Panthera leo (lion): 122213899 Help Entry 122213899         CDS       T10741                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism plez  Panthera leo (lion) Pathway plez04010   MAPK signaling pathway plez04014   Ras signaling pathway plez04015   Rap1 signaling pathway plez04022   cGMP-PKG signaling pathway plez04066   HIF-1 signaling pathway plez04068   FoxO signaling pathway plez04072   Phospholipase D signaling pathway plez04081   Hormone signaling plez04150   mTOR signaling pathway plez04151   PI3K-Akt signaling pathway plez04152   AMPK signaling pathway plez04211   Longevity regulating pathway plez04213   Longevity regulating pathway - multiple species plez04520   Adherens junction plez04910   Insulin signaling pathway plez04913   Ovarian steroidogenesis plez04923   Regulation of lipolysis in adipocytes plez04930   Type II diabetes mellitus plez04931   Insulin resistance plez04932   Non-alcoholic fatty liver disease plez04960   Aldosterone-regulated sodium reabsorption plez05010   Alzheimer disease plez05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     122213899 (INSR)    04014 Ras signaling pathway     122213899 (INSR)    04015 Rap1 signaling pathway     122213899 (INSR)    04066 HIF-1 signaling pathway     122213899 (INSR)    04068 FoxO signaling pathway     122213899 (INSR)    04072 Phospholipase D signaling pathway     122213899 (INSR)    04022 cGMP-PKG signaling pathway     122213899 (INSR)    04151 PI3K-Akt signaling pathway     122213899 (INSR)    04152 AMPK signaling pathway     122213899 (INSR)    04150 mTOR signaling pathway     122213899 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     122213899 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     122213899 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122213899 (INSR)    04923 Regulation of lipolysis in adipocytes     122213899 (INSR)    04913 Ovarian steroidogenesis     122213899 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     122213899 (INSR)   09149 Aging    04211 Longevity regulating pathway     122213899 (INSR)    04213 Longevity regulating pathway - multiple species     122213899 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     122213899 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     122213899 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     122213899 (INSR)    04932 Non-alcoholic fatty liver disease     122213899 (INSR)    04931 Insulin resistance     122213899 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:plez01001]     122213899 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:plez04090]     122213899 (INSR) Enzymes [BR:plez01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      122213899 (INSR) Protein kinases [BR:plez01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    122213899 (INSR) CD molecules [BR:plez04090]  Proteins   122213899 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 Motif Other DBs NCBI-GeneID:  122213899 NCBI-ProteinID:  XP_042784215 LinkDB All DBs Position A2:6347353..6462271 Genome browser AA seq 1351 aa AA seqDB search MCVLTCLALCLFSPLVCPGMDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSF PKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMN ITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPA TVINGQFVERCWTHSHCQKVCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNF YLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHNKCKNSRRQGCHQYVIHNNRCIPECPSG YTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLA AELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQL WDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENE LLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTV VDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAVFVKTLVTFSDERRTYGAKSDIIYVQTD ATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGL KLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHN VVFVPRPSRKRRALADAGNVTATVPTVPGFPNTSSSVPTSPEEHKPFEKVVNKESLVISG LRHFTGYRIELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLA GNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPL YASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAE TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDL KSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITS LAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLK DDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGL KRNYEDHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4056 nt NT seq  +upstreamnt  +downstreamnt atgtgcgtgctcacctgtcttgccttgtgcttgttttcgcctctagtctgccctggcatg gatatccggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaaggt catttgcagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagtttc cccaaactcgtcatgatcactgattacttgctgctctttcgggtgtacgggctggagagc ctgaaggacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaactac gcgctggtcatctttgagatggtgcacctgaaggagcttggcctctacagcttgatgaac attacccggggctccgtccgcatcgagaagaacaatgagctgtgctacctggccaccatc gactggtcacgcatcctggattcggtggaggataattacattgtgttgaacaaagacgac aacgaggagtgtggggacatttgtccaggcaccgcaaagggcaagaccaactgccctgcc actgtcatcaacgggcagtttgtggagcgatgttggacacacagccattgccagaaagtt tgtccgaccatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagcgag tgtctgggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttc tacctggacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagactgg cgctgcgtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccggaga cagggttgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcgggg tacacgatgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaaggtc tgccacatcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctccga ggctgcaccgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctggca gctgagctggaggccaacctcggactcattgaagaaatttctgggtacctgaagatccga aggtcctatgctcttgtgtcactttcctttttccggaagttacggctgattcggggagag accttggaaatcgggaactactctttctatgccttggacaaccagaacctgaggcagcta tgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataat cccaaactctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaaggggcgc caggagcggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaa ctacttaaattttcttacattcggacatcttacgacaagatcttgctgaaatgggagccg tactggccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggcccct tatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtg gtggacattgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccagggtgg ctgatgcggggtctcaagccctggacccagtatgctgtctttgtcaagaccttggtcacc ttttctgatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagaccgat gccaccaacccttccgtccccctggatcctatctcggtttcgaattcctcctctcagatc attctgaagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtgttc tgggagaggcaggcggaggacagtgagctgtatgagttggattattgcctcaaagggttg aagctgccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcacaat cagagtgagtatgaggagtccgctggcgaatgctgctcgtgtcccaagaccgactctcag atcctgaaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcacaat gtggttttcgtgcccaggccgtcgcggaagcgcagggccctcgccgacgctgggaacgtg accgccaccgtgcccacggtgcctggtttccccaacacttccagcagcgtgcccacgagc ccggaagagcacaagcccttcgagaaggtggtgaacaaagagtctctggtcatctccggc ctgcgtcacttcaccggctaccgcatcgagctgcaggcttgcaaccaagatgcccccgag gagaggtgcagcgtggccgcctacgtcagcgccaggaccatgcccgaagccaaggcagac gacattgttggccctgtgacccatgaaatcttcgagaacaacgtggttcacttgatgtgg caagagcctaaagaacccaatggattgatcgtgctgtatgaagtgagttaccgacggtat ggtgatgaggagctgcacctctgtgtctcccgtagacactttgctctggagcggggctgc aggctgcgagggctgccgccggggaattacagtgtgcgagttcgggccacctccctggcg ggcaacggctcctggacagaagccacttatttctatgtgacagactatttagatgtccca tcgaacattgcaaaaattatcatcgggcctctcatctttgtctttctcttcagtgttgtg attggaagtatttatctattcctgagaaagaggcagccggatgggccactggggccgctg tatgcttcttcaaaccctgagtacctcagtgccagtgatgtgtttccctgctctgtgtat gtgccggacgagtgggaggtgcctcgggagaagatcactctcctgcgcgagctggggcag ggctccttcggcatggtgtacgagggcaatgccagagacatcgtcaagggcgaggcggag acccgcgtggcggtgaagacggtcaacgagtccgccagtctgcgagagaggatcgagttt ctcaacgaggcctcagtcatgaagggcttcacctgtcatcacgtggtccgcctcctgggg gtggtgtccaaaggccagccgacgctggtggtgatggagctgatggttcacggagacctg aagagctacctccgctccctgcggccggaggctgagaataaccctggccgccctccccct actctgcaagagatgattcagatggcggcggagatcgccgacgggatggcgtacctgaat gccaagaagtttgtgcaccgggatctcgcagctcgaaattgcatggtggcccacgacttc accgtcaaaattggagacttcggaatgaccagagacatctatgaaacggattactaccgg aaaggaggcaagggtctgctccccgtgcggtggatggcaccggaatccctgaaggacggg gtcttcaccacttcttctgacatgtggtcctttggtgtggtcctttgggaaatcaccagc ttggcggaacaaccttaccaaggcctgtctaatgaacaggtgttgaaatttgtcatggac ggaggatatttggaccaacctgacaactgtccggagagagtcaccgacctgatgcacatg tgctggcagttcaatcccaagatgcggcccaccttcctggagatcgttgacctgctcaag gacgacctgcaccccagctttccggaagtttccttcttccacagcgaggagaacaaggcg cctgagagtgaggagttggaaatggagtttgaggacatggagagtgtccccctggatcgg gcctcacactcacagagggaagaggccgggggccgggatggagtgtcctcgctgggcctc aagcggaactacgaggaccacatcccctacacccacatgaacgggggcaagaaaaacgga cggattctgaccctgccgaggtcgaatccttcctaa

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