KEGG   Pongo abelii (Sumatran orangutan): 100437617
Entry
100437617         CDS       T01416                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon01524  Platinum drug resistance
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04015  Rap1 signaling pathway
pon04024  cAMP signaling pathway
pon04062  Chemokine signaling pathway
pon04066  HIF-1 signaling pathway
pon04068  FoxO signaling pathway
pon04070  Phosphatidylinositol signaling system
pon04071  Sphingolipid signaling pathway
pon04072  Phospholipase D signaling pathway
pon04081  Hormone signaling
pon04140  Autophagy - animal
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04152  AMPK signaling pathway
pon04210  Apoptosis
pon04211  Longevity regulating pathway
pon04213  Longevity regulating pathway - multiple species
pon04218  Cellular senescence
pon04360  Axon guidance
pon04370  VEGF signaling pathway
pon04380  Osteoclast differentiation
pon04510  Focal adhesion
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04611  Platelet activation
pon04613  Neutrophil extracellular trap formation
pon04620  Toll-like receptor signaling pathway
pon04625  C-type lectin receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04650  Natural killer cell mediated cytotoxicity
pon04660  T cell receptor signaling pathway
pon04662  B cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04666  Fc gamma R-mediated phagocytosis
pon04668  TNF signaling pathway
pon04670  Leukocyte transendothelial migration
pon04722  Neurotrophin signaling pathway
pon04725  Cholinergic synapse
pon04750  Inflammatory mediator regulation of TRP channels
pon04810  Regulation of actin cytoskeleton
pon04910  Insulin signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04915  Estrogen signaling pathway
pon04917  Prolactin signaling pathway
pon04919  Thyroid hormone signaling pathway
pon04923  Regulation of lipolysis in adipocytes
pon04926  Relaxin signaling pathway
pon04929  GnRH secretion
pon04930  Type II diabetes mellitus
pon04931  Insulin resistance
pon04932  Non-alcoholic fatty liver disease
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04935  Growth hormone synthesis, secretion and action
pon04960  Aldosterone-regulated sodium reabsorption
pon04973  Carbohydrate digestion and absorption
pon05010  Alzheimer disease
pon05017  Spinocerebellar ataxia
pon05020  Prion disease
pon05100  Bacterial invasion of epithelial cells
pon05135  Yersinia infection
pon05142  Chagas disease
pon05146  Amoebiasis
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05162  Measles
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05166  Human T-cell leukemia virus 1 infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05168  Herpes simplex virus 1 infection
pon05169  Epstein-Barr virus infection
pon05170  Human immunodeficiency virus 1 infection
pon05171  Coronavirus disease - COVID-19
pon05200  Pathways in cancer
pon05203  Viral carcinogenesis
pon05205  Proteoglycans in cancer
pon05206  MicroRNAs in cancer
pon05207  Chemical carcinogenesis - receptor activation
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05212  Pancreatic cancer
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05218  Melanoma
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05222  Small cell lung cancer
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
pon05230  Central carbon metabolism in cancer
pon05231  Choline metabolism in cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05415  Diabetic cardiomyopathy
pon05417  Lipid and atherosclerosis
pon05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100437617 (PIK3R2)
   04014 Ras signaling pathway
    100437617 (PIK3R2)
   04015 Rap1 signaling pathway
    100437617 (PIK3R2)
   04370 VEGF signaling pathway
    100437617 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100437617 (PIK3R2)
   04668 TNF signaling pathway
    100437617 (PIK3R2)
   04066 HIF-1 signaling pathway
    100437617 (PIK3R2)
   04068 FoxO signaling pathway
    100437617 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100437617 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100437617 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100437617 (PIK3R2)
   04024 cAMP signaling pathway
    100437617 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100437617 (PIK3R2)
   04152 AMPK signaling pathway
    100437617 (PIK3R2)
   04150 mTOR signaling pathway
    100437617 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100437617 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100437617 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    100437617 (PIK3R2)
   04218 Cellular senescence
    100437617 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100437617 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100437617 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100437617 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100437617 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    100437617 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100437617 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    100437617 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100437617 (PIK3R2)
   04660 T cell receptor signaling pathway
    100437617 (PIK3R2)
   04662 B cell receptor signaling pathway
    100437617 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100437617 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100437617 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100437617 (PIK3R2)
   04062 Chemokine signaling pathway
    100437617 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100437617 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    100437617 (PIK3R2)
   04929 GnRH secretion
    100437617 (PIK3R2)
   04915 Estrogen signaling pathway
    100437617 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    100437617 (PIK3R2)
   04917 Prolactin signaling pathway
    100437617 (PIK3R2)
   04926 Relaxin signaling pathway
    100437617 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100437617 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100437617 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100437617 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100437617 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100437617 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100437617 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100437617 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100437617 (PIK3R2)
   04380 Osteoclast differentiation
    100437617 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100437617 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100437617 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100437617 (PIK3R2)
   05206 MicroRNAs in cancer
    100437617 (PIK3R2)
   05205 Proteoglycans in cancer
    100437617 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    100437617 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100437617 (PIK3R2)
   05203 Viral carcinogenesis
    100437617 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100437617 (PIK3R2)
   05231 Choline metabolism in cancer
    100437617 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100437617 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100437617 (PIK3R2)
   05212 Pancreatic cancer
    100437617 (PIK3R2)
   05225 Hepatocellular carcinoma
    100437617 (PIK3R2)
   05226 Gastric cancer
    100437617 (PIK3R2)
   05214 Glioma
    100437617 (PIK3R2)
   05221 Acute myeloid leukemia
    100437617 (PIK3R2)
   05220 Chronic myeloid leukemia
    100437617 (PIK3R2)
   05218 Melanoma
    100437617 (PIK3R2)
   05211 Renal cell carcinoma
    100437617 (PIK3R2)
   05215 Prostate cancer
    100437617 (PIK3R2)
   05213 Endometrial cancer
    100437617 (PIK3R2)
   05224 Breast cancer
    100437617 (PIK3R2)
   05222 Small cell lung cancer
    100437617 (PIK3R2)
   05223 Non-small cell lung cancer
    100437617 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100437617 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100437617 (PIK3R2)
   05161 Hepatitis B
    100437617 (PIK3R2)
   05160 Hepatitis C
    100437617 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100437617 (PIK3R2)
   05164 Influenza A
    100437617 (PIK3R2)
   05162 Measles
    100437617 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    100437617 (PIK3R2)
   05163 Human cytomegalovirus infection
    100437617 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100437617 (PIK3R2)
   05169 Epstein-Barr virus infection
    100437617 (PIK3R2)
   05165 Human papillomavirus infection
    100437617 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100437617 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100437617 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100437617 (PIK3R2)
   05142 Chagas disease
    100437617 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100437617 (PIK3R2)
   05017 Spinocerebellar ataxia
    100437617 (PIK3R2)
   05020 Prion disease
    100437617 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100437617 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    100437617 (PIK3R2)
   05415 Diabetic cardiomyopathy
    100437617 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100437617 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100437617 (PIK3R2)
   04931 Insulin resistance
    100437617 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100437617 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100437617 (PIK3R2)
   01524 Platinum drug resistance
    100437617 (PIK3R2)
   01522 Endocrine resistance
    100437617 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100437617 (PIK3R2)
Membrane trafficking [BR:pon04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100437617 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 100437617
NCBI-ProteinID: XP_024094201
Ensembl: ENSPPYG00000009731
UniProt: A0A2J8T613
LinkDB
Position
20:18376450..18393812
AA seq 727 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDAAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPA
LPPKPPKAKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKI
QGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRL
LYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAI
EAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTK
LEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNET
EDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV
DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGP
GPPPAAR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggca
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aatgagcgcacacggcagcgaggtgacttccctggcacctacgtggagttcctagggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcctgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacgcggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcgggacccgtggggccggcgctggagccaccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
tcctcgccgccgccagggggcgctcccgacgggagtgagcccagccctgacttcccggcg
ctgctggtggagaagctgcttcaggagcacttggaagagcaggaggttgcacccccagcg
ctgccgcctaaaccccccaaggcaaagccggcccctacaggcctggccaatggagggagc
ccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtgaac
gagaaactccgggacactcctgatggcaccttcctagtccgagatgcttctagcaagatc
cagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtcttc
caccgagatgggcactatggcttctcagagccactcaccttctgctccgttgtggacctc
atcaatcactaccgccacgagtcgctggcccagtacaacgccaagctggacacacggctc
ctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggacagcgtggaggcg
gtgggcgcccagcttaaggtctatcaccagcagtaccaggacaagagccgcgagtatgac
cagctctatgaagagtacacacgaacctcccaggagctgcagatgaagcgtaccgcaatt
gaggccttcaatgagactatcaagatcttcgaagagcagggccagactcaagagaagtgc
agcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcagaggatc
ctgctgaactccgagcggctcaagtcccgcattgccgagatccacgagagccgcacgaag
ctggagcagcagctgcgggcccaggcctcggacaaccgggagatcgacaagcgcatgaac
agcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctc
acccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgagact
gaggaccagtacgcactgatggaggacgaggacgatctcccgcaccacgaggaacgcact
tggtacgtgggcaagatcaaccgcacgcaggcagaggagatgctgagcggcaagcgggat
ggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtggtagtg
gacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggag
ccctacaacctgtatgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctc
gtgcagcacaacgacgcactcaccgtcaccctggcgcacccagtgcgcgccccgggcccc
ggcccgccgcctgccgcccgctga

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