Panthera leo (lion): 122203074
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Entry
122203074 CDS
T10741
Symbol
ACACB
Name
(RefSeq) acetyl-CoA carboxylase 2 isoform X1
KO
K01946
acetyl-CoA carboxylase / biotin carboxylase 2 [EC:
6.4.1.2
6.3.4.14
2.1.3.15
]
Organism
plez Panthera leo (lion)
Pathway
plez00061
Fatty acid biosynthesis
plez00620
Pyruvate metabolism
plez00640
Propanoate metabolism
plez01100
Metabolic pathways
plez04152
AMPK signaling pathway
plez04910
Insulin signaling pathway
plez04920
Adipocytokine signaling pathway
plez04922
Glucagon signaling pathway
plez04931
Insulin resistance
plez04936
Alcoholic liver disease
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
122203074 (ACACB)
00640 Propanoate metabolism
122203074 (ACACB)
09103 Lipid metabolism
00061 Fatty acid biosynthesis
122203074 (ACACB)
09110 Biosynthesis of other secondary metabolites
00254 Aflatoxin biosynthesis
122203074 (ACACB)
09130 Environmental Information Processing
09132 Signal transduction
04152 AMPK signaling pathway
122203074 (ACACB)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
122203074 (ACACB)
04922 Glucagon signaling pathway
122203074 (ACACB)
04920 Adipocytokine signaling pathway
122203074 (ACACB)
09160 Human Diseases
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
122203074 (ACACB)
04931 Insulin resistance
122203074 (ACACB)
Enzymes [BR:
plez01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.3 Carboxy- and carbamoyltransferases
2.1.3.15 acetyl-CoA carboxytransferase
122203074 (ACACB)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.4 Other carbon-nitrogen ligases
6.3.4.14 biotin carboxylase
122203074 (ACACB)
6.4 Forming carbon-carbon bonds
6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
6.4.1.2 acetyl-CoA carboxylase
122203074 (ACACB)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ACC_central
Carboxyl_trans
CPSase_L_D2
ACCA_BT
Biotin_carb_N
Biotin_carb_C
Biotin_lipoyl
ATP-grasp
Dala_Dala_lig_C
Motif
Other DBs
NCBI-GeneID:
122203074
NCBI-ProteinID:
XP_042765578
LinkDB
All DBs
Position
D3:17984793..18083686
Genome browser
AA seq
2264 aa
AA seq
DB search
MGIFQSSRLWPWLFPGPSGRTSLRPSMSGLHLVKKGRELKKVDLHRDFTVASPAEFVTRF
GGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMA
DQYVPVPGGPNNNNYANVELVVDIAKRIPVQAVWAGWGHASENPKLPELLCKHDIAFLGP
PSEAMWALGDKIASTIVAQTLQVPTLPWSGSGLIIEWTEDNLQEGKRISVPEDIYDQGCV
KDVEEGLEVAEKIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKL
AQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIIEEAPATIATPAVFEFMEQCAVRL
AKTVGYVSAGTVEYLYSPDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH
RLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNF
RSNKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTV
EYLINLLETERFQNNDIDTGWLDHLIAEKVQAEKPDIMLGVVCGALNVADVMFRTCMTDF
LHSLERGQVLPAASLLNIVDVELIYDGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLND
GGLLLSYNGNSYTTYMKEEVDSYRVTIGNKTCVFEKENDPTVLRSPSAGKLIQYTVEDGG
HVEAGSSYAEMEVMKMIMTLNVQESGRVKYIKRAGAVLEAGCVVAKLELDDPSKVRPAEP
FTGELPSQQTLPIIGEKLHQVFHNVLENLTNVMNGYCLPEPIFSTKLKEWVQKLMTTLRH
PSLPLLELQEIMTSVSGRIPAPVEKSVRRVMAQYASNITSVLCQFPSQQIATILDCHAAT
LQRKADREVFFMNTQSIVQLVQRYRSGTRGYMKAVVLDLLRRYLRVEHHFQQAHYDKCVI
NLREQLKPNMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSEELTSILNELTQLSK
SEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKKLILSETTIF
DVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNR
MAVPISVTNPDLLRHSTELFMDSGFAPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPR
EIPLFRKACAPLYSEEENKSLREEPIHILNVAIQYADHLEDEELVPIFRTFVQSKKNILV
EYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELSRMRSFDLTAVP
CANHKMHLYLGAAKVKEGAEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMD
ELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRSMVMRYGSRLWKLRVLQAEVKI
NIRQTTAGSAVPIRLFITNESGYYLDISLYKEVTDPRSGNIMFHSFGNKQGPQHGMLINT
PYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALLKLWGSADKYPKDILTYTELVLDPQG
QLVEMNRLPGGNEVGMVAFKMRFKTREYPEGRDAIVISNDITFRIGSFGLEEDLLYLRAS
EMARAEGIPKIYLAANSGACISLAEEIKHMFQVAWVDPGDPHKGFKYLYLTPQDYTRISS
LNSVHCKHIEEEGESRYVITDIIGKDRGLGVENLKGSGMIAGESSLAYEEIVTISLVTCR
ALGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHV
TVPDDFEGVYTILEWLSYMPKDNRSPVPITTPSDPIDREIGFFPSRAPYDPRWLLAGRPH
PTLKGSWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVVVPADPAN
LDSEAKIIQQAGQVWFPDSAYKTAQAINDFNRERLPLIIFANWRGFSGGMKDMYDQVLKF
GAYIVDSLRQYKQPVLIYIPPNGELRGGSWVVVDSSINPLCIETYADKESRASILEPEGT
VEIKFRKKDLIKTMRRIDPVYKKLVEQLGVSELSDKDRKDLEGQLKAREDLLLPIYHQVA
VLFADLHDRAQGMLEKGVISDIVEWKTSRAFLYWRLRRLLLEDQVKQEILQASSELSHVH
IQSMLRRWFVETEGAVKAYLWDNNQMVVKWLEQHWQGGGGLRSTIRENIKCLKRDSVLKA
IRRLVQDNPDVAVDCIVYLSQHISSAERAEVIHLLSTMDSPAST
NT seq
6795 nt
NT seq
+upstream
nt +downstream
nt
atgggcatcttccaaagctctcgcctgtggccatggctcttcccaggcccctccgggcgt
acatccttaagacccagcatgtccggactccacctggtgaagaagggccgagaactaaag
aaggtggacctgcacagagacttcaccgtggcctccccggctgagtttgtcacgcgcttc
gggggggatcgggtcattgagaaggtgctcatcgccaacaacggcatcgccgccgtgaag
tgcatgcgctccatccgcaggtgggcctatgagatgttccgcaacgagcgggccatccgg
tttgttgtcatggtgaccccagaggacctgaaggccaatgcagagtatatcaagatggca
gatcagtacgtccctgtcccaggagggcccaacaacaacaactatgccaacgtggagctg
gttgtggacattgccaagaggatccccgtgcaggcggtgtgggctggctggggccatgct
tccgaaaaccccaaactcccggagctcctgtgcaagcatgacattgctttcttaggccct
cccagtgaggccatgtgggccttgggagataagatcgcctccaccattgtggcccagacg
ctgcaggtcccaacactgccttggagtggaagtggtctgataatagagtggacagaagat
aatctgcaggaggggaaaagaatcagtgtcccagaagacatttacgaccagggttgtgtg
aaagatgtggaggagggcctagaggtggcagagaaaattggttttcccttgatgatcaaa
gcttctgaaggcggtggagggaaaggaatccggaaagcagagagtgccgaggacttccca
atccttttcagacaagtgcagagtgagatcccgggctccccgatctttctcatgaagctg
gcccagcacgcccggcacctggaggtccagatcctcgccgaccagtacgggaacgccgtg
tctctgttcgggcgtgactgctccatccagcggcggcatcagaagatcatcgaggaggca
ccggccaccatcgccacaccggctgtgttcgagttcatggagcagtgtgccgtccgcctg
gccaagaccgtgggctacgtgagcgcggggacggtggaatacctctacagcccggatggc
agcttccactttctggagctgaatccccgcctgcaggtggagcacccgtgcacggaaatg
atcgccgacgtcaacctgccggccgcccagctacagatcgccatgggggtgccgttgcac
cggctgaaggatatccggcttctgtacggagagtcaccatggggggtgacacccatttca
tttgaaactccttctaaccctccgctcgcccgaggccatgtcatcgcggccagaatcacc
agcgagaacccagatgaggggtttaagccaagctccggaacggttcaggaactgaatttc
cgcagcaacaagaatgtgtggggttatttcagcgtggctgctactggcggcttacatgaa
tttgcggattcccagttcgggcactgcttctcctggggagagaaccgggaagaggccatt
tcgaacatggtggtggctttgaaggagctgtccatccggggcgacttcaggaccaccgtg
gagtatctcattaacctgctggagaccgagcgtttccagaacaatgacatcgacacaggg
tggttggatcacctcatcgctgagaaagtgcaggctgagaagccagatatcatgcttggg
gtggtgtgtggagccttgaacgtggccgatgtgatgttcagaacctgcatgacggatttc
ttacactcgctggaaaggggccaggtccttcctgccgcttctctgctgaacatcgtggat
gtggaattaatttatgatggtgttaagtacattctcaaggtggcccggcaatctctgacc
atgttcgtcctcatcatgaacggctgtcacatcgagatcgacgcccaccggctgaatgac
ggtgggttactgctgtcctacaatggcaacagctataccacctacatgaaagaagaggtt
gacagttaccgtgttaccattggcaacaagacctgtgtgtttgagaaggagaacgatccc
acggtcctgaggtccccttcggccgggaagctaatacagtacacggtggaggacgggggc
cacgtcgaggctgggagcagctacgcggagatggaggtgatgaagatgatcatgaccctg
aacgtgcaggaaagcggccgggtgaagtacatcaagcgtgcgggggctgtgctggaagca
ggctgtgtggtggccaagctggagctcgatgacccttccaaagtacgcccggccgagcca
ttcacaggagagctcccttcccagcaaactctgcccatcatcggagagaaactacaccag
gttttccacaacgtcctggaaaacctgaccaacgtcatgaatggctactgtctgccagag
cctatttttagcacaaagctgaaggagtgggtgcagaaactcatgacgaccctgcggcac
ccgtccctgccgctgctggagctgcaggagatcatgaccagcgtgtcgggccgcatcccc
gcccccgtggagaagtcggtccgcagggtgatggctcagtatgccagcaacatcacctcg
gtgctgtgccagttccccagccagcagatagccactatcctggactgccacgcggccacc
ctgcagcggaaggctgaccgggaggtgttcttcatgaacacccagagcatcgtgcagctg
gtccagaggtaccgcagcgggacccgcggctacatgaaggcagtggtgttggatctcctg
agaagatatttacgcgtggaacaccatttccaacaagctcactacgacaagtgtgtgatc
aacctcagggagcagctgaagccaaacatgtcccaggtgctggactgcatcttttcccac
gcgcaggtggccaagaagaaccagctggtgatcatgttgatcgatgagctctgtggccca
gacccttccctgtcggaagagctgacctccatcctcaacgagctcactcagctgagcaaa
agcgagcattgcaaagtggccctcagagcgagacagatcctgatcgcctcccacctcccg
tcctacgagctgaggcacaaccaggtggagtccattttcctgtccgccatcgacatgtat
ggccaccagttctgcccggaaaacctcaagaaattaatactgtcagagacgaccatattc
gacgtcctgcccactttcttctaccacgctaacaaggtcgtttgcatggcgtccctggag
gtttacgtgcgaaggggctacatcgcctatgagttaaacagcttgcagcaccggcagctc
ccagatggcacctgcgtggtagaattccagttcatgctgccctcctcccacccaaaccgg
atggccgtgcccatcagtgtcaccaaccccgacctgctgaggcacagcaccgagctcttc
atggacagcggctttgccccactgtgtcagcggatgggggccatggttgccttcaggaga
tttgaggacttcacaagaaacttcgacgaagtcatctcctgctttgccaacgtgcccagg
gaaatccccctcttcaggaaggcctgcgctcccttgtactctgaagaagagaacaagagc
ctcagagaggagccaatccacatcctgaatgtggccatccagtacgcagaccacctggaa
gatgaggagctggtgccgattttccggacgttcgtacagtccaagaaaaacatccttgtg
gaatatggactccgaagaatcacattcctgattgctcaagagaaagaatttccgaagttt
ttcacattcagagcaagagatgagtttgcagaagatcgcatttaccgtcacctggaaccc
gccctggccttccagctggagctcagccggatgcgcagcttcgatctgaccgccgtgccc
tgcgccaaccacaagatgcacctgtacctgggcgccgccaaagtgaaagaaggcgcggag
gtgacagaccacagattcttcatccgcgccatcatcaggcactcggacctcattacgaag
gaagcctcctttgagtacctgcagaacgagggtgagcgtctgctcctggaagccatggat
gagctggaggtggcgttcaacaacaccagtgtgcgcactgactgcaaccacatcttcctg
aacttcgtgcccaccgtcatcatggaccccttcaagatcgaggagtccgtgcgttccatg
gttatgcgctacggcagccggctgtggaaactccgcgtgctgcaggccgaggtcaagatc
aacatccgccagaccaccgccggcagtgctgttcccatccgcctgttcatcaccaacgaa
tcgggctactacctggacatcagcctctacaaagaagtcaccgaccccagatctggaaac
atcatgtttcactcctttggcaacaagcagggcccccagcacgggatgctgatcaacact
ccctacgtcaccaaggatctgcttcaggccaagcgattccaggcccagtccctgggcacc
acctacgtgtacgacttcccggagatgttcaggcaggctctccttaaactgtggggctcc
gcggacaagtaccccaaagacatcctgacatacaccgagctcgtgctggaccctcagggc
cagctggtggagatgaaccgcctccctggaggaaatgaggtgggcatggtggccttcaag
atgaggtttaagacccgagagtatccagaagggcgggacgcgattgtcatcagcaatgac
atcaccttccgcattgggtccttcggcctggaagaagaccttttgtacctgcgtgcgtct
gagatggcccgggcggagggtatccccaaaatctacctcgcagccaacagcggggcctgt
atcagccttgcagaggagatcaagcacatgttccaggtggcttgggtggacccaggagac
ccccacaaaggatttaaatacctgtacctgacgcctcaagactacaccagaatcagctcc
ctaaactctgtccattgtaaacacatcgaggaagagggagagtccaggtatgtcatcacg
gatatcatcgggaaggaccgtggcctgggcgtggagaacctcaagggctcgggcatgatt
gcaggggagtcctccctagcttacgaagagatcgtcaccatcagtctggtgacctgccga
gcccttgggatcggggcctacttggtgaggctgggccagcgagtgatccaggtggaaaat
tcgcacatcatcctgacgggagccagcgctctcaacaaggtcctgggcagagaggtttac
acctccaacaaccagctgggcggcgtgcagatcatgcattacaacggcgtctcccacgtc
actgtgccagacgacttcgagggcgtgtacaccatcctggagtggctgtcctatatgcca
aaggataatcgcagtccagtccccatcaccacaccctcggaccccatcgaccgagaaatt
ggattcttcccgtccagggctccctacgacccccggtggctgcttgcaggacggcctcac
ccaactctgaagggatcctggcagagtggattctttgaccacggcagtttcaaggaaatc
atggcgccttgggcccagacggtggtgacaggaagagcgaggctaggggggatccctgtt
ggagtgatcgccgtggagacgcggaccgtggaggtggtagtgcctgcagaccctgccaac
ctggattccgaggccaagataatccagcaggcgggccaggtgtggttcccagactcagcc
tacaagacggcccaggccatcaacgatttcaaccgagagagattgcccctgataatcttt
gccaactggagggggttctccggtggcatgaaagacatgtacgaccaggtgctgaagttt
ggagcctacatcgtggacagcctcaggcagtacaaacagcccgtcctgatctatatccca
cccaacggggaactccgggggggctcctgggtggtcgtggactcctccatcaaccccctg
tgcatagaaacgtacgcagacaaggagagcagggcgagcattctggagccggagggaaca
gtggagattaagttccggaagaaagatctgataaagaccatgaggaggatcgacccagtt
tataagaagctcgtggaacagctaggagtgtccgagctctccgataaggaccgcaaggac
ctggagggccagctgaaggcccgggaggacctgctcctgcccatctaccaccaggtggcg
gtgctgttcgccgacctccacgacagggcccaaggcatgctggagaagggtgtcatctct
gacatcgtggagtggaagacctcacgcgccttcctgtactggcgtctgcgccgcctcctg
ctggaggaccaggtcaagcaggagatcctgcaggccagcagtgagctgagccacgtgcac
atccagtccatgctgcgtcggtggttcgtggagacggagggggccgtcaaggcctacctg
tgggataacaaccagatggtggtaaagtggctggaacagcactggcagggcgggggcggc
ctgcgttccaccatccgcgagaacatcaagtgtttgaagcgcgactccgtcctcaaggcc
atcagacgcctggttcaagacaaccctgacgtggccgtggactgcatagtgtacctgagc
cagcacattagctcagcagagcgggccgaagtcattcacctcctgtccaccatggacagc
ccagcctccacctga
DBGET
integrated database retrieval system
