Pongo abelii (Sumatran orangutan): 100447042 Help Entry 100447042         CDS       T01416                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04020   Calcium signaling pathway pon04371   Apelin signaling pathway pon04713   Circadian entrainment pon04730   Long-term depression pon04921   Oxytocin signaling pathway pon05017   Spinocerebellar ataxia pon05020   Prion disease pon05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100447042 (RYR1)    04020 Calcium signaling pathway     100447042 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100447042 (RYR1)   09156 Nervous system    04730 Long-term depression     100447042 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     100447042 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     100447042 (RYR1)    05020 Prion disease     100447042 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     100447042 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pon01009]     100447042 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pon04147]     100447042 (RYR1)    04040 Ion channels [BR:pon04040]     100447042 (RYR1) Protein phosphatases and associated proteins [BR:pon01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100447042 (RYR1) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100447042 (RYR1) Ion channels [BR:pon04040]  Voltage-gated cation channels   Ryanodine receptor    100447042 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  100447042 NCBI-ProteinID:  XP_054396335 Ensembl:  ENSPPYG00000009936 LinkDB All DBs Position 20:44044562..44193217 Genome browser AA seq 4975 aa AA seqDB search MLTGEKNVPPDLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLR HAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDII LVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDEC LTISPADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGRY LALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQH VASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGL YNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRS LRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLI RGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLL DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFV GRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDD LYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFES FNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYR REGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQG WTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNL KKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAV QDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWD RVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQ RWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLP VCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPL EHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPL APPGLQPPAEDEARAAEPDPDYENLRRSAGGWGEAENGKEGTAKEGAPGGTPQAGGEAQP ARAENEKDATTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNT TTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCS NCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFP AVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPN HFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLY RAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSM LSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAA GAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLL VMGIFGDEDVKQILKMIEPEVFTEEEEEEEEEEEEDEEEDEEEKEEDEEETAQEKEDEEK EEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDK LQANQRSRYGLLIKSFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIR QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEE SKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSS VEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVM EVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQ GSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGG ERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISE DPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKG EALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDR VYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPL FAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVF DVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAH KKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIP EKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWP IKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLS RELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLK FLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEK SPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAA LVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVE NLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRT LCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERA ILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERG PEAPPPALPAGTPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSR ARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYAL YPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMS FLTADNKSKMAKSGGSDQERTKKKRRGDRYSVRTSLIVATLKKMLPIGLNMCAPTDQDLI TLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIV RRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMF LESYKAAWILTEDHSFEDRMIDDLSKAGEPEEEEEEVEEKKPDPLHQLVLHFSRTALTEK SKLDEDYLYMAYADIMAKSCHLEEGGENGEGEEEVEVSFEEKEMEKQRLLYQQARLHTRG AAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQA LMQTCSVLDLNAFERQNKAEGLGMVNEDGTGEKVMADDEFTQDLFRFLQLLCEGHNNDFQ NYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQ VFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQ KDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDY VTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIG FNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISET NRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPET DEDEGAAEAGAEGVEEGAAGPEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLR RLTAREAATAVAALLWAAVTRAGAAGAGAAAGAVGLLWGSLFGGGLVEGAKKVTVTELLA GMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVT DGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPELEPEK ADAENGEKEEVPEPPPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTL RFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGGSGWGLGAGEEAEGD EDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLE FDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLG MDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLG HYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKF YNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFF FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEE HNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 14928 nt NT seq  +upstreamnt  +downstreamnt atgctgacaggagagaaaaatgtgcctcccgatctggccatctgttgcttcgtcctggag cagtccctgtctgtacgagccctgcaggagatgctggccaacacggtggaggctggcgtg gagtcatcccagggcgggggacacaggacgctcctgtatggccatgctatcctgctccgg catgcacacagccgcatgtatctgagctgcctcaccacctcccgctccatgactgacaag ctggccttcgatgttggactgcaggaggacgcaacaggagaggcttgctggtggactatg cacccagcctccaagcagaggtctgaaggagaaaaggtccgcgttggggatgacatcatc cttgtcagtgtctcctccgagcgctacctgcacctgtcgaccgccagtggggagctccag gttgatgcttccttcatgcagacactgtggaacatgaaccccatctgctcccgctgcgaa gagggcttcgtgacgggaggtcacgtcctccgcctctttcatggacatatggatgagtgt ctgaccatttcccctgctgacagtgatgaccagcgcagacttgtctactatgagggggga gctgtgtgcacccacgcccgctccctctggagactggagccactgagaatcagctggagt gggagccacctgcgctggggccagccactccgagtccggcatgtcaccaccgggcggtac ctagcgctcactgaggaccagggcctggtggtggttgacgccagcaaggcccacaccaag gctacctccttctgcttccgcatctccaaggagaagctggatgtggcccccaagcgggat gtggagggcatgggcccccctgagatcaagtacggggagtcactgtgctttgtgcagcat gtggcctcaggactgtggctcacctatgccgccccagaccccaaggccctgcggctcggc gtgctcaagaagaaggccatgctgcaccaggagggccacatggacgacgcactgtcgctg acccgctgccagcaggaggagtcccaggccgcccgcatgatccacagcaccaatggccta tacaaccagttcatcaagagcctggacagcttcagcgggaagccacggggctcagggccg ccggctggcacagcgctgcccatcgagggcgttatcctgagcctgcaggacctcatcatc tacttcgagcctccctccgaggacttgcagcacgaggagaagcagagcaagctgcgaagc ctgcgcaaccgccagagcctcttccaggaggaggggatgctctccatggtcctgaattgc attgaccgcctaaatgtctacaccactgctgcccactttgccgagtttgcaggggaggag gcagctgagtcctggaaagagattgtgaatcttctctatgaactcctagcttctctaatc cgtggcaatcgtagcaactgtgccctcttctccacaaacttggactggctggtcagcaag ctggatcggctggaggcctcatctggcatcctggaggtcctgtactgtgtcctcattgag agtccagaggttctgaacatcatccaggagaatcacatcaagtccatcatctccctcctg gacaagcatgggaggaaccacaaggtcctggacgtgctatgctccctgtgtgtgtgtaat ggtgtggctgtacgctccaaccaagatcttattactgagaacttgctgcctggccgtgag cttctgctgcagacaaacctcatcaactatgtcaccagcatccgccccaacatctttgtg ggccgagcggaaggcaccacgcagtacagcaaatggtactttgaggtgatggtggacgag gtgactccatttctgacagctcaggccacccacttgcgggtgggctgggccctcaccgag ggctacagcccctaccctgggggcggcgagggctggggcggcaacggggtcggcgatgac ctctattcctacggctttgatggactgcatctctggacaggacacgtggcacgcccagtg acttccccagggcagcacctcctggcccctgaagacgtgatcagctgctgcctggacctc agcgtgccgtccatctccttccgcatcaacggctgccccgtgcagggcgtctttgaatcc ttcaacctggacgggctcttcttccctgttgtcagcttctcggctggtgtcaaggtgcgg ttcctccttggtggccgccatggtgaattcaagttcctgcccccacctggctatgcccca tgccatgaggctgtgctccctcgagagcgactccatcttgaacccatcaaggagtatcga cgggaggggccccgggggcctcacctggtgggccccagtcgctgcctctcacacaccgat ttcgtgccctgccctgtggacactgtccagatcgtcctgccgccccatctggagcgcatt cgggagaagctggcggagaacatccatgagctctgggcactaacccgcatcgagcagggc tggacctatggcccggttcgggatgacaataagaggctgcacccgtgtcttgtggacttc cacagccttccagagcctgagaggaactacaacctgcagatgtctggggagacgctcaag actctgctggctctgggctgccacgtgggcatggcagatgagaaggcggaggacaacctg aagaagacaaaactccccaagacgtatatgatgagcaatgggtacaagccggctccgctg gacctgagccatgtgcggctgacgccggcgcagacgacactggtggaccgtctggcagaa aatgggcacaacgtatgggcccgagaccgtgtgggccagggctggagctacagcgcggtg caggacatcccagcgcgccgaaaccctcgactggtgccctaccgcctgctggatgaggcc accaagcgcagcaaccgggacagcctctgccaggccgtgcgcaccctcctgggctacggc tacaacattgagcctcctgaccaggagcccagtcaggtggagaatcagtctcgttgggac cgggtgcgcatcttccgggcagagaaatcctatgcagtgcaaagtggccgctggtacttc gagtttgaagcagtcaccacaggcgagatgcgagtgggctgggcgaggcccgagctgagg cctgatgtagagctgggagctgacgaactggcctatgtcttcaatgggcaccgcggccag cgctggcacttgggcagtgaaccatttgggcgcccctggcagccgggcgatgtcgttggc tgtatgatcgacctcacagagaacaccattatcttcaccctcaatggcgaggtcctcatg tctgactcaggctccgaaacagccttccgggagattgagatcggggacggcttcctgccc gtctgcagcttgggacctggccaggtgggtcatctgaacctgggccaggacgtgagctct ctgaggttcttcgccatctgtggcctccaggaaggctttgagccatttgccatcaacatg cagcgcccagtcaccacctggttcagcaaaggcctgccccagtttgagccagtgcccctt gaacaccctcactatgaggtatcccgagtggacggcactgtggacacgcccccctgcctg cgcctgacccaccgcacctggggctcccagaacagcctggtggagatgctcttcctgcgg ctgagcctcccagtccagttccaccagcacttccgctgcactgcaggggccaccccgttg gcacctcctggcctgcagcccccggccgaggatgaggcccgggcagcggaacccgaccct gactacgaaaacctgcgccgctcagctgggggctggggcgaggccgagaacggcaaagaa gggactgcgaaggagggcgcccccggaggcaccccgcaggcagggggagaggcgcagccc gccagggcggagaatgagaaggacgccaccaccgagaagaacaagaagagaggcttccta ttcaaggccaagaaggtcgccatgatgacccaaccaccggccacccccacgctgccccga ctccctcacgacgtggtgcctgcagacaaccgcgatgaccccgagatcatcctcaacacc accacgtactattactccgtgagggtctttgccggacaggagcccagttgcgtgtgggtg ggctgggtcacccctgactaccatcagcatgacatgagcttcgacctcagcaaggtccgg gtcgtgacggtgaccatgggggatgaacaaggcaacgtccacagcagcctcaagtgcagc aactgctacatggtgtggggcggggactttgtgagtcccgggcagcagggccggatcagc cacacagaccttgtcattgggtgcctggtggacttggccactggcttaatgacctttaca gccaatggcaaagagagcaacacctttttccaggtggaacccaacacaaaactatttcct gccgtcttcgtcctgcccacccaccagaacgtcatccagtttgagctggggaagcagaag aacatcatgccgttgtcagccgccatgttccaaagcgagcgcaagaacccggccccgcag tgcccaccgcggctggagatgcagatgctgatgccagtgtcctggagccgcatgcccaac cacttcctgcaggtggagacgaggcgtgccggcgagcgtctgggctgggccgtgcagtgc caggagccgctgaccatgatggcgctgcacatccccgaggagaaccggtgcatggacatc ctggagctgtcggagcgcctggacctgcagcgcttccactcgcacaccctgcgcctctac cgcgctgtgtgcgccctgggcaacaatcgcgtggcgcacgctctgtgcagccacgtagac caggctcagctgctgcacgccctggaggacgcgcacctgccaggcccactgcgcgcaggc tactatgacctcctcatcagcatccacctcgaaagtgcctgccgcagccgccgctccatg ctttctgaatacatcgtgcccctcacgcctgagacccgcgccatcacgctcttccctcct ggaaggagcacagaaaatggtcacccccggcatggcctgccgggagttggagtcaccact tcgctgaggcccccgcatcatttctcgcccccctgtttcgtggccgctctgccagctgct ggggcagcagaggccccggcccgcctcagccccgccatcccgctggaggccctgcgggac aaggcactgaggatgctgggggaggcggtgcgcgacggtgggcagcacgctcgcgacccc gtcgggggctccgtggagttccagtttgtgcctgtgctcaagcttgtgtccaccctgctg gtgatgggcatcttcggcgatgaggatgtgaaacagatcttgaagatgattgagcctgaa gtcttcactgaggaagaagaggaggaggaggaggaagaggaagaggatgaagaggaagat gaggaggagaaggaggaggatgaggaggaaacagcacaggaaaaggaagatgaggaaaaa gaggaagaggaggcagcagaaggggagaaagaagaaggcttggaggaagggctgctccag atgaagttgccagagtctgtgaagttacagatgtgccacctgctggagtatttctgtgac caagagctgcagcaccgtgtggagtccctggcagcctttgcggagcgctatgtggacaag ctccaggccaaccagcggagccgctatggcctcctcataaaatccttcagcatgaccgca gcagagactgcaagacgcacccgcgagttccgctccccaccccaggaacagatcaatatg ctattgcaattcaaagatggtacagatgaggaagactgtcctctccctgaagagattcga caggatttgcttgactttcatcaagacctgctggcacactgtggaattcagctggatgga gaggaggaggaaccagaggaagagaccaccctgggcagccgcctcatgagcctgttggag aaagtgcggctggtgaagaagaaggaagagaaacctgaggaggagcggtcagcagaagag agcaaaccccggtccttgcaggagctggtgtcccacatggtggtgcgctgggcccaagag gacttcgtgcagagccctgagctggtgcgggccatgttcagcctcctgcaccggcagtac gacgggctgggtgagttgctgcgtgccctgccgcgggcgtacaccatctcgccatcctct gtggaagacaccatgagcctgctcgagtgcctcggccagatccgctcgctgctcatcgtg cagatgggcccccaggaggagaacctcatgatccagagcatcgggaacatcatgaacaac aaagtcttctaccaacacccgaacctgatgagggcgctgggcatgcacgagacagtcatg gaggttatggtcaacgtcctcgggggcggcgagtccaaggagatccgcttccccaagatg gtgacaagctgctgccgcttcctctgctatttctgccgcatcagccggcagaaccagcgc tccatgtttgaccacctgagctacctgctggagaacagtggcatcggcctgggcatgcag ggctccacgcccctggacgtggctgctgcctccgtcattgacaacaatgagctggccctg gcattgcaggagcaggacctggaaaaggttgtgtcctacctggcaggctgtggcctccag agctgccccatgcttgtggccaaagggtacccagacattggctggaacccctgtggtgga gagcgctacctggacttcctgcgcttcgctgtcttcgtcaacggcgagagcgtggaggag aacgccaatgtggtggtgcggctgctcatccggaagcctgagtgcttcggacccgccctg cggggtgagggtggctcagggctgctggctgccatcgaagaggccatccgcatctccgag gaccctgcgagggatggcccaggcatccgcagggaccggcggcgcgagcactttggtgag gaaccgcctgaagaaaaccgggtgcacctgggacacgccatcatgtccttctatgccgcc ttgatcgacctgctcggacgctgtgcgccagagatgcatctaatccaagccggcaagggt gaggccctgcggatccgcgccatcctccgctcccttgtgcccttggaggaccttgtgggc atcatcagcctcccactgcagattcccaccctgggcaaagacggggctctggtgcagcca aagatgtcggcatccttcgtgccggaccacaaggcgtccatggtgcttttcctggaccgt gtatatggcatcgagaaccaggacttcttgctgcacgtgctggacgtggggttcctgccc gacatgagggcagccgcctcgctggacacggccactttcagcaccaccgagatggcgctg gcgctgaaccgctacctgtgcctggccgtgctgccgctcatcaccaagtgtgcgccgctc tttgcgggcacagaacaccgcgccatcatggtggactctatgctgcataccgtgtaccgc ctgtctcggggtcgttcgctcaccaaggcgcagcgtgacgtcatcgaggactgcctcatg tcgctctgcaggtacatccggccgtcgatgctgcagcacctgctgcggcgcctggtgttc gacgtgcccatcctcaacgagttcgccaagatgccactcaagctcctcaccaaccactat gagcgctgttggaagtactactgcctacccacaggctgggccaacttcggggtcacctcg gaggaggagctgcacctcacgcggaaactcttctggggcatctttgactctctggcccat aagaaatacgacccggagctttaccgcatggccatgccttgtctgtgcgccatcgctggg gctctgccccccgactatgtggatgcctcatactcatctaaagcagagaaaaaggccaca gtggatgctgaaggcaactttgatccccggcctgtggagaccctcaatgtgatcatcccg gagaagctggactccttcattaacaagtttgcagagtacacacatgagaagtgggccttc gacaagatccagaacaactggtcctatggagagaacatagatgaggagctgaagacccac cccatgctgaggccctacaagaccttttcagagaaggacaaagagatttaccgctggccc atcaaggagtccctgaaggccatgattgcctgggaatggacaatagagaaggccagggag ggtgaggaggagaagacggaaaagaaaaaaacgaggaagatatcacaaagtgcccagacc tacgatcctcgagaaggctacaaccctcagccccccgaccttagcgctgttacgctgtcc cgggagctgcaggccatggcagaacaactggcagaaaattaccacaacacttggggacgg aagaagaagcaggagctggaagccaaaggtggtgggacccaccccttgctggtcccctac gacacgctcacggccaaggagaaggcacgagatcgagagaaggcccaggagctgctgaaa ttcctgcagatgaatggctacgcggttacaagaggccttaaggacatggaactggactcg tcttccattgaaaagcggtttgcctttggcttcctgcagcagctgctgcgctggatggac atttctcaggagttcattgcccacctggaggctgtggtcagcagtgggcgagtggaaaag tccccacatgaacaggagattaaattctttgccaagatcctgctccctttgatcaaccag tacttcaccaaccactgcctctatttcttgtccactccggctaaagtgctgggcagtggc ggccacgcctccaacaaggagaaggaaatgatcaccagcctcttctgcaaacttgctgct cttgtccgccaccgagtctctctctttgggacggacgccccggctgtggtcaactgtctt cacatcttggcccgttccctggatgccaggacagtgatgaagtcaggccctgagatcgtg aaggctggcctccgctccttctttgagagtgcctcggaggacatcgagaagatggtggag aacctgcggctgggcaaggtgtcgcaggcgcgcacccaggtgaaaggcgtgggccagaac ctcacctacaccaccgtggcgctgctgccggtcctcaccaccctcttccagcacatcgcc cagcaccagttcggagatgacgtcatcctggacgacgtccaggtctcttgctaccgaacg ctgtgcagtatctactccctgggaaccaccaagaacacttatgtggaaaagcttcggcca gccctcggggagtgcctggcccgtctggcagcagccatgccagtggcgttcctggagccg cagctgaacgagtacaacgcctgctccgtgtacaccaccaagtctccgcgggagcgggcc atcctggggctccccaacagcgtggaggagatgtgtcccgacatcccggtgctggagcgg ctcatggcagacatcggggggctggctgagtcaggagcccgctacacagagatgccgcat gtcatcgagatcacgctgcccatgctatgcagctacctgccccgatggtgggagcgcggg cccgaggcaccccctcccgccctgcccgccggcacccccccaccctgcacagctgtcacc tctgaccacctcaactccctgctggggaatatcctgagaatcatcgtcaacaacctgggc attgatgaggcctcctggatgaagcgactggctgtgttcgcacagcccatcgtgagccgt gcacggccggagctcctgcagtcccacttcataccaactattgggcggctgcgcaagagg gcagggaaggtggtgtccgaggaggagcagctgcgcctggaggccaaggctgaggcccag gagggcgagctgctggtgcgggacgagttctccgtgctctgccgggacctgtacgccctg tatccactgctcatccgctatgtggacaacaacagggcgcagtggctgacggagccgaat cccagcgcagaggagctgttcaggatggtgggcgagatcttcatctactggtccaagtcc cacaacttcaagcgcgaggagcagaactttgtggtccagaacgagatcaacaacatgtcc ttcctgactgctgacaacaagagcaaaatggctaagtccggtggctcggaccaggaacgc accaagaagaagcgccggggggaccggtactctgtgcggacgtcactgatcgtggccaca ctaaagaagatgctgcccatcggcctgaatatgtgtgcgcccaccgaccaagacctcatc acgctggccaagacccgctacgccctgaaagacacagatgaggaggtccgggaatttctg cacaacaaccttcaccttcagggaaaggtcgaaggctccccgtctctgcgctggcagatg gccctgtaccggggcgtcccgggtcgcgaggaggacgccgatgaccccgagaaaattgtg cgcagagtccaggaagtgtcagccgtgctctactacctggaccagaccgagcacccttac aagtctaagaaggccgtgtggcacaagcttttgtccaagcagcgccggcgggcagtagtg gcctgtttccgtatgacgcccctgtacaacctgcccacgcaccgggcatgtaacatgttc ctggagagctacaaggctgcatggatcctgactgaagaccacagttttgaggaccgcatg atagatgacctttcaaaagctggggagccggaggaggaggaggaagaggtggaagagaag aagccagaccccctgcaccaattggtcctgcacttcagccgcactgccctgacggaaaag agcaaactggacgaggattacctgtacatggcctatgccgatatcatggcaaagagctgc cacctggaggagggaggggagaacggcgaaggtgaagaggaggttgaggtctcttttgag gagaaagagatggagaagcagaggctcttgtaccagcaagcacggctgcacacccgggga gcggccgagatggtgctgcagatgatcagtgcctgcaaaggagagacaggtgccatggtg tcctccaccctgaagctgggcatctccatcctcaatggaggcaatgctgaggtccagcag aaaatgctggattatcttaaggacaagaaggaagttggcttcttccagagtatccaggca ctgatgcaaacatgcagcgtcctggatctcaatgcctttgagagacagaacaaggccgag gggctgggcatggtgaacgaggatggcactggagagaaggtcatggcggatgatgaattc acacaagacctgttccgattcctacaattgctctgtgaggggcacaataatgatttccag aactacctacggacacagacagggaacacgaccactattaacatcatcatttgcactgtg gactacctcctgcggctgcaggaatccatcagcgacttctactggtactactcgggcaag gatgtcattgaagagcagggcaagaggaacttctccaaagccatgtcggtggctaagcag gtgttcaacagcctcactgagtacatccagggtccctgcaccgggaaccagcagagcctg gcgcacagccgcctatgggacgcagtggtgggattcctgcacgtgttcgcccacatgatg atgaagctcgctcaggactcaagccagatcgagctgctgaaggagctgctggatctgcag aaggacatggtggtgatgttgctgtcgctactagaagggaacgtggtgaatggcatgatc gcccggcagatggtggacatgctcgtggaatcctcatccaacgtggagatgatcctcaag ttcttcgacatgttcctgaaactcaaggacattgtgggctctgaagcgttccaggactac gtaacggatccccgtggcctcatctccaagaaggacttccagaaggccatggacagccag aagcagttcagcggtccagaaatccagttcctgctttcgtgctccgaagcggatgagaac gaaatgatcaactgcgaggagttcgccaaccgcttccaggagccagcacgcgacatcggc ttcaacgtggcggtgctgctgaccaacctgtcggagcatgtgccgcatgaccctcgcctg cacaacttcctggagctggccgagagcatccttgagtacttccgcccctacctgggccgc atcgagatcatgggcgcctcgcgccgcatcgagcgcatctacttcgagatctcagagacc aaccgcgcccagtgggagatgccccaggtgaaggagtccaagcgccagttcatcttcgac gtggtgaacgagggcggcgaggctgagaagatggagctcttcgtgagtttctgcgaggac accatcttcgagatgcagatagccgcgcagatctcggagcccgagggcgagccggagacc gacgaggacgagggcgcggcggaggcgggcgcggagggcgtggaggagggcgcggcgggg cccgagggcacggcggccacggcggcagcgggggcgacggcgcgggtggtggcggccgca ggccgggccctgcgcggcctcagctaccgcagcctccggcggcgcgtgcggcggctgcgc cggctcacggcccgcgaggcggccaccgcggtggcggcgctgctctgggcagcagtgacg cgcgctggggccgctggcgcgggggcggcggcgggcgcggtgggcctgctctggggctcg ctgtttggcggcggcctggtggagggcgccaagaaagtgacggtgaccgagctcctggcg ggcatgcccgaccccaccagcgacgaggtgcacggcgagcagccggccggaccgggcgga gacgcagacggcgagggtgccagcgagggcgctggagacgccgcggagggcgctggagac gaggaggaggcggtgcacgaggccgggccgggcggcgccgacggggcggtggccgtgacc gatgggggccccttccggcctgaaggggctggcggtctcggggacatgggggacacgacg cctgcggaaccgcccacacccgagggctctcccatcctcaagaggaagttgggggtggat ggagtggaggaggagctcccgccagagccagagcctgaaccagagctggagccggagaaa gccgatgccgagaatggggagaaggaagaagttcccgaacccccaccagagccccccaag aagcaagcacctccctcaccccctccaaagaaggaggaagctgggggcgaattctgggga gaactggaggtgcagagggtgaagttcctgaactacctgtcccggaatttttacaccctg cggttccttgccctcttcttggcatttgccatcaacttcatcttgctgttttataaggtc tcagactctccaccaggggaggacgacatggaaggctcagctgctggggatgtgtcaggt gcaggctctggtggcggctctggctggggcttgggggccggagaggaggcagagggcgat gaggatgagaacatggtgtactacttcctggaggagagcacaggctacatggagcccgcc ctgcggtgtctgagcctcctgcatacactggtggcctttctctgcatcattggctataac tgtctcaaggtgcccctggtaatctttaagcgggagaaggagctggcccggaagctggag tttgacggcctgtacatcacggagcaacctgaggacgatgacgtgaaggggcagtgggac cgactggtgctcaacacgccgtctttccccagcaactactgggacaagtttgtcaagcgc aaggtcctggacaaacatggggacatctacgggcgggagcggattgctgagctactgggc atggacctggccacactagagatcaccgcccacaatgagcgcaagcccaacccgccgcca gggctgctgacctggctcatgtccatcgatgtcaagtaccagatctggaagttcggggtc atcttcacagacaactccttcctgtacctgggctggtatatggtgatgtccctcttggga cactacaacaacttcttctttgctgcccatctcctggacatcgccatgggggtcaagacg ctgcgcaccatcctctcctccgtcacccacaatgggaaacagctggtgatgaccgtgggc cttctggcggtggtcgtctacctgtacaccgtggtggccttcaacttcttccgcaagttc tacaacaagagcgaggatgaggatgaacctgacatgaagtgtgatgacatgatgacgtgt tacctgtttcacatgtacgtgggtgtccgggctggcggaggcattggggacgagatcgag gaccccgcgggtgatgaatacgagctctacagggtggtcttcgacatcaccttcttcttc ttcgtcatcgtcatcctgttggccatcatccagggtctgatcatcgatgcttttggtgag ctccgagaccaacaagagcaagtgaaggaggatatggaaaccaagtgcttcatctgcgga atcggcagcgactactttgatacgacaccgcatggcttcgagactcacacgctggaggag cacaacctggccaattacatgtttttcctgatgtatttgataaacaaggatgagacagaa cacacgggtcaggagtcttatgtctggaagatgtaccaagagagatgttgggatttcttc ccagctggcgattgtttccgcaagcagtacgaggaccagcttagctga

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