Panthera leo (lion): 122216242 Help Entry 122216242         CDS       T10741                                  Symbol HK2 Name (RefSeq) hexokinase-2   KO K00844   hexokinase [EC:2.7.1.1] Organism plez  Panthera leo (lion) Pathway plez00010   Glycolysis / Gluconeogenesis plez00051   Fructose and mannose metabolism plez00052   Galactose metabolism plez00500   Starch and sucrose metabolism plez00520   Amino sugar and nucleotide sugar metabolism plez00524   Neomycin, kanamycin and gentamicin biosynthesis plez01100   Metabolic pathways plez01200   Carbon metabolism plez01250   Biosynthesis of nucleotide sugars plez04066   HIF-1 signaling pathway plez04910   Insulin signaling pathway plez04930   Type II diabetes mellitus plez04973   Carbohydrate digestion and absorption plez05230   Central carbon metabolism in cancer Module plez_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate plez_M00549   UDP-Glc biosynthesis, Glc => UDP-Glc plez_M01015   GDP-Man biosynthesis, Man => GDP-Man Brite KEGG Orthology (KO) [BR:plez00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     122216242 (HK2)    00051 Fructose and mannose metabolism     122216242 (HK2)    00052 Galactose metabolism     122216242 (HK2)    00500 Starch and sucrose metabolism     122216242 (HK2)   09107 Glycan biosynthesis and metabolism    00520 Amino sugar and nucleotide sugar metabolism     122216242 (HK2)   09110 Biosynthesis of other secondary metabolites    00524 Neomycin, kanamycin and gentamicin biosynthesis     122216242 (HK2)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     122216242 (HK2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122216242 (HK2)   09154 Digestive system    04973 Carbohydrate digestion and absorption     122216242 (HK2)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     122216242 (HK2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     122216242 (HK2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:plez04131]     122216242 (HK2) Enzymes [BR:plez01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.1  hexokinase      122216242 (HK2) Membrane trafficking [BR:plez04131]  Autophagy   Mitophagy    Other mitophagy associated  proteins     122216242 (HK2) SSDB OrthologParalogGFIT Motif Pfam:  Hexokinase_2 Hexokinase_1 Motif Other DBs NCBI-GeneID:  122216242 NCBI-ProteinID:  XP_042788746 UniProt:  A0A8C9CZI9 LinkDB All DBs Position A3:90753510..90815332 Genome browser AA seq 917 aa AA seqDB search MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDENLLEISQRFRKEMEKGLGATTHPTAS VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQKVEMENQIYAIPEDLMR GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCVQTKLDESFLVSWTKGFKSSGV EGKDVVTLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYME EMRHIDMVEGDEGRMCINMEWGAFGDDGTLDDFRTEFDQEIDMGSLNPGKQLFEKMISGM YMGELVRLILVKMAKEELLFGGKLSPGLLATGHFETKDVSDIEGEKDGIRKAREVLVRLG IDPTQEDCVATHRVCQIVSTRSASLCAATLAAVLRRIKENKGEERLRSTIGVDGSVYKKH PHFAKRLHKTVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQNTLESLKLN REQLLEVKKRMKVEMERGLSKETHAIAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV LLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG TMMTCGYEDPHCEIGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG IFETKFLSQIESDCLALLQVRAILHHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA VVDKIRENRGLDTLKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLESEDGSGKG AALITAVACRIREAGQR NT seq 2754 nt NT seq  +upstreamnt  +downstreamnt atgatcgcctcacatctgctcgcctacttcttcacggagctcaaccatgaccaagtgcag aaggtggaccagtatctctaccacatgcgtctttctgatgagaaccttctggagatctct cagcggttccgcaaggagatggagaaagggcttggagccaccacccaccccactgcttca gtgaaaatgctgcccacctttgtgaggtctactccagatgggacagaacatggagagttt ctggctctggaccttggggggaccaacttccgtgtgcttcgtgtaagagtaacagacaat gggctccagaaggtcgagatggagaaccagatctatgccatccctgaggacctcatgcga ggcagcggcacccagctgtttgaccacattgctgaatgcctggctaacttcatggataag ctacaaatcaaagacaagaagctccccttgggttttactttctcattcccctgtgtccaa acgaagctagatgagagtttcctggtctcctggaccaaggggttcaagtccagtggcgtg gaaggcaaagacgtggttactctgatccggaaggccatccagaggagaggggactttgat attgatattgtggccgtggtgaatgacacagttgggaccatgatgacctgtggttatgat gaccagaattgtgagattggtctcattgtgggcacgggcagcaacgcctgctacatggaa gagatgcgccacattgacatggtggagggcgacgaggggcggatgtgtatcaacatggag tggggggcctttggggacgacggcacacttgatgacttccgcactgagtttgatcaggag atcgacatgggctccctgaaccctgggaaacaactatttgagaagatgatcagtgggatg tatatgggtgaactggtgagacttatcctggtgaagatggccaaggaggagctgcttttt ggggggaagctcagcccagggctcctcgccactggccactttgagaccaaagacgtttca gatattgaaggggagaaggacggcatccggaaggcccgtgaggtgctagtgcggctgggc atagacccgacgcaggaggactgcgtggccactcaccgggtgtgccagatcgtgtccaca cgctcagccagcctgtgtgcagccaccctggcagccgtgctgcggcgcatcaaggagaac aagggcgaggagaggctgcgctccaccattggggttgatggttctgtctacaagaagcac cctcatttcgccaagcgtcttcacaagacggttcggcgcctggtgcccgactgcgacgtc cgtttcctgcgttccgaggatggcagtggcaagggggcagccatggtgacggcagtggcc taccggctggctgaccaacacagagcccgccagaataccctggagtctctgaagctgaac cgtgagcagctgctggaggttaagaagaggatgaaggtagaaatggagcgaggtctgagc aaggagacccacgccattgcccccgtcaagatgctgcccacctacgtgtgtgccacccct gatggcacagagaaaggtgacttcctggccttggaccttgggggtaccaatttccgggtc ctgctggtacgtgtgaggaatgggaagaggcgcggagtggagatgcacaacaagatctac tctatcccacaggaggtcatgcatggcacaggggatgagctctttgaccacatcgtccag tgcatcgccgacttccttgagtacatgggcatgaagggcgtgtccctgcctctgggtttc accttctccttcccctgccagcagaacagcctggatgagagcatcctcctcaagtggact aaaggcttcaaggcatcgggctgcgagggagaggatgtggtcaccctgctgaaggaagcc attcaccggcgagaggagtttgacctggatgtggtcgccgtggtgaatgacacagttggg acgatgatgacctgtggctatgaagaccctcactgtgaaatcggcctcattgttggcacg ggcagcaacgcctgctacatggaggagatgcggaacgtggagctggtggaaggggaggag ggccggatgtgtgtcaacatggagtggggggccttcggggacaacgggtgcctggacgac ttccgcacggaatttgatgtggctgtggatgagctttctctcaaccctggcaaacagagg tttgagaaaatgatcagtggcatgtatttgggcgagattgtccgtaacatcctcatcgat ttcaccaagcgtgggctgctcttccgtggccgcatctcagaacgactcaagacaagagga atctttgaaactaagttcctgtctcagattgagagtgactgcctagccctgctgcaggta cgtgccatcctgcaccacctggggctcgagagcacctgtgacgacagcatcatcgtcaaa gaggtgtgcacggtggtggcacggcgggcggcccagctctgtggtgcgggcatggccgcc gtggtggacaaaatacgagaaaaccgtgggctggacaccctcaaagtgacagtaggcgtg gatgggaccctctacaagctacatcctcactttgccaaagtcatgcatgagacggtgaaa gacctggctccgaaatgtgatgtgtccttcctggagtcagaggatggcagcgggaagggg gcagctctcatcactgctgtggcctgccgcatccgtgaggctggacagcgatag

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