Pongo abelii (Sumatran orangutan): 100436326 Help Entry 100436326         CDS       T01416                                  Symbol LCK Name (RefSeq) tyrosine-protein kinase Lck   KO K05856   lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04064   NF-kappa B signaling pathway pon04380   Osteoclast differentiation pon04517   IgSF CAM signaling pon04650   Natural killer cell mediated cytotoxicity pon04658   Th1 and Th2 cell differentiation pon04659   Th17 cell differentiation pon04660   T cell receptor signaling pathway pon05135   Yersinia infection pon05166   Human T-cell leukemia virus 1 infection pon05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pon05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     100436326 (LCK)   09133 Signaling molecules and interaction    04517 IgSF CAM signaling     100436326 (LCK)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     100436326 (LCK)    04660 T cell receptor signaling pathway     100436326 (LCK)    04658 Th1 and Th2 cell differentiation     100436326 (LCK)    04659 Th17 cell differentiation     100436326 (LCK)   09158 Development and regeneration    04380 Osteoclast differentiation     100436326 (LCK)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100436326 (LCK)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100436326 (LCK)   09171 Infectious disease: bacterial    05135 Yersinia infection     100436326 (LCK)   09163 Immune disease    05340 Primary immunodeficiency     100436326 (LCK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100436326 (LCK)   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:pon03036]     100436326 (LCK) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      100436326 (LCK) Protein kinases [BR:pon01001]  Non-receptor tyrosine kinases   SRC family    100436326 (LCK) Chromosome and associated proteins [BR:pon03036]  Eukaryotic type   Centrosome formation proteins    Kinases and associated factors     100436326 (LCK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 SH2_1 Haspin_kinase SH3_16 SH3_3 Motif Other DBs NCBI-GeneID:  100436326 NCBI-ProteinID:  XP_054411597 Ensembl:  ENSPPYG00000001596 LinkDB All DBs Position 1:complement(201287336..201321887) Genome browser AA seq 509 aa AA seqDB search MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGKLPIRNGSEVRDPLVTYEGSNPPASP LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH YKIRNLDNGGFYISPRITFSGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV PRETLKLVERLGAGQFGEVWMGFYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVCPDNCPEELYQLMRLCWKER PEDRPTFDYLRSVLEDFFTATEGQYQPQP NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggctgtggctgcagctcacacccggaagatgactggatggaaaacattgatgtgtgt gagaactgccattatcccatagtcccactggatggcaagggcaagctgcccatccgaaat ggctctgaggtgcgggacccactggttacctacgaaggctccaatccaccggcttcccca ctgcaagacaacctggttatcgccctgcacagctatgagccctctcacgacggagacctg ggctttgagaagggggaacagctccgcatcctggagcagagcggcgagtggtggaaggcg cagtccctgaccacgggtcaggaaggcttcatccccttcaattttgtggccaaagcgaac agcctggagcccgaaccctggttcttcaagaaccttagccgcaaggacgcggagcggcag ctcctggcgcccgggaacactcacggctccttcctcatccgggagagcgagagcaccgcg ggatcgttttcactgtcggtccgggacttcgaccagaaccagggagaggtggtgaaacat tacaagatccgtaatctggacaacggtggcttctacatctccccccgaatcactttttcc ggcctgcatgaactggtccgccattacaccaatgcttcagatgggctctgtacacggttg agccgcccctgccagacccagaagccccagaagccgtggtgggaggacgagtgggaggtt cccagggagacgctgaagctggtggagcggctgggggctggacagttcggggaggtgtgg atggggttctacaacgggcacacgaaggtggcggtgaagagcctgaagcagggcagcatg tccccggacgccttcctggccgaggccaacctcatgaagcagctgcaacaccagcggctg gttcggctctacgctgtggtcacccaggagcccatctacatcatcactgaatacatggag aacgggagtctagtggattttctcaagaccccttcaggcatcaagttgaccatcaacaaa ctcctggacatggcagcccaaattgcagaaggcatggcattcattgaagagcggaattat attcatcgtgaccttcgggctgccaacattctggtgtctgacaccctgagctgcaagatt gcagactttggcctagcacgcctcattgaggacaacgagtacacagctagggagggggcc aagtttcccattaagtggacagcaccagaagccattaactatgggacattcaccatcaag tcggatgtgtggtcttttgggatcctgctgacggaaattgtcacccatggccgcatccct tacccagggatgaccaacccggaggtgattcagaacctggagcgaggctaccgcatggtg tgccctgacaactgtccagaggagctgtaccaactcatgaggctgtgctggaaggagcgc ccagaggaccggcccacctttgactacctgcgcagtgtgctggaggacttcttcacggcc acagagggccagtaccagcctcagccttga

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