KEGG   Pteronotus mesoamericanus (Parnell's mustached bat): 129070698
Entry
129070698         CDS       T09558                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ppam  Pteronotus mesoamericanus (Parnell's mustached bat)
Pathway
ppam00562  Inositol phosphate metabolism
ppam01100  Metabolic pathways
ppam01521  EGFR tyrosine kinase inhibitor resistance
ppam04012  ErbB signaling pathway
ppam04014  Ras signaling pathway
ppam04015  Rap1 signaling pathway
ppam04020  Calcium signaling pathway
ppam04062  Chemokine signaling pathway
ppam04064  NF-kappa B signaling pathway
ppam04066  HIF-1 signaling pathway
ppam04070  Phosphatidylinositol signaling system
ppam04072  Phospholipase D signaling pathway
ppam04360  Axon guidance
ppam04370  VEGF signaling pathway
ppam04613  Neutrophil extracellular trap formation
ppam04650  Natural killer cell mediated cytotoxicity
ppam04658  Th1 and Th2 cell differentiation
ppam04659  Th17 cell differentiation
ppam04660  T cell receptor signaling pathway
ppam04664  Fc epsilon RI signaling pathway
ppam04666  Fc gamma R-mediated phagocytosis
ppam04670  Leukocyte transendothelial migration
ppam04722  Neurotrophin signaling pathway
ppam04750  Inflammatory mediator regulation of TRP channels
ppam04919  Thyroid hormone signaling pathway
ppam04933  AGE-RAGE signaling pathway in diabetic complications
ppam04935  Growth hormone synthesis, secretion and action
ppam05012  Parkinson disease
ppam05022  Pathways of neurodegeneration - multiple diseases
ppam05135  Yersinia infection
ppam05167  Kaposi sarcoma-associated herpesvirus infection
ppam05170  Human immunodeficiency virus 1 infection
ppam05171  Coronavirus disease - COVID-19
ppam05200  Pathways in cancer
ppam05205  Proteoglycans in cancer
ppam05206  MicroRNAs in cancer
ppam05214  Glioma
ppam05223  Non-small cell lung cancer
ppam05225  Hepatocellular carcinoma
ppam05231  Choline metabolism in cancer
ppam05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppam05417  Lipid and atherosclerosis
Module
ppam_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppam00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129070698 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129070698 (PLCG1)
   04014 Ras signaling pathway
    129070698 (PLCG1)
   04015 Rap1 signaling pathway
    129070698 (PLCG1)
   04370 VEGF signaling pathway
    129070698 (PLCG1)
   04064 NF-kappa B signaling pathway
    129070698 (PLCG1)
   04066 HIF-1 signaling pathway
    129070698 (PLCG1)
   04020 Calcium signaling pathway
    129070698 (PLCG1)
   04070 Phosphatidylinositol signaling system
    129070698 (PLCG1)
   04072 Phospholipase D signaling pathway
    129070698 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    129070698 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    129070698 (PLCG1)
   04660 T cell receptor signaling pathway
    129070698 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    129070698 (PLCG1)
   04659 Th17 cell differentiation
    129070698 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    129070698 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    129070698 (PLCG1)
   04670 Leukocyte transendothelial migration
    129070698 (PLCG1)
   04062 Chemokine signaling pathway
    129070698 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    129070698 (PLCG1)
   04919 Thyroid hormone signaling pathway
    129070698 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    129070698 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129070698 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    129070698 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129070698 (PLCG1)
   05206 MicroRNAs in cancer
    129070698 (PLCG1)
   05205 Proteoglycans in cancer
    129070698 (PLCG1)
   05231 Choline metabolism in cancer
    129070698 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129070698 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    129070698 (PLCG1)
   05214 Glioma
    129070698 (PLCG1)
   05223 Non-small cell lung cancer
    129070698 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129070698 (PLCG1)
   05171 Coronavirus disease - COVID-19
    129070698 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129070698 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    129070698 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    129070698 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    129070698 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129070698 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129070698 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129070698 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppam04131]
    129070698 (PLCG1)
Enzymes [BR:ppam01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129070698 (PLCG1)
Membrane trafficking [BR:ppam04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129070698 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129070698 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 129070698
NCBI-ProteinID: XP_054429727
LinkDB
Position
Unknown
AA seq 1291 aa
MAGVSSPCANGCGPGAPSDAEVLNLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLTEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRFQVQEFMLDFLQDPLREIEEPYFSLDEFVT
FLFSKENSVWNSKLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSNDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAQWSLDVAAESQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDIFPAKQENGDLSPFSGTSLRERGSDASCPLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDSRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgtctcgtccccttgcgccaatggctgcgggcctggcgcgccctcagacgcc
gaggtgctgaacctctgccgcagccttgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagactcggcagatc
acgtggagccgcggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacctcgcgggactttgatcgctaccaagaggaccctgctttccgg
ccggaccagtcacactgctttgtcatcctgtatgggatggaattccgcctgaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggcttgacttggctg
acagaggacacattgcaggcggccacacccctgcagattgagaggtggctgcggaagcag
ttctactcggtggatcggaatcgtgaggatcgtatctcagccaaggacctgaagaatatg
ctgtcccaagtcaactaccgggtccccaacatgcgcttccttcgagagcggctgacggac
ctggagcagcgcagcagcgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagcgccctgagggcg
ggggagcggccggagctctgccgagtgtcccttcctgagttccagcagttcctccttgaa
taccagggggagctatgggctgtcgaccggttccaggtgcaggagttcatgctcgacttc
ctccaggaccccctgcgagagattgaggagccatacttctccctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgaagctggacgcggtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagcgagtcctctctggaagcctacgcgcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggccccgacggcatgccggtcatttaccac
ggacacaccctcaccaccaagatcaagttttcggacgttctgcacaccatcaaggaacat
gccttcgtggcctcagagtacccggtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaaaaaggtccttggggacacactcctcaccaag
cccgtggacattgccgctgacgggctcccgtcacccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgcctacgtctgtgatg
tactctgagaatgacatcagcaactccatcaagaacggcatcctctacctggaggacccc
gtgaaccacgagtggtatccgcactactttgtcctgaccagcagcaagatctactactct
gaggagaccagcaatgaccagggcaatgaggatgaggaagagcccaaggaggccagtggc
agcacagagctgcactccaatgagaagtggtttcatgggaagcttggggccggacgggat
gggcggcacatcgccgagcgcctgctgaccgagtactgcatcgagactggggcccctgac
ggctccttcctagtgcgcgagagcgagacctttgtgggcgactacaccctgtctttctgg
cggaacgggaaagtccagcactgccggattcactcccggcaggatgctgggacccccaag
ttcttcttgacagacaacctcgtcttcgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgaatttgagatgcgcctctcagagcccgtcccacagacc
aatgcccacgaaagcaaagagtggtaccacgcaagcctgaccagagcacaggctgagcac
atgctgatgcgcgtcccccgtgatggagccttcttggtgcggaaacggaacgagcccaac
tcctatgccatctccttccgggcggaaggcaagatcaagcattgccgcgtgcagcaggag
ggccagacggtgatgctgggcaactcggagtttgacagcctcgtcgacctcatcagctac
tacgagaagcacccactgtaccgcaagatgaagctgcgctatcccatcaacgaggaggcg
ctggagaagatcggcacagctgagcctgactacggggccttgtatgagggacgcaaccct
ggcttttatgtggaggcaaaccctatgccgacttttaagtgtgcggtcaaagccctcttc
gactacaaggcgcagagagacgacgagctgactttcaccaagagcgccatcatccagaac
gtggagaagcaggacgggggctggtggcggggagactacggtgggaagaagcagctctgg
ttcccgtccaactacgtggaggagatggtcagccctgcagccctggagcccgagagggag
cacttggatgagaacagccccctgggagacttgctgcggggcgtcttggatgtgccagcc
tgtcagattgccatccgtcccgagggcaagaacaaccggctcttcgtcttctccatcagt
atggcgtcggtggcgcagtggtccctggatgttgccgctgagtcacaggaggagctgcag
gactgggtgaaaaagatccgcgaagtggcccagactgcggacgccaggctcacagagggg
aagatgatggaacggaggaagaagatcgccctggagctctccgagctcgtcgtctactgc
cggcctgtccccttcgatgaagagaagattggcacagaacgtgcctgctacagggacatg
tcatccttcccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgactgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaattatgatcccttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagaccccagacaaacctatgcagatgaaccaggccctgttcatgaccggggggcactgt
ggctacgtgctgcagcccagcaccatgcgggatgaggccttcgacccctttgacaagagc
agccttcgtgggctggagccgtgcgccatctgcatcgaggtgctaggtgcccggcatctg
ccaaagaatggccgaggcattgtgtgtccctttgtggagatcgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggcctgaaccccgtgtgg
ccggccaagcccttccacttccagatcagtaaccctgaattcgctttcctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcctggctcaggctactttcccagtg
aagggcctgaagacaggatacagagcggtgcctttgaagaacaactacagtgaagacctg
gagttggcttccctgttggtcaagatcgacattttccctgccaagcaggagaacggcgac
ctcagcccgttcagtggcacatcgctgcgggagcggggctccgacgcctcgtgcccgctg
ttccacggccgggcccgcgagggctcctttgaagcacgctaccagcagccgtttgaggac
ttccgcatctcccaggagcaccttgcagaccattttgacagccgggaacgaagggcccca
cgaaggactcgggtcaatggagacagccgcctctag

DBGET integrated database retrieval system