KEGG   Pongo abelii (Sumatran orangutan): 100173589
Entry
100173589         CDS       T01416                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon01524  Platinum drug resistance
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04015  Rap1 signaling pathway
pon04024  cAMP signaling pathway
pon04062  Chemokine signaling pathway
pon04066  HIF-1 signaling pathway
pon04068  FoxO signaling pathway
pon04070  Phosphatidylinositol signaling system
pon04071  Sphingolipid signaling pathway
pon04072  Phospholipase D signaling pathway
pon04081  Hormone signaling
pon04140  Autophagy - animal
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04152  AMPK signaling pathway
pon04210  Apoptosis
pon04211  Longevity regulating pathway
pon04213  Longevity regulating pathway - multiple species
pon04218  Cellular senescence
pon04360  Axon guidance
pon04370  VEGF signaling pathway
pon04380  Osteoclast differentiation
pon04510  Focal adhesion
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04611  Platelet activation
pon04613  Neutrophil extracellular trap formation
pon04620  Toll-like receptor signaling pathway
pon04625  C-type lectin receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04650  Natural killer cell mediated cytotoxicity
pon04660  T cell receptor signaling pathway
pon04662  B cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04666  Fc gamma R-mediated phagocytosis
pon04668  TNF signaling pathway
pon04670  Leukocyte transendothelial migration
pon04722  Neurotrophin signaling pathway
pon04725  Cholinergic synapse
pon04750  Inflammatory mediator regulation of TRP channels
pon04810  Regulation of actin cytoskeleton
pon04910  Insulin signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04915  Estrogen signaling pathway
pon04917  Prolactin signaling pathway
pon04919  Thyroid hormone signaling pathway
pon04923  Regulation of lipolysis in adipocytes
pon04926  Relaxin signaling pathway
pon04929  GnRH secretion
pon04930  Type II diabetes mellitus
pon04931  Insulin resistance
pon04932  Non-alcoholic fatty liver disease
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04935  Growth hormone synthesis, secretion and action
pon04960  Aldosterone-regulated sodium reabsorption
pon04973  Carbohydrate digestion and absorption
pon05010  Alzheimer disease
pon05017  Spinocerebellar ataxia
pon05020  Prion disease
pon05100  Bacterial invasion of epithelial cells
pon05135  Yersinia infection
pon05142  Chagas disease
pon05146  Amoebiasis
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05162  Measles
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05168  Herpes simplex virus 1 infection
pon05169  Epstein-Barr virus infection
pon05170  Human immunodeficiency virus 1 infection
pon05171  Coronavirus disease - COVID-19
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05205  Proteoglycans in cancer
pon05206  MicroRNAs in cancer
pon05207  Chemical carcinogenesis - receptor activation
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05212  Pancreatic cancer
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05218  Melanoma
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05222  Small cell lung cancer
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
pon05230  Central carbon metabolism in cancer
pon05231  Choline metabolism in cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05415  Diabetic cardiomyopathy
pon05417  Lipid and atherosclerosis
pon05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100173589 (PIK3R1)
   04015 Rap1 signaling pathway
    100173589 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100173589 (PIK3R1)
   04668 TNF signaling pathway
    100173589 (PIK3R1)
   04066 HIF-1 signaling pathway
    100173589 (PIK3R1)
   04068 FoxO signaling pathway
    100173589 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100173589 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100173589 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100173589 (PIK3R1)
   04024 cAMP signaling pathway
    100173589 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100173589 (PIK3R1)
   04152 AMPK signaling pathway
    100173589 (PIK3R1)
   04150 mTOR signaling pathway
    100173589 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100173589 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100173589 (PIK3R1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100173589 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100173589 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    100173589 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100173589 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100173589 (PIK3R1)
   04660 T cell receptor signaling pathway
    100173589 (PIK3R1)
   04662 B cell receptor signaling pathway
    100173589 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100173589 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    100173589 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100173589 (PIK3R1)
   04062 Chemokine signaling pathway
    100173589 (PIK3R1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100173589 (PIK3R1)
   04929 GnRH secretion
    100173589 (PIK3R1)
   04915 Estrogen signaling pathway
    100173589 (PIK3R1)
   04917 Prolactin signaling pathway
    100173589 (PIK3R1)
   04926 Relaxin signaling pathway
    100173589 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100173589 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100173589 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100173589 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100173589 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100173589 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100173589 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100173589 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100173589 (PIK3R1)
   04380 Osteoclast differentiation
    100173589 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100173589 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100173589 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100173589 (PIK3R1)
   05206 MicroRNAs in cancer
    100173589 (PIK3R1)
   05205 Proteoglycans in cancer
    100173589 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    100173589 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100173589 (PIK3R1)
   05203 Viral carcinogenesis
    100173589 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100173589 (PIK3R1)
   05231 Choline metabolism in cancer
    100173589 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100173589 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100173589 (PIK3R1)
   05212 Pancreatic cancer
    100173589 (PIK3R1)
   05225 Hepatocellular carcinoma
    100173589 (PIK3R1)
   05226 Gastric cancer
    100173589 (PIK3R1)
   05214 Glioma
    100173589 (PIK3R1)
   05221 Acute myeloid leukemia
    100173589 (PIK3R1)
   05220 Chronic myeloid leukemia
    100173589 (PIK3R1)
   05218 Melanoma
    100173589 (PIK3R1)
   05211 Renal cell carcinoma
    100173589 (PIK3R1)
   05215 Prostate cancer
    100173589 (PIK3R1)
   05213 Endometrial cancer
    100173589 (PIK3R1)
   05224 Breast cancer
    100173589 (PIK3R1)
   05222 Small cell lung cancer
    100173589 (PIK3R1)
   05223 Non-small cell lung cancer
    100173589 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100173589 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100173589 (PIK3R1)
   05161 Hepatitis B
    100173589 (PIK3R1)
   05160 Hepatitis C
    100173589 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    100173589 (PIK3R1)
   05164 Influenza A
    100173589 (PIK3R1)
   05162 Measles
    100173589 (PIK3R1)
   05163 Human cytomegalovirus infection
    100173589 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100173589 (PIK3R1)
   05169 Epstein-Barr virus infection
    100173589 (PIK3R1)
   05165 Human papillomavirus infection
    100173589 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100173589 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100173589 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100173589 (PIK3R1)
   05142 Chagas disease
    100173589 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100173589 (PIK3R1)
   05017 Spinocerebellar ataxia
    100173589 (PIK3R1)
   05020 Prion disease
    100173589 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100173589 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    100173589 (PIK3R1)
   05415 Diabetic cardiomyopathy
    100173589 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100173589 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100173589 (PIK3R1)
   04931 Insulin resistance
    100173589 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100173589 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100173589 (PIK3R1)
   01524 Platinum drug resistance
    100173589 (PIK3R1)
   01522 Endocrine resistance
    100173589 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100173589 (PIK3R1)
Membrane trafficking [BR:pon04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100173589 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 Nucleopor_Nup85 FANCI_S2 FWWh Exonuc_VII_L
Other DBs
NCBI-GeneID: 100173589
NCBI-ProteinID: NP_001126593
Ensembl: ENSPPYG00000015520
UniProt: Q5R685
LinkDB
Position
4:77380536..77465983
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QLAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTASVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagttagcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgattgatgtgcac
gttttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacactt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggtaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttacccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattgcatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccagatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaacctgaccttatccagctgagaaagacaagagaccaatac
ttgatgtggctgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacgtggaacgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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