Entry Name Protein export - Poeciliopsis prolifica (blackstripe livebearer)
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Other DBs Organism Poeciliopsis prolifica (blackstripe livebearer) [GN:
pprl ]
Gene 129357259 spcs1; signal peptidase complex subunit 1 [KO:K12946 ] [EC:3.4.-.-]
129358847 get1; guided entry of tail-anchored proteins factor 1 isoform X1 [KO:K22384 ]
129359336 srpra; signal recognition particle receptor subunit alpha [KO:K13431 ]
129359416 spcs2; signal peptidase complex subunit 2 [KO:K12947 ] [EC:3.4.-.-]
129362945 immp2l; mitochondrial inner membrane protease subunit 2 isoform X1 [KO:K09648 ] [EC:3.4.21.-]
129364436 immp1l; mitochondrial inner membrane protease subunit 1 [KO:K09647 ] [EC:3.4.21.-]
129364835 sec61g; protein transport protein Sec61 subunit gamma [KO:K07342 ]
129369228 sec63; LOW QUALITY PROTEIN: translocation protein SEC63 homolog [KO:K09540 ]
129369925 srprb; signal recognition particle receptor subunit beta [KO:K12272 ]
129379308 sgta; small glutamine-rich tetratricopeptide repeat-containing protein alpha [KO:K16365 ]
129379964 bag6; LOW QUALITY PROTEIN: large proline-rich protein BAG6 [KO:K23390 ]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway
