KEGG   Panthera pardus (leopard): 109247606
Entry
109247606         CDS       T06062                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad01524  Platinum drug resistance
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04081  Hormone signaling
ppad04140  Autophagy - animal
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04152  AMPK signaling pathway
ppad04210  Apoptosis
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04218  Cellular senescence
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04510  Focal adhesion
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04625  C-type lectin receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04668  TNF signaling pathway
ppad04670  Leukocyte transendothelial migration
ppad04722  Neurotrophin signaling pathway
ppad04725  Cholinergic synapse
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04923  Regulation of lipolysis in adipocytes
ppad04926  Relaxin signaling pathway
ppad04929  GnRH secretion
ppad04930  Type II diabetes mellitus
ppad04931  Insulin resistance
ppad04932  Non-alcoholic fatty liver disease
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad04960  Aldosterone-regulated sodium reabsorption
ppad04973  Carbohydrate digestion and absorption
ppad05010  Alzheimer disease
ppad05017  Spinocerebellar ataxia
ppad05020  Prion disease
ppad05100  Bacterial invasion of epithelial cells
ppad05135  Yersinia infection
ppad05142  Chagas disease
ppad05146  Amoebiasis
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05162  Measles
ppad05163  Human cytomegalovirus infection
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05168  Herpes simplex virus 1 infection
ppad05169  Epstein-Barr virus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease - COVID-19
ppad05200  Pathways in cancer
ppad05203  Viral carcinogenesis
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05218  Melanoma
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05222  Small cell lung cancer
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
ppad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109247606 (PIK3R2)
   04014 Ras signaling pathway
    109247606 (PIK3R2)
   04015 Rap1 signaling pathway
    109247606 (PIK3R2)
   04370 VEGF signaling pathway
    109247606 (PIK3R2)
   04630 JAK-STAT signaling pathway
    109247606 (PIK3R2)
   04668 TNF signaling pathway
    109247606 (PIK3R2)
   04066 HIF-1 signaling pathway
    109247606 (PIK3R2)
   04068 FoxO signaling pathway
    109247606 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    109247606 (PIK3R2)
   04072 Phospholipase D signaling pathway
    109247606 (PIK3R2)
   04071 Sphingolipid signaling pathway
    109247606 (PIK3R2)
   04024 cAMP signaling pathway
    109247606 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    109247606 (PIK3R2)
   04152 AMPK signaling pathway
    109247606 (PIK3R2)
   04150 mTOR signaling pathway
    109247606 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109247606 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109247606 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    109247606 (PIK3R2)
   04218 Cellular senescence
    109247606 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109247606 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    109247606 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109247606 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109247606 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    109247606 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    109247606 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    109247606 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    109247606 (PIK3R2)
   04660 T cell receptor signaling pathway
    109247606 (PIK3R2)
   04662 B cell receptor signaling pathway
    109247606 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    109247606 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    109247606 (PIK3R2)
   04670 Leukocyte transendothelial migration
    109247606 (PIK3R2)
   04062 Chemokine signaling pathway
    109247606 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109247606 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    109247606 (PIK3R2)
   04929 GnRH secretion
    109247606 (PIK3R2)
   04915 Estrogen signaling pathway
    109247606 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    109247606 (PIK3R2)
   04917 Prolactin signaling pathway
    109247606 (PIK3R2)
   04926 Relaxin signaling pathway
    109247606 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    109247606 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    109247606 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109247606 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109247606 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    109247606 (PIK3R2)
   04722 Neurotrophin signaling pathway
    109247606 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109247606 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    109247606 (PIK3R2)
   04380 Osteoclast differentiation
    109247606 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    109247606 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    109247606 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109247606 (PIK3R2)
   05206 MicroRNAs in cancer
    109247606 (PIK3R2)
   05205 Proteoglycans in cancer
    109247606 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    109247606 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    109247606 (PIK3R2)
   05203 Viral carcinogenesis
    109247606 (PIK3R2)
   05230 Central carbon metabolism in cancer
    109247606 (PIK3R2)
   05231 Choline metabolism in cancer
    109247606 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109247606 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109247606 (PIK3R2)
   05212 Pancreatic cancer
    109247606 (PIK3R2)
   05225 Hepatocellular carcinoma
    109247606 (PIK3R2)
   05226 Gastric cancer
    109247606 (PIK3R2)
   05214 Glioma
    109247606 (PIK3R2)
   05221 Acute myeloid leukemia
    109247606 (PIK3R2)
   05220 Chronic myeloid leukemia
    109247606 (PIK3R2)
   05218 Melanoma
    109247606 (PIK3R2)
   05211 Renal cell carcinoma
    109247606 (PIK3R2)
   05215 Prostate cancer
    109247606 (PIK3R2)
   05213 Endometrial cancer
    109247606 (PIK3R2)
   05224 Breast cancer
    109247606 (PIK3R2)
   05222 Small cell lung cancer
    109247606 (PIK3R2)
   05223 Non-small cell lung cancer
    109247606 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109247606 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    109247606 (PIK3R2)
   05161 Hepatitis B
    109247606 (PIK3R2)
   05160 Hepatitis C
    109247606 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    109247606 (PIK3R2)
   05164 Influenza A
    109247606 (PIK3R2)
   05162 Measles
    109247606 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    109247606 (PIK3R2)
   05163 Human cytomegalovirus infection
    109247606 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109247606 (PIK3R2)
   05169 Epstein-Barr virus infection
    109247606 (PIK3R2)
   05165 Human papillomavirus infection
    109247606 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    109247606 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    109247606 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109247606 (PIK3R2)
   05142 Chagas disease
    109247606 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109247606 (PIK3R2)
   05017 Spinocerebellar ataxia
    109247606 (PIK3R2)
   05020 Prion disease
    109247606 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109247606 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    109247606 (PIK3R2)
   05415 Diabetic cardiomyopathy
    109247606 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109247606 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    109247606 (PIK3R2)
   04931 Insulin resistance
    109247606 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109247606 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109247606 (PIK3R2)
   01524 Platinum drug resistance
    109247606 (PIK3R2)
   01522 Endocrine resistance
    109247606 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109247606 (PIK3R2)
Membrane trafficking [BR:ppad04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109247606 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 109247606
NCBI-ProteinID: XP_019271893
Ensembl: ENSPPRG00000006838
UniProt: A0A9V1E0X8
LinkDB
Position
Unknown
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREATGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgagcagccctgcaggtg
ctgggcgtggccgagggcaacgagcgctgcccacagagcgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagagcagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaggcccgccgggccctgcgggag
gccacggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctcgtggagaagttgcttcaggaacatctggaagagcaggaggtcgcacccccagcgctg
ccgcccaaaccccccaaggccaagccagcccccgcaggcctagccaatggggggagcccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccgctcaccttctgctccgttgtggacctcatc
acccactaccgccacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcagtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtatgaccag
ctctacgaggagtacacacgcacctcccaggagttgcagatgaagcgcacagcaatcgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacacaagagaagtgtagc
aaggagtatttggagcgcttccggcgtgagggcaacgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gagcaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagaccgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaggctgaggaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctctgtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgcgggcccccgggcccggg
cccccgccggccacccgctga

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