Panthera leo (lion): 122214992 Help Entry 122214992         CDS       T10741                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism plez  Panthera leo (lion) Pathway plez04022   cGMP-PKG signaling pathway plez04068   FoxO signaling pathway plez04081   Hormone signaling plez04140   Autophagy - animal plez04152   AMPK signaling pathway plez04211   Longevity regulating pathway plez04213   Longevity regulating pathway - multiple species plez04910   Insulin signaling pathway plez04920   Adipocytokine signaling pathway plez04923   Regulation of lipolysis in adipocytes plez04930   Type II diabetes mellitus plez04931   Insulin resistance plez04932   Non-alcoholic fatty liver disease plez04935   Growth hormone synthesis, secretion and action plez05010   Alzheimer disease plez05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     122214992 (IRS2)    04022 cGMP-PKG signaling pathway     122214992 (IRS2)    04152 AMPK signaling pathway     122214992 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     122214992 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     122214992 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122214992 (IRS2)    04923 Regulation of lipolysis in adipocytes     122214992 (IRS2)    04920 Adipocytokine signaling pathway     122214992 (IRS2)    04935 Growth hormone synthesis, secretion and action     122214992 (IRS2)   09149 Aging    04211 Longevity regulating pathway     122214992 (IRS2)    04213 Longevity regulating pathway - multiple species     122214992 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     122214992 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     122214992 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     122214992 (IRS2)    04932 Non-alcoholic fatty liver disease     122214992 (IRS2)    04931 Insulin resistance     122214992 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  122214992 NCBI-ProteinID:  XP_042786128 LinkDB All DBs Position A1:complement(79100280..79129276) Genome browser AA seq 1334 aa AA seqDB search MASPPLHGPPGPAGGDGANLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGDEAAAA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYF AVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAATAASCSASLPGALGGSAGAAAADD SYGLVAPASAAYREVWQVNLKPKGLGQSRNLTGVYRLCLSARTIGFVKLNCEQPSVTLQL MNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRP RSKSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVR TASEGDGGAAAAGAGAAGGRPVSVAGSPLSPGPVRTPLSRSHTLSGGGGGGGGCGGRAGK VALAPAGGALQHSRSMSMPVAHSPPAATSPSSLSSSSGHGSGSYPPPPGPHPHLQHPLHQ PASQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSG GELYGYMTMDRPLSHCGRPYRRVSGDGAQDVDRGLRKRTYSLTTPARQRPVPQPSSASLD EYTLMRVSFSGSSGRLCPSCPASSPKAAYHPYPEDYGDVEIGSHRSSSSNLGTDDGYMPM TPGAALTGGGSGSCRSDDYMPMSPTSVSAPKQILQPRAAAAALPPAGAPVSMPAAGRAFP ASGGSYKASSPAESSPEDSGYMRMWCGSKLSMENADSKLLPNGDYLNMSPSDAGASGTPP DFFSAALHGSGETLRGVPGYCHSSLPRSYKAPYTCNGDNNDQYVLMSSPVGRILEEERLE PPASPGTAPSSGCGGGGHAQPPHPAVPSPGRPSGSVGGRPEGFLNQRCRAVRPTRLSLEG LQTLPSMHEYPLPPEPKSPGEYINIDFGDAGARLSPPAPPLLASAASSSSLLSASSPASS LGSGTPGTSGDSRQRSPLSDYMNLDFSSPKSPKPGPQGGDSVGSLDALLSPEASSPYPPL PPRPAAPASALQQQPLPPPPPGELYRLPPAPAAQGPSAASSSSSETGDNGDYTEMAFGVA ATPPQPIAAPPKPEGARVTSPTSGVKRLSLRDQVSGVEAFLQASQPPDPHRGAKVIRADP QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGAGGGGLAGGDER PTSPRQLQPPPPQQARPWLPSQPGGLVGCPGGSGSPMRRETSAGFQNGLNYIAIDVRDEP GLSPSPQQLPHPQPGDKSAWGRTRSLGGLLSAVGGSSTGGVCGGPGPGALPSANTYASID FLSHHLKEATIVKE NT seq 4005 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgctgcacgggccccccgggccggcgggtggcgacggcgccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgacgaggcggcggcggcg ggcggggggccggcgccgcagccgccgcggctcgagtactacgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctgaatatcaac aagcgcgccgacgccaagcacaagtacctgatcgcgctctacaccaaggacgagtacttc gccgtggcggccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctg gtcagcgagggccgcgcgggcgccggcgacgcgccccccgccgccgccaccgccgcgtcc tgcagcgcctccctgcccggcgccctgggcggctcggccggcgccgccgcggccgatgac agctacgggctggtggcgcccgcctcggccgcctaccgcgaggtgtggcaggtgaacctg aagcccaagggcctgggccagagcaggaacctgacgggcgtgtaccgcttgtgcctgtcg gcgcgcaccatcggctttgtgaaacttaactgtgagcagccgtcggtgacgctgcagctc atgaacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccggtcg gccgtcacgggcccaggtgagctgtggatgcaggccgacgactcggtggtggctcagaac atccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttccggccg cgcagcaagagccagtcgtcgggctcgtcctccacacaccccatcagcgtccccggcgcg cgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgccgctcg cgcaccgacagcctggccgccaccccgccggcagccaagtgcagctcgtgccgggtgcgc acggccagcgagggcgacggcggcgcggcggcggcgggggccggggcggcgggcggcagg cccgtgtcggtggccgggagtcccctgagccccggaccggtgcgaacgcccctgagccgc tcacacaccctgagcggcggcggcggcggcggcggcggctgcggcggccgcgcgggcaag gtggcgctggcgccggcagggggcgccctgcaacacagccgctccatgtccatgcccgtg gcgcactcgcccccagcagctaccagccctagcagcttgtcgtccagcagcgggcacggc tccggctcctacccgccgcctccgggcccgcacccgcacctgcagcaccccctgcaccag cccgcgagccagcggccctccagcggcagcgcctcggcctcggggtcccccagcgacccc ggcttcatgtctctggacgagtacggctccagccctggggacctgagagccttctgcagc caccggagcaacacgcccgagtccattgccgagacgcccccggcccgggacggcagcggg ggcgagctgtacgggtacatgaccatggaccggcccctgagccactgtggccgcccctac cgcagagtctccggggacggagcccaggacgtggacagaggcctgaggaagcggacgtac tccctgaccacacctgcccggcagcgtcccgtgccccagccctcctctgcgtccctggac gaatacaccctgatgcgggtctccttctctggcagctccggccgcctctgcccgtcctgc cccgcctcgtctcccaaagcggcctaccacccctaccccgaggactacggggacgtcgag atcggctcccacaggagctccagcagtaacctgggcacggacgacggctacatgcccatg acccccggcgcggccctcacggggggtggcagtggcagctgtaggagtgacgactacatg cccatgagccccaccagcgtgtccgccccaaagcagatcctgcagcctcgggctgccgct gcggccttgccccccgcgggagcgccggtgtccatgcccgcggccggcagggccttcccg gccagcgggggcagctataaggcgagctccccggcggagagctcccccgaggacagcggg tacatgcgtatgtggtgtggctccaagctgtccatggagaacgcagacagcaagctgctg cccaacggggactacctcaacatgtcccccagcgacgcaggcgcctccgggacccctccc gacttcttctccgccgccttgcatggcagcggggagacgctcaggggagtgcccggctat tgccacagctccctgccccgctcctacaaggctccctacacctgcaacggggacaacaac gaccagtatgtgctcatgagctctccggtggggcgcatcctggaagaggagaggctggag ccgccggccagcccagggaccgcgccgtccagcggctgcggcggtggcggccacgcccag cctcctcacccagcagtgccttcacctggcaggccaagtggcagcgttggcggccgccca gagggcttcctgaaccagcgctgccgggccgtgcggcccacgcgcctgtccctggagggg cttcagaccctgcccagcatgcacgagtacccgctgccacccgagcccaagagccccggt gagtacatcaacattgacttcggcgacgcgggagctcgcctgtcgcctcccgcacccccg ctgctggcctcggccgcgtcgtcgtcctcgctgctgtccgccagcagcccggcctcctcc ctgggctcgggcaccccgggcacgagcggcgacagccgacagcgctccccgctgtccgac tacatgaacctcgacttcagctcgcccaagtcacccaagccgggcccccagggcggggac tccgtgggctcgctggacgccctcctgtcccccgaggcctcctccccctatccgccgctg cccccgcgccctgcggcgcccgcctccgccctgcagcagcagccgctgcctccgccccct ccaggcgagctgtaccgcctgccccccgcccccgccgcccagggccccagtgctgcctcc tcgtcgtcctcggagactggggacaatggtgactacaccgagatggccttcggcgtggct gccaccccgccgcaacccatcgccgcccccccgaagccggaaggtgcccgcgtgaccagc cccacgtccggcgtcaagaggctgagtctcagggatcaagtgtcgggagtggaggccttc ctgcaggccagccagcccccggacccgcaccggggggccaaggtcatccgcgcagacccg caggggggccgccgccgccacagctccgagaccttctcctcgaccaccactgtgaccccc gtgtccccgtccttcgcccacaacccgaagcgccacaactcggcttccgtggaaaacgtc tctctcaggaaaagcagcgaaggggccggcggcggcggcctggctgggggcgacgagcgc cccacgtccccccgccagctgcagccaccgcccccccagcaggcgcggccgtggctaccg agtcagccagggggcttggtcgggtgccccgggggcagcggctctccgatgcgcagggag acctctgccggcttccagaatggcctcaactacatcgccatcgacgtgagggacgaacct gggctgtcacccagcccgcagcagcttccgcacccgcagccgggagacaagagcgcctgg ggccggacccggagcctggggggtctcctcagcgcggtggggggcagcagcaccggtggg gtgtgcggggggcccggccctggcgccctgccctccgccaacacctatgccagcattgac tttttgtcgcatcacctgaaggaggccaccattgtgaaagagtga

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