Pleuronectes platessa (European plaice): 128457533 Help Entry 128457533         CDS       T09923                                  Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism pplt  Pleuronectes platessa (European plaice) Pathway pplt04020   Calcium signaling pathway pplt04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pplt00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128457533    04020 Calcium signaling pathway     128457533  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pplt01009]     128457533   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pplt04147]     128457533    04040 Ion channels [BR:pplt04040]     128457533 Protein phosphatases and associated proteins [BR:pplt01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      128457533 Exosome [BR:pplt04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    128457533 Ion channels [BR:pplt04040]  Voltage-gated cation channels   Ryanodine receptor    128457533 BRITE hierarchy Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  128457533 NCBI-ProteinID:  XP_053298242 EnsemblRapid:  ENSOESG00000029003 LinkDB All DBs Position 15:12701949..12747052 Genome browser AA seq 5012 aa AA seqDB search MAEGADGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNSSVDESSQGGGHRTLLYGHAILLKHTHSSMYLSCLT TSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHL SYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAIPGAEQGD DPRRVAHYEGGAVCSHARSLWRLEPLRIGWSGGHIKWGQSFRIRHITTGRYLCLDEEKGL LLVDPEKAVSKMSAFCFRISKEKIEVTQKRDVEGMGIPEIKYGESMCFVQHVSTGLWLTY AAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIHSTTGLFNQFIKGLD ALSGKNKSSNPPSLPMDAVVLYLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQNLFQEEG MITHVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFCD NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDV LCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIINYVTSMRPNIFLGTCEGSTQYKKW YFEVMVDHVEPFLTAQAYHLRVGWALTEGYSPYPGGGEGWGANGVGDDLYSYSFDGLNLW SGRVPRHVATPNQHILAAEDVISCCLDLSVPSISFRINGYPVQGMFENFNLDGLFFPAVS FSAGVKLRFLLGGRHGDFKFQPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFEGIRNLLGP TQSLSHTAFTPCPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGPFRDDNKK LHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKNKLPKTYMQS SGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPRLV PYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQEGCIGPGSTRGDKIRVFRAEKSYA VTQGKWYFEFEAVTVGEMRVGWARPNVRADTELGADEFAYVFNGFKAQRWHVGNESFGRQ WLSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSLGLSQVGRI NLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPEFNIVPTDHPHIEVSRVDG TVESAPCLKATHKTFGSQNANTDLLFFRLSMPVEFHETFKVTAGTTLLTRTLTNPEDEVI EVDPDSDFEILKKSATRNEQEEEKKEPSVPKEIPKNGENEKDASTEKSKKKGFLFKAKKA ALMSSPPIVPTMPRLMEDVVPDDRDDVDIILNTTTYYYSVRVFAGQEPSGVWVGWITPDY HQYDLHFDISKVRNVTVTVGDDKGNIHGSIKRSNCYMVCGGEFSSSQQTRVSQEDFVIGC LIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMIQFELGKLKNIMPISAA MFRSERKNAVPQCPPRLDVQMLTPVIWSRMPNHFLAPETGRISERLGWVVQCKEPLTMMA LHIPEENRCIDILELSERMDLLKFHYHTLKLYGSVCALGNNRVAHALCSHVDESQLFYSI ENTYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTDETRSITLYSDKSHALPGV GLTTCLRPKLHFSSIGFVGTDQDIYTLSPVIPLQVLKTKALNMLTEAVQDGGQAMRDPVG GSVEFHFVPILKLISTLLIMGVFDDEDVTHILKMIEPTVFTAEEEEEEEYEDDGLGDDEE EEEFEEEEELEEETEKEMKPAEAKEGEAKEHLEQGLFQMKLPESVKLQMCTLLQYFCDCE LRHRVEAITAFSDQFVSQIQSNQRHRYNELMLAFTMSAAETARKTREFRSPPQEQVNMLM NFKNCAEDEECPIPDEVRESLLVFHNVLLVHCGVHIEEEEQEEEVDYSLRGRLLRLLVKV KKFHEKKVVLEPEPQEDKKPSTLQELISDTMIHWAQESFIQNPELVRMMFSLLHRQYDGL GELMRALPKAYTINAVSIRDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSNKVF YQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRISRQNQRSMF DHLNYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGCGLQSCP MLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGE GGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENKVHLGNAIMSFYSALI DLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGVISLSLQIPALGKDNSIIEPKM SASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTTEMALAL NRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRDIIEECLMAL CKHLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGLASEE ELHLTRKLFWGIFESLAHKKFDAEIFKISMPCICAIAGAIPPDYVDASYSSKTEKKASVD AEGNFDPKPVETTNTIIPERLDPYINKYAEYTHDRWAFEKIQNNWSYGEVLDENAKTHPM LRPYKTFSEKDKEIYRWPIKESIKAMVAWEWTIDKAREDEESDKKKASSRKISQTAQATY DPSHGYSPQPIDITHMALSRDLQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLLVPYD TLTAKEKARDREKAHELLKFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQKLLKWMEI AQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPAKVLGSGG HSSNKEKEMIASIFCKMSALVRHRVSLFGTDASAIVNCLHILARSLDARTVMKSGPEIVK AGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFDHIAQ HQFGDDVMLDDLQMSCYRIMCSIYSLGTVKNPHVERQRPALGECLAHLAAAMPVAYVEPH LNEYNAFSVYTTKTPRERAILGLPSEVQELCPDIPELDSLLKEIGDLAESGARYTEMPHV IEITLPMLCNYLPRWWERGFENFPEMEGQLCTEVTSEHLNQLLGSIMKIVVNNLGIDEAS WMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSEGDEEDGT IRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKR EEQNFVVMNEINNMSFLTADSKSKMTKGGDSEGGGSDTERTKKKKRGDRYSVQTSLIVAA LKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVDNPSMRWQMA LYKEMAGKAEDADAPMKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQRRRAVVA CFRMTPLYNIPRHRASNMFLEGYKRNWLHTEGYSFEDRMIDDLSKAMEQEEGDEEEERET KPDPLHQLILHFSRTALTEKSKLDTDHLYMAYADIMAKSCHIGEEEEGEEMVESAEDELP FEVRQTELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVSTTLKLGISILN GGNSEVQRKMLEYLRDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTNE KVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQESISD FYWYYSGKDVIDEPGKKNFSKAMIVAKQIFNSLTEYIQGPCTGNQQSLAHSRLWDAIVGF LHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESS SNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYAPSEIQFLL SCSEADENDMINYEEFASRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLGQAESVLN YFRPFLGRIEIMGASRKIERIYFEISEVNRKQWEMPQVRESKRQFIFDVVNEGGESEKME MFVNFCEDTIFEMNIASQISEQEEEEKGEEDDEVEESGGEAGQGGGANGGGDEDSNGEEG EPESSSAFADFINSMLGFFSIFTFRNLRRQYRRVRKMTIKEIVVALSTFFWTILMSILHF IYNVCKGFFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHGDGPGEPRTGEEQE TGGVTDTGETGSGEEEEEDTQEKEGGRIPGMDAPGGLGDMGVEAAVEPPTPEGTPITKRK KAPEETDVSQKPPEPVAEPPPEPEKADVESGEKAEKDSQSKEKEQPDKPRKSAKKKEKPK REGGFQIWAELETQRMKFMNYLSRNFYNLRFLALFLAFALNFILLFYKVSEIPPGGEEME GSGMGEGSGLFEGSGLFEGSGEEAEGSGWDEEGEEDEEDVPVYFYLEESTGYMQPTMAFI ALLHTVISFICIIGYNCLKIPLVIFRREKELARKLEFDGLYITEQPEDDDIKGQWDRLVL NTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDVSQQHEKKQEEPDNSVF AWATTVDIKYQIWKFGVVFTDGTFLYLCWYLIMSLLGHYNNFFYACHLLDIAMGVKTLRT ILSSVTHNGKQLMMTVGLLAVVVYLYTVIAFNFFRKFYNKGEEEDEPDMKCDDMMTCYLF HMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRD QQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLDEHNLANYMFFLMYLINKDDTEHTG QESYVWKMYQERCWDFYPAGDCFRKQYEDQLS NT seq 15039 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtgcagatggagaggaagagattcagttcctgcgtacagacgatcaagtg gtgctgcagtgcactgcgtctattcttaaggaacagatcaagctgtgtctgtcatgtgaa gggttcgggaatcgtctctgcttccttgagaccacctccaacgctcagaatgtccctcca gacctcgctatctgctgcttcatcttggagcagtccctgtccgtgcgggctctgcaggag atgctgtccaactcttctgtggatgagtcatcacaaggagggggtcacagaacgctactg tatggacacgccattctccttaagcacacacactccagcatgtacttgagctgtttgact acttcgcgttcactgacagacaaactggcttttgatgtgggcttgcaggaggactccaca ggggaggcctgctggtggaccatccatccagcctcaaagcagaggtctgagggcgagaag gtcagggtgggagatgacctcattcttgtcagtgtatcttcagagcgatacctgcatctg tcctatgccagtggcgacttgatggtcgatgcttccttcatgcaaacgctgtggaccatg acgcctgtgatgtcaggatgtgagcttgctgaaggttttctgacgggaggttatgtgctc aggctgttccatggtcacatggatgagtgcttggcaatccctggagctgagcaaggggac gacccgcgcagagttgctcattatgaaggtggggctgtatgcagccatgccagatcctta tggagacttgagccgcttcgtatcggttggagcggaggtcacattaaatggggccagtca ttccggatccgtcacataacaacaggcaggtacctctgtctggatgaagagaaaggactg ctgctggtggaccctgagaaggccgtttccaagatgtcagccttctgcttcagaatttca aaggaaaaaattgaagtgacccagaagcgagatgtggaaggtatgggcattcctgagatc aagtatggagagtccatgtgcttcgtacagcacgtgtcaacaggcctctggcttacatac gctgctgtcgatgctaaatctgcccgtctaggtcctttaaaaagaaaggcaatactccat aaagaaggtcacatggatgatgcgctcacagtggccagatctcagaccgaagagtcccaa gcagccagaatgattcacagcacaacaggcctctttaaccagttcatcaaaggtctagat gctctaagtgggaaaaacaaatcttccaatcccccatctctgcctatggacgctgtggtg ctctatctgcaggacctcattttctacttcagaccccccgaggaggagctggagcacgag gacaaacagttcaagcttcgctccctcaagaacagacagaacctcttccaggaagagggg atgataactcatgttctggactgtgttgatcggctcaatgtctacaacacagcagcccac ttctcagagtatgcaggggaggaagctgcagagtcctggaaggagatagtcaatttactg tatgaactgctagcctctttgatcagagggaatcgtgcaaactgtgctttgttctgtgat aacctcgactggttggtcagcaaactcgatcgtttggaagcgtcttcaggaatcctggag gtgttgtattgtgttctgattgagagtccagaggtgttgaacattatccaggagaatcac atcaaatcaatcatctccctgctggataaacatggacgcaatcacaaggtgttggatgtc ctctgttctctgtgtgtgtgtaatggggtggctgtgaggtcaaatcagaatctcatcaca gagaatctacttccaggtcgtgacctactacttcaaaccaacattatcaattatgtaacc agcatgagacccaacattttccttggaacctgtgaaggatccactcagtataagaagtgg tattttgaggtgatggtggaccacgtggagccattcctcacggctcaggcttatcacctg cgtgtgggctgggctctgacggagggctatagtccttaccctggtggaggtgaaggctgg ggtgctaacggcgtcggagatgacctctactcctacagttttgacggacttaacctctgg tcaggacgtgttccgcgtcacgttgccacacccaatcagcacatcctggcagcagaggac gtcataagctgctgtttggatctgagcgtgccgagcatttcctttcgtatcaacgggtat cctgttcaaggaatgtttgagaacttcaacctggacggcctgtttttccccgctgtcagc ttctctgcgggcgttaagttgcgattccttctcggagggcgtcatggggatttcaagttc caaccaccccccggctacgctccttgctatgaggcagtgcttcctagggaccgtttgcgg atcgagcccatcaaggagtataagcatgatttcgagggcatccgcaacctgctgggtcca actcagtccctatcacacacagctttcactccttgccccgtggacactatacagattgtg ttgcctcctcatttggaacgcattcgagagaagcttgcagaaaatagccacgagttatgg gctgttactcgcattgaacaaggatggacctacggaccatttcgtgacgacaacaagaag ctgcatccctgcctggtggatttccagagtctgccggaaccagagaagaactacaattta gccatgtcaggagagacactgaagaccctgctggcactcggctgccatgtaggaatgggt gatgagaaagcagaggagaatctgaaaaagaacaagctccccaaaacttacatgcagagt agtggatataagccggcgcctctggacctcaaccacgtcaagctgaccccgaatcaaaac actctcgttgagagactggcagaaaacggacacaacgtgtgggcaagagaccgagttcgc cagggctggacgtacagcattgtccaggatataatgaacaagcgcaatccgcgcttggtt ccttacaacctacttgacgaaaagactaagaagacgaacagagacacagtgtgtgcagct gttcgcactctcattggatatggttacaatatagaaccacctgaccaggagggctgcatt ggacctggcagcacccgtggagataagatccgagttttccgagcagagaaatcatacgct gtcactcaggggaagtggtactttgagtttgaggccgtgacagtcggggagatgagagtg ggctgggcaagacccaatgttcgtgcagacactgaactcggtgcagacgagttcgcatac gtcttcaatggtttcaaggctcaacgttggcatgtgggaaatgagtcatttggtcgtcag tggctgtccggggacgtggtgggttgtatgattgacctgaccgagatgaacatcatgttc acactcaacggggagatgttgatcagtgactcaggctcagagatggcctttaaggatatt gagattggtgaaggatttatacccgtgtgcagtttgggcctctcccaggtcggaaggatc aacttgggtcagaacgtcagcagtcttcgttactttaccatctgtggcctgcaggaggga tttgaaccctttgccatcaacatgaagagagacatcaccatgtggttcagcaagagcctt cccgagtttaatattgtgcctacggatcatcctcacattgaggtctcccgtgttgatggg acagtggaatctgccccttgcctcaaagcgacccacaagacattcggttctcagaacgcg aacacagatctgctgttcttcagactcagtatgccagtagagtttcacgagaccttcaaa gtcacagcaggcaccaccctccttacccgtacactgaccaaccctgaggatgaggtgatc gaggtggacccggactctgattttgaaatactcaagaagtctgccactcgcaatgagcag gaggaggagaagaaagaaccctctgtgcccaaagagatacccaagaatggagagaatgag aaggatgcctcaactgagaaaagcaagaagaaaggattcctcttcaaggctaagaaggct gcgcttatgtcatcaccgcctattgttcccaccatgccccgcttaatggaggatgtggtg ccagacgacagggacgatgttgacattatcctcaacactacgacatattactactctgtg cgagtgtttgcgggacaggagcccagtggcgtgtgggtgggctggatcacacctgactat caccagtacgaccttcattttgacatcagcaaagtgagaaatgttacagtcactgtaggt gatgataaaggcaacattcacggcagtataaaacgcagtaactgctacatggtttgtgga ggagagttcagcagctcccagcagaccagagtcagtcaggaggattttgtgattggctgt ctcattgatctggacacaggacttatgactttcactgctaatggaaaagagataaacaca ttttaccaggtggagcccaacacaaagctgttcccagctgtcttcgtgcttccttccagt cagaatatgattcagtttgaactgggcaagctgaagaacattatgccaatctctgccgcc atgttccggagtgagcgcaagaatgccgtcccccagtgccctcctagactggacgtccaa atgttaaccccggtcatctggagccgcatgcccaaccacttcctggctccggagacaggc cgtattagtgagagactgggctgggtggtgcagtgtaaggagccgcttaccatgatggcc ctccacattccagaggagaacagatgtatagacatcctggagctgtctgaacgaatggac ctgctgaagttccactatcataccctgaagctgtacggctcagtgtgtgctctgggaaac aatcgtgtggctcacgctctgtgcagccacgtggatgaatcccagctcttctactccatc gagaacacctacctacccggaccaatgaggagtggcttctacgacctgctcatcagcatg cacctggagtccgccaagaggaaccgactgggaaccaacaaggaattcatagttccaatg acggatgaaacacgcagtattactctgtactcagacaaatctcacgctttacctggggtc ggcctcacgacatgtctacgtcccaaactccatttctcgtctattggctttgtgggaaca gatcaagacatctacacactgagtccagtcatccccttacaggtgttaaagaccaaggcc ctaaacatgctgactgaggcggtgcaagacggtggtcaagccatgagggatcctgtggga ggtagtgtcgagtttcactttgttccaatcctgaagctcatcagtactctcctcatcatg ggtgtgttcgatgatgaagacgtcacacacattctgaagatgattgagccgacggtcttc actgcagaggaagaagaagaagaggagtatgaggatgacggtttgggtgatgatgaggag gaggaagagttcgaagaagaggaagaattagaggaggaaacggagaaagagatgaaacct gcagaggctaaagaaggggaagctaaagaacatctggagcaaggacttttccagatgaag cttccagagtctgttaaattacagatgtgcactctactgcagtatttctgtgactgtgag ctacgccacagagtggaggccatcactgccttttctgaccagttcgtcagccagatccag tccaaccagcggcatcgctacaacgaactgatgctcgccttcaccatgagtgcggccgag accgcccgcaagacccgagaatttcggtccccaccacaggagcaggtcaacatgctaatg aacttcaagaactgcgctgaagatgaagagtgccccattcccgatgaggtccgagaatcc ctgctggtttttcacaatgttctgctcgtccactgtggtgttcatattgaagaagaagag caagaggaggaggtggattattccctccgcggacgactgttgcgtttgttggtaaaggtg aagaagttccacgagaagaaggtggtgctggagccggagccacaggaagataaaaaacca agcacactgcaggagctgatttccgataccatgatccactgggcccaggaatcattcatc cagaaccctgagcttgtgcgcatgatgttcagcctccttcacaggcagtacgacgggctg ggcgagctcatgcgggccctccccaaggcctacaccatcaatgcggtatcaattcgggac actatggacctgctggagtgcctggggcagatccgctcactgcttattgtccagatgggt ccagaggaagagaggcttatgattcaaagcatcgggaacatcatgagtaacaaagttttc tatcagcaccccaacctgatgcgagcgctgggcatgcatgaaactgtaatggaggtcatg gttaatgttctgggtggtggggattcaaaggagatcagattccctcgggtggtgacaaac tgttgccgtttcctttgctatttctgtcgcatcagtcgccaaaatcagcgctctatgttt gaccacctcaactaccttctgcagaacagtggcatcggccttggaatgcggggctccacc cccttggacgtggctgcggcgtcttgtatcgacaacaatgagcttgcattggctctccag gagcaggacctggaaatggtggtcaagtatttagctggatgtggactgcagagctgcccg atgctgctgtctaaaggctaccctgacattggttggaatccgtgtggtggagagaaatac ttggactttcttcgttttgctgtgtttgtcaacggagagagcgtagaagagaatgccaac gtggtggtacgtctcctcatccgcagacctgagtgctttggtccggccctgagaggggaa ggaggcaatggtcttctggccgcaatagaggaggccatcaagatatcagaggaccctgca agagatggacctagcgtaaagaaagacagacgctttccaatgtttgggggagaggagcag catgaggagaacaaggtgcacctgggaaatgccatcatgtcgttctactccgctctgatc gacttgctgggacgctgcgctccagagatgcacttgattcaggctggtaagggtgaggct ctgaggatcagggccattctgaggtctcttgtccctcttgaggatctggtgggagtcatc agcctttctcttcagattcctgctttaggaaaagacaacagcatcatagagccaaagatg tccgctagttttgtgccggatcacaaggcgcccatggtgctgttcctggacagggtgtat ggtattgacaaccaggatttcttgctccacgtgctggaggttggatttctgcctgacatg agggctgctgcctctctggacacggttgctttcagcaccacagagatggccctcgctttg aaccgctacctgtgctctgctgtgttgccactcatcaccaagtgcgccccactctttgct ggcagcgaccaccgcgccataatgatcgactccatgttgcacacaatctaccggctttct cgtggacgagcctttacaaaggcccaaagagacatcattgaagagtgcctaatggctttg tgcaaacatctacgtccctccatgcttcagcacctgctcagaaggctggtgtttgatgtg cccattctgaatgagtacgccaaaatgccactgaagcttctaaccaatcactatgagcgt tgttggaaatattattgcctccctaatggttgggcaaactttgggctggcgtcagaggag gagctgcatctgacccgaaaactgttttggggaatctttgaatcgttggcacacaagaaa tttgatgcagagattttcaaaatatctatgccatgcatctgtgcgatcgctggagccatt cctcccgactatgtagatgccagttactcctccaaaacagagaaaaaggcgtcagtagat gcagagggaaactttgatccgaaaccagtagagacgacaaataccatcatccctgagaga ctggatccctacatcaacaaatatgctgaatatacacatgatagatgggcctttgaaaag atccagaataactggtcctatggtgaagtgttggatgaaaatgcaaaaactcatccgatg ctgaggccgtacaaaaccttctcagagaaagacaaagagatctaccgttggccgatcaaa gagtcgatcaaagccatggtggcgtgggagtggaccatagataaagcgagagaggatgag gagtcggacaagaagaaagcatcctcacgtaaaatctcacagaccgctcaggcaacctat gacccaagccatggctacagtccacagcccattgacatcacacacatggctctttcaagg gatctgcagtctatggcagagcaactggcagaaaattatcataacacctggggacgaaag aaaaagttggagctgcagtccaagggaggtggaacacatcctctactggtgccatacgat actctgacggccaaagaaaaggcacgagacagagagaaggctcatgaactgctcaagttc ctgcagcttaatggatatgctgtcacaaggggcctgaaagacatggagtctgacatctca tccatcgagaagagatttgcttatggtttcctgcagaagctgttgaaatggatggaaatt gcccaggagttcattgctcatcttgaggctgtggttagcagtggacgagtggaaaagtct cctcacgagcaggaaatcaaattcttcgccaagatcttgatgcctctaatcaaccagtat ttcaaaaaccactgcctctacttcttgtcaacacctgcgaaagtccttggcagcggtggc cattcgtccaataaggagaaggagatgattgcaagcatcttctgtaaaatgtccgctctg gtgagacacagagtttctctctttggaaccgatgcttcagcaatcgttaactgtcttcac atcctggcaaggtcactggacgcaaggacagtaatgaagtcagggccggagattgtgaaa gcggggctgcggtccttctttgagagcgctgctgatgatatagagaagatggtagagaat ctcaaactgggcaaagtttccaaagggaatcagcaagtcaaaggcgtgtctcagaacatc aactacaccaccatcgccctgctgccagtgctcacctccctgttcgaccacatcgcacag caccagtttggagatgatgtcatgttggatgatctacagatgtcgtgctatcgcatcatg tgcagcatctactccttagggactgtcaagaatccacatgttgagaggcagaggccagct ctcggagaatgtttggctcaccttgcagcagccatgccagtcgcctacgtagaaccccat ctgaatgaatacaatgctttctctgtctacaccacgaagacgccgagggagagagccatc ttgggtctgcccagcgaggtccaggaactctgtccagacattcccgagctggattctctg ttgaaggagattggagacttggccgagtcgggggctcgttacactgagatgcctcacgtg attgaaataactttgcccatgctgtgtaactacctgcctcgctggtgggagagagggttc gaaaacttccctgagatggagggccagctctgcactgaggtcacgtcagaacacctcaat cagctgctgggcagcatcatgaaaattgtagtcaacaacttgggtattgatgaggcctct tggatgaagaggttggctgtgttttcgcagcccattgtcagcagggcaaagccagagatg ctcaagtcccacttcatcccaacaatggagaagctgaagaaacgcacatcgaaggtggtg gctgaagaggaccatctgaggatggagggcaaatccgagggagatgaagaagatggaacg atacgggatgagtttgctgtcctctgcagggacttgtatgcactctaccctctactgatt cgctatgtggacaacaacagggcaagatggctgacatgccccgaccccgatgcagaagag ctcttccgaatggttggagaagtctttattttttggtccaaatctcacaacttcaagaga gaagaacagaactttgtggtgatgaatgagatcaataacatgtcattcctcactgctgac agcaagagcaaaatgaccaagggcggggactcagagggaggaggctccgacaccgaacgc accaagaaaaagaaacggggagatcgttactctgtgcagacgtcacttattgtggccgct ttgaaaaagatgctccccataggcctcaacatgtgctcccccgccgatcaggagcttatc aacttggccaagatccgatactctttgagagacactgatgaagaagtgagagagttcctg cagaacaatcttcatcttcaggggaaggtggacaacccatccatgcgctggcagatggct ctatacaaggagatggcggggaaggccgaagatgctgatgctccgatgaaagttgtgaag agagttcaggaggtttctgctgtcctctaccacctggaagttacggagcacccgtttaaa tccaagaagatggtgtggcacaaactgttgtccaagcagagacgcagggctgtggtcgct tgcttcaggatgacgccactatacaacatccccaggcacagagcttcaaatatgttcctc gagggatacaagcgcaactggcttcacactgagggttactcatttgaagacaggatgata gatgacttgtcgaaagcgatggagcaagaggaaggagatgaagaggaggagagagaaaca aagccagatcctcttcaccagctcattctgcatttcagtcgtaccgctctaacagaaaag agtaaacttgatacagatcacctttatatggcttatgccgatattatggcaaagagttgc catattggtgaggaagaagaaggagaggaaatggtggaaagtgctgaagatgagctgcct tttgaggtgcgacaaacagaactggaaaaagaaatggagaaacaaaggctcctgtaccag cagtccagacttcataatcgtggggctgcagagatggttctgcaaatgatcagtgcctgc aaaggtgagacaggcccgatggtgtccacaacactaaagctgggtatctccatcctgaac ggtggaaacagtgaggttcaacgaaaaatgctggagtacctgagggataagaaggatgtg ggcttctttttgagtgtccaagctttgatgcagacatgctctgtcctggatctaaatgcc tttgagaggcagaacaaggcagaggggctcggcatggtttccgaagagggcacgaatgag aaagtgatggcagacgatgagttcacctgtgacctcttccgtttcttgcagttgctttgt gaaggtcacaataacgactttcagaactatttgcggacccagacgggaagcacgacgacc atcaacgtcatcatctgcaccgtagattacctcctccgacttcaggagtctatcagtgat ttctactggtactactctgggaaggacgtaatcgatgaaccaggcaaaaagaatttctcc aaagctatgattgttgcgaagcagatttttaacagtctaactgaatatattcagggccca tgcactggcaaccagcagtccctggcccacagcaggctgtgggatgctattgttgggttc cttcatgtctttgcccatatgatgatgaagctggcacaggactcgagccagattggtttg ctgaaggagcttcttgacctgcagaaagacatggttgttatgttgctctcactgttggag ggcaacgtggtcaatggaacgatcgcccgccagatggtggacatgctggtggagtcctcc agtaacgttgagatgatcctcaagttctttgacatgttcctcaaactgaaagacatcgtg gcttcggacgctttccgcgattatgtcacggacccgcgaggactgatctccaagaaggac ttccagaaggccatggacagtcagaagcagtacgctccctcagagatccagtttcttctg tcctgctcggaggccgatgagaacgacatgatcaactacgaggagtttgccagtcgcttt caggaacccgcaaaagatatcggcttcaacatcgctgtgctgctcaccaacctgtctgag cacgtcccccatgacaccaggctacagaacttcctcgggcaggcagagagtgtgctcaac tacttccgccccttccttggccgtattgaaataatgggcgccagcagaaagattgagcgc atctactttgaaatcagtgaagtgaaccgcaagcagtgggagatgccccaagtcagagag tccaaacgacagttcatctttgatgtggtgaatgagggcggtgaatccgagaaaatggaa atgtttgtcaacttctgtgaggacaccatctttgagatgaatatagcctctcagatttca gagcaggaggaggaggagaagggagaggaggatgacgaagtagaggaaagtggaggtgag gcaggacaaggagggggagcaaacggaggaggggatgaggacagtaacggagaggaagga gagcccgaatcgagctcggcctttgcagactttataaacagcatgttgggcttcttcagc attttcaccttccgtaaccttcgcagacaatatcgccgagtgaggaaaatgaccatcaaa gagattgtggtggctctgtccaccttcttctggaccatcctgatgagcatactccacttc atttacaatgtgtgcaaaggcttctttatgatcatctggcaaactctgttcggtggtggc ttagtggagggggcgaagaatatcacggtgacggagattttagccagcatgccagacccc acgcaggacgacgtgcacggggacggaccaggggagccgaggacaggggaggaacaagag actgggggggtgacggacactggagagactggcagtggggaggaggaagaggaggacacc caggaaaaagagggtgggaggataccaggtatggatgctccaggtggactcggtgacatg ggtgtagaggcagctgtcgaaccccctactcccgaaggaactcccataacaaagaggaaa aaggctccagaagagactgatgtgagtcagaaaccccctgaacctgtagcagagcctcct ccagaacctgaaaaggcagatgtcgaatctggagagaaagcggagaaagattcccagagc aaagagaaagagcagccagataaacccaggaaatctgcaaagaaaaaagagaagccgaaa agggagggaggctttcagatctgggctgagctggaaacccaaagaatgaaattcatgaac tacctctccagaaacttttacaacctgcgctttttggctctgttccttgcatttgcactg aacttcattctgctgttctacaaggtgtctgaaatcccacccggtggtgaggaaatggaa ggatctggaatgggggagggcagcgggctgttcgagggctctggcttgtttgaaggttca ggggaagaagctgagggatctggatgggatgaagaaggagaagaggatgaggaagacgtg ccggtttatttctacctagaggagagcacgggctacatgcagcccaccatggccttcatc gccctcctgcacacagtcatctcgttcatctgcatcatcggctacaactgcctcaagatt ccacttgtgatctttagaagagagaaagaactcgcaagaaagcttgagtttgatggactt tacatcaccgagcagcctgaggacgatgacatcaagggccagtgggaccgtctggtcctc aatacaccctctttcccaaacaactattgggataaatttgtcaagcgaaaggttcttgat aagtacggagacatttacggcagagaaagaatcgcagaactgctcggtgttgatttagcc tccctggacgtgagtcagcagcacgagaagaaacaggaggaaccagacaactctgtgttt gcatgggcgaccaccgtcgacatcaagtaccagatctggaaatttggtgttgtgttcaca gacggtactttcctgtatctctgttggtacctgataatgtccttgcttggacattacaac aacttcttctatgcctgtcacctgctggacatcgccatgggtgtgaaaactctccgcacg atcctgtcctcagtcacacacaatggcaaacagctcatgatgactgtgggcttgttggcc gtggtggtgtacctctacaccgtcatcgccttcaatttcttccgcaagttttacaacaag ggcgaggaggaggacgaaccagatatgaaatgcgatgacatgatgacttgttacttgttc cacatgtacgtgggtgtgcgggcaggaggaggcatcggggatgagatcgaggatcctgct ggagatgaatacgagttgtatcgagtggtctttgatataaccttcttcttcttcgtcatt gtcattctgctggctattattcagggtctgatcattgatgcctttggagaactcagagac caacaagagcaggtcaaggaagacatggagacaaaatgcttcatatgtggcatcgggagc gactacttcgacacgacgccgcatggtttcgagactcacactttagatgagcacaacctg gccaattacatgttcttcttaatgtatcttatcaacaaagatgatacagagcacactgga caggagtcgtacgtgtggaagatgtaccaggagcgatgctgggacttctaccccgctgga gactgtttcagaaaacaatacgaggatcagctctcctaa

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