Pongo abelii (Sumatran orangutan): 100434557
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Entry
100434557 CDS
T01416
Symbol
AKR1C4
Name
(RefSeq) aldo-keto reductase family 1 member C4 isoform X1
KO
K00037
3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:
1.1.1.50
1.1.1.357
1.1.1.225
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00120
Primary bile acid biosynthesis
pon00140
Steroid hormone biosynthesis
pon01100
Metabolic pathways
pon05208
Chemical carcinogenesis - reactive oxygen species
Module
pon_M00104
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
pon_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09103 Lipid metabolism
00120 Primary bile acid biosynthesis
100434557 (AKR1C4)
00140 Steroid hormone biosynthesis
100434557 (AKR1C4)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
100434557 (AKR1C4)
Enzymes [BR:
pon01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
100434557 (AKR1C4)
1.1.1.225 chlordecone reductase
100434557 (AKR1C4)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
100434557 (AKR1C4)
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Gene cluster
GFIT
Motif
Pfam:
Aldo_ket_red
Motif
Other DBs
NCBI-GeneID:
100434557
NCBI-ProteinID:
XP_002820533
Ensembl:
ENSPPYG00000002053
UniProt:
A0A2J8S320
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All DBs
Position
8:5259395..5286127
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AA seq
323 aa
AA seq
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MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYDNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGEMLLPKDENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIALVAYSALGTQRHELWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYIVMDFLMDHPDYPFSDEY
NT seq
972 nt
NT seq
+upstream
nt +downstream
nt
atggatcccaaatatcagcgtgtggagctaaatgatggtcacttcatgccggtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtggaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacgataatgaggagcaa
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctcaagccaggtgagatgctactaccaaaagatgaaaatggaaaagtaatatttgac
acagtggatctctgtgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtccaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtggaatgccatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgctctggttgcctatagtgctctggga
acccaacgacatgaactatgggtggacccgaactccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaagcacaaacgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaac
atccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggcctaaac
agaaattatcgatatattgtcatggattttcttatggaccaccctgattatccattttca
gatgaatattag
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