KEGG   Pan paniscus (bonobo): 100977025
Entry
100977025         CDS       T02283                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X3
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04022  cGMP-PKG signaling pathway
pps04024  cAMP signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04148  Efferocytosis
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04210  Apoptosis
pps04218  Cellular senescence
pps04270  Vascular smooth muscle contraction
pps04370  VEGF signaling pathway
pps04371  Apelin signaling pathway
pps04517  IgSF CAM signaling
pps04540  Gap junction
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04720  Long-term potentiation
pps04722  Neurotrophin signaling pathway
pps04730  Long-term depression
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04912  GnRH signaling pathway
pps04915  Estrogen signaling pathway
pps04916  Melanogenesis
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04921  Oxytocin signaling pathway
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04934  Cushing syndrome
pps04935  Growth hormone synthesis, secretion and action
pps05010  Alzheimer disease
pps05022  Pathways of neurodegeneration - multiple diseases
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05170  Human immunodeficiency virus 1 infection
pps05200  Pathways in cancer
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05216  Thyroid cancer
pps05218  Melanoma
pps05219  Bladder cancer
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100977025 (MAP2K2)
   04012 ErbB signaling pathway
    100977025 (MAP2K2)
   04014 Ras signaling pathway
    100977025 (MAP2K2)
   04015 Rap1 signaling pathway
    100977025 (MAP2K2)
   04370 VEGF signaling pathway
    100977025 (MAP2K2)
   04371 Apelin signaling pathway
    100977025 (MAP2K2)
   04066 HIF-1 signaling pathway
    100977025 (MAP2K2)
   04068 FoxO signaling pathway
    100977025 (MAP2K2)
   04072 Phospholipase D signaling pathway
    100977025 (MAP2K2)
   04071 Sphingolipid signaling pathway
    100977025 (MAP2K2)
   04024 cAMP signaling pathway
    100977025 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    100977025 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    100977025 (MAP2K2)
   04150 mTOR signaling pathway
    100977025 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    100977025 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100977025 (MAP2K2)
   04148 Efferocytosis
    100977025 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    100977025 (MAP2K2)
   04218 Cellular senescence
    100977025 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100977025 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100977025 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100977025 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100977025 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    100977025 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    100977025 (MAP2K2)
   04660 T cell receptor signaling pathway
    100977025 (MAP2K2)
   04662 B cell receptor signaling pathway
    100977025 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    100977025 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100977025 (MAP2K2)
   04929 GnRH secretion
    100977025 (MAP2K2)
   04912 GnRH signaling pathway
    100977025 (MAP2K2)
   04915 Estrogen signaling pathway
    100977025 (MAP2K2)
   04917 Prolactin signaling pathway
    100977025 (MAP2K2)
   04921 Oxytocin signaling pathway
    100977025 (MAP2K2)
   04926 Relaxin signaling pathway
    100977025 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    100977025 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    100977025 (MAP2K2)
   04916 Melanogenesis
    100977025 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100977025 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    100977025 (MAP2K2)
   04730 Long-term depression
    100977025 (MAP2K2)
   04722 Neurotrophin signaling pathway
    100977025 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100977025 (MAP2K2)
   05206 MicroRNAs in cancer
    100977025 (MAP2K2)
   05205 Proteoglycans in cancer
    100977025 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    100977025 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100977025 (MAP2K2)
   05230 Central carbon metabolism in cancer
    100977025 (MAP2K2)
   05231 Choline metabolism in cancer
    100977025 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100977025 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100977025 (MAP2K2)
   05225 Hepatocellular carcinoma
    100977025 (MAP2K2)
   05226 Gastric cancer
    100977025 (MAP2K2)
   05214 Glioma
    100977025 (MAP2K2)
   05216 Thyroid cancer
    100977025 (MAP2K2)
   05221 Acute myeloid leukemia
    100977025 (MAP2K2)
   05220 Chronic myeloid leukemia
    100977025 (MAP2K2)
   05218 Melanoma
    100977025 (MAP2K2)
   05211 Renal cell carcinoma
    100977025 (MAP2K2)
   05219 Bladder cancer
    100977025 (MAP2K2)
   05215 Prostate cancer
    100977025 (MAP2K2)
   05213 Endometrial cancer
    100977025 (MAP2K2)
   05224 Breast cancer
    100977025 (MAP2K2)
   05223 Non-small cell lung cancer
    100977025 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100977025 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    100977025 (MAP2K2)
   05161 Hepatitis B
    100977025 (MAP2K2)
   05160 Hepatitis C
    100977025 (MAP2K2)
   05164 Influenza A
    100977025 (MAP2K2)
   05163 Human cytomegalovirus infection
    100977025 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100977025 (MAP2K2)
   05165 Human papillomavirus infection
    100977025 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100977025 (MAP2K2)
   05135 Yersinia infection
    100977025 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100977025 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    100977025 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100977025 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100977025 (MAP2K2)
   01522 Endocrine resistance
    100977025 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100977025 (MAP2K2)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100977025 (MAP2K2)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: STE group
  STE7 family
   100977025 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 100977025
NCBI-ProteinID: XP_034802562
LinkDB
Position
20:complement(8488392..8523027)
AA seq 400 aa
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccctaccatcgccgag
ggcccatcccctaccagcgagggcgcctccgaggcaaacctggtggacctgcagaagaag
ctggaggagctggaacttgacgagcagcagaagaagcggctggaagcctttctcacccag
aaagccaaggtcggcgaactcaaagacgatgacttcgaaaggatctcagagctgggcgcg
ggcaacggcggggtggtcaccaaagtccagcacagaccctcgggcctcatcatggccagg
aagctgatccaccttgagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtcctgcacgaatgcaactcgccgtacatcgtgggcttctacggggccttctacagtgac
ggggagatcagcatctgtatggaacacatggatggcggctccctggaccaggtgctaaaa
gaggccaagaggattcccgaggagatcctggggaaagtcagcatcgcggttctccggggc
ttggcgtacctccgagagaagcaccagatcatgcaccgagatgtgaagccctccaacatc
ctcgtgaactctagaggggagatcaagctgtgtgacttcggggtgagcggccagctcatc
gactccatggccaactccttcgtgggcacgcgctcctacatggctccggagcggttgcag
ggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
gccgtcggaaggtaccccatccccccgcccgacgccaaagagctggaggccatctttggc
cggcccgtggtcgacggggaagaaggagagcctcacagcatctcgcctcggccgaggccc
cccgggcgccccgtcagcggtcacgggatggatagccggcccgccatggccatctttgaa
ctcctggactatattgtgaacgagccgcctcctaagctgcccaacggtgtgttcaccccc
gacttccaggagtttgtcaataaatgcctcatcaagaacccagcggagcgggcggacctg
aagatgctcacaaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaaccctgcggctgaaccagcccggcacacccacgcgcaccgccgtg
tga

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