KEGG   Panthera leo (lion): 122207223
Entry
122207223         CDS       T10741                                 
Symbol
BRCA1
Name
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
plez  Panthera leo (lion)
Pathway
plez01524  Platinum drug resistance
plez03440  Homologous recombination
plez03460  Fanconi anemia pathway
plez04120  Ubiquitin mediated proteolysis
plez04151  PI3K-Akt signaling pathway
plez05206  MicroRNAs in cancer
plez05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:plez00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    122207223 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    122207223 (BRCA1)
   03460 Fanconi anemia pathway
    122207223 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    122207223 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    122207223 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    122207223 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    122207223 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:plez01009]
    122207223 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:plez04121]
    122207223 (BRCA1)
   03036 Chromosome and associated proteins [BR:plez03036]
    122207223 (BRCA1)
   03400 DNA repair and recombination proteins [BR:plez03400]
    122207223 (BRCA1)
Enzymes [BR:plez01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     122207223 (BRCA1)
Protein phosphatases and associated proteins [BR:plez01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     122207223 (BRCA1)
Ubiquitin system [BR:plez04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    122207223 (BRCA1)
  Multi subunit type E3
   BRCC complex
    122207223 (BRCA1)
Chromosome and associated proteins [BR:plez03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     122207223 (BRCA1)
DNA repair and recombination proteins [BR:plez03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     122207223 (BRCA1)
    BRCA1-A complex
     122207223 (BRCA1)
    BRCA1-B complex
     122207223 (BRCA1)
    BRCA1-C complex
     122207223 (BRCA1)
    BRCA complex
     122207223 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     122207223 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-RING_UBOX zf-C3HC4_4 zf-C3HC4_3 zf-RING_2 zf-RING_5 RING_XB3-XBAT31 zf-Nse BRCT_2 zf-RING_6 zf-ANAPC11 zf-RING_10 zf-rbx1 RTT107_BRCT_5
Other DBs
NCBI-GeneID: 122207223
NCBI-ProteinID: XP_042773079
LinkDB
Position
E1:complement(41184937..41243877)
AA seq 1874 aa
MDLSADRVEEVQSVLNAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQRKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLNIIHAFELDTGLQFANSYNFSKKENNSPEHLKE
EVSIIQSMGYRNRAKRLRQSEPENPSLQETSLSVQLSNFGIVRSLRTKQQIQPQNKSVYI
ELGSDSSEDTVNKASYFSVGDDELLGITPQGARAEASLNPAKKASCEFSEEITNIEHRQP
SNKDLTTTEKHATEKHPEKYQGISVSNLHVEPCATNTHASSLQHENSSLLLTKDRMNVEK
AEFCNESKQPGVARSQQSRWAESKETRNDRQTPSTEKKVVLNADPLCRRKLSKQKSPCSD
SPRDSQDVPWITLNSSIQKVNEWFSRSDEMLTSDDSHDGGSESNPGVAGAVEVPNEVDGY
SGSSEKIDLMASDPHDALICESERVHTKPVESNIEDKIFGKTYRRKASLPNLSHTSEDLI
IGACAIEPQITQAHPLTNKTKRKRRSTAGLHPEDFIKKVDLAIVQKTPEKLIEGTDRIGQ
NGHVMNITNNGPENGTKGDYVQKEKNAKPTESLEKESAFRTKAEPISSSISNMESELNSH
SSRAPKENRLRRKSSTRHMHALELVVNRNPSPPDHTELQIDSCSSSEEMVKRKSLEQMLV
RHSKTLQLVENKEPAPGAKKRNKPNEQINKRLASNTFPELNLTNIPGVFTNCSSSNTLQE
FVNPGIQREELEESRGTIHVSDRTRDPKELVSSGGRSLQTERSIESTSISLVPDADYGTQ
DSISLLEADTLGKAKTAPNQHVSLCAVIENPKEAIHGCSKDTRNGTEGFTDPLRREDNHT
QETSIEMEENELDTQYLYNTFKVSKRQSFALFSNPGNPEKECATVWARSTSLRKQSPKVA
LEYEQKEENQGKKQSEIKHVQAVRATAGFSAVSQKVEKPGDYAKCSIKGVPGLCQSSQFR
GNETELFIANNHDISKNPYHIPPLSPIRSSVNAVCKKNLSEEKFEQRSMSPERAVGNESV
IQSTVSTISQNNIRENTFKEVSSSSVNEVGSSANEVGSSINEVGSSGENIQTELGRNRGP
KLSAMLRLGLMQPEVYEQSLPISNCKCPEMKRQGENEGVVQSVNADFSPCLISDNVEQPM
ESSRASQVCSETPNDLLNGAEIKGKISFAESAKERSAVFGKSVQKGEFRRSPSPLDHTHL
AQGHQTETRKLQSSEENVSSEEEELPCFQHLLFGKATSIPSQSTSHNAIATEGLSKKTGA
NLESLKDSLHDCSNQVTSAKESQEHHLSEEARCSGSLFSSQCSASEDSAVNTNTQDPFLM
FDPPSKQVRHQSKNVDVLSDEELVSYDDEREPGLEEDNHEEEQSVDSNLGEAASGYESET
SLSEDCSGVSSQSDILTTQQRDTMQDNLIKLQQEMAELEAVLEQHESQPSNSSPALITDS
YAPEDLFNPEQNTSEKAVLTSEKSSDCLISQNPESLSADKFQVSLDSSTSKTKEPGMRRS
SPSQSRLLDTRQCVHSHSSSLQSTNCLSQKELIKVVDGEELQLTKSEPRDFMEQSYMPRQ
DLEGTPYFESGISLFSDDPESDLSVDRAPEPVHVSSMPTSTSALKLPQFQVEESAKSTAA
VHITNTAGYNKREDIEGKEKPETMSSTKRVNKRISMVASGLTPKELVLVQKFARRHQITL
TNVISEETTHVIMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLDEHDFEV
RGDVVNGRNHQGPKRARESRDRKIFGGLEICCYGPFTNMPTDQLEWMVRLCGASVVKRPS
LFTLSKATHPVVVVQPDAWTEDSGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIP
QIPRATADLSQPCV
NT seq 5625 nt   +upstreamnt  +downstreamnt
atggatttatctgcagatcgtgttgaagaagtacaaagtgtccttaatgctatgcagaaa
atcttagagtgtccaatctgtctggagttgatcaaagagcctgtttccacaaagtgtgat
cacatattttgcaaattttgtatgctgaaacttctcaaccagaggaaagggccttcacag
tgtcctttgtgtaagaatgatataaccaaaagaagcctacaggaaagtacaagatttagt
caacttgttgaagagctgttgaacatcattcatgcttttgagcttgacacaggattgcag
tttgcaaacagctataacttttcaaaaaaggaaaataactctcctgagcatctgaaggag
gaggtttctattatccaaagtatgggctatcgaaaccgtgctaaaagacttcgacagagt
gaacctgaaaaccctagcttgcaggaaaccagtcttagtgtccaactctctaactttgga
attgtgagatctctgaggacaaagcagcagatacaaccacagaataagtctgtctacatt
gaattgggatctgattcttctgaagatacagtgaataaggcaagttatttcagtgtggga
gatgacgaattgttaggaatcacccctcaaggagccagagctgaagccagtttgaatcct
gcaaaaaaggcctcttgtgaattttctgaggagataacaaatattgaacatcgtcaaccc
agtaataaagatttgaccaccactgagaagcatgcaactgaaaagcatccagaaaagtat
cagggtatttctgtttcaaacttgcatgtggagccatgtgccacaaatactcatgccagc
tcattacagcatgagaacagcagtttattactcactaaagacagaatgaatgtagaaaag
gctgaattctgtaatgaaagcaaacagcctggcgtagcaaggagccaacagagcagatgg
gctgaaagtaaggaaacacgtaatgataggcagactcccagcacagagaaaaaggtagtt
ctgaatgctgatcccctgtgtaggagaaaactgagtaagcagaaatctccatgctctgac
agtcctagagattcccaagatgtaccttggataacactgaatagtagcatacagaaagtt
aacgagtggttttccagaagtgatgaaatgttaacttctgatgactcacatgatggggga
tctgaatcgaatcctggagtagctggtgcagtagaagttccaaatgaagtggatggatat
tctggttcttctgagaaaatagacttaatggccagtgatcctcatgatgctttgatatgt
gaaagtgaaagagtccacaccaaaccagtagagagtaatattgaagataaaatatttggg
aaaacctatcggaggaaggcaagccttcctaatttgagccacacaagtgaagatctcatt
ataggagcatgtgctatagaacctcagataacacaagcccatcccctcacaaataaaaca
aagcgtaaaaggagatctacagcaggccttcatcctgaggattttatcaagaaagtagat
ttggccattgttcaaaagactcctgaaaagctaattgagggaactgatcgaatagggcaa
aatggtcatgtgatgaatataacaaataatggtcctgagaatgggacaaaaggtgattat
gttcagaaagagaaaaatgctaagccaacagaatcattggaaaaagaatctgcttttaga
accaaagctgaaccaataagcagcagtataagtaatatggaatcagaattaaatagccac
agttcaagggcacctaaggagaacaggctgaggaggaagtcctctaccaggcacatgcat
gcgctggaattagtagtcaatagaaatccaagcccacctgatcataccgaactacagatt
gatagctgttctagcagtgaagagatggtgaaaagaaaaagtttggaacaaatgctagtc
agacacagcaaaacacttcaactcgtggaaaataaagaacctgcacctggagccaagaag
cgtaacaagccaaatgaacaaataaataaaagacttgccagtaacacttttccagagcta
aatttaacaaacatacctggggtttttactaactgttcaagttctaatacacttcaagag
tttgtcaaccctggcattcaaagagaagaactagaagagagccgaggaacgattcacgtg
tctgataggaccagagatcccaaagagctggtatcgagtggaggaagaagtttgcaaact
gaaagatctatagagagtaccagtatttcattggtacctgatgccgattatggcactcag
gatagtatctcattactggaagctgacaccctagggaaggcaaaaacagcaccaaatcaa
catgtgagtctgtgtgcagtaattgaaaaccccaaggaagctatccatggttgttccaaa
gatactagaaatggcacagagggttttacagatcctctgagacgtgaagataaccatact
caggagacaagtatagaaatggaagagaatgaacttgatacgcagtatttatacaatacg
ttcaaggtttcaaaacgtcagtcatttgctctgttttcaaatccaggaaatccagaaaag
gaatgtgctacagtctgggcccgttccacgtccttaaggaaacaaagtccaaaagttgct
cttgaatatgaacaaaaagaagaaaatcagggaaagaaacagtctgaaatcaagcacgtg
caggcagtccgtgcaactgcaggcttttctgcagtcagtcagaaagtggagaagccaggt
gattatgccaaatgtagcataaaaggagtccctgggctctgtcagtcatctcagttcaga
ggcaatgaaactgaactctttattgcaaataaccatgacatttcaaaaaatccttatcat
ataccaccactttctcccatcagatcatctgttaatgctgtatgtaagaaaaacctgtca
gaggaaaagtttgagcagcgttcaatgtcacctgaaagagcagtgggaaatgagagcgtc
attcaaagtacagtgagcacaattagccaaaataacattagagaaaacacttttaaagaa
gttagctcaagcagtgttaatgaagtaggttccagtgctaatgaagtaggctctagcatt
aatgaagtaggttccagtggtgaaaacattcaaacagaactgggtagaaaccgaggacct
aagttaagtgctatgctcaggttaggtcttatgcaacctgaagtctatgagcaaagtctt
cctataagtaattgtaaatgtccagaaatgaaaaggcaaggagaaaatgaaggagtagtt
cagtctgttaatgcagatttttctccatgtctaatttccgataatgtagaacaacctatg
gaaagtagccgtgcttctcaggtttgttctgagacacccaatgatctattaaatggtgct
gaaataaagggaaaaatcagctttgctgaaagtgctaaggaaagatctgctgtttttggc
aagagtgtccagaaaggagaattcagaaggagccctagccctttagaccatacacatctg
gctcagggtcaccaaacagagaccaggaagttacagtcctcagaagagaacgtgtctagt
gaggaggaagagcttccctgcttccaacacttactatttggtaaagcaaccagtatacct
tctcagtctaccagccataatgccattgccacggagggtctgtctaagaaaacaggggcg
aacctagaatcattgaaggatagcttacatgactgcagtaaccaggtaacatcagcaaag
gagtcccaggaacatcaccttagtgaggaagcgaggtgttccggtagcttattttcttca
cagtgcagtgcatcggaagactcggctgttaatacaaatacccaggatcctttcttgatg
tttgatcctccttccaaacaagtgaggcatcagtccaaaaatgtggacgttctgagtgat
gaggaattggtttcatatgatgatgaaagggaacctggcctggaagaggataatcacgaa
gaagagcagagtgtggattcaaacttaggtgaagcggcatctgggtacgagagtgaaaca
agcctctctgaagactgttcaggggtgtcctctcagagtgatattttaaccactcagcag
agggataccatgcaagacaacctgatcaagctccagcaggaaatggccgaactggaagcc
gtgttagagcagcacgagagccagccttctaacagctcccctgccctcataacagattct
tatgcccctgaggacctgttcaatccggaacaaaacacatcagagaaagcagtattaact
tcagagaaaagtagtgactgccttataagccagaatcccgaaagcctctctgctgacaaa
tttcaagtatctctggatagttccaccagtaaaactaaagaaccgggaatgagaaggtct
tctccttctcaatcacggctgttagatactaggcagtgtgtgcacagccactcaagcagt
cttcagagcacaaactgcctgtctcagaaggagctaattaaggttgtcgatggggaggag
ctacaactgactaagtcagagccccgagatttcatggagcagtcttatatgccaagacaa
gatctggagggaaccccttacttcgaatctggaatcagcctcttctctgatgaccctgag
tctgatctctctgtggacagagccccagaaccggttcatgttagcagcatgccaacttca
acctctgccttgaaattaccccaatttcaagttgaagaatcagccaagagtacagctgct
gttcatattactaatactgctgggtataataagagggaagacattgagggcaaggagaag
ccagaaacgatgtcttcaacaaaaagagtcaacaaaagaatatctatggtggcatcaggc
ttgactccaaaagaattggtgcttgtgcagaagtttgccagaagacaccaaatcacctta
actaatgtaatttctgaagagactactcatgtcattatgaaaacagatgctgagtttgtg
tgtgaacggacactgaaatattttctgggtattgcaggaggaaaatgggtagttagctat
ttctgggtgacccagtccattaaagaaagaaagatgctagatgagcatgattttgaagtc
agaggagatgttgtcaatggaagaaaccaccagggtccgaagcgagcaagagaatcccgg
gacagaaagatcttcgggggcctagaaatctgttgctatgggccctttaccaacatgccc
acagatcaactagagtggatggtgcgcctctgtggggcttctgtggtgaagaggccttcg
ttattcactctcagcaaggctactcacccagttgtggtcgtgcaaccggatgcctggaca
gaggacagtggcttccatgcgattgggcagatgtgtgaggcacctgtggtgacccgagag
tgggtattggacagtgtagccctctaccagtgccaggagctggacacctacctgatcccc
cagattcccagagctactgctgacctcagccagccatgtgtgtag

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