KEGG   Peromyscus leucopus (white-footed mouse): 114706924
Entry
114706924         CDS       T07241                                 
Symbol
Pik3r3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pleu  Peromyscus leucopus (white-footed mouse)
Pathway
pleu01521  EGFR tyrosine kinase inhibitor resistance
pleu01522  Endocrine resistance
pleu01524  Platinum drug resistance
pleu04012  ErbB signaling pathway
pleu04014  Ras signaling pathway
pleu04015  Rap1 signaling pathway
pleu04024  cAMP signaling pathway
pleu04062  Chemokine signaling pathway
pleu04066  HIF-1 signaling pathway
pleu04068  FoxO signaling pathway
pleu04070  Phosphatidylinositol signaling system
pleu04071  Sphingolipid signaling pathway
pleu04072  Phospholipase D signaling pathway
pleu04081  Hormone signaling
pleu04140  Autophagy - animal
pleu04150  mTOR signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04152  AMPK signaling pathway
pleu04210  Apoptosis
pleu04211  Longevity regulating pathway
pleu04213  Longevity regulating pathway - multiple species
pleu04218  Cellular senescence
pleu04360  Axon guidance
pleu04370  VEGF signaling pathway
pleu04380  Osteoclast differentiation
pleu04510  Focal adhesion
pleu04550  Signaling pathways regulating pluripotency of stem cells
pleu04611  Platelet activation
pleu04613  Neutrophil extracellular trap formation
pleu04620  Toll-like receptor signaling pathway
pleu04625  C-type lectin receptor signaling pathway
pleu04630  JAK-STAT signaling pathway
pleu04650  Natural killer cell mediated cytotoxicity
pleu04660  T cell receptor signaling pathway
pleu04662  B cell receptor signaling pathway
pleu04664  Fc epsilon RI signaling pathway
pleu04666  Fc gamma R-mediated phagocytosis
pleu04668  TNF signaling pathway
pleu04670  Leukocyte transendothelial migration
pleu04722  Neurotrophin signaling pathway
pleu04725  Cholinergic synapse
pleu04750  Inflammatory mediator regulation of TRP channels
pleu04810  Regulation of actin cytoskeleton
pleu04910  Insulin signaling pathway
pleu04914  Progesterone-mediated oocyte maturation
pleu04915  Estrogen signaling pathway
pleu04917  Prolactin signaling pathway
pleu04919  Thyroid hormone signaling pathway
pleu04923  Regulation of lipolysis in adipocytes
pleu04926  Relaxin signaling pathway
pleu04929  GnRH secretion
pleu04930  Type II diabetes mellitus
pleu04931  Insulin resistance
pleu04932  Non-alcoholic fatty liver disease
pleu04933  AGE-RAGE signaling pathway in diabetic complications
pleu04935  Growth hormone synthesis, secretion and action
pleu04960  Aldosterone-regulated sodium reabsorption
pleu04973  Carbohydrate digestion and absorption
pleu05010  Alzheimer disease
pleu05017  Spinocerebellar ataxia
pleu05020  Prion disease
pleu05100  Bacterial invasion of epithelial cells
pleu05135  Yersinia infection
pleu05142  Chagas disease
pleu05146  Amoebiasis
pleu05160  Hepatitis C
pleu05161  Hepatitis B
pleu05162  Measles
pleu05163  Human cytomegalovirus infection
pleu05164  Influenza A
pleu05165  Human papillomavirus infection
pleu05166  Human T-cell leukemia virus 1 infection
pleu05167  Kaposi sarcoma-associated herpesvirus infection
pleu05168  Herpes simplex virus 1 infection
pleu05169  Epstein-Barr virus infection
pleu05170  Human immunodeficiency virus 1 infection
pleu05171  Coronavirus disease - COVID-19
pleu05200  Pathways in cancer
pleu05203  Viral carcinogenesis
pleu05205  Proteoglycans in cancer
pleu05206  MicroRNAs in cancer
pleu05207  Chemical carcinogenesis - receptor activation
pleu05208  Chemical carcinogenesis - reactive oxygen species
pleu05210  Colorectal cancer
pleu05211  Renal cell carcinoma
pleu05212  Pancreatic cancer
pleu05213  Endometrial cancer
pleu05214  Glioma
pleu05215  Prostate cancer
pleu05218  Melanoma
pleu05220  Chronic myeloid leukemia
pleu05221  Acute myeloid leukemia
pleu05222  Small cell lung cancer
pleu05223  Non-small cell lung cancer
pleu05224  Breast cancer
pleu05225  Hepatocellular carcinoma
pleu05226  Gastric cancer
pleu05230  Central carbon metabolism in cancer
pleu05231  Choline metabolism in cancer
pleu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pleu05415  Diabetic cardiomyopathy
pleu05417  Lipid and atherosclerosis
pleu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pleu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114706924 (Pik3r3)
   04014 Ras signaling pathway
    114706924 (Pik3r3)
   04015 Rap1 signaling pathway
    114706924 (Pik3r3)
   04370 VEGF signaling pathway
    114706924 (Pik3r3)
   04630 JAK-STAT signaling pathway
    114706924 (Pik3r3)
   04668 TNF signaling pathway
    114706924 (Pik3r3)
   04066 HIF-1 signaling pathway
    114706924 (Pik3r3)
   04068 FoxO signaling pathway
    114706924 (Pik3r3)
   04070 Phosphatidylinositol signaling system
    114706924 (Pik3r3)
   04072 Phospholipase D signaling pathway
    114706924 (Pik3r3)
   04071 Sphingolipid signaling pathway
    114706924 (Pik3r3)
   04024 cAMP signaling pathway
    114706924 (Pik3r3)
   04151 PI3K-Akt signaling pathway
    114706924 (Pik3r3)
   04152 AMPK signaling pathway
    114706924 (Pik3r3)
   04150 mTOR signaling pathway
    114706924 (Pik3r3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    114706924 (Pik3r3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114706924 (Pik3r3)
  09143 Cell growth and death
   04210 Apoptosis
    114706924 (Pik3r3)
   04218 Cellular senescence
    114706924 (Pik3r3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114706924 (Pik3r3)
   04550 Signaling pathways regulating pluripotency of stem cells
    114706924 (Pik3r3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114706924 (Pik3r3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114706924 (Pik3r3)
   04613 Neutrophil extracellular trap formation
    114706924 (Pik3r3)
   04620 Toll-like receptor signaling pathway
    114706924 (Pik3r3)
   04625 C-type lectin receptor signaling pathway
    114706924 (Pik3r3)
   04650 Natural killer cell mediated cytotoxicity
    114706924 (Pik3r3)
   04660 T cell receptor signaling pathway
    114706924 (Pik3r3)
   04662 B cell receptor signaling pathway
    114706924 (Pik3r3)
   04664 Fc epsilon RI signaling pathway
    114706924 (Pik3r3)
   04666 Fc gamma R-mediated phagocytosis
    114706924 (Pik3r3)
   04670 Leukocyte transendothelial migration
    114706924 (Pik3r3)
   04062 Chemokine signaling pathway
    114706924 (Pik3r3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114706924 (Pik3r3)
   04923 Regulation of lipolysis in adipocytes
    114706924 (Pik3r3)
   04929 GnRH secretion
    114706924 (Pik3r3)
   04915 Estrogen signaling pathway
    114706924 (Pik3r3)
   04914 Progesterone-mediated oocyte maturation
    114706924 (Pik3r3)
   04917 Prolactin signaling pathway
    114706924 (Pik3r3)
   04926 Relaxin signaling pathway
    114706924 (Pik3r3)
   04935 Growth hormone synthesis, secretion and action
    114706924 (Pik3r3)
   04919 Thyroid hormone signaling pathway
    114706924 (Pik3r3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114706924 (Pik3r3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    114706924 (Pik3r3)
  09156 Nervous system
   04725 Cholinergic synapse
    114706924 (Pik3r3)
   04722 Neurotrophin signaling pathway
    114706924 (Pik3r3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114706924 (Pik3r3)
  09158 Development and regeneration
   04360 Axon guidance
    114706924 (Pik3r3)
   04380 Osteoclast differentiation
    114706924 (Pik3r3)
  09149 Aging
   04211 Longevity regulating pathway
    114706924 (Pik3r3)
   04213 Longevity regulating pathway - multiple species
    114706924 (Pik3r3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114706924 (Pik3r3)
   05206 MicroRNAs in cancer
    114706924 (Pik3r3)
   05205 Proteoglycans in cancer
    114706924 (Pik3r3)
   05207 Chemical carcinogenesis - receptor activation
    114706924 (Pik3r3)
   05208 Chemical carcinogenesis - reactive oxygen species
    114706924 (Pik3r3)
   05203 Viral carcinogenesis
    114706924 (Pik3r3)
   05230 Central carbon metabolism in cancer
    114706924 (Pik3r3)
   05231 Choline metabolism in cancer
    114706924 (Pik3r3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114706924 (Pik3r3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114706924 (Pik3r3)
   05212 Pancreatic cancer
    114706924 (Pik3r3)
   05225 Hepatocellular carcinoma
    114706924 (Pik3r3)
   05226 Gastric cancer
    114706924 (Pik3r3)
   05214 Glioma
    114706924 (Pik3r3)
   05221 Acute myeloid leukemia
    114706924 (Pik3r3)
   05220 Chronic myeloid leukemia
    114706924 (Pik3r3)
   05218 Melanoma
    114706924 (Pik3r3)
   05211 Renal cell carcinoma
    114706924 (Pik3r3)
   05215 Prostate cancer
    114706924 (Pik3r3)
   05213 Endometrial cancer
    114706924 (Pik3r3)
   05224 Breast cancer
    114706924 (Pik3r3)
   05222 Small cell lung cancer
    114706924 (Pik3r3)
   05223 Non-small cell lung cancer
    114706924 (Pik3r3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114706924 (Pik3r3)
   05170 Human immunodeficiency virus 1 infection
    114706924 (Pik3r3)
   05161 Hepatitis B
    114706924 (Pik3r3)
   05160 Hepatitis C
    114706924 (Pik3r3)
   05171 Coronavirus disease - COVID-19
    114706924 (Pik3r3)
   05164 Influenza A
    114706924 (Pik3r3)
   05162 Measles
    114706924 (Pik3r3)
   05168 Herpes simplex virus 1 infection
    114706924 (Pik3r3)
   05163 Human cytomegalovirus infection
    114706924 (Pik3r3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114706924 (Pik3r3)
   05169 Epstein-Barr virus infection
    114706924 (Pik3r3)
   05165 Human papillomavirus infection
    114706924 (Pik3r3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    114706924 (Pik3r3)
   05100 Bacterial invasion of epithelial cells
    114706924 (Pik3r3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114706924 (Pik3r3)
   05142 Chagas disease
    114706924 (Pik3r3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114706924 (Pik3r3)
   05017 Spinocerebellar ataxia
    114706924 (Pik3r3)
   05020 Prion disease
    114706924 (Pik3r3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114706924 (Pik3r3)
   05418 Fluid shear stress and atherosclerosis
    114706924 (Pik3r3)
   05415 Diabetic cardiomyopathy
    114706924 (Pik3r3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114706924 (Pik3r3)
   04932 Non-alcoholic fatty liver disease
    114706924 (Pik3r3)
   04931 Insulin resistance
    114706924 (Pik3r3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114706924 (Pik3r3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114706924 (Pik3r3)
   01524 Platinum drug resistance
    114706924 (Pik3r3)
   01522 Endocrine resistance
    114706924 (Pik3r3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pleu04131]
    114706924 (Pik3r3)
Membrane trafficking [BR:pleu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    114706924 (Pik3r3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Bap31_Bap29_C Transcrip_act Cupin_8 Exonuc_VII_L
Other DBs
NCBI-GeneID: 114706924
NCBI-ProteinID: XP_028745313
LinkDB
Position
2:117522828..117621957
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVTNGMKDSFISL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKN
LQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNDYADESYFINEEDETLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagcagttacaaatggaatgaaggacagttttatttctctt
caagatgcagaatggtactggggagatatttcaagggaagaggtaaatgacaaattacgg
gacatgccagatggtactttcttagtgcgtgatgcctcaacaaaaatgcagggggactat
acattgactttgaggaagggaggcaataataaattaataaagatctatcatcgggatggt
aaatacggcttttctgaccccctgacatttaattctgtggtggagctcattaaccactat
caccatgaatctcttgctcagtacaatcccaaactcgatgtgaagctgatgtacccggta
tccagataccaacaggaccagttggtaaaagaagataacattgatgcagtaggtaaaaac
ctgcaagagttccactcgcagtatcaggagaagagtaaagagtatgacaggctgtatgaa
gagtacaccaggacatctcaggaaatacagatgaagaggactgcaattgaagcctttaat
gaaactattaaaatatttgaggagcagtgtcatacccaggaacaacacagtaaagaatat
attgagcggtttcgcagagaggggaatgaaaaggagattgaacgaattatgatgaattat
gataagttgaaatcacgtcttggtgagattcatgatagcaaagtgcgtctagagcaggac
ttgaagaaacaagctttggacaaccgggaaatagataaaaaaatgaatagcatcaaacct
gacctgatccagctgcgtaaaatccgggatcagcaccttgtatggctcaatcacaaaggg
gtgaggcagaagcgcctgaatgcctggctggggatcaagaacgactatgctgatgaaagc
tactttatcaatgaggaagatgagaccctgccgcattatgatgagaaaacctggtttgtg
gaggatatcaaccgagtacaagcagaggacctgctttatgggaaaccagacggtgcattc
ttaattcgtgaaagtagcaagaaaggatgttatgcttgttctgtggttgcggatggggaa
gtgaaacactgtgtgatctacagcaccgctcgaggatacggctttgcagaaccctacaac
ctgtacagctcgctgaaggagttggtgctccattaccagcagacatccctggttcagcac
aatgactccctcaacgtcaggcttgcctaccctgtccatgcacagatgccctcactctgc
agataa

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