KEGG   Pan paniscus (bonobo): 100983009
Entry
100983009         CDS       T02283                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00140  Steroid hormone biosynthesis
pps01100  Metabolic pathways
pps04913  Ovarian steroidogenesis
pps04925  Aldosterone synthesis and secretion
pps04927  Cortisol synthesis and secretion
pps04934  Cushing syndrome
Module
pps_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
pps_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
pps_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pps_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100983009
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100983009
   04925 Aldosterone synthesis and secretion
    100983009
   04927 Cortisol synthesis and secretion
    100983009
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100983009
Enzymes [BR:pps01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100983009
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100983009
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind KR NmrA Ldh_1_N Sacchrp_dh_NADP Ilm1 Semialdhyde_dh
Other DBs
NCBI-GeneID: 100983009
NCBI-ProteinID: XP_003806349
Ensembl: ENSPPAG00000028838
LinkDB
Position
1:112123869..112131658
AA seq 375 aa
MAMTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFRPELREEFSKLQNKTKLTV
LEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVP
VFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASVNEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALR
ALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSLPLSLMYWIGFLL
EIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVG
SLVDRHKENLKSKTQ
NT seq 1128 nt   +upstreamnt  +downstreamnt
atggccatgacgggctggagctgccttgtgacaggagcaggagggtttctgggacagagg
atcatccgcctcttggtgaaggagaaggagctgaaggagatcagggtcttggacaaggcc
ttcagaccagaattgagagaggaattttctaaactccagaacaagaccaagctgacagtg
ctggaaggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtc
atcatccacaccgcctgtatcattgatgtctttggtgtcactcacagggagtctatcatg
aatgtcaatgtgaaaggtacccagctcctgttagaggcctgtgtccaagctagtgtgcca
gtcttcatctacaccagtagcatagaggtagccgggcccaactcctacaaggaaatcatc
cagaatggccacgaagaagagcctctggaaaacacatggcccgctccatacccacacagc
aaaaagcttgctgagaaggctgtgctggcggctaatgggtggaatctgaaaaacggcggc
accctgtacacttgtgccttacgacccatgtatatctatggggaaggaagccgattcctt
tctgctagtgtaaatgaggccctgaacaacaatgggatcctgtcaagtgttggaaagttc
tccactgttaacccagtctatgttggcaatgtggcctgggcccacattctggccttgagg
gccctgcaggaccccaagaaggccccaagcatccgaggacagttctactatatctcagat
gacacgcctcaccaaagctatgataaccttaattacaccctgagcaaagagttcggcctc
cgccttgattccagatggagccttcctttatccctgatgtattggattggcttcctgctg
gaaatagtgagcttcctactcaggccaatttacacctatcgaccgcccttcaaccgccac
atagtcacattgtcaaatagcgtattcaccttctcttataagaaggctcagcgagatctg
gcatataagccactctacagctgggaggaagccaagcagaaaacggtggagtgggttggt
tcccttgtggaccggcacaaggagaacctgaagtccaagactcagtga

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