KEGG   Pan paniscus (bonobo): 100969981
Entry
100969981         CDS       T02283                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04081  Hormone signaling
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05415  Diabetic cardiomyopathy
pps05417  Lipid and atherosclerosis
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100969981 (PIK3R2)
   04014 Ras signaling pathway
    100969981 (PIK3R2)
   04015 Rap1 signaling pathway
    100969981 (PIK3R2)
   04370 VEGF signaling pathway
    100969981 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100969981 (PIK3R2)
   04668 TNF signaling pathway
    100969981 (PIK3R2)
   04066 HIF-1 signaling pathway
    100969981 (PIK3R2)
   04068 FoxO signaling pathway
    100969981 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100969981 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100969981 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100969981 (PIK3R2)
   04024 cAMP signaling pathway
    100969981 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100969981 (PIK3R2)
   04152 AMPK signaling pathway
    100969981 (PIK3R2)
   04150 mTOR signaling pathway
    100969981 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100969981 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100969981 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    100969981 (PIK3R2)
   04218 Cellular senescence
    100969981 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100969981 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100969981 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100969981 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100969981 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    100969981 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100969981 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    100969981 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100969981 (PIK3R2)
   04660 T cell receptor signaling pathway
    100969981 (PIK3R2)
   04662 B cell receptor signaling pathway
    100969981 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100969981 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100969981 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100969981 (PIK3R2)
   04062 Chemokine signaling pathway
    100969981 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100969981 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    100969981 (PIK3R2)
   04929 GnRH secretion
    100969981 (PIK3R2)
   04915 Estrogen signaling pathway
    100969981 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    100969981 (PIK3R2)
   04917 Prolactin signaling pathway
    100969981 (PIK3R2)
   04926 Relaxin signaling pathway
    100969981 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100969981 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100969981 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100969981 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100969981 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100969981 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100969981 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100969981 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100969981 (PIK3R2)
   04380 Osteoclast differentiation
    100969981 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100969981 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100969981 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100969981 (PIK3R2)
   05206 MicroRNAs in cancer
    100969981 (PIK3R2)
   05205 Proteoglycans in cancer
    100969981 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    100969981 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100969981 (PIK3R2)
   05203 Viral carcinogenesis
    100969981 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100969981 (PIK3R2)
   05231 Choline metabolism in cancer
    100969981 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100969981 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100969981 (PIK3R2)
   05212 Pancreatic cancer
    100969981 (PIK3R2)
   05225 Hepatocellular carcinoma
    100969981 (PIK3R2)
   05226 Gastric cancer
    100969981 (PIK3R2)
   05214 Glioma
    100969981 (PIK3R2)
   05221 Acute myeloid leukemia
    100969981 (PIK3R2)
   05220 Chronic myeloid leukemia
    100969981 (PIK3R2)
   05218 Melanoma
    100969981 (PIK3R2)
   05211 Renal cell carcinoma
    100969981 (PIK3R2)
   05215 Prostate cancer
    100969981 (PIK3R2)
   05213 Endometrial cancer
    100969981 (PIK3R2)
   05224 Breast cancer
    100969981 (PIK3R2)
   05222 Small cell lung cancer
    100969981 (PIK3R2)
   05223 Non-small cell lung cancer
    100969981 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100969981 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100969981 (PIK3R2)
   05161 Hepatitis B
    100969981 (PIK3R2)
   05160 Hepatitis C
    100969981 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100969981 (PIK3R2)
   05164 Influenza A
    100969981 (PIK3R2)
   05162 Measles
    100969981 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    100969981 (PIK3R2)
   05163 Human cytomegalovirus infection
    100969981 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100969981 (PIK3R2)
   05169 Epstein-Barr virus infection
    100969981 (PIK3R2)
   05165 Human papillomavirus infection
    100969981 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100969981 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100969981 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100969981 (PIK3R2)
   05142 Chagas disease
    100969981 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100969981 (PIK3R2)
   05017 Spinocerebellar ataxia
    100969981 (PIK3R2)
   05020 Prion disease
    100969981 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100969981 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    100969981 (PIK3R2)
   05415 Diabetic cardiomyopathy
    100969981 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100969981 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100969981 (PIK3R2)
   04931 Insulin resistance
    100969981 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100969981 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100969981 (PIK3R2)
   01524 Platinum drug resistance
    100969981 (PIK3R2)
   01522 Endocrine resistance
    100969981 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100969981 (PIK3R2)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100969981 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 100969981
NCBI-ProteinID: XP_034802759
Ensembl: ENSPPAG00000028206
LinkDB
Position
20:23013784..23031178
AA seq 728 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggcg
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacacggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
ccgtcctcgccgccgccagggggcgctcccgacgggagtgagcccagccctgacttcccg
gcgctgctggtggagaagctgcttcaggaacacttggaagagcaggaggttgcgccccca
gcgctgccgcctaaaccccccaaggcaaagccggcccccacagtcctggccaatggaggg
agcccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtg
aacgagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaag
atccagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtc
ttccaccgagatgggcactatggcttctcagagccactcaccttctgctccgttgtggac
ctcatcaatcactaccgccacgagtctctggcccagtacaacgccaagctggacacacgg
ctcctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggacagtgtggag
gcagtgggcgcccagcttaaggtctatcaccagcagtaccaggacaagagccgcgagtat
gaccagctttatgaagagtacacacggacctcccaggagctgcagatgaagcgtactgca
attgaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaaa
tgcagcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcaaagg
atcctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacg
aagctggagcagcagctgcgggcccaggcctcggacaacagagagatcgacaagcgcatg
aacagcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtgg
ctcacccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgag
actgaggaccagtacgcactcatggaggacgaggacgatctcccgcaccacgaggaacgc
acttggtacgtgggcaagatcaaccgcacgcaggcagaggagatgttgagcggcaagcgg
gatggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtggta
gtggacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcg
gagccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcg
ctggtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgccccgggc
cccggcccgccgcctgccgcccgctga

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