KEGG   PATHWAY: plui03070
Entry
plui03070                   Pathway                                
Name
Bacterial secretion system - Photorhabdus luminescens
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
plui03070  Bacterial secretion system
plui03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Photorhabdus luminescens [GN:plui]
Gene
CE143_13475  hypothetical protein [KO:K12340]
CE143_19835  outer membrane channel protein TolC [KO:K12340]
CE143_18865  EscF/YscF/HrpA family type III secretion system needle major subunit [KO:K03221]
CE143_18800  type III secretion protein [KO:K04056]
CE143_18805  type III secretion system needle length determinant [KO:K04057]
CE143_18770  type III secretion protein, YscX family [KO:K04059]
CE143_18850  EscC/YscC/HrcC family type III secretion system outer membrane ring protein [KO:K03219]
CE143_18785  type III secretion protein [KO:K04058]
CE143_18885  EscJ/YscJ/HrcJ family type III secretion inner membrane ring protein [KO:K03222]
CE143_18815  EscR/YscR/HrcR family type III secretion system export apparatus protein [KO:K03226]
CE143_18820  EscS/YscS/HrcS family type III secretion system export apparatus protein [KO:K03227]
CE143_18825  EscT/YscT/HrcT family type III secretion system export apparatus protein [KO:K03228]
CE143_18830  EscU/YscU/HrcU family type III secretion system export apparatus switch protein [KO:K03229]
CE143_18760  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
CE143_18795  EscN/YscN/HrcN family type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
CE143_18810  type III secretion protein [KO:K03225]
CE143_18895  type III secretion system protein [KO:K03223]
CE143_05905  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
CE143_08805  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
CE143_05520  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
CE143_21400  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
CE143_19455  secD; protein translocase subunit SecD [KO:K03072]
CE143_19450  secF; protein translocase subunit SecF [KO:K03074]
CE143_02035  preprotein translocase subunit SecE [KO:K03073]
CE143_22865  preprotein translocase subunit SecG [KO:K03075]
CE143_23865  preprotein translocase subunit SecY [KO:K03076]
CE143_19460  preprotein translocase subunit YajC [KO:K03210]
CE143_25115  membrane protein insertase YidC [KO:K03217]
CE143_18400  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
CE143_18405  SecA regulator SecM [KO:K13301]
CE143_20890  signal recognition particle-docking protein FtsY [KO:K03110]
CE143_24785  protein-export chaperone SecB [KO:K03071]
CE143_06300  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
CE143_22395  twin-arginine translocase subunit TatA [KO:K03116]
CE143_22390  tatB; twin-arginine translocase subunit TatB [KO:K03117]
CE143_22385  tatC; twin-arginine translocase subunit TatC [KO:K03118]
CE143_01470  hemolysin activation protein [KO:K11017]
CE143_01465  hemolysin activation protein [KO:K11016]
CE143_04160  Vrg family protein [KO:K11904]
CE143_04490  type VI secretion protein [KO:K11904]
CE143_07705  type VI secretion protein [KO:K11904]
CE143_09770  type IV secretion protein Rhs [KO:K11904]
CE143_10795  Vrg family protein [KO:K11904]
CE143_11760  hypothetical protein [KO:K11904]
CE143_12920  type IV secretion protein Rhs [KO:K11904]
CE143_16830  type IV secretion protein Rhs [KO:K11904]
CE143_17060  type IV secretion protein Rhs [KO:K11904]
CE143_21960  type IV secretion protein Rhs [KO:K11904]
CE143_22185  type IV secretion protein Rhs [KO:K11904]
CE143_23310  Vrg family protein [KO:K11904]
CE143_01630  type IV secretion protein Rhs [KO:K11904]
CE143_01690  type IV secretion protein Rhs [KO:K11904]
CE143_02185  type VI secretion protein [KO:K11904]
CE143_08655  hypothetical protein [KO:K11904]
CE143_16835  Hcp family T6SS protein CtsH1 [KO:K11903]
CE143_21910  Hcp1 family type VI secretion system effector [KO:K11903]
CE143_01770  Hcp1 family type VI secretion system effector [KO:K11903]
CE143_11780  hypothetical protein [KO:K11903]
CE143_21875  type VI secretion system-associated lipoprotein [KO:K11906]
CE143_01735  type VI secretion lipoprotein [KO:K11906]
CE143_11725  hypothetical protein [KO:K11891]
CE143_12890  type VI secretion protein VasK [KO:K11891]
CE143_16735  type VI secretion protein VasK [KO:K11891]
CE143_22140  type VI secretion protein VasK [KO:K11891]
CE143_01640  type VI secretion protein IcmF [KO:K11891]
CE143_01700  type VI secretion protein IcmF [KO:K11891]
CE143_11730  hypothetical protein [KO:K11892]
CE143_16845  type VI secretion protein ImpK [KO:K11892]
CE143_22020  hypothetical protein [KO:K11892]
CE143_01725  hypothetical protein [KO:K11892]
CE143_11720  clpV; ClpV1 family T6SS ATPase [KO:K11907]
CE143_22010  clpV; ClpV1 family T6SS ATPase [KO:K11907]
CE143_01720  clpV; ClpV1 family T6SS ATPase [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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