KEGG   ORTHOLOGY: K01946
Entry
K01946                      KO                                     
Symbol
ACACB
Name
acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
Pathway
map00061  Fatty acid biosynthesis
map00254  Aflatoxin biosynthesis
map00620  Pyruvate metabolism
map00640  Propanoate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map04152  AMPK signaling pathway
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04922  Glucagon signaling pathway
map04931  Insulin resistance
map04936  Alcoholic liver disease
Reaction
R00742  acetyl-CoA:carbon-dioxide ligase (ADP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   00640 Propanoate metabolism
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04922 Glucagon signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04920 Adipocytokine signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04931 Insulin resistance
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15  acetyl-CoA carboxytransferase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14  biotin carboxylase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2  acetyl-CoA carboxylase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
Other DBs
GO: 0003989 0004075
Genes
HSA: 32(ACACB)
PTR: 452219(ACACB)
PPS: 100985999(ACACB)
GGO: 101135848(ACACB)
PON: 100448476(ACACB)
NLE: 100606756(ACACB)
HMH: 116477970(ACACB)
MCC: 706909(ACACB)
MCF: 102116004(ACACB)
MTHB: 126931421
MNI: 105493456(ACACB)
CSAB: 103239081(ACACB)
CATY: 105573223(ACACB)
PANU: 101012644(ACACB)
TGE: 112635049(ACACB)
MLEU: 105534647
RRO: 104660172(ACACB)
RBB: 108534384(ACACB)
TFN: 117089443(ACACB)
PTEH: 111538813(ACACB)
CANG: 105508229(ACACB)
CJC: 100402980(ACACB)
SBQ: 101037726(ACACB)
CIMI: 108313154(ACACB)
CSYR: 103274926(ACACB)
MMUR: 105866938(ACACB)
LCAT: 123625896(ACACB)
PCOQ: 105815036(ACACB)
OGA: 100959432(ACACB)
MMU: 100705(Acacb)
MCAL: 110294922(Acacb)
MPAH: 110312771(Acacb)
RNO: 116719(Acacb)
MCOC: 116068218(Acacb)
ANU: 117698256(Acacb)
MUN: 110547269(Acacb)
CGE: 100753124(Acacb)
MAUA: 101823042(Acacb)
PROB: 127215967(Acacb)
PLEU: 114681306(Acacb)
MORG: 121446056(Acacb)
MFOT: 126487966
AAMP: 119824641(Acacb)
NGI: 103746695(Acacb)
HGL: 101717399(Acacb)
CPOC: 100728089(Acacb)
CCAN: 109690552(Acacb)
DORD: 105984210(Acacb)
DSP: 122102681(Acacb)
PLOP: 125349023(Acacb)
NCAR: 124990202
OCU: 100339362
OPI: 101529798(ACACB)
TUP: 102480265(ACACB)
GVR: 103588162(ACACB)
CFA: 100685468(ACACB)
CLUD: 112676715(ACACB)
VVP: 112910485(ACACB)
VLG: 121475814(ACACB)
NPO: 129507647(ACACB)
AML: 100474644(ACACB)
UMR: 103678344(ACACB)
UAH: 113267083(ACACB)
UAR: 123788217(ACACB)
ELK: 111156399
LLV: 125081691
MPUF: 101681819(ACACB)
MNP: 132023261(ACACB)
NVS: 122903326(ACACB)
ORO: 101365780(ACACB)
EJU: 114219120(ACACB)
ZCA: 113912480(ACACB)
MLX: 118018582(ACACB)
NSU: 110592557(ACACB)
LWW: 102737604(ACACB)
FCA: 101086680(ACACB)
PYU: 121010188(ACACB)
PCOO: 112870451(ACACB)
PBG: 122470345(ACACB)
LRUF: 124518440
PTG: 102963315(ACACB)
PPAD: 109277478(ACACB)
PUC: 125914050
AJU: 106979653
HHV: 120237339(ACACB)
BTA: 515338(ACACB)
BOM: 102275206(ACACB)
BIU: 109571092(ACACB)
BBUB: 102404793(ACACB)
BBIS: 104980082(ACACB)
CHX: 102178200(ACACB)
OAS: 101114816(ACACB)
BTAX: 128062624(ACACB)
ODA: 120871398(ACACB)
CCAD: 122422201
MBEZ: 129542700(ACACB)
SSC: 100154993(ACACB)
CFR: 102512242(ACACB)
CBAI: 105075668(ACACB)
CDK: 105105357(ACACB)
VPC: 102524937(ACACB)
BACU: 103020229(ACACB)
LVE: 103089998(ACACB)
OOR: 101272632(ACACB)
DLE: 111162815(ACACB)
PCAD: 102992865(ACACB)
PSIU: 116765119(ACACB)
NASI: 112397285(ACACB)
ECB: 100066740(ACACB)
EPZ: 103551425(ACACB)
EAI: 106848074(ACACB)
MYB: 102239000(ACACB)
MYD: 102759463(ACACB)
MMYO: 118678332(ACACB)
MLF: 102439451(ACACB)
MNA: 107533881(ACACB)
PKL: 118725382(ACACB)
EFUS: 103286902(ACACB)
HAI: 109386154(ACACB)
DRO: 112310890(ACACB)
SHON: 118991210(ACACB)
AJM: 119057414(ACACB)
PDIC: 114509274(ACACB)
PHAS: 123822289(ACACB)
MMF: 118639830(ACACB)
RFQ: 117017281(ACACB)
PPAM: 129087286(ACACB)
PALE: 102887451(ACACB)
PGIG: 120601871(ACACB)
PVP: 105303961(ACACB)
RAY: 107500131(ACACB)
MJV: 108399878(ACACB)
TOD: 119244882(ACACB)
SARA: 101546832(ACACB)
LAV: 100657186(ACACB)
TMU: 101351597
ETF: 101664465(ACACB)
DNM: 101426352(ACACB)
GAS: 123256906(ACACB)
SHR: 100932425(ACACB)
AFZ: 127545590
PCW: 110222829(ACACB)
OAA: 100076923(ACACB)
GGA: 430557(ACACB)
PCOC: 116228545(ACACB)
MGP: 100539060(ACACB)
CJO: 107321488(ACACB)
TPAI: 128084701(ACACB)
LMUT: 125701541(ACACB)
NMEL: 110406566(ACACB)
APLA: 119718533(ACACB)
ACYG: 106031086(ACACB)
CATA: 118257611(ACACB)
AFUL: 116496348(ACACB)
TGU: 100222747(ACACB)
LSR: 110478192(ACACB)
SCAN: 103818295(ACACB)
PMOA: 120509538(ACACB)
OTC: 121338832(ACACB)
PRUF: 121364815(ACACB)
GFR: 102045244(ACACB)
FAB: 101819106(ACACB)
OMA: 130259538(ACACB)
PHI: 102104651(ACACB)
PMAJ: 107211484(ACACB)
CCAE: 111936444(ACACB)
CCW: 104688808(ACACB)
CBRC: 103616066(ACACB)
ETL: 114062660(ACACB)
ZAB: 102071196(ACACB)
ACHL: 103808394(ACACB)
SVG: 106852463(ACACB)
MMEA: 130580515(ACACB)
HRT: 120760756(ACACB)
FPG: 101913090(ACACB)
FCH: 102057711(ACACB)
CLV: 102094512(ACACB)
EGZ: 104123683(ACACB)
NNI: 104019168(ACACB)
PCRI: 104028157(ACACB)
PLET: 104628539(ACACB)
EHS: 104509803(ACACB)
ACUN: 113486251(ACACB)
TALA: 104361116(ACACB)
PADL: 103925656(ACACB)
AFOR: 103902755(ACACB)
ACHC: 115346453(ACACB)
HALD: 104313361
HLE: 104840951(ACACB)
AGEN: 126041164
GCL: 127022704
CCRI: 104164563(ACACB)
MUI: 104545440(ACACB)
BREG: 104637633
FGA: 104076869(ACACB)
GSTE: 104259302
LDI: 104352539(ACACB)
OHA: 104331924(ACACB)
NNT: 104412559(ACACB)
SHAB: 115614467(ACACB)
DPUB: 104308504(ACACB)
CPEA: 104388037(ACACB)
AVIT: 104279589(ACACB)
CVF: 104282293(ACACB)
RTD: 128917225(ACACB)
CUCA: 104058883(ACACB)
BRHI: 104495923
AAM: 106487455(ACACB)
AROW: 112963361(ACACB)
NPD: 112945200(ACACB)
TGT: 104573449(ACACB)
DNE: 112991862(ACACB)
SCAM: 104149382(ACACB)
ASN: 102388393(ACACB)
AMJ: 102565973(ACACB)
CPOO: 109312689(ACACB)
GGN: 109290535(ACACB)
PSS: 102461239(ACACB)
CMY: 102942822(ACACB)
CCAY: 125622905(ACACB)
DCC: 119843568(ACACB)
CPIC: 101941488(ACACB)
TST: 117888262(ACACB)
CABI: 116839462(ACACB)
MRV: 120386003(ACACB)
ACS: 100566852(acacb)
PVT: 110083411(ACACB)
SUND: 121916415(ACACB)
PBI: 103057144(ACACB)
PMUR: 107287268(ACACB)
CTIG: 120316750(ACACB)
PGUT: 117672279(ACACB)
APRI: 131185569(ACACB)
PTEX: 113448653(ACACB)
NSS: 113423907(ACACB)
VKO: 123028590(ACACB)
PMUA: 114581463(ACACB)
PRAF: 128400787(ACACB)
ZVI: 118094218(ACACB)
HCG: 128338024(ACACB)
GJA: 107112178(ACACB)
STOW: 125442513(ACACB)
EMC: 129341574(ACACB)
XLA: 108715603
XTR: 100192373(acacb)
NPR: 108790508(ACACB)
RTEM: 120938141(ACACB)
BBUF: 120988859(ACACB)
BGAR: 122924353(ACACB)
MUO: 115481190(ACACB)
GSH: 117364775(ACACB)
DRE: 556236(acacb)
SRX: 107752147
SANH: 107684993
SGH: 107597297
CCAR: 109079488 109092869(acacb)
CAUA: 113048915 113096061(acacb)
CGIB: 127957899 128013082
PTET: 122344977(acacb)
LROH: 127165045(acacb)
OMC: 131541304(acacb)
PPRM: 120469545(acacb)
MAMB: 125267209(acacb)
CIDE: 127512572
MASI: 127418333 127438260
TROS: 130565610(acacb)
MANU: 129439815(acacb)
IPU: 108255442
IFU: 128625450(acacb)
PHYP: 113524973(acacb)
SMEO: 124380419(acacb)
TFD: 113656619
AMEX: 103026070
CMAO: 118827132(acacb)
EEE: 113589900
CHAR: 105889968(acacb)
TRU: 101077743(acacb)
TFS: 130525566(acacb)
TNG: GSTEN00029540G001
LCO: 104921250(acacb)
NCC: 104945029(acacb)
CGOB: 115012970(acacb)
ELY: 117252866(acacb)
EFO: 125889833(acacb)
PLEP: 121944662(acacb)
SLUC: 116056576(acacb)
ECRA: 117944549(acacb)
ESP: 116689793(acacb)
PFLV: 114555987(acacb)
GAT: 120830227(acacb)
PPUG: 119224780(acacb)
AFB: 129100949(acacb)
CLUM: 117736297(acacb)
MSAM: 119892400(acacb)
SCHU: 122876475(acacb)
CUD: 121510493(acacb)
ALAT: 119019207(acacb)
MZE: 101477909(acacb)
ONL: 100711220(acacb)
OAU: 116332374(acacb)
OLA: 101171338(acacb)
OML: 112147886(acacb)
XMA: 102217269(acacb)
XCO: 114154254(acacb)
XHE: 116729438(acacb)
PRET: 103470346(acacb)
PFOR: 103142895(acacb)
PLAI: 106944558(acacb)
PMEI: 106918451(acacb)
GAF: 122828188(acacb)
CVG: 107100048
CTUL: 119786620(acacb)
GMU: 124877619(acacb)
NFU: 107393958(acacb)
KMR: 108234549(acacb)
ALIM: 106521707
NWH: 119413964(acacb)
AOCE: 111568287(acacb)
MCEP: 125011855(acacb)
CSEM: 103397308
POV: 109638102(acacb)
SSEN: 122769173(acacb)
HHIP: 117767659(acacb)
HSP: 118114652(acacb)
LCF: 108878118
SDU: 111228114(acacb)
SLAL: 111660366(acacb)
XGL: 120805566(acacb)
HCQ: 109510822(acacb)
SSCV: 125993760
BPEC: 110156685(acacb)
MALB: 109956888(acacb)
BSPL: 114862068(acacb)
SASA: 106580110(acacb) 106585658
STRU: 115164864 115199799(acacb)
OTW: 112248237 112263291(acacb)
OMY: 110525352 110535755
OGO: 124034566 124036038
ONE: 115111329 115139760
OKI: 109876227 109895658(acacb)
OKE: 118358057(acacb) 118392929
SALP: 111957851 111974209
SNH: 120050553 120063072
CCLU: 121550183 121584521
ELS: 105014434(acacb)
SFM: 108932552(acacb)
PKI: 111854891(acacb)
AANG: 118237551(acacb)
LOC: 102687665(acacb)
PSPA: 121307729
ARUT: 117426575 117428031
PSEX: 120540759(acacb)
LCM: 102353666(ACACB)
CMK: 103184024(acacb)
RTP: 109937888(acacb)
LERI: 129709189(acacb)
OLU: OSTLU_11
OTA: OT_ostta10g03450
BPG: Bathy11g03860
MIS: MICPUN_104872
MPP: MICPUCDRAFT_16401
 » show all
Reference
PMID:19190759
  Authors
Castle JC, Hara Y, Raymond CK, Garrett-Engele P, Ohwaki K, Kan Z, Kusunoki J, Johnson JM
  Title
ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected].
  Journal
PLoS One 4:e4369 (2009)
DOI:10.1371/journal.pone.0004369
  Sequence
[hsa:32]
Reference
PMID:16854592
  Authors
Cheng D, Chu CH, Chen L, Feder JN, Mintier GA, Wu Y, Cook JW, Harpel MR, Locke GA, An Y, Tamura JK
  Title
Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
  Journal
Protein Expr Purif 51:11-21 (2007)
DOI:10.1016/j.pep.2006.06.005
  Sequence
[hsa:32]
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