Parus major (Great Tit): 107201934 Help Entry 107201934         CDS       T04864                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X4   KO K04962   ryanodine receptor 2 Organism pmaj  Parus major (Great Tit) Pathway pmaj04020   Calcium signaling pathway pmaj04260   Cardiac muscle contraction pmaj04261   Adrenergic signaling in cardiomyocytes pmaj04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pmaj00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107201934 (RYR2)    04020 Calcium signaling pathway     107201934 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     107201934 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     107201934 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pmaj04040]     107201934 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pmaj04990]     107201934 (RYR2) Ion channels [BR:pmaj04040]  Voltage-gated cation channels   Ryanodine receptor    107201934 (RYR2) Domain-containing proteins not elsewhere classified [BR:pmaj04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    107201934 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  107201934 NCBI-ProteinID:  XP_015477483 Ensembl:  ENSPMJG00000004243 LinkDB All DBs Position 3:44732152..45111093 Genome browser AA seq 4959 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWSAQGGGHRTLLYGHAILLRHSY SGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECL TVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKY LSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQH VDTGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFL FNRFIRGLDSLSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHENKQNRLRALKNR QNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISE GSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSY GFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNID GLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRS YTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYG PVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMK LPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVK NRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHATRLDVCSGIMEKF RIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRW HQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADGFLPVC SLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNH EHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGS GLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLK QRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGW ITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGL EIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMP LSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPL QFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQL LYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKK HGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLH VRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFREAMSQEDEIDFSE KEFSSGDLKSEEGEEETKGEQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIV AFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDC PCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDSTIRGRLLYLMEKVAYLKKKQAEK TVDDDDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTY TINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA MEEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFCPDHKA AMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQ HLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFW GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPV DTSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYKLLSEK EKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAI DMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLVPYDTLTAKEKAKD REKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG GSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVT SLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRAFLDNAA EDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILED VQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYN TKNARDRAVLNLPSSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSY MSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQP IISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARD LYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEI NNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGD QELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPE KTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAV NLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALT EKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQA RLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGF FQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEG HNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKA IQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLK ELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSS DAFKEYDPDGKGIISKRDFHRAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHE PAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVY FEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISES DLNERSANKEENEKDNPEEEDPRMSFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMK KVKKMTMKDMVMALFSSYWSILVGLVHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAE LLANMPDPTQDEVRGEEEEGERKPTEAALPAEDLTDLQTLTEESDLLSDIFGLDLKREGG QYKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEKVKEDEKEEKEETKSEPEKAEGEDGE KEEKTKEDKGKQKLRQLHTHRYGEPEVQESVFWKNIIAYQQKLLNYFARNFYNMRMLALF VAFAINFILLFYKVSTSAVPEEKELPVVSDGESTKLNILESDDERVIAVHYVLEESSGYM EPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKG QWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKP KKDSSFSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAM GFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDD MLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINK DETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14880 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctatgctttttggaatccacatctaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgagccctccaggaa atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggtctgca caaggtggtggacatcgaacgctgctctacgggcatgcaatcttgctgcgccattcctac agcggcatgtacctgtgctgtctctctacatctcgatcgtcaatggataagctggcattt gatgtaggattgcaagaggacacaacaggtgaggcttgctggtggaccatacatcctgct tccaaacaacgatctgaaggagaaaaagtgcgtgttggagatgatctgattttagtcagt gtctcttcagaaagatatttgcatctctcttatggcaatggtagcttacatgttgatgca gccttccagcagaccctctggagtgtagcaccaatcagttcaggaagtgaagttgcccaa ggatacctgataggaggggatgttctgaggttattgcatggtcacatggatgaatgtttg acagtcccttcgggtgaacatggagaagaacaaagaagaactgtccattatgaaggtggt gctgtgtctattcatgctcgttccctttggcgactagagactctaagagttgcgtggagt ggcagccacattagatggggacagccattcagactaagacatataacaacaggaaaatat ttaagtctcctggatgacaagagcctacttcttacagacaaagagaaggcagatgtaaaa tctacagcgttctgttttcggtcttctaaggaaaagttggacataggtacaagaaaagag gtggatggaatgggagcacctgaaataaagtatggggattcaatctgcttcatacagcac gtagatacaggcttatggctcacgtaccagtctgctgatgcaaagtctgtaaggatgggc tctctgcagcgaaaggcaataatgcaccatgaagggcacatggatgatggtttaacactg tctagatctcagaatgaagaatctcgtacagcacgtgtcatccgtagtacagtcttcctt ttcaacaggttcataaggggccttgattccctcagcaagaaagtgaagtcttccaccatc gatctgcctatcgagtcagtcagtctgagccttcaggacttgattggctactttcacccc cctgatgaacatttggagcatgaaaacaaacaaaacaggctaagagctctgaagaatcgc cagaacctcttccaagaagagggtatgatcaaccttgttcttgaatgtattgatcgcttg aatgtatacagcagtgcagctcactttgcagatgtagctgggaaggaagctggagaagca tggaaatctattctgaattctttgtatgaattactagccgctctgattcgaggaaatcgt aaaaactgtgctcagttttctggatctcttgattggctgatcagcagattagaaagactg gaagcctcttctggaattctagaggttttacattgtgtgttggtagaaagcccagaagca ctgaacattattaaggaaggacatattaaatcaatcatctgccttttggacaaacatgga agaaaccataaggttttggatgttttgtgttctctctgtgtttgtcatggagtagctgtg cggtccaatcaacatctaatttgtgataatcttctgccaggaagagatctgctcttacag acacgccttgtcaaccatgtgagcagcatgcgacccaacatcttcttggggatcagtgaa ggctcagcccaatacagaaaatggtactatgaacttatggtggaccatctagagcccttt gtgactgcagaatcaactcatctacgcgtgggttgggcttcaacagaaggctactcaccc tacccgggaggaggagcagaatggggcggaaacggtgttggtgatgacttatattcctat ggctttgatgggctacatctgtggtcaggttgtgtagcacgaacagtaaattctcccaac cagcatctcttaagaactgatgatgttattagctgctgtttggacctgagtgcccccagc atctccttccgaataaatggtcagccagttcaaggaatgtttgaaaacttcaacatagat ggcctcttcttcccagttgtcagcttctctgcaggaataaaggttcgtttcttgcttgga ggtcgccatggagagttcaagttccttcctccacctggatatgctccatgctttgaagcc gtcctgccaaaagagaagctgaaagtggagcacagccgagagtacaaacaggatcgcagc tacacaagagacctactgggtcccactgtctctctgtcacaagcagctttcactccagtt cctgtagatactagccagattgttttgccaccccacctggaaagaataagagaaaaatta gcagagaacatccatgaactttgggttatgaataagattgaacttggctggcagtatgga ccagttagagatgacaacaaaagacaacacccgtgcttagtggagttctcgaaattgccg gagcaggaaagaaattataacttgcaaatgtcgcttgaaacactgaaaaccctactggca ttaggctgccatgttggaattgctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaa cttccaaagaactatcaattgttgagtggctataagccagcacccatggatctgagtttt atcaaactgaccccctctcaagaagctatggtggataaattagcagagaatgctcacaat gtttgggcaagggaccgtataaggcaaggctggacatacggcatccagcaggatgtgaaa aatcgacgaaatcctcgccttgtaccgtacgctcttttggatgatcggacaaagaagtcc aacaaggacagccttcgggaagcggtccgcacccttctaggctatggttaccatctggaa gctcctgaccaagatcatgcaacaaggctggatgtgtgcagtgggataatggaaaagttc aggatcttccgcacagaaaagacttacgcagtgaaggctgggaagtggtactttgagttt gaggcagttactgcaggagacatgagagttggctggaccaggccaggttgtctgccagat caggagcttggctcagatgaagaagcttttgtttttgatggctttaaggcacagcggtgg catcaaggtaatgagcattttggccgctcttggctggcaggagatgttgttggatgtatg gttgacatgaatgaacacactatgatgttcaccttaaatggtgaaatcctgcttgatgac tcaggctcagaacttgcatttaaggactttgaggttgctgacggattcctacctgtgtgc agcctgggcccatctcaagttggaagaatgaactttggaaaagatgtcagcaccctaaaa tatttcactatatgtggtttacaggaagggtatgaaccctttgctgttaatacaaacaga gacatcaccatttggctgagtaaaaggcttcctcagtttctaccagtgccacaaaaccat gaacacattgaggtaatgagaattgatggcaccatagacagctgcccctgtctgaaggtc acacagaagtcttttggttcacagaacagtaaaacagatgtcatgttttttcgattaagc atgcccattgaatgtgctgaggtgttctccagatcagctgcaggaggcttaccaggctct ggtctttttggcccaaaaaatgacttggaggattatgatgctgattctgattttgaggtt ctcatgaaaactgcacatggtcatctggttcctgaccggacagaaagagaaaaagatgcc acaaaaccagaattgaataaccataaagattatgttcaagaaaagccctcacgtcttaaa caaagatttatgctcaggaggacaaagccagattatagcacgagtcactctgcacggctt actgaggatgtgctagcagatgatagggatgactatgattatttgatgcagacttccacg tactattattctgtaagaatatttcctggtcaagaacctgctaatgtctgggtgggctgg attacatcagacttccaccagtatgacacaagctttgacttggacagagtgcgcaccgtc acagttacactgggagatgaaaaagggaaggttcatgagagtataaaacgcagcaactgc tatatggtgtgcgcaggagagagcctgagccctgggcaaggacgtaataataatggtctg gagattggttgcttggttgatgctgccagtggcctgctgaccttcacagctaatggcaag gaactaggcacctactatcaggttgaaccaagtacaaagttgtttcctgctgtatttgct caagctacaagccccaatgtttttcagtttgaattgggaagaataaagaatgtaatgcca ttatctgctggattattcaaaagtgaacacaaaaacccagtctctcagtgtcctccacgt ctccatgtccagtttctgactcatgtgctttggagcagagtgccaaaccacttcttgaag gtggatgtgtctcggatcagtgaacgtcaaggctggatgatacagtgcctgaatcctttg cagttcatggcccttcatattcctgaggaaaacagaacaattgatattttagagctgaca gaacaagaagaactgctgaaatttcactaccacactctccgattgtattcagctgtttgt gctttaggcaacaaccgagtggcccatgctctgtgtagccatgtggatgaatctcagctc ctctatgctattgagaataaatacatgccaggattattacgtgcaggatattatgactta ctcattgacatccatctcaatacctatgcaactgccaggctgatgatgaataatgaattt atagttccaatgacagatgagaccaagagtattactttgtttcctgatgaaaacaaaaaa cacggccttcctggtataggacttagcacttcactgaggccaagaatgcagttttcttcc ccgagttttgtaagcattagcagtgaatgctttcaattcagtcccgaattccctctggaa attttgaaggccaaaaccatagagatgctgactgaagctgtccaagagggaagcctccat gtcagagatccagttggaggttctactgaatttctgtttgtccctctgatcaagctcttt tataccctcctaattatgggaatcttccacaatgaggatctgaaacatatcttgcagttg attgagccccgggttttcagagaagcaatgagccaggaggatgaaattgatttctcagag aaggagttcagttcaggtgacctcaagtcagaagaaggagaggaagaaaccaaaggggag caaatgccaaaggaaggactccttcagatgaaacttccagaacctgttaaattacagatg tgtcacctactccagtacctgtgtgattgccaagtacggcacaggatagaagccattgta gcattttccgatgattttgtggccaagctccaagagaatcaacgctttcggtacaatgaa gtgatgcaggccttgaacatgtctgctgccctgacagctagaaaaacaaaagaatttcga tcccctcctcaggaacagattaacatgctgctgaactttaaagatgataaaaatgattgt ccttgccctgaagaaattcgggatcaactcttggatttccatgaagacctaatgacacac tgtggaattgaactagatgaagatgggaccttggatggcaacagtgattcaactattagg ggtcgcctcctataccttatggaaaaagttgcatatctgaagaaaaaacaagctgagaag acagtagatgatgatgataagacatcctctactctccagcagctgatttcggacacgatg gtgcgttgggcccaggagtcagtgatagaagacccggagttagtgagggccatgtttgtg ctgctgcatcgccagtatgatggtattggtggcctggttcgagctctaccaaagacctac accataaatagcgtgtctgtggaagacaccatcaatctcctggcatcccttggccaaatc cgttccttgcttagtgtcagaatggggaaggaagaggagaagcttatgattcgtggatta ggtgacattatgaataataaagtattttaccaacatccaaacctcatgagagctttaggc atgcatgaaactgtcatggaagtgatggtgaatgtgcttggtggaggagaatccaaggaa atcactttcccaaagatggtggcaaactgctgtcgttttctctgttatttttgccgcatc agcaggcagaaccaaaaagctatgtttgatcatcttagctatttattggaaaacagcagt gttggccttgcctctccttctatgcgagggtcaactcctttagatgttgccgcagcatct gtaatggataacaatgaacttgctctggctttaagggaacctgatctggagaaggtggtt cgctacttggctggatgtgggttgcagagttgtcctttgttgatttgtaaaggctacccg gacattggatggaatccggttgaaggagaacgatacctggattttctccgttttgctgtt ttttgcaatggagagagcgtggaggagaatgctaatgttgtagtcagactgcttattcgc cgacctgaatgttttggtcctgccctaagaggagaaggaggcaatgggttgcttgctgcc atggaggaggcaatacaaatatcagaagatcgaacaagagatgggccttccccaagtaat ggatctagtaaaacccttgaaatagaagaacaagaagatgacactattcatatgggaaat gcaatcatgaccttttatgctgccttgattgatctcttaggacgttgtgcccctgaaatg catctaatccatgctgggaaaggggaagccattagaatcagatcaattctacggtctttg attccacttgaagatttggtgggagtaatcagtattgctttccacatgccaaccatagca aaagatggtactgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggca gccatggttttgttccttgacagggtctatggaattgaggaccaggattttcttctacac cttcttgaagttggctttctgccagaccttcgtgctgctgcctcattagatacggctgct ttaagtgctacagatatggctttggctctgaatcgatacctttgcacagcggtcttgcct ctcttgaccagatgtgctcctctgtttgctggcacggagcaccatgcttccctcatcgat tccttattacacactgtgtacagactctcaaagggatgctctcttaccaaagctcagcga gattctattgaagagtgtttgctgtctatctgtgggcagttgcggccctccatgatgcag catttgctgaggagattagtatttgatgttcctctgttaaatgaacatgcaaagatgcct ctcaagttgctgacaaatcattatgaaagatgctggaagtattattgtttgccaagtgga tggggtaacttcggtgctgcctcagaagaagaacttcatttatccagaaagttgttctgg ggtatttttgatgctttatctcaaaagaagtacgaacaggaactgttcaaactggctttg ccttgtctcagtgcagttgcaggagccttaccaccagattatatggaatcaaattatgtc aatatgatggaaaaacagtcttcgatggattcagatgggaactttaatcctcaacctgtt gatacctcaaacattacaatccctgagaagctagaatatttcattaacaaatatgcagaa catgctcatgacaaatggtcaatggaaaagtttgccaatggatggacctatggtgaaacc ttttctgaatctgcaaaagtgcagccattaatgaaacaatataagttgctgtctgaaaag gagaaagaaatttatcgatggccaatcaaagaatcactaaaaaccatgctggcatgggga tggcgaattgaaaggacacgggaaggagattccatggcgctctataatcggacgcgtcgc atatctcaaaccagtcaaatctctgtagatacagcccatggttacactcctcgagcaatt gacatgagcaatgtcaccctctccagagacttacatgctatggctgagatgatggctgaa aactaccataacatatgggcaaagaaaaagaaactggagcttgaagcaaaagtaggagga ggcaaccatccccttcttgttccttatgatacactcacagccaaagaaaaagccaaagac agagaaaaagcacaggatattctgaaatttctacagattaatggatatgttgtctccaga ggacttaaggacctggaattagacactccttccattgagaaacgttttgcctacagtttc cttcagcagcttataagatatgtggatgaagcccatcagtacattttggagtttgatggt ggcagcagaggcaaaggagagcagttcccatatgaacaagaaatcaagttttttgccaaa gttgtgctccctttgatcgatcagtattttaaaaatcatcgcctgtatttcttatcttca gcaagcaggcctctcagcagtggaggccatgcctctaataaagagaaagaaatggtgaca agcctgttctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaacgat gcaacatcaatagtcaactgtcttcacattctgggacagactttggatgcaaggactgtg atgaaaactggtctggaatctgttaggatggcattgagagcatttttggacaatgctgct gaggatctggagaaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaac cagccaaaaggagttacacaaataattaattataccacagttgctctcctgccagtgcta tcttcgttatttgagcatattggacagcaccagtttggggaagatttgatattggaagat gttcaggtctcttgttacagaatattggccagtttgtatgctctgggaaccagcaagagt atatatgtagagaggcaacgatcagcactaggagagtgcttggctgctttctcaggggcc tttccagtggcttttttggaaactcatttgaacaaacataatatctactcaatctacaat accaagaatgcaagagacagagcagttctgaatttgccaagtagtgtagaagaggtttgc ccaaatattccttccttggtgaagctaatggaagaaatagtggaactggcagaatccggt attcgttacacacaaatgccacatatcatggaagtcatactgccaatgctgtgcagttac atgtcacactggtgggagcatgggccagagaacaatcctgacaaggctgaaatgtgttgc acagccttgacgtcagagcacatgaacactctgttgggtaacatattgaaaatcatctat aacaaccttggtattgatgaaggagcctggatgaagagattagcagtgttttcccagccc atcataagtaaagcgaagccacagctcttaaagacacacttccttccactgatggataaa ctaaagaaaaaggcagcagtggttgtatcggatgaagaacatctaagagcagaaggcaga ggtgacatgtcggaggctgaactgctcatcctagatgagttcaccactttggcacgggac ctctatgccttctaccctttgttgattagatttgtggactataacagggcaaaatggctg aaagagcccaatcctgaagcagaagagctgttccgcatggtggctgaggtcttcatttac tggtcaaagtctcataatttcaaaagggaagagcagaactttgtggtacaaaatgaaatc aacaacatgtctttccttatcagtgacaccaaatctaagatgtctaaggcagcagtttct gaccaggaaaggaagaagatgaagcgaaaaggtgaccgctactccatgcaaacctctctc attgtggcagcactaaagagattgcttccaataggcctgaacatctgtgctcctggagac caagagctaattgcactggccaaaaatcgatttagcatgaaagacactgaagatgaagta cgagatgtcatccgcagtaatctccatcttcagggcaagcttgaggatcccgccattaga tggcagatggcactttacaaagatttgccaaacaggactgaagattcttcagatccagag aagactgtggaaagggtccttgatatagctaatgtgctgtttcacctggaacaggttgag catcctcagcgatccaaaaaagcagtgtggcataagctgctgtctaagcagaggaaaaga gcagtggtggcctgttttagaatggcaccattgtataatctgccaagacatcgagccgtc aatctctttcttcaaggctatgataaatcttggattgaaacagaagagcactattttgaa gacaaactgatagaagacttagcaaaacctggagaggaaccaccagaagaagatgaaagc cttaaaagagttgatcctttacatcaacttattctgctattcagtcgaacagccttgact gaaaaatgtaaattggaagaagatttcctgtatatggcttatgctgacattatggcaaag agctgccatgatgaagaagatgatgatggtgaagaagaagtgaagagctttgaagtgaca ggatcacaacgcagcaaggaaaaagaaatggaaaagcaaaaacttctgtatcaacaagcc agactgcatgatcgaggtgctgctgagatggttctgcagacaatcagtgcaagtaaaggt gagatggggccaatggttgcagctaccctaaagctaggaattgccatcttaaatggagga aattctactgttcaacagaaaatgcttgactacctcaaagataaaaaggatgtggggttc tttcagagccttgctggtcttatgcagtcctgtagcgttcttgacctaaatgcgtttgaa cgacagaacaaagcagaaggccttggcatggtgactgaagagggatcaggagaaaaggtg atgcaggatgatgagttcacctgtgacctcttccgcttccttcagttgctttgtgaagga cacaattcagattttcagaattacctgagaactcaaactggtaacaacacaactgttaat attatcatttctactgtggattacttattgagagttcaggaatccatcagtgatttctat tggtattattctgggaaggatgttattgatgaacaaggacagcgaaatttttccaaagcc atccaggttgcaaaacaagttttcaatactctcacagagtatatccaggggccatgtact gggaatcagcaaagtctggcacacagcaggctgtgggatgctgtagttggtttccttcat gtgtttgcacacatgcagatgaagctgtctcaggattccagtcaaattgaactattgaag gaattaatggatcttcagaaagatatggttgtcatgttgctgtctatgctggaaggtaat gttgtgaatggaactattggaaagcagatggtcgatatgcttgtggaatcatcaaacaat gtggaaatgattctgaagttttttgatatgttcttaaaattgaaagatttgacttcctct gatgcattcaaagaatatgaccctgatggtaaagggatcatttcgaagagggattttcac agggcaatggaaagccacaagcactacactcagtctgaaactgagtttctgctgtcatgt gctgaaacagatgagaatgagactttggactatgaggagtttgtgaaacgatttcatgag cctgcgaaagacattggtttcaatgttgctgttctcctgaccaacctgtcagaacacatg ccccacgatacacgcttgcaaactttccttgagctctcagagagtgtgctgaattacttt cagcctttcctcggacgtatagagatcatgggcagcgcaaagcgcattgaacgagtttat tttgaaataagtgagtcaagtcggactcaatgggaaaaacctcaggtaaaagagtcaaag agacagtttatatttgatgttgtaaatgaaggtggggagaaagaaaagatggagcttttt gttaacttctgtgaggataccatctttgaaatgcaactggctgcccagatctctgagtca gatctgaatgaaaggtcagctaataaagaggaaaatgagaaggataatcctgaggaggaa gatcctagaatgagtttcttctctctcgtgaccatgaagtcagctttagtagctctcaag tataatttaatgactcttatgaaaatgctcagcatgaagagtctaaagaaacaaatgaaa aaggtgaagaaaatgaccatgaaggacatggtcatggctttgttttcttcctactggagc attttggtaggcttagtacattttgcttgtagtgttgtccggggcttttttcgcatcata tgcagtttgctgcttggaggaagcctagtagaaggagccaagaaaatcaaggtggctgag ctgctggctaatatgccagatcccactcaggatgaggtgcgtggggaagaagaagaaggg gagaggaaaccaacagaagctgcactgcctgcagaagacttgacggatctgcagacatta acagaagagagtgatctgctctcagatatatttggtttggatttgaaacgagaaggtgga cagtataaactgatccctcacaatccaaatgctggtttgagtgatttactgagcactccc tccttagcaccaatgcccgaggtacaggaaaaaatccaggagaaggtgaaagaagatgaa aaggaagagaaagaagaaacaaaatcagaacctgaaaaagctgaaggagaagatggagaa aaagaagagaaaaccaaggaagacaaagggaaacaaaaattaagacaactgcatacgcac agatacggagaaccagaagttcaggaatcagttttctggaagaatatcattgcataccag cagaagcttcttaattactttgcacgcaacttttacaacatgaggatgttggcgttattt gttgcttttgccatcaacttcatccttcttttctataaggtctccacatctgctgtgcca gaagaaaaggaacttcctgtggtatctgatggtgaaagtaccaagttgaacatcctggaa agtgatgatgagagggtcattgcagtgcactatgtcctggaagaaagcagtggctacatg gagcccacactgaggattttggccatcctacacacggtcatctcattcttctgcatcata gggtattactgtttgaaagttccattggttatttttaagagagaaaaggaagtggcaagg aaattggaatttgatgggctatatataactgagcagccatcagaagatgatattaaggga cagtgggatcgacttgtaatcaacacacagtcttttccaaataactattgggacaagttt gtgaaaagaaaggtaatggataaatacggtgagttctatggccgtgacaggatcagtgaa ttactaggaatggacaaagctgctcttgattttagtgatgctcgagaaaagaagaaacca aagaaggatagctccttttctgctgtgttaaattccattgatgttaagtatcagatgtgg aaattaggagttgttttcactgataattctttcctttacctagcatggtacatgaccatg tcagtccttggccattacaacaattttttctttgctgctcatctccttgacattgcaatg ggattcaagacattacgaactatcctgtcatcggtcacccacaatggcaaacagcttgtc ctaacagtgggactactggcagtagtggtatacttgtatacagtagtggcattcaatttt ttccgcaagttctacaacaagagtgaagacggtgatatgccagacatgaaatgtgatgat atgctaacatgctacatgtttcatatgtatgttggagtacgggcaggaggaggcattggt gacgaaatagaagatccagcaggagatgaatatgaaatctatcggattatctttgacatc actttcttcttctttgtgattgtcatcctgcttgcaattatccaaggtttaattattgat gcttttggtgagttaagagatcagcaagagcaagttaaggaagacatggagacgaagtgc tttatctgtggaataggaaatgactactttgatacagtgcctcatggctttgaaacacac acactacaggagcacaacttggccaattatttgttttttctgatgtatcttattaacaaa gatgaaaccgagcatacaggacaggaatcatatgtatggaaaatgtaccaagaacgatgc tgggagtttttccctgctggtgattgcttccgaaaacaatatgaagaccagctcaactaa

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