSTGSVPPTNTNVNTNTSTSEGATSGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVD
QHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNY
EQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQNKEFDPLGPLPSGWEKRTDSNGRVYFV
NHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNKRTTTYIDPRTGKSALD
NGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRL
WVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKY
FRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIE
ECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAF
FEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVK
EIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDL
PPYKSYEQLKEKLLFAIEETEGFGQE
NT seq
2601 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggatcacagcttcattcagtgggtagcttgaccatgaaatcacaactt
cagatcactgtcatctcagccaaacttaaagaaaataaaaagaattggtttggaccaagt
ccttatgtagaagtcacagtagatgggcagtcaaagaagacagaaaaatgcaacaataca
aacagtcccaagtggaagcaaccccttacagttatcgttacccctacgagtaaattacat
tttcgtgtgtggagtcaccagaccttgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttattactttg
cagcttctaggagacaaagagccaacagagacaatcggagacttgtcagtttgtcttgat
gggctgcaagtagaagctgaagtggttactaatggtgaaacttcatgctcagaaagtatt
tcacagaatgatgatggctgcagacccaaagatgaaacaagagtgagcacgaatggatca
gatgaccctgaggttgcagcgtcaggggaaaacaagaggacaaacgggaacaattctcca
tccctttcaaatggtggctttaagccttctagacctccgagaccttcgagaccacctcca
cccactccacgaagaccagcatctgtaaacggttcaccatccaccaactctgaaagtgat
gggtctagtacaggctctgtgccaccaacaaatacaaatgtaaacacaaacacaagtaca
tccgaaggcgcaacatctgggttaataattcctcttactatatctggaggctcaggcccg
aggccactgaatactgtaagtcaagctcccctcccacctgggtgggagcagagagtagac
cagcatgggcgtgtttactatgtagaccatgttgaaaagcgaacaacatgggatagacca
gaacctctacctcctggttgggaacggcgtgtggacaatatgggacgtatttattatgtt
gaccatttcacaagaacaacaacgtggcagaggccaacattggagtctgtccggaactat
gaacagtggcagctacaacgcagtcagcttcagggagcgatgcagcagtttaaccagagg
ttcatctatgggaaccaagatttgtttgctacatcacaaaataaagaatttgatcccctt
ggtcctctgccctctgggtgggagaagagaactgatagcaacggcagagtgtatttcgtc
aaccacaacactcggattacgcagtgggaagaccccagaagccaaggtcaattaaatgaa
aagcccttacctgaaggctgggaaatgagattcacagtggatggaatcccatattttgtg
gaccacaataaaagaacaaccacttacatagatccacgtacaggaaaatctgccctagac
aacggaccccagatagcctatgttcgggacttcaaggcaaaggttcagtatttccggttc
tggtgtcagcaactggccatgccacagcatataaagatcacagtgacaagaaaaacattg
tttgaggattcctttcaacagataatgagcttcagcccgcaagatctgagaagacgtttg
tgggtgattttcccaggagaagaaggtttagattatggaggtgtagcaagagaatggttc
tttcttttgtcacatgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaa
gataactactgcctgcagataaaccccgcttcttacatcaatccagaccacctgaaatat
tttcgctttattggaagatttattgccatggctctattccatgggaaattcatagatact
gggttttctttaccattctataaacgtatcttgaacaaaccagttggacttaaggattta
gaatctattgatccagaattttacaattctctcatctgggttaaagaaaacaatattgaa
gaatgtggtttggaaatgtacttctctgttgataaagaaattctaggtgaaattaagagt
catgatttgaaacccaatggtggcaatattcttgtgacagaagaaaataaggaggaatac
atcaggatggtagctgagtggagattatctcgaggtgttgaagaacagacacaagctttc
tttgagggctttaatgaaattcttccccagcaatatttacaatattttgatgcaaaggaa
ttagaggtcctcttgtgtggaatgcaggagattgacttgaatgactggcagaggcatgcc
atctaccgccactacactaggaccagcaagcagatcatgtggttctggcagtttgttaaa
gaaattgataacgagaagaggatgagacttctgcagttcgtgactggaacctgccgattg
ccagtaggaggatttgccgacctcatggggagtaatggaccacagaagttctgcatcgag
aaagttgggaaagaaaattggttacccagaagccatacttgttttaaccgcctggacctc
ccaccctacaagagctatgagcaactgaaggaaaaactgttatttgccattgaagaaaca
gaaggatttggacaagagtaa
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