Pongo abelii (Sumatran orangutan): 100173589
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Entry
100173589 CDS
T01416
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha
KO
K02649
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon01524
Platinum drug resistance
pon04012
ErbB signaling pathway
pon04014
Ras signaling pathway
pon04015
Rap1 signaling pathway
pon04024
cAMP signaling pathway
pon04062
Chemokine signaling pathway
pon04066
HIF-1 signaling pathway
pon04068
FoxO signaling pathway
pon04070
Phosphatidylinositol signaling system
pon04071
Sphingolipid signaling pathway
pon04072
Phospholipase D signaling pathway
pon04140
Autophagy - animal
pon04150
mTOR signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04152
AMPK signaling pathway
pon04210
Apoptosis
pon04211
Longevity regulating pathway
pon04213
Longevity regulating pathway - multiple species
pon04218
Cellular senescence
pon04360
Axon guidance
pon04370
VEGF signaling pathway
pon04380
Osteoclast differentiation
pon04510
Focal adhesion
pon04550
Signaling pathways regulating pluripotency of stem cells
pon04611
Platelet activation
pon04613
Neutrophil extracellular trap formation
pon04620
Toll-like receptor signaling pathway
pon04625
C-type lectin receptor signaling pathway
pon04630
JAK-STAT signaling pathway
pon04650
Natural killer cell mediated cytotoxicity
pon04660
T cell receptor signaling pathway
pon04662
B cell receptor signaling pathway
pon04664
Fc epsilon RI signaling pathway
pon04666
Fc gamma R-mediated phagocytosis
pon04668
TNF signaling pathway
pon04670
Leukocyte transendothelial migration
pon04722
Neurotrophin signaling pathway
pon04725
Cholinergic synapse
pon04750
Inflammatory mediator regulation of TRP channels
pon04810
Regulation of actin cytoskeleton
pon04910
Insulin signaling pathway
pon04914
Progesterone-mediated oocyte maturation
pon04915
Estrogen signaling pathway
pon04917
Prolactin signaling pathway
pon04919
Thyroid hormone signaling pathway
pon04923
Regulation of lipolysis in adipocytes
pon04926
Relaxin signaling pathway
pon04929
GnRH secretion
pon04930
Type II diabetes mellitus
pon04931
Insulin resistance
pon04932
Non-alcoholic fatty liver disease
pon04933
AGE-RAGE signaling pathway in diabetic complications
pon04935
Growth hormone synthesis, secretion and action
pon04960
Aldosterone-regulated sodium reabsorption
pon04973
Carbohydrate digestion and absorption
pon05010
Alzheimer disease
pon05017
Spinocerebellar ataxia
pon05020
Prion disease
pon05100
Bacterial invasion of epithelial cells
pon05135
Yersinia infection
pon05142
Chagas disease
pon05146
Amoebiasis
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05162
Measles
pon05163
Human cytomegalovirus infection
pon05164
Influenza A
pon05165
Human papillomavirus infection
pon05166
Human T-cell leukemia virus 1 infection
pon05167
Kaposi sarcoma-associated herpesvirus infection
pon05168
Herpes simplex virus 1 infection
pon05169
Epstein-Barr virus infection
pon05170
Human immunodeficiency virus 1 infection
pon05171
Coronavirus disease - COVID-19
pon05200
Pathways in cancer
pon05203
Viral carcinogenesis
pon05205
Proteoglycans in cancer
pon05206
MicroRNAs in cancer
pon05207
Chemical carcinogenesis - receptor activation
pon05208
Chemical carcinogenesis - reactive oxygen species
pon05210
Colorectal cancer
pon05211
Renal cell carcinoma
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05214
Glioma
pon05215
Prostate cancer
pon05218
Melanoma
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05222
Small cell lung cancer
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05225
Hepatocellular carcinoma
pon05226
Gastric cancer
pon05230
Central carbon metabolism in cancer
pon05231
Choline metabolism in cancer
pon05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05415
Diabetic cardiomyopathy
pon05417
Lipid and atherosclerosis
pon05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
100173589 (PIK3R1)
04014 Ras signaling pathway
100173589 (PIK3R1)
04015 Rap1 signaling pathway
100173589 (PIK3R1)
04370 VEGF signaling pathway
100173589 (PIK3R1)
04630 JAK-STAT signaling pathway
100173589 (PIK3R1)
04668 TNF signaling pathway
100173589 (PIK3R1)
04066 HIF-1 signaling pathway
100173589 (PIK3R1)
04068 FoxO signaling pathway
100173589 (PIK3R1)
04070 Phosphatidylinositol signaling system
100173589 (PIK3R1)
04072 Phospholipase D signaling pathway
100173589 (PIK3R1)
04071 Sphingolipid signaling pathway
100173589 (PIK3R1)
04024 cAMP signaling pathway
100173589 (PIK3R1)
04151 PI3K-Akt signaling pathway
100173589 (PIK3R1)
04152 AMPK signaling pathway
100173589 (PIK3R1)
04150 mTOR signaling pathway
100173589 (PIK3R1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100173589 (PIK3R1)
09143 Cell growth and death
04210 Apoptosis
100173589 (PIK3R1)
04218 Cellular senescence
100173589 (PIK3R1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100173589 (PIK3R1)
04550 Signaling pathways regulating pluripotency of stem cells
100173589 (PIK3R1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100173589 (PIK3R1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100173589 (PIK3R1)
04613 Neutrophil extracellular trap formation
100173589 (PIK3R1)
04620 Toll-like receptor signaling pathway
100173589 (PIK3R1)
04625 C-type lectin receptor signaling pathway
100173589 (PIK3R1)
04650 Natural killer cell mediated cytotoxicity
100173589 (PIK3R1)
04660 T cell receptor signaling pathway
100173589 (PIK3R1)
04662 B cell receptor signaling pathway
100173589 (PIK3R1)
04664 Fc epsilon RI signaling pathway
100173589 (PIK3R1)
04666 Fc gamma R-mediated phagocytosis
100173589 (PIK3R1)
04670 Leukocyte transendothelial migration
100173589 (PIK3R1)
04062 Chemokine signaling pathway
100173589 (PIK3R1)
09152 Endocrine system
04910 Insulin signaling pathway
100173589 (PIK3R1)
04923 Regulation of lipolysis in adipocytes
100173589 (PIK3R1)
04929 GnRH secretion
100173589 (PIK3R1)
04915 Estrogen signaling pathway
100173589 (PIK3R1)
04914 Progesterone-mediated oocyte maturation
100173589 (PIK3R1)
04917 Prolactin signaling pathway
100173589 (PIK3R1)
04926 Relaxin signaling pathway
100173589 (PIK3R1)
04935 Growth hormone synthesis, secretion and action
100173589 (PIK3R1)
04919 Thyroid hormone signaling pathway
100173589 (PIK3R1)
09154 Digestive system
04973 Carbohydrate digestion and absorption
100173589 (PIK3R1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
100173589 (PIK3R1)
09156 Nervous system
04725 Cholinergic synapse
100173589 (PIK3R1)
04722 Neurotrophin signaling pathway
100173589 (PIK3R1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100173589 (PIK3R1)
09158 Development and regeneration
04360 Axon guidance
100173589 (PIK3R1)
04380 Osteoclast differentiation
100173589 (PIK3R1)
09149 Aging
04211 Longevity regulating pathway
100173589 (PIK3R1)
04213 Longevity regulating pathway - multiple species
100173589 (PIK3R1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100173589 (PIK3R1)
05206 MicroRNAs in cancer
100173589 (PIK3R1)
05205 Proteoglycans in cancer
100173589 (PIK3R1)
05207 Chemical carcinogenesis - receptor activation
100173589 (PIK3R1)
05208 Chemical carcinogenesis - reactive oxygen species
100173589 (PIK3R1)
05203 Viral carcinogenesis
100173589 (PIK3R1)
05230 Central carbon metabolism in cancer
100173589 (PIK3R1)
05231 Choline metabolism in cancer
100173589 (PIK3R1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100173589 (PIK3R1)
09162 Cancer: specific types
05210 Colorectal cancer
100173589 (PIK3R1)
05212 Pancreatic cancer
100173589 (PIK3R1)
05225 Hepatocellular carcinoma
100173589 (PIK3R1)
05226 Gastric cancer
100173589 (PIK3R1)
05214 Glioma
100173589 (PIK3R1)
05221 Acute myeloid leukemia
100173589 (PIK3R1)
05220 Chronic myeloid leukemia
100173589 (PIK3R1)
05218 Melanoma
100173589 (PIK3R1)
05211 Renal cell carcinoma
100173589 (PIK3R1)
05215 Prostate cancer
100173589 (PIK3R1)
05213 Endometrial cancer
100173589 (PIK3R1)
05224 Breast cancer
100173589 (PIK3R1)
05222 Small cell lung cancer
100173589 (PIK3R1)
05223 Non-small cell lung cancer
100173589 (PIK3R1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100173589 (PIK3R1)
05170 Human immunodeficiency virus 1 infection
100173589 (PIK3R1)
05161 Hepatitis B
100173589 (PIK3R1)
05160 Hepatitis C
100173589 (PIK3R1)
05171 Coronavirus disease - COVID-19
100173589 (PIK3R1)
05164 Influenza A
100173589 (PIK3R1)
05162 Measles
100173589 (PIK3R1)
05168 Herpes simplex virus 1 infection
100173589 (PIK3R1)
05163 Human cytomegalovirus infection
100173589 (PIK3R1)
05167 Kaposi sarcoma-associated herpesvirus infection
100173589 (PIK3R1)
05169 Epstein-Barr virus infection
100173589 (PIK3R1)
05165 Human papillomavirus infection
100173589 (PIK3R1)
09171 Infectious disease: bacterial
05135 Yersinia infection
100173589 (PIK3R1)
05100 Bacterial invasion of epithelial cells
100173589 (PIK3R1)
09174 Infectious disease: parasitic
05146 Amoebiasis
100173589 (PIK3R1)
05142 Chagas disease
100173589 (PIK3R1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100173589 (PIK3R1)
05017 Spinocerebellar ataxia
100173589 (PIK3R1)
05020 Prion disease
100173589 (PIK3R1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100173589 (PIK3R1)
05418 Fluid shear stress and atherosclerosis
100173589 (PIK3R1)
05415 Diabetic cardiomyopathy
100173589 (PIK3R1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100173589 (PIK3R1)
04932 Non-alcoholic fatty liver disease
100173589 (PIK3R1)
04931 Insulin resistance
100173589 (PIK3R1)
04933 AGE-RAGE signaling pathway in diabetic complications
100173589 (PIK3R1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100173589 (PIK3R1)
01524 Platinum drug resistance
100173589 (PIK3R1)
01522 Endocrine resistance
100173589 (PIK3R1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pon04131
]
100173589 (PIK3R1)
Membrane trafficking [BR:
pon04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
100173589 (PIK3R1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI3K_P85_iSH2
SH2
RhoGAP
SH3_1
SH3_2
Laminin_I
SH3_9
Nucleopor_Nup85
FANCI_S2
FWWh
Exonuc_VII_L
Transcrip_act
Bap31_Bap29_C
Motif
Other DBs
NCBI-GeneID:
100173589
NCBI-ProteinID:
NP_001126593
Ensembl:
ENSPPYG00000015520
UniProt:
Q5R685
LinkDB
All DBs
Position
5:66153014..66238406
Genome browser
AA seq
724 aa
AA seq
DB search
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QLAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTASVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq
2175 nt
NT seq
+upstream
nt +downstream
nt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagttagcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgattgatgtgcac
gttttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacactt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggtaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttacccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattgcatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccagatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaacctgaccttatccagctgagaaagacaagagaccaatac
ttgatgtggctgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacgtggaacgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga
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integrated database retrieval system
