KEGG   Panthera pardus (leopard): 109267249
Entry
109267249         CDS       T06062                                 
Symbol
PAK1
Name
(RefSeq) serine/threonine-protein kinase PAK 1
  KO
K04409  p21-activated kinase 1 [EC:2.7.11.1]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad04010  MAPK signaling pathway
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04360  Axon guidance
ppad04392  Hippo signaling pathway - multiple species
ppad04510  Focal adhesion
ppad04625  C-type lectin receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04810  Regulation of actin cytoskeleton
ppad05132  Salmonella infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05205  Proteoglycans in cancer
ppad05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109267249 (PAK1)
   04012 ErbB signaling pathway
    109267249 (PAK1)
   04014 Ras signaling pathway
    109267249 (PAK1)
   04392 Hippo signaling pathway - multiple species
    109267249 (PAK1)
   04024 cAMP signaling pathway
    109267249 (PAK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109267249 (PAK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109267249 (PAK1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    109267249 (PAK1)
   04650 Natural killer cell mediated cytotoxicity
    109267249 (PAK1)
   04660 T cell receptor signaling pathway
    109267249 (PAK1)
   04666 Fc gamma R-mediated phagocytosis
    109267249 (PAK1)
   04062 Chemokine signaling pathway
    109267249 (PAK1)
  09158 Development and regeneration
   04360 Axon guidance
    109267249 (PAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    109267249 (PAK1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    109267249 (PAK1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109267249 (PAK1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109267249 (PAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109267249 (PAK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109267249 (PAK1)
   03036 Chromosome and associated proteins [BR:ppad03036]
    109267249 (PAK1)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     109267249 (PAK1)
Protein kinases [BR:ppad01001]
 Serine/threonine kinases: STE group
  STE20 family
   109267249 (PAK1)
Membrane trafficking [BR:ppad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    109267249 (PAK1)
 Endocytosis
  Macropinocytosis
   Kinases
    109267249 (PAK1)
Chromosome and associated proteins [BR:ppad03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     109267249 (PAK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PBD ABC1 Kinase-like Pkinase_fungal APH DSHCT YrbL-PhoP_reg
Other DBs
NCBI-GeneID: 109267249
NCBI-ProteinID: XP_019305460
Ensembl: ENSPPRG00000017647
UniProt: A0A9V1FM92
LinkDB
Position
Unknown
AA seq 544 aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDD
DDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTIPPDALTRNTEK
QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM
NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM
DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR
STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT
PELQNPEKLSAFFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
KNNH
NT seq 1635 nt   +upstreamnt  +downstreamnt
atgtcaaataacggcctagacattcaagacaaacctccagcccctccgatgagaaacacc
agcactatgattggagctggcagcaaagatgctggaaccctaaaccacggttccaaacct
ctgcctccaaacccagaggagaagaaaaagaaggaccgattttaccgatccatcttacct
ggagataaaacaaataaaaagaaggagaaggaacggccagagatttctcttccttcagat
tttgagcacacaattcacgttggttttgatgctgtcacaggggagtttacaggaatgcca
gagcagtgggctcgcttgcttcaaacatcaaatatcactaagtcagagcagaagaaaaac
ccacaagctgttctggatgtattggaattttataactcaaagaagacctccaacagccag
aagtacatgagctttacagataaatcagctgaagattataattcttctaacactttgaat
gtgaagacggtgtctgagactcctgcagtgccaccagtttcagaagatgaagatgatgat
gatgatgctacccctcctccagtgattgctccacgcccagagcacacaaaatctgtatac
acacggtctgtgattgaaccgcttcctgttactccaactcgggatgtggctacatctccc
atttcacctactgagaataataccattccaccagatgctctgacccggaatactgagaag
cagaagaagaagcctaaaatgtctgatgaggagatcttggagaaattacggagcatagtg
agtgtgggcgatcctaagaagaaatatacacggtttgagaagattggacaaggtgcttca
ggcactgtgtacactgcaatggatgtggccacaggacaggaggtggccattaagcagatg
aaccttcagcagcagccgaagaaagagctgattattaatgagatcctggtcatgagggaa
aacaagaacccaaatattgtcaactacttggacagttacctcgtgggagatgagctgtgg
gttgtcatggaatacttggctggaggctctttgacagatgtggtaacagaaacttgcatg
gatgaaggccagatcgcagctgtctgccgtgagtgcctgcaggctttggagtttctgcat
tcgaaccaggtcattcacagagacatcaagagtgacaatatcctgttgggaatggatggt
tctgtcaagctaactgactttggattctgtgcccagatcaccccagagcagagcaaacgg
agcaccatggtgggaaccccatactggatggcaccagaggttgtgacacggaaagcctat
gggcccaaggttgacatctggtccctgggcatcatggccattgaaatgattgaaggggag
cccccatacctcaatgaaaatcctctcagagccttgtacctcattgccaccaatgggacc
cccgagcttcagaacccagagaagctatcagcttttttccgggactttctgaaccgctgt
cttgagatggatgtggagaagagaggttcagctaaagagctgctgcagcatcagttcctg
aagattgccaagcccctttccagcctcactccactgattgctgcagcaaaggaggcaacc
aagaacaatcactaa

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