Panthera pardus (leopard): 109267948 Help Entry 109267948         CDS       T06062                                  Symbol ADCY1 Name (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism ppad  Panthera pardus (leopard) Pathway ppad00230   Purine metabolism ppad01100   Metabolic pathways ppad01522   Endocrine resistance ppad04015   Rap1 signaling pathway ppad04020   Calcium signaling pathway ppad04022   cGMP-PKG signaling pathway ppad04024   cAMP signaling pathway ppad04062   Chemokine signaling pathway ppad04072   Phospholipase D signaling pathway ppad04081   Hormone signaling ppad04082   Neuroactive ligand signaling ppad04114   Oocyte meiosis ppad04211   Longevity regulating pathway ppad04213   Longevity regulating pathway - multiple species ppad04261   Adrenergic signaling in cardiomyocytes ppad04270   Vascular smooth muscle contraction ppad04371   Apelin signaling pathway ppad04540   Gap junction ppad04611   Platelet activation ppad04713   Circadian entrainment ppad04714   Thermogenesis ppad04720   Long-term potentiation ppad04723   Retrograde endocannabinoid signaling ppad04724   Glutamatergic synapse ppad04725   Cholinergic synapse ppad04727   GABAergic synapse ppad04750   Inflammatory mediator regulation of TRP channels ppad04911   Insulin secretion ppad04912   GnRH signaling pathway ppad04913   Ovarian steroidogenesis ppad04914   Progesterone-mediated oocyte maturation ppad04915   Estrogen signaling pathway ppad04916   Melanogenesis ppad04918   Thyroid hormone synthesis ppad04921   Oxytocin signaling pathway ppad04923   Regulation of lipolysis in adipocytes ppad04925   Aldosterone synthesis and secretion ppad04926   Relaxin signaling pathway ppad04927   Cortisol synthesis and secretion ppad04928   Parathyroid hormone synthesis, secretion and action ppad04934   Cushing syndrome ppad04935   Growth hormone synthesis, secretion and action ppad04970   Salivary secretion ppad04971   Gastric acid secretion ppad04972   Pancreatic secretion ppad04976   Bile secretion ppad05032   Morphine addiction ppad05142   Chagas disease ppad05146   Amoebiasis ppad05163   Human cytomegalovirus infection ppad05166   Human T-cell leukemia virus 1 infection ppad05200   Pathways in cancer ppad05207   Chemical carcinogenesis - receptor activation ppad05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ppad00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     109267948 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     109267948 (ADCY1)    04371 Apelin signaling pathway     109267948 (ADCY1)    04020 Calcium signaling pathway     109267948 (ADCY1)    04072 Phospholipase D signaling pathway     109267948 (ADCY1)    04024 cAMP signaling pathway     109267948 (ADCY1)    04022 cGMP-PKG signaling pathway     109267948 (ADCY1)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     109267948 (ADCY1)    04081 Hormone signaling     109267948 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     109267948 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     109267948 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     109267948 (ADCY1)    04062 Chemokine signaling pathway     109267948 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     109267948 (ADCY1)    04923 Regulation of lipolysis in adipocytes     109267948 (ADCY1)    04912 GnRH signaling pathway     109267948 (ADCY1)    04913 Ovarian steroidogenesis     109267948 (ADCY1)    04915 Estrogen signaling pathway     109267948 (ADCY1)    04914 Progesterone-mediated oocyte maturation     109267948 (ADCY1)    04921 Oxytocin signaling pathway     109267948 (ADCY1)    04926 Relaxin signaling pathway     109267948 (ADCY1)    04935 Growth hormone synthesis, secretion and action     109267948 (ADCY1)    04918 Thyroid hormone synthesis     109267948 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     109267948 (ADCY1)    04916 Melanogenesis     109267948 (ADCY1)    04925 Aldosterone synthesis and secretion     109267948 (ADCY1)    04927 Cortisol synthesis and secretion     109267948 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     109267948 (ADCY1)    04270 Vascular smooth muscle contraction     109267948 (ADCY1)   09154 Digestive system    04970 Salivary secretion     109267948 (ADCY1)    04971 Gastric acid secretion     109267948 (ADCY1)    04972 Pancreatic secretion     109267948 (ADCY1)    04976 Bile secretion     109267948 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     109267948 (ADCY1)    04727 GABAergic synapse     109267948 (ADCY1)    04725 Cholinergic synapse     109267948 (ADCY1)    04720 Long-term potentiation     109267948 (ADCY1)    04723 Retrograde endocannabinoid signaling     109267948 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     109267948 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     109267948 (ADCY1)    04213 Longevity regulating pathway - multiple species     109267948 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     109267948 (ADCY1)    04714 Thermogenesis     109267948 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     109267948 (ADCY1)    05207 Chemical carcinogenesis - receptor activation     109267948 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     109267948 (ADCY1)    05163 Human cytomegalovirus infection     109267948 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     109267948 (ADCY1)    05142 Chagas disease     109267948 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     109267948 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     109267948 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     109267948 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     109267948 (ADCY1) Enzymes [BR:ppad01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      109267948 (ADCY1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA DUF6688 Motif Other DBs NCBI-GeneID:  109267948 NCBI-ProteinID:  XP_019306510 UniProt:  A0A9V1FP89 LinkDB All DBs Position Unknown AA seq 903 aa AA seqDB search MYGVFVRILAERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCR RIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVL CGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNSF LKAHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS NVLTCEDDDKRRALRTASEKLRNRSSFSANAVYTTPGTRVNRYIGRLLEARQTELEMADL DFFTLKYKQAERERKYHQLQDEYFTSAVVLALVLAALFGLVYLLIIPQNLVLLLLLAFCI CFLVACVLYLHVTQVQCFPGCLTIQIRTVLCIFVVVLIYSVAQGCVVGCLPWSWSSTPNG SLVVLTPSGRNAVLPAAPCESAPHALLCGLVGTLPLAVFLRVSSLPKMILLFVLTTSYIL VLELSGYTRAPGGGVASGRSFEPIMAILLFSCTLALHARQVDVKLRLDYLWAAQAEEERD DMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFDDFYIEL DGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTTGTKAKKGI SSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVN VASRMDSTGVQGRIQVTEEVHRLLRRGTYRFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQ ARERKVCGYGRAGLQGRLGTGPPPVSSMAGLPVRAGMGALQGSGLPPCPHGQHLPPGAAG KEA NT seq 2712 nt NT seq  +upstreamnt  +downstreamnt atgtatggggtgtttgtgcgcatcctggccgagcgctcccagcggaaagccttcctgcaa gcccggaactgcatcgaagatcggctgaggctggaggatgagaacgagaagcaggagcgg ctgctcatgagccttctgccccggaatgttgcgatggagatgaaggaggacttcttgaag ccccccgagaggattttccacaagatttacatccagcggcatgacaacgtgagcatcctc tttgcggacattgtgggcttcacgggcctggcgtcgcagtgcacggcacaggagctggtc aagctcctcaacgagctgttcggcaagtttgatgaactggccacggagaatcactgtcgc cgcatcaagatcctaggggactgttactactgtgtgtccggcctcacccagcccaagacc gaccacgcccactgctgcgtggagatgggcctggacatgatcgacaccatcacgtctgtg gccgaggccaccgaggtggacctgaacatgcgcgtggggctgcacacaggcagggtcctc tgcggggtcctgggcctgcgcaagtggcagtacgatgtgtggtccaatgacgtgaccctg gccaacgtcatggaggcggctggcctacctgggaaggtccacatcacgaagacgaccctg gcgtgcctgaacggggactacgaggtggagccaggtcacggacatgagaggaacagtttt ctgaaagctcacaacatcgagaccttcttcatcgtgccgtcacatcggcggaagatattt ccagggctgatcctctctgacataaaaccagccaagaggatgaagttcaagaccgtgtgc tacctgctcgtgcagctgatgcactgtcggaagatgttcaaagcagagatcccgttctct aatgtcctgacgtgtgaggacgatgacaagcggagggcgctgagaaccgcgtcggagaaa ctgcgaaaccgctcgtcgttctccgcaaacgctgtctacaccaccccgggcacgcgcgtc aacaggtacatcggccgcctcctggaagcacgccagacggagctggagatggcggacctg gacttcttcactctcaagtacaagcaggctgagcgggagcgcaagtaccaccagctccag gacgagtattttaccagcgccgtcgttctggccctcgtcctggccgccttgttcggcctc gtctacctgctcatcatcccacagaacctggtcctcctgctgctgctggccttctgtatc tgcttcctggtggcctgcgtcctgtacctgcacgtcacccaggtccagtgttttccaggg tgcctgacgattcagatccgcaccgtcttgtgtatcttcgtcgtggtcttaatctactct gtggcccaaggatgtgtggtgggctgcctgccctggtcctggagctccacccccaacggg tccctggtggtcctgacacccagcggccgcaacgccgtgctgcctgccgcgccctgtgag tcggcgccccacgccctgctctgcggccttgtgggtaccctcccgctggccgtcttcctg cgggtgtcctccctgcccaaaatgatcctgctctttgtgctcacgacgtcctacatcctg gtcctggagctcagcggctacaccagggcccccgggggcggcgtggcgtcggggcgcagt ttcgagccgatcatggccatcctgctgttttcctgcaccctggccctgcacgcccgtcag gtggacgtcaagctgcggctggactacctctgggcggcacaggcagaggaggagagagac gacatggagagggtgaagttggacaacaagaggattctcttcaacctcctgccggcccac gtggctcagcacttcctcatgtccaacccccgcaacatggacctgtactaccagtcctac tcacaggtgggcgtcatgtttgcttccatccccaacttcgacgacttctacatcgagctg gacggcaacaacatgggggtggagtgtctgcgtctcctgaacgagatcatcgcagacttc gacgagctcatggacaaagacttttacaaggacttggagaagatcaagaccatcgggagc acctacatggccgctgtggggctggcgcctaccactgggaccaaggccaagaagggcatc tcctcccacctgagcacactggccgacttcgccatcgagatgttcgacgtcctggatgaa atcaactaccagtcttacaacgactttgtgctccgtgtgggcatcaacgtgggccctgtg gtggccggggtgattggggctcggaggccgcagtacgacatttgggggaacacggtcaac gtggccagtcggatggacagcaccggcgtccagggcagaatccaggtgactgaggaggtt caccggctgctgcgccgggggacctaccgcttcgtgtgccgcgggaaggtcagcgtcaag ggcaagggtgagatgctaacgtacttcctggaaggcaggacggacggaaacggctcccaa gccagggagcggaaagtgtgtggctacgggcgagccggcctccagggcagactgggcacg ggcccgcccccggtgtcctccatggccggcctcccggtcagagctgggatgggggctctg cagggctcagggctccccccctgcccccatggccagcacctgccccccggagcagctggg aaggaggcttag

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