Panthera leo (lion): 122214160
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Entry
122214160 CDS
T10741
Symbol
JAK3
Name
(RefSeq) tyrosine-protein kinase JAK3 isoform X1
KO
K11218
Janus kinase 3 [EC:
2.7.10.2
]
Organism
plez Panthera leo (lion)
Pathway
plez04062
Chemokine signaling pathway
plez04151
PI3K-Akt signaling pathway
plez04217
Necroptosis
plez04550
Signaling pathways regulating pluripotency of stem cells
plez04630
JAK-STAT signaling pathway
plez04658
Th1 and Th2 cell differentiation
plez04659
Th17 cell differentiation
plez05161
Hepatitis B
plez05162
Measles
plez05166
Human T-cell leukemia virus 1 infection
plez05169
Epstein-Barr virus infection
plez05200
Pathways in cancer
plez05203
Viral carcinogenesis
plez05223
Non-small cell lung cancer
plez05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
122214160 (JAK3)
04151 PI3K-Akt signaling pathway
122214160 (JAK3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
122214160 (JAK3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
122214160 (JAK3)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
122214160 (JAK3)
04659 Th17 cell differentiation
122214160 (JAK3)
04062 Chemokine signaling pathway
122214160 (JAK3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122214160 (JAK3)
05203 Viral carcinogenesis
122214160 (JAK3)
09162 Cancer: specific types
05223 Non-small cell lung cancer
122214160 (JAK3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
122214160 (JAK3)
05161 Hepatitis B
122214160 (JAK3)
05162 Measles
122214160 (JAK3)
05169 Epstein-Barr virus infection
122214160 (JAK3)
09163 Immune disease
05340 Primary immunodeficiency
122214160 (JAK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
plez01001
]
122214160 (JAK3)
Enzymes [BR:
plez01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
122214160 (JAK3)
Protein kinases [BR:
plez01001
]
Non-receptor tyrosine kinases
JAK family [OT]
122214160 (JAK3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
SH2_1
FERM_F1
Jak1_Phl
ABC1
Kdo
Kinase-like
FERM_C_FAK1
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
122214160
NCBI-ProteinID:
XP_042784808
UniProt:
A0A8C8WLJ6
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All DBs
Position
A2:complement(13120932..13136858)
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AA seq
1106 aa
AA seq
DB search
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVWAAKA
SGILPVYHSLFALATEDLSYWYPPSHIFSVEDASTQVLLYRLRFYFPNWFGLEKCHRFGL
RKDLASAVLDLPVLEHLFAQHRNDLVSGRLAVGLSLKEQGECLSLAVLDLARMAREQAQQ
PEELLKTVSYKACLPPDLRDLIQGLSFVTRKRIRRTVRRALGRVTACQADRHSLMAKYIM
DLERLDPARAAETFLVSLPGAAGGQDAPGLLRVAGDSGIHWSPGGHEALQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDSRHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSLPGSYVLRRSPQDFDSFLLTVCVQTP
LGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACWDAGLHVDGVALNLTSCCAPRPK
EKSNLIVVRRGCSAPTSSLVWPQSQCQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEAVDGEARETEVLLKVMDAKHRNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSVMVQ
EFVRLGALDTYLRKSGPLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGNLPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS
GIPMPISTLDPAKKLQFYEERQHLPAPKWMELATLIQQCMAYEPGQRPSFRAIIRDLNSL
ITSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSRRCVHRDLAARNILVESE
THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYGSKNCSPSAEFLRMMGCERDVPALCRLLELLAEGQRLPAPPTCPGEVHELMKLCWAP
SPQDRPTFSALGPQLDTLWSGSRGVA
NT seq
3321 nt
NT seq
+upstream
nt +downstream
nt
atggcgcctccaagtgaggagacacccctgatccctcagcgttcctgcagcctctcatct
tcagaggctggtgccctgcacgtgctgctgccccctcggggccccggacccccacaacgc
ctgtccttctcctttggggaccattcagctgaagagctgtgtgtttgggctgctaaggcc
agtggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctac
tggtaccccccgagccacatcttctccgtggaggatgcaagcacccaagtcctgctctac
aggctccgcttttacttccccaactggtttgggttggagaaatgccaccgcttcgggctg
cggaaggacttggccagtgccgtccttgacctgccagtcctggagcatctcttcgcccag
caccgaaatgacctggtgagcggccgcctcgccgtgggcctcagtctcaaggagcagggt
gaatgtctcagcctggcagtgctggacctggctcggatggcccgtgagcaggctcagcag
cctgaggagctgctgaagaccgtcagctacaaggcctgcctgccccccgatctgcgcgac
ctgatccagggcctgagcttcgtgacgcggaagcgtatccggaggactgtgcgccgggcc
ctgggccgcgtgaccgcctgccaggctgacaggcactcgctcatggccaagtacatcatg
gacctggagaggctggacccggccagggccgccgagaccttcctcgtgagcctccccggg
gctgccggtggccaggatgctccggggctgctccgagtggctggtgacagcggcatccac
tggagtccgggaggacacgaggccctccagcccttctgcgactttccagaaattgtggac
atcagcatcaagcaggcgcctcgtgttggccccgccggggagcaccgcctggtcaccgtc
accaggacggacaaccagatcctggaggccgagttcccggggctgcccgcggccctgtcc
ttcgtggcgctcgtggacggctacttccggctgacttccgactccaggcacttcttctgc
aaggaggttgcgccgccgcggctgctggaggaggtggccgagcagtgccacggtcccatc
accctggattttgccatcaacaagctcaagaccgggggctcccttcctggctcctatgtt
ctccgccgcagcccccaggatttcgacagcttcctcctcactgtctgcgtccagaccccc
ctgggtcctgattacaagggctgcctcatccggtgtgaccccacgggaaccttctccctg
gctggcctcggccggccccacagcagtcttcgagagctcttggcagcctgctgggatgct
gggctgcacgtggatggggttgcgctgaacctcacctcctgctgcgcccccagacccaaa
gaaaagtccaacctgatcgtggtgcggagaggttgcagcgctcccacgtcatcccttgtt
tggccccaatcccagtgccagctgagtcagatgacgtttcacaagatccctgctgacagc
ctggagtggcatgagaacctgggtcatgggtccttcaccaagatttaccgaggttgtcgc
catgaggctgtggacggggaagcccgggagacagaggtgctactcaaagtgatggatgcc
aagcacagaaactgcatggagtccttcctggaagcagcgagcctgatgagccaagtgtcg
tatcagcacctcgtgttgctccacggcgtgtgcatggctggagacagtgtcatggtgcag
gaattcgtgcgcctgggagccctggatacatatctgcgcaagtctggccccctggtacca
gccagctggaagctgcaggtgatcaaacagctggcctatgccctcaactatctggaagac
aaaggcctcccccatggcaatgtctcagcccggaaggtgctcttggctcgggagggggct
gacgggaacctgcccttcatcaagttgagtgaccctggtgtcagccccactgtgctgagc
ctggagatgctcactgacaggatcccctgggtggcccctgagtgtctccaggaggcccgg
acccttggcttggaagctgacaagtggggtttcggtgccacagtctgggaagtgttcagc
gggatcccgatgcccatcagtaccctggatcctgccaagaagctccagttttatgaggaa
cggcagcaccttcctgcccccaagtggatggagctggccacactgatccaacagtgcatg
gcctatgagccaggccagaggccctccttccgcgccatcatccgtgacctgaacagcctc
atcacttcagattatgagctcctctcagaccccacacctggtgccttggcgccccgtgat
gggctgtggaatggcgcccagctctacgcctgccaggaccctaccatttttgaggagagg
catctcaagtacatctcacagctgggcaagggcaactttggcagcgtggagctgtgccgc
tatgacccgctgggcgacaacacgggcgccctagtggctgtgaagcagcttcagcacagc
gggccagaccagcagagggacttccagcgggagatccagatcctcaaagccctccacagc
gacttcattgtcaagtaccgcggtgtcagctatggcccgggccgccagagcctgcggctg
gtgatggagtacctgcccagcggctgcctgcgcgacttcctgcagcgacaccgcgcgcgc
ctcgacgccagccgcctgctcctctacgcctcgcagatctgcaagggcatggagtacctg
ggctcccgccgctgcgtgcaccgcgacctggcggcccgtaacatcctggtggagagcgag
acgcacgtcaagatcgccgactttggcctcgccaagctgctgccgctcgacaaagactac
tacgtggtccgcgagcccggccagagccccatcttctggtacgccccagagtccctctct
gacaacatcttctcgcgccagtcggacgtctggagcttcggggtcgtcctgtacgagctt
ttcacctacggcagcaagaattgcagcccctcagccgagttcctccgtatgatgggatgt
gagcgagacgtccccgccctctgccgcctcctggagctgctggctgagggccagaggctg
cccgcgcctcccacctgccccggtgaggttcatgagctcatgaagctgtgctgggccccg
agcccgcaagaccggccaacattcagtgccctgggcccccagctggatacactgtggagt
ggaagccggggggtagcatag
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