KEGG   Pongo abelii (Sumatran orangutan): 100455460
Entry
100455460         CDS       T01416                                 
Name
(RefSeq) LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00140  Steroid hormone biosynthesis
pon01100  Metabolic pathways
pon04913  Ovarian steroidogenesis
pon04925  Aldosterone synthesis and secretion
pon04927  Cortisol synthesis and secretion
pon04934  Cushing syndrome
Module
pon_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
pon_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
pon_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pon_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100455460
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100455460
   04925 Aldosterone synthesis and secretion
    100455460
   04927 Cortisol synthesis and secretion
    100455460
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100455460
Enzymes [BR:pon01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100455460
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100455460
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 NAD_binding_10 GDP_Man_Dehyd ALO NmrA KR
Other DBs
NCBI-GeneID: 100455460
NCBI-ProteinID: XP_054384738
LinkDB
Position
1:complement(113232670..113240154)
AA seq 464 aa
MTGWSCLVTGAGGFLGQRIICLLVEETELKEIRALDRAFRPGLREEFSKRQNKTKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGLTHRESIMNVSVKACSFWAGTQLLLEVCVQ
ATVPVFIYTSTLQLARPNPYKEIIENAHEEDCLENTRSAPXPYSKKLAEKAVLAANGWTL
KNGDTLYTCALRPMYIHGEGSPFLTANINEALNNNGILSSVSKFSTANAVYVGNMAWAHI
LALRALRDPKKAPSVLGQLYYISDDTPHQSYDNPNYILSKEFGLCLDSRWSLLLPLMYWT
GFLLEIVSLLLRPICAYQPPFDCHTVTLSNSMFTFSYKKAQRDLAYKPLYSWEEAKQKTM
EWADSLVDQHKETLKSKSQRFKDDRDVHVGIVRRCHQAPSSWLHTECDKGISPGPAASLS
HNAQLIVFLVSSKPPHSLAQPEAFCPNHIPEDRQYDLLFPNLSG
NT seq 1395 nt   +upstreamnt  +downstreamnt
atgacaggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcctgttagtggaggagacagagctgaaggagatcagggccttggacagggccttcaga
ccaggattgagggaggaattttctaaacgccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaaaagagcctgccaagatgtctcggtcatcatc
cacaccgcctgtatcattgatgtcttcggactcactcacagagagtctatcatgaatgtc
agtgtgaaagcatgctctttctgggctggtacccagctcctgttagaggtctgtgtccaa
gctactgtgccagtcttcatctacaccagtaccctacagttagccaggcccaacccctac
aaggaaatcattgagaatgcccatgaagaagactgtctggaaaatacacgctccgctcca
taaccatacagcaaaaagcttgctgagaaggccgtgctggcagctaatgggtggactctg
aaaaatggtgataccttgtacacttgtgccttaagacccatgtatatccatggggaagga
agcccatttcttactgccaatataaatgaggccctgaacaacaatgggatcctgtcgagt
gtcagcaagttctccacagccaacgcagtctatgttggcaacatggcctgggcccacatt
ctggccttgagggccctgcgggaccccaagaaggccccaagtgtcctaggacagttgtac
tacatctcagatgacacgcctcaccaaagctatgataaccctaattacatcctgagcaaa
gagtttggcctctgccttgattccagatggagccttcttttacccctgatgtactggact
ggcttcctgctggaaatagtgagcctcctgctcaggccaatttgcgcctatcaaccaccc
ttcgactgccacacagtgacattgtcaaatagcatgttcaccttctcttacaagaaggct
cagcgagatctggcatataagccactttacagctgggaggaagccaagcagaaaaccatg
gagtgggctgattcccttgtggaccagcacaaggagaccctgaagtccaagtctcagcga
tttaaggatgacagagatgtgcatgtgggcattgttaggagatgtcatcaagctccatcc
tcctggctccatacagaatgtgacaagggcataagcccaggtcctgctgcctccctttca
cacaatgcccaacttattgtcttcctcgtgtcatcaaaacctccccattccctggcccaa
ccagaagctttctgtcctaatcatataccagaggacagacaatatgatttgctttttcca
aatctcagtggctga

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