KEGG   PATHWAY: pon00531
Entry
pon00531                    Pathway                                
Name
Glycosaminoglycan degradation - Pongo abelii (Sumatran orangutan)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
pon00531  Glycosaminoglycan degradation
pon00531

Module
pon_M00076  Dermatan sulfate degradation [PATH:pon00531]
pon_M00077  Chondroitin sulfate degradation [PATH:pon00531]
pon_M00078  Heparan sulfate degradation [PATH:pon00531]
pon_M00079  Keratan sulfate degradation [PATH:pon00531]
Other DBs
GO: 0006027
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100458070  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
100462117  SPAM1; hyaluronidase PH-20 isoform X1 [KO:K01197] [EC:3.2.1.35]
100453650  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
100455010  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
100455370  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
100461750  LOW QUALITY PROTEIN: hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
100173726  GUSB; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
100439268  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
100435640  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
100458752  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
100457196  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
100448281  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
100437923  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100459478  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
100447325  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
100455729  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
100457027  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
100173272  GLB1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
100434320  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
100438794  HEXA; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
100438599  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00634  Chondroitin 4-sulfate
C00925  Heparan sulfate
G00526   
G00711   
G00872  DWA-2
G01391   
G01945   
G01977   
G02632   
G09660   
G10008   
G10505  Hyaluronic acid
G12336   
G13034   
G13035   
G13036   
G13037   
G13038   
G13039   
G13040   
G13041   
G13042   
G13043   
G13073   
G13074   
Reference
PMID:27570
  Authors
Greiling H, Stuhlsatz HW, Cantz M, Gehler J
  Title
Increased urinary excretion of keratan sulfate in fucosidosis.
  Journal
J Clin Chem Clin Biochem 16:329-34 (1978)
DOI:10.1515/cclm.1978.16.6.329
Reference
PMID:3161730
  Authors
Fuchs W, Beck M, Kresse H
  Title
Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate.
  Journal
Eur J Biochem 151:551-6 (1985)
DOI:10.1111/j.1432-1033.1985.tb09138.x
Related
pathway
pon00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
pon00533  Glycosaminoglycan biosynthesis - keratan sulfate
pon00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
KO pathway
ko00531   
LinkDB

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