Panthera pardus (leopard): 109260762 Help Entry 109260762         CDS       T06062                                  Symbol CASP8 Name (RefSeq) caspase-8 isoform X1   KO K04398   caspase 8 [EC:3.4.22.61] Organism ppad  Panthera pardus (leopard) Pathway ppad01524   Platinum drug resistance ppad04115   p53 signaling pathway ppad04210   Apoptosis ppad04215   Apoptosis - multiple species ppad04217   Necroptosis ppad04620   Toll-like receptor signaling pathway ppad04621   NOD-like receptor signaling pathway ppad04622   RIG-I-like receptor signaling pathway ppad04623   Cytosolic DNA-sensing pathway ppad04625   C-type lectin receptor signaling pathway ppad04657   IL-17 signaling pathway ppad04668   TNF signaling pathway ppad04932   Non-alcoholic fatty liver disease ppad04936   Alcoholic liver disease ppad05010   Alzheimer disease ppad05016   Huntington disease ppad05022   Pathways of neurodegeneration - multiple diseases ppad05132   Salmonella infection ppad05134   Legionellosis ppad05142   Chagas disease ppad05145   Toxoplasmosis ppad05152   Tuberculosis ppad05160   Hepatitis C ppad05161   Hepatitis B ppad05162   Measles ppad05163   Human cytomegalovirus infection ppad05164   Influenza A ppad05165   Human papillomavirus infection ppad05167   Kaposi sarcoma-associated herpesvirus infection ppad05168   Herpes simplex virus 1 infection ppad05169   Epstein-Barr virus infection ppad05170   Human immunodeficiency virus 1 infection ppad05200   Pathways in cancer ppad05203   Viral carcinogenesis ppad05416   Viral myocarditis ppad05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ppad00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     109260762 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     109260762 (CASP8)    04215 Apoptosis - multiple species     109260762 (CASP8)    04217 Necroptosis     109260762 (CASP8)    04115 p53 signaling pathway     109260762 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     109260762 (CASP8)    04621 NOD-like receptor signaling pathway     109260762 (CASP8)    04622 RIG-I-like receptor signaling pathway     109260762 (CASP8)    04623 Cytosolic DNA-sensing pathway     109260762 (CASP8)    04625 C-type lectin receptor signaling pathway     109260762 (CASP8)    04657 IL-17 signaling pathway     109260762 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     109260762 (CASP8)    05203 Viral carcinogenesis     109260762 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     109260762 (CASP8)    05161 Hepatitis B     109260762 (CASP8)    05160 Hepatitis C     109260762 (CASP8)    05164 Influenza A     109260762 (CASP8)    05162 Measles     109260762 (CASP8)    05168 Herpes simplex virus 1 infection     109260762 (CASP8)    05163 Human cytomegalovirus infection     109260762 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     109260762 (CASP8)    05169 Epstein-Barr virus infection     109260762 (CASP8)    05165 Human papillomavirus infection     109260762 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     109260762 (CASP8)    05134 Legionellosis     109260762 (CASP8)    05152 Tuberculosis     109260762 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     109260762 (CASP8)    05142 Chagas disease     109260762 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     109260762 (CASP8)    05016 Huntington disease     109260762 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     109260762 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     109260762 (CASP8)    05416 Viral myocarditis     109260762 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     109260762 (CASP8)    04932 Non-alcoholic fatty liver disease     109260762 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     109260762 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:ppad01002]     109260762 (CASP8) Enzymes [BR:ppad01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      109260762 (CASP8) Peptidases and inhibitors [BR:ppad01002]  Cysteine peptidases   Family C14: caspase family    109260762 (CASP8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Peptidase_C14 DED PYRIN Motif Other DBs NCBI-GeneID:  109260762 NCBI-ProteinID:  XP_019294751 UniProt:  A0A9V1F3W9 LinkDB All DBs Position Unknown AA seq 479 aa AA seqDB search MDFSKCLYNIGEQLGSDELASLKFLSLDYIPQKKQEPIKDALMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLFNYLNTSKEAMEQELQIPGRAQIPPYRVMLFQISEDVNKLELRSF KFLLSQEISRCKVDDDMNLLDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE LSREGRMSLQRSPDELSNGEESLAMMALSDSLEEQDSESQTSDKVYRMKSKPRGYCLIFN NYDFSRARKDVPKLQNIKDRNGTNFDAEALSKTFSELHFEIVNFKDSTAKTICEVLKSYQ RMDHNNKDCFICCILSHGDKGIIYGSDGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQAC QGDNYQRGIAVETDSEQKEDYLEMDSSFQKRYIPDEADFLLGMATVNNCVSYRNPTEGTW YIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDKKNMGKQMPQPTFTLRKKLFFPLN NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt atggatttcagtaaatgtctgtataatattggggaacagctgggcagtgatgagctggcc tccctcaaattcctgagcctggactacatcccacaaaagaagcaagaacccatcaaagat gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc ttcttgaaggagctgcttttccgaattaatagactggacctgctgttcaactacctgaac accagcaaggaagcaatggagcaggagcttcagataccaggcagagcccagatccctccc tacagggtcatgctttttcagatttcagaagatgtaaacaaattggaattgaggtcattt aagtttcttttgagccaggagatctccagatgtaaagtggatgatgatatgaacttgctt gatattttcatagagatggaaaagagggtcatcctaggggaaagaaatttggacactctg aaaagaatctgtgaccaaatcaacaagagcctgctgaagaaaatcactgattatgaagaa ttaagcagagagggaagaatgagccttcaaagaagtccagatgaattgtcaaatggggag gaatccctggcaatgatggcattatcggactctctagaagaacaggacagtgagtcacag acatcggacaaagtttaccgaatgaaaagcaaacctcgcggatattgtttgatctttaac aattatgattttagcagagcacggaaggatgtgcccaaacttcagaacattaaggatagg aatggaacaaacttcgatgcagaagctttgagtaagacctttagtgagcttcattttgag attgtgaatttcaaagactctacagcaaagacaatctgtgaagttctgaaatcctaccaa agaatggaccataataacaaagattgcttcatctgctgtatcctctcccatggagacaaa ggcattatttatggctctgatgggcaggaagcccccatctatgagctgacttcttacttc actggttcaaagtgcccttcccttgcaggcaagcccaaaatcttttttattcaggcttgt caaggggataactaccagagaggtatagctgttgagactgactctgaacagaaggaagac tacttagaaatggactcatcatttcagaagagatatatcccagatgaggctgattttctg ctggggatggccactgtgaacaactgtgtttcctaccgaaaccctacggaggggacctgg tatatccagtcactttgccagagcctaagagaaagatgtcctaggggcgaagatatcctc accatccttactgaggtgaactttgaagtgagcaataaggatgacaagaaaaacatgggg aaacaaatgccacaacctactttcacactgaggaaaaaactcttcttccctcttaattga

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