Panthera leo (lion): 122210738 Help Entry 122210738         CDS       T10741                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism plez  Panthera leo (lion) Pathway plez00230   Purine metabolism plez01100   Metabolic pathways plez01522   Endocrine resistance plez04015   Rap1 signaling pathway plez04020   Calcium signaling pathway plez04022   cGMP-PKG signaling pathway plez04024   cAMP signaling pathway plez04062   Chemokine signaling pathway plez04072   Phospholipase D signaling pathway plez04081   Hormone signaling plez04082   Neuroactive ligand signaling plez04114   Oocyte meiosis plez04211   Longevity regulating pathway plez04213   Longevity regulating pathway - multiple species plez04261   Adrenergic signaling in cardiomyocytes plez04270   Vascular smooth muscle contraction plez04371   Apelin signaling pathway plez04540   Gap junction plez04611   Platelet activation plez04713   Circadian entrainment plez04714   Thermogenesis plez04720   Long-term potentiation plez04723   Retrograde endocannabinoid signaling plez04724   Glutamatergic synapse plez04725   Cholinergic synapse plez04727   GABAergic synapse plez04742   Taste transduction plez04750   Inflammatory mediator regulation of TRP channels plez04911   Insulin secretion plez04912   GnRH signaling pathway plez04913   Ovarian steroidogenesis plez04914   Progesterone-mediated oocyte maturation plez04915   Estrogen signaling pathway plez04916   Melanogenesis plez04918   Thyroid hormone synthesis plez04921   Oxytocin signaling pathway plez04923   Regulation of lipolysis in adipocytes plez04925   Aldosterone synthesis and secretion plez04926   Relaxin signaling pathway plez04927   Cortisol synthesis and secretion plez04928   Parathyroid hormone synthesis, secretion and action plez04934   Cushing syndrome plez04935   Growth hormone synthesis, secretion and action plez04970   Salivary secretion plez04971   Gastric acid secretion plez04972   Pancreatic secretion plez04976   Bile secretion plez05032   Morphine addiction plez05163   Human cytomegalovirus infection plez05166   Human T-cell leukemia virus 1 infection plez05200   Pathways in cancer plez05207   Chemical carcinogenesis - receptor activation plez05414   Dilated cardiomyopathy Brite Enzymes [BR:plez01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      122210738 (ADCY8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Other DBs NCBI-GeneID:  122210738 NCBI-ProteinID:  XP_042779551 LinkDB All DBs Position F2:complement(72392117..72612267) Genome browser AA seq 1252 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG SGSRGSGKASDAAGGGPNHHAAQLSGDSALPLYSLGPGERAHSSGGTKVFPERSGSGSGS GGGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVVVQVAIPRLAVISINQVMAQAVLFMCMNTAGTFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLTLPE DIVKESVSFSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSCPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKE ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKQLLNENINTGIIKGHYNRRTLLTASGPEPGAQAEGADKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctgagcggcagcgaggaactctacaccatccacccg acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgaggcacatcaccgagcagcgcttcattcacgggcaccggggcagcggcggcggc agcgggagtagaggctccggcaaagcctcggacgctgcaggcggcggccccaaccaccac gcggcgcagctgtccggggactcggcgctgcccctctactcgctgggccccggggagaga gcgcacagctccggtggcaccaaagtcttcccggaacgcagcggcagcggcagcggcagc gggggcgggggcgggggcgatctgggcttcctgcacctggactgcgccccgagcaactcg gatttcttcctcaatgggggctacagctaccgaggggtcattttccccactctgcgcaac tccttcaagtccagggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggtcctc cacctgagcctggcctcggcccccatggacccgctcaagggcattctcctgggcttcttc actggcatcgaggtggtgatctgcgcgctcgtggtggtcaggaaggacaccacctcgcac acgtacctgcagtacagcggcgtggtcacttgggtggccatgaccacccagatcttggca gcaggcctcggctacgggcttctgggtgatggcatcggctacgtcctcttcacgctgttt gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctgggcacc tcgctgctgcaggtggtcgtgcaggtggccattcctcggctggcggtcatctccatcaac caggtgatggcccaggcagtgctgttcatgtgtatgaacacggctggaaccttcatcagt tacctgtcagaccgggcccagcgccaagcctttctggagacacggaggtgtgtggaggcc aggctgcgcctggagacggaaaaccaaagacaggagcggctcgtgctgtctgtgcttccc cggtttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacctgcag caccaattccatcggatctacatccaccgctacgagaatgtcagtattctttttgcagat gttaaaggatttaccaacctctccacaaccttgtctgcccaggagctggtcaggatgctc aacgagctctttgccagatttgatcgactggcccacgagcatcactgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttccagagccccgccaggaccacgcc cactgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgagatcaagg acgaagcatgatgttgacatgcggatcggaatccactcgggctcggtgctgtgtggcgtg ttgggtctgaggaagtggcagtttgatgtctggtcttgggacgtggacatcgcgaacaaa cttgagtctggaggaatccctgggaggattcacatttccaaagccacgctggactgcctc aacggtgactataatgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag cataacatagagacctatttgattaagcagcctgaggagagcctactgacgttgcccgaa gacattgtcaaggagtcggtgagcttctcagacaggagaaacagtggggcgacattcaca gaaggatcctggagccccgagctgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtctgtgca tttatcgttctcctatttatcacggcaatacaaagtttgcttccttcttcaagggtgatg ccaatggccatccagttttccatcctgatcatgctgcactcggctctggtcctcatcacc acggcagaagattacaagtgtttgcctctcgtcctccggaaaacttgctgttggattaac gagacctacttagcccggaacgtcatcatctttgcatccatcttgattaacttcctgggc gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact ttcaattcctcagctgtgtttacagatatctgctcctgcccagagtacttcgtcttcact ggggtgttggccatggtgacctgtgcggttttcctccgcctgaactctgtcctgaagctg gccgtgctgctgattatgatcgccatctacgcgctgctgactgagaccgtctacgcgggc ctcttcctgcgctatgacaacctaaaccacagcggagaagatttcctggggaccaaggag gcgtcactgctgctgatggccatgttcctccttgccgtgttctaccacggacagcagctg gagtacacggcccgcctggacttcctttggcgagtgcaggccaaagaggagatcaacgag atgaaggagctcagggagcataatgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaacgaggagctgtattcccaatcttatgat gccgtcggggtgatgttcgcctccatcccggggtttgcagacttttactctcagactgag atgaataaccagggggtagaatgcctgcgtctgttgaatgagatcattgctgacttcgat gagctgctaggcgaagaccggtttcaggacattgaaaagattaagaccatcggcagcacc tacatggccgtgtcgggcctgtcacctgaaaaacagcaatgtgaagacaagtggggacat ctgtgtgccctggccgacttctccctcgccctgaccgaaagcatacaggagatcaacaaa cattccttcaacaatttcgaactccggattggcatcagtcacggctccgtggtagctggg gtcatcggcgctaagaagccacaatatgacatttggggcaaaactgtgaacctggcgagc cgaatggacagcacaggggtcagcggcaggatccaagtccccgaggagacctatctcatc ctgaaggaccagggctttgccttcgactaccgaggggagatctacgtgaagggcatcagt gagcaggaaggaaaaatcaaaacgtactttctcctgggaagagtccaacccaacccgttc atcctgcccccgagaagactgcccgggcagtactcactggccgcggtcgtcctgggcctt gtccagtccctcaacaggcaaaggcagaagcagttgctcaatgagaacatcaacacaggg atcatcaagggccactacaaccggcggactttgctgacagccagtgggccagagcccggg gcccaggctgagggcgccgacaagtccgacttgccatga

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