KEGG   Panthera pardus (leopard): 109272160
Entry
109272160         CDS       T06062                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00140  Steroid hormone biosynthesis
ppad01100  Metabolic pathways
ppad04913  Ovarian steroidogenesis
ppad04925  Aldosterone synthesis and secretion
ppad04927  Cortisol synthesis and secretion
ppad04934  Cushing syndrome
Module
ppad_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ppad_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ppad_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ppad_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    109272160
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    109272160
   04925 Aldosterone synthesis and secretion
    109272160
   04927 Cortisol synthesis and secretion
    109272160
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109272160
Enzymes [BR:ppad01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     109272160
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     109272160
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind NmrA KR Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 109272160
NCBI-ProteinID: XP_019313563
Ensembl: ENSPPRG00000013982
UniProt: A0A9V1G1Y3
LinkDB
Position
Unknown
AA seq 373 aa
MAGWICLVTGAGGFLGQRIVHLLVEEKDLQEIRALDKVFSPELREEFSKLQSKIKLTILE
GDILDEQCLKKACQDTSVIIHTASIIDVMDVVHRETIMNVNLKGTQLLLEACVQASVPIF
IYTSTIEVAGPNSYREIIQNGHEDEHLESTWTASYPYSKKLAEKAVLAANGWALKNGGTL
HTCALRPMYIYGEGSIFLYNQIYQALRNNGIIKQSSKFSIVNPVYVGNVAWAHILASRTL
QDPKKAPRVGGQFYYISDDTPHQSYDNLNYSLSKEWGFSLDSRMSLPLFLEYWLAFLLEI
VSFLLSPIYKYRPPFTRHTVTLLNSVFTFSYKKAQRDLGYEPLFSWEEAKQKTMEWIGSI
VKEHKKSLKTKTH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctgggtggatctgccttgtgacaggggcaggagggtttctgggtcagagaatcgtg
catttgctggtggaggagaaggacctacaggagatccgggcactggacaaagtcttcagc
ccagaattgcgggaggaattttctaagctccagagcaagatcaagctgaccattctggaa
ggagacattctggatgaacagtgcttgaagaaggcctgccaggacacctcagtcatcatc
cacaccgcctctatcattgacgtcatggatgttgttcaccgagaaaccatcatgaatgtc
aatctgaagggtacccagctccttttggaagcctgtgtccaggctagtgtgccaatcttc
atctataccagcaccatagaggtggctgggcccaactcctacagggagatcatccagaac
ggccacgaagacgaacatctcgaatccacatggaccgcttcgtatccatacagcaaaaaa
cttgcggagaaagctgtgctggctgctaatgggtgggctcttaaaaatggtggcaccttg
cacacttgtgccttaaggcccatgtatatctatggggaaggaagcatattcctttataac
caaatataccaggccctgaggaacaatgggatcatcaaacagagcagcaaattctccata
gtcaaccctgtctatgtaggcaacgtggcctgggctcacattctggcctcgaggacccta
caggaccccaagaaggcccccagagttggaggacagttctattatatctcagatgacaca
cctcaccaaagctatgataacctcaattacagtttgagcaaagaatggggcttctccctt
gactccagaatgagccttcctctatttctggagtactggcttgccttcctgctggaaata
gtgagcttcctactcagtccaatttacaaataccgccccccctttacccgccacacggtg
acattgttaaatagcgtgttcaccttctcctataagaaagctcagcgggacctggggtat
gagccactcttcagctgggaggaagcaaagcaaaagaccatggagtggattggttccata
gtgaaagagcacaagaagtccctaaaaacaaagactcactga

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